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Volumn 8, Issue 12, 2007, Pages 1142-1148

Interleukin 2: From immunostimulation to immunoregulation and back again

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; FAS LIGAND; FK 506 BINDING PROTEIN; FLICE INHIBITORY PROTEIN; GAMMA INTERFERON; INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 2 RECEPTOR BETA; INTERLEUKIN 2 RECEPTOR GAMMA; JANUS KINASE 1; JANUS KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN KINASE LCK; PROTEIN KINASE SYK; RAF PROTEIN; RAS PROTEIN; S6 KINASE; STAT5 PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA;

EID: 36749041328     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/sj.embor.7401099     Document Type: Review
Times cited : (225)

References (83)
  • 1
    • 0141595965 scopus 로고    scopus 로고
    • The control of T cell activation vs. tolerance
    • Abbas AK (2003) The control of T cell activation vs. tolerance. Autoimmun Rev 2: 115-118
    • (2003) Autoimmun Rev , vol.2 , pp. 115-118
    • Abbas, A.K.1
  • 3
    • 0036668240 scopus 로고    scopus 로고
    • Balancing protective immunity and immunopathology
    • Bachmann MF, Kopf M (2002) Balancing protective immunity and immunopathology. Curr Opin Immunol 14: 413-419
    • (2002) Curr Opin Immunol , vol.14 , pp. 413-419
    • Bachmann, M.F.1    Kopf, M.2
  • 7
    • 34250787647 scopus 로고    scopus 로고
    • Differential role of IL-2R signaling for CD8(+)T cell responses in acute and chronic viral infections
    • Bachmann MF, Wolint P, Walton S, Schwarz K, Oxenius A (2007) Differential role of IL-2R signaling for CD8(+)T cell responses in acute and chronic viral infections. Eur J Immunol 37: 1502-1512
    • (2007) Eur J Immunol , vol.37 , pp. 1502-1512
    • Bachmann, M.F.1    Wolint, P.2    Walton, S.3    Schwarz, K.4    Oxenius, A.5
  • 8
    • 0028363377 scopus 로고
    • The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells
    • Bamford RN, Grant AJ, Burton JD, Peters C, Kurys G, Goldman CK, Brennan J, Roessler E, Waldmann TA (1994) The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc Natl Acad Sci USA 91 4940-4944
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4940-4944
    • Bamford, R.N.1    Grant, A.J.2    Burton, J.D.3    Peters, C.4    Kurys, G.5    Goldman, C.K.6    Brennan, J.7    Roessler, E.8    Waldmann, T.A.9
  • 10
    • 33645465526 scopus 로고    scopus 로고
    • Selective stimulation of T cell subsets with antibody-cytokine immune complexes
    • Boyman O, Kovar M, Rubinstein MP, Surh CD, Sprent J (2006) Selective stimulation of T cell subsets with antibody-cytokine immune complexes. Science 311: 1924-1927
    • (2006) Science , vol.311 , pp. 1924-1927
    • Boyman, O.1    Kovar, M.2    Rubinstein, M.P.3    Surh, C.D.4    Sprent, J.5
  • 12
    • 0028983657 scopus 로고
    • Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas
    • Brunner T et al (1995) Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature 373: 441-444
    • (1995) Nature , vol.373 , pp. 441-444
    • Brunner, T.1
  • 15
    • 33745837261 scopus 로고    scopus 로고
    • Differential regulation of T-cell growth by IL-2 and IL-15
    • Cornish GH, Sinclair LV, Cantrell DA (2006) Differential regulation of T-cell growth by IL-2 and IL-15. Blood 108: 600-608
    • (2006) Blood , vol.108 , pp. 600-608
    • Cornish, G.H.1    Sinclair, L.V.2    Cantrell, D.A.3
  • 16
    • 85176694809 scopus 로고    scopus 로고
    • Cousens LP, Orange J5, Biron CA (1995) Endogenous IL-2 contributes to T cell expansion and IFN-γ production during lymphocytic choriomeningitis virus infection. J Immunol 155: 5690-5699
    • Cousens LP, Orange J5, Biron CA (1995) Endogenous IL-2 contributes to T cell expansion and IFN-γ production during lymphocytic choriomeningitis virus infection. J Immunol 155: 5690-5699
  • 17
    • 27544446622 scopus 로고    scopus 로고
    • + regulatory T cells in the absence of interleukin 2 signaling
    • + regulatory T cells in the absence of interleukin 2 signaling. Nat Immunol 6: 1152-1159
    • (2005) Nat Immunol , vol.6 , pp. 1152-1159
    • D'Cruz, L.M.1    Klein, L.2
  • 18
    • 0345447666 scopus 로고    scopus 로고
    • IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion
    • D'Souza WN, Lefrancois L (2003) IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion. J Immunol 171: 5727-5735
    • (2003) J Immunol , vol.171 , pp. 5727-5735
    • D'Souza, W.N.1    Lefrancois, L.2
  • 19
    • 0036604208 scopus 로고    scopus 로고
    • Essential role for IL-2 in the regulation of antiviral extralymphoid CD8 T cell responses
    • D'Souza WN, Schluns KS, Masopust D, Lefrancois L (2002) Essential role for IL-2 in the regulation of antiviral extralymphoid CD8 T cell responses. J Immunol 168: 5566-5572
    • (2002) J Immunol , vol.168 , pp. 5566-5572
    • D'Souza, W.N.1    Schluns, K.S.2    Masopust, D.3    Lefrancois, L.4
  • 23
    • 33947394423 scopus 로고    scopus 로고
    • + T cell memory by promoting the generation of IL-7R α-expressing cells
    • + T cell memory by promoting the generation of IL-7R α-expressing cells. J Exp Med 204: 547-557
    • (2007) J Exp Med , vol.204 , pp. 547-557
    • Dooms, H.1    Wolslegel, K.2    Lin, P.3    Abbas, A.K.4
  • 24
    • 0036826914 scopus 로고    scopus 로고
    • IL-15Rα recycles and presents IL-15 in trans to neighboring cells
    • Dubois S, Mariner J, Waldmann TA, Tagaya Y (2002) IL-15Rα recycles and presents IL-15 in trans to neighboring cells. Immunity 17 537-547
    • (2002) Immunity , vol.17 , pp. 537-547
    • Dubois, S.1    Mariner, J.2    Waldmann, T.A.3    Tagaya, Y.4
  • 25
    • 0344198591 scopus 로고    scopus 로고
    • Distinct pathways involving the FK506-binding proteins 12 and 12.6 underlie IL-2-versus IL-15-mediated proliferation of T cells
    • Dubois S, Shou W, Haneline LS, Fleischer S, Waldmann TA, Muller JR (2003) Distinct pathways involving the FK506-binding proteins 12 and 12.6 underlie IL-2-versus IL-15-mediated proliferation of T cells. Proc Natl Acad Sci USA 100: 14169-14174
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 14169-14174
    • Dubois, S.1    Shou, W.2    Haneline, L.S.3    Fleischer, S.4    Waldmann, T.A.5    Muller, J.R.6
  • 27
    • 27544481941 scopus 로고    scopus 로고
    • A function for interleukin 2 in Foxp3-expressing regulatory T cells
    • Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY (2005) A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 6: 1142-1151
    • (2005) Nat Immunol , vol.6 , pp. 1142-1151
    • Fontenot, J.D.1    Rasmussen, J.P.2    Gavin, M.A.3    Rudensky, A.Y.4
  • 28
    • 0017402665 scopus 로고
    • Long term culture of tumour-specific cytotoxic T cells
    • Gillis S, Smith KA (1977) Long term culture of tumour-specific cytotoxic T cells. Nature 268: 154-156
    • (1977) Nature , vol.268 , pp. 154-156
    • Gillis, S.1    Smith, K.A.2
  • 29
    • 0018077309 scopus 로고
    • Long-term culture of human antigen-specific cytotoxic T-cell lines
    • Gillis S, Baker PE, Ruscetti FW, Smith KA (1978) Long-term culture of human antigen-specific cytotoxic T-cell lines. J Exp Med 148 1093-1098
    • (1978) J Exp Med , vol.148 , pp. 1093-1098
    • Gillis, S.1    Baker, P.E.2    Ruscetti, F.W.3    Smith, K.A.4
  • 33
    • 34547824186 scopus 로고    scopus 로고
    • + T cells differentiate into protective memory-like cells after IL-2 anti IL-2 complex treatment in vivo
    • + T cells differentiate into protective memory-like cells after IL-2 anti IL-2 complex treatment in vivo. J Exp Med 204: 1803-1812
    • (2007) J Exp Med , vol.204 , pp. 1803-1812
    • Kamimura, D.1    Bevan, M.J.2
  • 35
    • 0020077493 scopus 로고
    • Helper activity is required for the in vivo generation of cytotoxic T lymphocytes
    • Keene JA, Forman J (1982) Helper activity is required for the in vivo generation of cytotoxic T lymphocytes. J Exp Med 155: 768-782
    • (1982) J Exp Med , vol.155 , pp. 768-782
    • Keene, J.A.1    Forman, J.2
  • 36
    • 0031965469 scopus 로고    scopus 로고
    • A natural immunological adjuvant enhances T cell clonal expansion through a CD28-dependent, interleukin (IL)-2-independent mechanism
    • Khoruts A, Mondino A, Pape KA, Reiner SL, Jenkins MK (1998) A natural immunological adjuvant enhances T cell clonal expansion through a CD28-dependent, interleukin (IL)-2-independent mechanism. J Exp Med 187: 225-236
    • (1998) J Exp Med , vol.187 , pp. 225-236
    • Khoruts, A.1    Mondino, A.2    Pape, K.A.3    Reiner, S.L.4    Jenkins, M.K.5
  • 38
    • 0029118133 scopus 로고
    • Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice
    • Kneitz B, Herrmann T, Yonehara S, Schimpl A (1995) Normal clonal expansion but impaired Fas-mediated cell death and anergy induction in interleukin-2-deficient mice. Eur J Immunol 25: 2572-2577
    • (1995) Eur J Immunol , vol.25 , pp. 2572-2577
    • Kneitz, B.1    Herrmann, T.2    Yonehara, S.3    Schimpl, A.4
  • 39
    • 9644295710 scopus 로고    scopus 로고
    • Cytokines and immunodeficiency diseases: Critical roles of the γ(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways
    • Kovanen PE, Leonard WJ (2004) Cytokines and immunodeficiency diseases: critical roles of the γ(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways. Immunol Rev 202: 67-83
    • (2004) Immunol Rev , vol.202 , pp. 67-83
    • Kovanen, P.E.1    Leonard, W.J.2
  • 40
    • 0028142358 scopus 로고
    • Thymic selection and peptide-induced activation of T cell receptor-transgenic CD8 T cells in interleukin-2-deficient mice
    • Kramer S, Mamalaki C, Horak I, Schimpl A, Kioussis D, Hung T (1994) Thymic selection and peptide-induced activation of T cell receptor-transgenic CD8 T cells in interleukin-2-deficient mice. Eur J Immunol 24: 2317-2322
    • (1994) Eur J Immunol , vol.24 , pp. 2317-2322
    • Kramer, S.1    Mamalaki, C.2    Horak, I.3    Schimpl, A.4    Kioussis, D.5    Hung, T.6
  • 41
    • 0034641898 scopus 로고    scopus 로고
    • CD95s deadly mission in the immune system
    • Krammer PH (2000) CD95s deadly mission in the immune system. Nature 407: 789-795
    • (2000) Nature , vol.407 , pp. 789-795
    • Krammer, P.H.1
  • 45
    • 33947162110 scopus 로고    scopus 로고
    • Interleukin-2 signaling via STATS constrains T helper 17 cell generation
    • Laurence A et al (2007) Interleukin-2 signaling via STATS constrains T helper 17 cell generation. Immunity 26: 371-381
    • (2007) Immunity , vol.26 , pp. 371-381
    • Laurence, A.1
  • 46
    • 0026017971 scopus 로고
    • Interleukin-2 programs mouse αβ T lymphocytes for apoptosis
    • Lenardo MJ (1991) Interleukin-2 programs mouse αβ T lymphocytes for apoptosis. Nature 353: 858-861
    • (1991) Nature , vol.353 , pp. 858-861
    • Lenardo, M.J.1
  • 47
    • 0021193219 scopus 로고
    • Molecular cloning and expression of cDNAs for the human interleukin-2 receptor
    • Leonard WJ et al (1984) Molecular cloning and expression of cDNAs for the human interleukin-2 receptor. Nature 311: 626-631
    • (1984) Nature , vol.311 , pp. 626-631
    • Leonard, W.J.1
  • 48
    • 33646186619 scopus 로고    scopus 로고
    • Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis
    • Ma A, Koka R, Burkett P (2006) Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis. Annu Rev Immunol 24: 657-679
    • (2006) Annu Rev Immunol , vol.24 , pp. 657-679
    • Ma, A.1    Koka, R.2    Burkett, P.3
  • 49
    • 0034654319 scopus 로고    scopus 로고
    • Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors
    • Malek TR, Porter BO, Codias EK, Scibelli P, Yu A (2000) Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors. J Immunol 164: 2905-2914
    • (2000) J Immunol , vol.164 , pp. 2905-2914
    • Malek, T.R.1    Porter, B.O.2    Codias, E.K.3    Scibelli, P.4    Yu, A.5
  • 50
    • 0035253708 scopus 로고    scopus 로고
    • Broad programming by IL-2 receptor signaling for extended growth to multiple cytokines and functional maturation of antigen-activated T cells
    • Malek TR, Yu A, Scibelli P, Lichtenheld MG, Codias EK (2001) Broad programming by IL-2 receptor signaling for extended growth to multiple cytokines and functional maturation of antigen-activated T cells. J Immunol 166: 1675-1683
    • (2001) J Immunol , vol.166 , pp. 1675-1683
    • Malek, T.R.1    Yu, A.2    Scibelli, P.3    Lichtenheld, M.G.4    Codias, E.K.5
  • 51
    • 0036669298 scopus 로고    scopus 로고
    • CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rβ-deficient mice. Implications for the nonredundant function of IL-2
    • Malek TR, Yu A, Vincek V, Scibelli P, Kong L (2002) CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rβ-deficient mice. Implications for the nonredundant function of IL-2. Immunity 17 167-178
    • (2002) Immunity , vol.17 , pp. 167-178
    • Malek, T.R.1    Yu, A.2    Vincek, V.3    Scibelli, P.4    Kong, L.5
  • 53
    • 0017199306 scopus 로고
    • Selective in vitro growth of T lymphocytes from normal human bone marrow
    • Morgan DA, Ruscetti FW, Gallo RC (1976) Selective in vitro growth of T lymphocytes from normal human bone marrow. Science 193: 1007-1009
    • (1976) Science , vol.193 , pp. 1007-1009
    • Morgan, D.A.1    Ruscetti, F.W.2    Gallo, R.C.3
  • 55
    • 33745861718 scopus 로고    scopus 로고
    • Epigenetic remodeling of the IL-2 and IFN-γ loci in memory CD8 T cells is influenced by CD4 T cells
    • Northrop JK, Thomas RM, Wells AD, Shen H (2006) Epigenetic remodeling of the IL-2 and IFN-γ loci in memory CD8 T cells is influenced by CD4 T cells. J Immunol 177: 1062-1069
    • (2006) J Immunol , vol.177 , pp. 1062-1069
    • Northrop, J.K.1    Thomas, R.M.2    Wells, A.D.3    Shen, H.4
  • 56
    • 7144259082 scopus 로고    scopus 로고
    • Regulatory CD4 T cells: Expression of IL-2R a chain, resistance to clonal deletion and IL-2 dependency
    • Papiernik M, de Moraes ML, Pontoux C,Vasseur F, Penit C (1998) Regulatory CD4 T cells: Expression of IL-2R a chain, resistance to clonal deletion and IL-2 dependency. Int Immunol 10: 371-378
    • (1998) Int Immunol , vol.10 , pp. 371-378
    • Papiernik, M.1    de Moraes, M.L.2    Pontoux, C.3    Vasseur, F.4    Penit, C.5
  • 57
    • 0031725323 scopus 로고    scopus 로고
    • Molecular regulation of interleukin-2 expression by CD28 co-stimulation and anergy
    • Powell JD, Ragheb JA, Kitagawa-Sakakida S, Schwartz RH (1998) Molecular regulation of interleukin-2 expression by CD28 co-stimulation and anergy. Immunol Rev 165: 287-300
    • (1998) Immunol Rev , vol.165 , pp. 287-300
    • Powell, J.D.1    Ragheb, J.A.2    Kitagawa-Sakakida, S.3    Schwartz, R.H.4
  • 58
    • 17544398702 scopus 로고    scopus 로고
    • Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis
    • Refaeli Y, Van Parijs L, London CA, Tschopp J, Abbas AK (1998) Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis. Immunity 8: 615-623
    • (1998) Immunity , vol.8 , pp. 615-623
    • Refaeli, Y.1    Van Parijs, L.2    London, C.A.3    Tschopp, J.4    Abbas, A.K.5
  • 59
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • Sadlack B, Merz H, Schorle H, Schimpl A, Feller AC, Horak I (1993) Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75: 253-261
    • (1993) Cell , vol.75 , pp. 253-261
    • Sadlack, B.1    Merz, H.2    Schorle, H.3    Schimpl, A.4    Feller, A.C.5    Horak, I.6
  • 60
    • 9144241114 scopus 로고    scopus 로고
    • Cutting edge: Transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15R α by the same cells
    • Sandau MM, Schluns KS, Lefrancois L, Jameson SC (2004) Cutting edge: transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15R α by the same cells. J Immunol 173: 6537-6541
    • (2004) J Immunol , vol.173 , pp. 6537-6541
    • Sandau, M.M.1    Schluns, K.S.2    Lefrancois, L.3    Jameson, S.C.4
  • 62
    • 0025899598 scopus 로고
    • Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting
    • Schorle H, Holtschke T, Hunig T, Schimpl A, Horak I (1991) Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352: 621-624
    • (1991) Nature , vol.352 , pp. 621-624
    • Schorle, H.1    Holtschke, T.2    Hunig, T.3    Schimpl, A.4    Horak, I.5
  • 63
    • 0030056468 scopus 로고    scopus 로고
    • Models of T cell anergy: Is there a common molecular mechanism? J Exp Med
    • 11996
    • Schwartz RH (11996) Models of T cell anergy: Is there a common molecular mechanism? J Exp Med 184: 1-8
    • , vol.184 , pp. 1-8
    • Schwartz, R.H.1
  • 65
    • 0037432787 scopus 로고    scopus 로고
    • Requirement for CD4 T cell help in generating functional CD8T cell memory
    • Shedlock DJ, Shen H (2003) Requirement for CD4 T cell help in generating functional CD8T cell memory. Science 300: 337-339
    • (2003) Science , vol.300 , pp. 337-339
    • Shedlock, D.J.1    Shen, H.2
  • 66
    • 0023907493 scopus 로고
    • Interleukin-2: Inception, impact, and implications
    • Smith KA (1988) Interleukin-2: Inception, impact, and implications. Science 240: 1169-1176
    • (1988) Science , vol.240 , pp. 1169-1176
    • Smith, K.A.1
  • 67
    • 0019197783 scopus 로고
    • Lymphocyte activating factor promotes T-cell growth factor production by cloned murine lymphoma cells
    • Smith KA, Gilbride KJ, Favata MF (1980) Lymphocyte activating factor promotes T-cell growth factor production by cloned murine lymphoma cells. Nature 287: 853-855
    • (1980) Nature , vol.287 , pp. 853-855
    • Smith, K.A.1    Gilbride, K.J.2    Favata, M.F.3
  • 68
    • 0037432776 scopus 로고    scopus 로고
    • Defective CD8T cell memory following acute infection without CD4 T cell help
    • Sun JC, Bevan MJ (2003) Defective CD8T cell memory following acute infection without CD4 T cell help. Science 300: 339-342
    • (2003) Science , vol.300 , pp. 339-342
    • Sun, J.C.1    Bevan, M.J.2
  • 69
    • 0029028363 scopus 로고
    • Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor β
    • Suzuki H et al (1995) Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor β. Science 268: 1472-1476
    • (1995) Science , vol.268 , pp. 1472-1476
    • Suzuki, H.1
  • 70
    • 0342632839 scopus 로고    scopus 로고
    • Normal regulatory a/β T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor β in vivo
    • Suzuki H, Zhou YW, Kato M, Mak TW, Nakashima I (1999) Normal regulatory a/β T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor β in vivo. J Exp Med 190: 1561-1572
    • (1999) J Exp Med , vol.190 , pp. 1561-1572
    • Suzuki, H.1    Zhou, Y.W.2    Kato, M.3    Mak, T.W.4    Nakashima, I.5
  • 72
    • 17044410174 scopus 로고    scopus 로고
    • Signals from CD28 induce stable epigenetic modification of the IL-2 promoter
    • Thomas RM, Gao L, Wells AD (2005) Signals from CD28 induce stable epigenetic modification of the IL-2 promoter. J Immunol 174: 4639-4646
    • (2005) J Immunol , vol.174 , pp. 4639-4646
    • Thomas, R.M.1    Gao, L.2    Wells, A.D.3
  • 73
    • 0028568313 scopus 로고
    • T lymphocyte-mediated antiviral immune responses in mice are diminished by treatment with monoclonal antibody directed against the interleukin-2 receptor
    • Utermohlen O, Tarnok A, Bonig L, Lehmann-Grube F (1994) T lymphocyte-mediated antiviral immune responses in mice are diminished by treatment with monoclonal antibody directed against the interleukin-2 receptor. Eur J Immunol 24: 3093-3099
    • (1994) Eur J Immunol , vol.24 , pp. 3093-3099
    • Utermohlen, O.1    Tarnok, A.2    Bonig, L.3    Lehmann-Grube, F.4
  • 74
    • 0031569514 scopus 로고    scopus 로고
    • Functional responses and apoptosis of CD25 (IL-2R α -deficient T cells expressing a transgenic antigen receptor
    • Van Parijs L, Biuckians A, Ibragimov A, Alt FW, Willerford DM, Abbas AK (1997) Functional responses and apoptosis of CD25 (IL-2R α -deficient T cells expressing a transgenic antigen receptor. J Immunol 158 3738-3745
    • (1997) J Immunol , vol.158 , pp. 3738-3745
    • Van Parijs, L.1    Biuckians, A.2    Ibragimov, A.3    Alt, F.W.4    Willerford, D.M.5    Abbas, A.K.6
  • 75
    • 0032031457 scopus 로고    scopus 로고
    • Functional roles of Fas and Bcl-2-regulated apoptosis of T lymphocytes
    • Van Parijs L, Biuckians A, Abbas AK (1998) Functional roles of Fas and Bcl-2-regulated apoptosis of T lymphocytes. J Immunol 160: 2065-2071
    • (1998) J Immunol , vol.160 , pp. 2065-2071
    • Van Parijs, L.1    Biuckians, A.2    Abbas, A.K.3
  • 77
    • 33746547247 scopus 로고    scopus 로고
    • The biology of interieukin-2 and interleukin-15: Implications for cancer therapy and vaccine design
    • Waldmann TA (2006) The biology of interieukin-2 and interleukin-15: implications for cancer therapy and vaccine design. Nat Rev Immunol 6: 595-601
    • (2006) Nat Rev Immunol , vol.6 , pp. 595-601
    • Waldmann, T.A.1
  • 78
    • 0035102242 scopus 로고    scopus 로고
    • Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: Implications for immunotherapy
    • Waldmann TA, Dubois S, Tagaya Y (2001) Contrasting roles of IL-2 and IL-15 in the life and death of lymphocytes: Implications for immunotherapy. Immunity 14: 105-110
    • (2001) Immunity , vol.14 , pp. 105-110
    • Waldmann, T.A.1    Dubois, S.2    Tagaya, Y.3
  • 79
    • 0028784289 scopus 로고
    • Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment
    • Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt FW (1995) Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3: 521-530
    • (1995) Immunity , vol.3 , pp. 521-530
    • Willerford, D.M.1    Chen, J.2    Ferry, J.A.3    Davidson, L.4    Ma, A.5    Alt, F.W.6
  • 81
    • 0034965185 scopus 로고    scopus 로고
    • Control of T cell hyperactivation in IL-2-deficient mice by CD4(+)CD25(-) and CD4(+)CD25(+) T cells: Evidence for two distinct regulatory mechanisms
    • Wolf M, Schimpl A, Hunig T (2001) Control of T cell hyperactivation in IL-2-deficient mice by CD4(+)CD25(-) and CD4(+)CD25(+) T cells: Evidence for two distinct regulatory mechanisms. Eur J Immunol 31: 1637-1645
    • (2001) Eur J Immunol , vol.31 , pp. 1637-1645
    • Wolf, M.1    Schimpl, A.2    Hunig, T.3
  • 82
    • 0037222183 scopus 로고    scopus 로고
    • Efficient induction of primary and secondary T cell-dependent immune responses in vivo in the absence of functional IL-2 and IL-15 receptors
    • Yu A, Zhou J, Marten N, Bergmann CC, Mammolenti M, Levy RB, Malek TR (2003) Efficient induction of primary and secondary T cell-dependent immune responses in vivo in the absence of functional IL-2 and IL-15 receptors. J Immunol 170: 236-242
    • (2003) J Immunol , vol.170 , pp. 236-242
    • Yu, A.1    Zhou, J.2    Marten, N.3    Bergmann, C.C.4    Mammolenti, M.5    Levy, R.B.6    Malek, T.R.7
  • 83
    • 0031975910 scopus 로고    scopus 로고
    • T cell growth cytokines cause the superinduction of molecules mediating antigen-induced T lymphocyte death
    • Zheng L, Trageser CL, Willerford DM, Lenardo MJ (1998) T cell growth cytokines cause the superinduction of molecules mediating antigen-induced T lymphocyte death. J Immunol 160: 763-769
    • (1998) J Immunol , vol.160 , pp. 763-769
    • Zheng, L.1    Trageser, C.L.2    Willerford, D.M.3    Lenardo, M.J.4


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