Inflammation in anxiety

Advances in Protein Chemistry and Structural Biology

Volumn 88, Issue , 2012, Pages 1-25

  Salim, Samina ^a   Chugh, Gaurav ^a   Asghar, Mohammad ^a  

^a UNIVERSITY OF HOUSTON   (United States)

Author keywords

Antioxidants; Anxiety; Inflammation; Oxidative stress

Indexed keywords

EID: 84863916269     PISSN: 18761623     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-398314-5.00001-5     Document Type: Chapter

References (152)

1. S.M. Allan, and N.J. Rothwell Inflammation in central nervous system injury Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 358 2003 1669 1677 (Pubitemid 37298635)
2. H. Anisman, A.V. Ravindran, J. Griffiths, and Z. Merali Endocrine and cytokine correlates of major depression and dysthymia with typical or atypical features Molecular Psychiatry 4 1999 182 188 (Pubitemid 29163982)
3. J. Apelt, M. Bigl, P. Wunderlich, and R. Schliebs Aging-related increase in oxidative stress correlates with developmental pattern of beta-secretase activity and beta-amyloid plaque formation in transgenic Tg2576 mice with Alzheimer-like pathology International Journal of Developmental Neuroscience 22 2004 475 484 (Pubitemid 39311436)
4. L. Arranz, N. Guayerbas, and M. De la Fuente Impairment of several immune functions in anxious women Journal of Psychosomatic Research 62 2007 1 8 (Pubitemid 44937349)
5. H. Aviles, M.T. Johnson, and F.P. Monroy Effects of cold stress on spleen cell proliferation and cytokine production during chronic Toxoplasma gondii infection Neuroimmunomodulation 11 2004 93 102 (Pubitemid 38182777)
6. S. Barra, A. Vitagliano, V. Cuomo, G. Vitagliano, and G. Gaeta Vascular and metabolic effects of angiotensin II receptor blockers Expert Opinion on Pharmacotherapy 10 2009 173 189
7. H.O. Besedovsky, and A. del Rey Immune-neuro-endocrine interactions: Facts and hypotheses Endocrine Reviews 17 1996 64 102 (Pubitemid 26061368)
8. J.R. Bethea Spinal cord injury-induced inflammation: A dual-edged sword Progress in Brain Research 128 2000 33 42 (Pubitemid 35461224)
9. E.R. Blackmore, J.A. Moynihan, D.R. Rubinow, E.K. Pressman, M. Gilchrist, and T.G. O'Connor Psychiatric symptoms and proinflammatory cytokines in pregnancy Psychosomatic Medicine 73 2011 656 663
10. P. Bob, J. Raboch, M. Maes, M. Susta, J. Pavlat, and D. Jasova Depression, traumatic stress and interleukin-6 Journal of Affective Disorders 120 2010 231 234
11. U. Boer, C. Noll, I. Cierny, D. Krause, C. Hiemke, and W. Knepel A common mechanism of action of the selective serotonin reuptake inhibitors citalopram and fluoxetine: Reversal of chronic psychosocial stress-induced increase in CRE/CREB-directed gene transcription in transgenic reporter gene mice European Journal of Pharmacology 633 2010 33 38
12. L.V. Borovikova, S. Ivanova, M. Zhang, H. Yang, G.I. Botchkina, and L.R. Watkins Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin Nature 405 2000 458 462 (Pubitemid 30367422)
13. J.A. Boscarino Posttraumatic stress disorder and physical illness: Results from clinical and epidemiologic studies Annals of the New York Academy of Sciences 1032 2004 141 153 (Pubitemid 40298466)
14. J. Bouayed, H. Rammal, and R. Soulimani Oxidative stress and anxiety: Relationship and cellular pathways Oxidative Medicine and Cellular Longevity 2 2009 63 67
15. J. Bouayed, H. Rammal, C. Younos, and R. Soulimani Positive correlation between peripheral blood granulocyte oxidative status and level of anxiety in mice European Journal of Pharmacology 564 2007 146 149 (Pubitemid 46957515)
16. J.E. Bower, P.A. Ganz, M.L. Tao, W. Hu, T.R. Belin, and S. Sepah Inflammatory biomarkers and fatigue during radiation therapy for breast and prostate cancer Clinical Cancer Research 15 2009 5534 5540
17. P.S. Brocardo, F. Boehme, A. Patten, A. Cox, J. Gil-Mohapel, and B.R. Christie Anxiety- and depression-like behaviors are accompanied by an increase in oxidative stress in a rat model of fetal alcohol spectrum disorders: Protective effects of voluntary physical exercise Neuropharmacology 62 2012 1607 1618
18. V. Calabrese, T.E. Bates, and A.M. Stella NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: The role of oxidant/antioxidant balance Neurochemical Research 25 2000 1315 1341
19. I.L. Campbell Structural and functional impact of the transgenic expression of cytokines in the CNS Annals of the New York Academy of Sciences 840 1998 83 96 (Pubitemid 28302039)
20. I.L. Campbell Transgenic mice and cytokine actions in the brain: Bridging the gap between structural and functional neuropathology Brain Research. Brain Research Reviews 26 1998 327 336 (Pubitemid 28318088)
21. I.L. Campbell, C.R. Abraham, E. Masliah, P. Kemper, J.D. Inglis, and M.B. Oldstone Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6 Proceedings of the National Academy of Sciences of the United States of America 90 1993 10061 10065 (Pubitemid 23328251)
22. L. Capuron, and A.H. Miller Cytokines and psychopathology: Lessons from interferon-alpha Biological Psychiatry 56 2004 819 824
23. L. Capuron, and A.H. Miller Immune system to brain signaling: Neuropsychopharmacological implications Pharmacology & Therapeutics 130 2011 226 238
24. J. Carrasco, M. Giralt, M. Penkowa, A.K. Stalder, I.L. Campbell, and J. Hidalgo Metallothioneins are upregulated in symptomatic mice with astrocyte-targeted expression of tumor necrosis factor-alpha Experimental Neurology 163 2000 46 54 (Pubitemid 30314359)
25. D. Chambers, A.M. Bagnall, S. Hempel, and C. Forbes Interventions for the treatment, management and rehabilitation of patients with chronic fatigue syndrome/myalgic encephalomyelitis: An updated systematic review Journal of the Royal Society of Medicine 99 2006 506 520 (Pubitemid 44690264)
26. S.H. Chan, C.W. Wu, A.Y. Chang, K.S. Hsu, and J.Y. Chan Transcriptional upregulation of brain-derived neurotrophic factor in rostral ventrolateral medulla by angiotensin II: Significance in superoxide homeostasis and neural regulation of arterial pressure Circulation Research 107 2010 1127 1139
27. H.Y. Chen, I.C. Cheng, Y.J. Pan, Y.L. Chiu, S.P. Hsu, and M.F. Pai Cognitive-behavioral therapy for sleep disturbance decreases inflammatory cytokines and oxidative stress in hemodialysis patients Kidney International 80 2011 415 422
28. A. Compston, and A. Coles Multiple sclerosis Lancet 372 2008 1502 1517
29. T.J. Connor, and B.E. Leonard Depression, stress and immunological activation: The role of cytokines in depressive disorders Life Sciences 62 1998 583 606 (Pubitemid 28045567)
30. E.E. Corcoran, and A.R. Means Defining Ca2 +/calmodulin-dependent protein kinase cascades in transcriptional regulation The Journal of Biological Chemistry 276 2001 2975 2978
31. R. Dantzer, L. Capuron, M.R. Irwin, A.H. Miller, H. Ollat, and V.H. Perry Identification and treatment of symptoms associated with inflammation in medically ill patients Psychoneuroendocrinology 33 2008 18 29
32. R. Dantzer, J.C. O'Connor, G.G. Freund, R.W. Johnson, and K.W. Kelley From inflammation to sickness and depression: When the immune system subjugates the brain Nature Reviews. Neuroscience 9 2008 46 56 (Pubitemid 350295688)
33. K.L. Davis Neuropsychopharmacology: The fifth generation of progress 5th ed. 2002 Lippincott Williams & Wilkins (LWW) Philadelphia, PA 901 930 Ch 63
34. M.R. de Oliveira, R.B. Silvestrin, E. Mello, T. Souza, and J.C. Moreira Oxidative stress in the hippocampus, anxiety-like behavior and decreased locomotory and exploratory activity of adult rats: Effects of sub acute vitamin A supplementation at therapeutic doses Neurotoxicology 28 2007 1191 1199 (Pubitemid 350026597)
35. B. Dell'Osso, M. Buoli, D.S. Baldwin, and A.C. Altamura Serotonin norepinephrine reuptake inhibitors (SNRIs) in anxiety disorders: A comprehensive review of their clinical efficacy Human Psychopharmacology 25 2010 17 29
36. S. Di Loreto, V. Zimmitti, P. Sebastiani, C. Cervelli, S. Falone, and F. Amicarelli Methylglyoxal causes strong weakening of detoxifying capacity and apoptotic cell death in rat hippocampal neurons The International Journal of Biochemistry & Cell Biology 40 2008 245 257 (Pubitemid 350137877)
37. Y. Dowlati, N. Herrmann, W. Swardfager, H. Liu, L. Sham, and E.K. Reim A meta-analysis of cytokines in major depression Biological Psychiatry 67 2010 446 457
38. R.S. Duman, G.R. Heninger, and E.J. Nestler A molecular and cellular theory of depression Archives of General Psychiatry 54 1997 597 606 (Pubitemid 27306570)
39. H. Einat, P. Yuan, T.D. Gould, J. Li, J. Du, and L. Zhang The role of the extracellular signal-regulated kinase signaling pathway in mood modulation The Journal of Neuroscience 23 2003 7311 7316 (Pubitemid 36999520)
40. I.J. Elenkov, R.L. Wilder, G.P. Chrousos, and E.S. Vizi The sympathetic nerve - An integrative interface between two supersystems: The brain and the immune system Pharmacological Reviews 52 2000 595 638
41. C.M. Elks, N. Mariappan, M. Haque, A. Guggilam, D.S. Majid, and J. Francis Chronic NF-{kappa}B blockade reduces cytosolic and mitochondrial oxidative stress and attenuates renal injury and hypertension in SHR American Journal of Physiology. Renal Physiology 296 2009 F298 F305
42. D.L. Evans, D.S. Charney, L. Lewis, R.N. Golden, J.M. Gorman, and K.R. Krishnan Mood disorders in the medically ill: Scientific review and recommendations Biological Psychiatry 58 2005 175 189 (Pubitemid 41112265)
43. M. Fiore, E. Alleva, L. Probert, G. Kollias, F. Angelucci, and L. Aloe Exploratory and displacement behavior in transgenic mice expressing high levels of brain TNF-alpha Physiology & Behavior 63 1998 571 576 (Pubitemid 28119191)
44. R.A. Floyd Antioxidants, oxidative stress, and degenerative neurological disorders Proceedings of the Society for Experimental Biology and Medicine 222 1999 236 245 (Pubitemid 129708638)
45. R.A. Floyd Neuroinflammatory processes are important in neurodegenerative diseases: An hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development Free Radical Biology & Medicine 26 1999 1346 1355 (Pubitemid 29262724)
46. R.A. Floyd, K. Hensley, F. Jaffery, L. Maidt, K. Robinson, and Q. Pye Increased oxidative stress brought on by pro-inflammatory cytokines in neurodegenerative processes and the protective role of nitrone-based free radical traps Life Sciences 65 1999 1893 1899 (Pubitemid 29506924)
47. P.R. Gard, S.J. Haigh, P.T. Cambursano, and C.A. Warrington Strain differences in the anxiolytic effects of losartan in the mouse Pharmacology, Biochemistry, and Behavior 69 2001 35 40 (Pubitemid 32566243)
48. P.J. Gebicke-Haerter Microglia in neurodegeneration: Molecular aspects Microscopy Research and Technique 54 2001 47 58 (Pubitemid 32537334)
49. A. Ghosh, and M.E. Greenberg Calcium signaling in neurons: Molecular mechanisms and cellular consequences Science 268 1995 239 247
50. J.A. Gingrich Oxidative stress is the new stress Nature Medicine 11 2005 1281 1282 (Pubitemid 41752903)
51. M. Giralt, J. Carrasco, M. Penkowa, M.A. Morcillo, J. Santamaría, and I.L. Campbell Astrocyte-targeted expression of interleukin-3 and interferon-alpha causes region-specific changes in metallothionein expression in the brain Experimental Neurology 168 2001 334 346 (Pubitemid 32289769)
52. R. Glaser, B. Rabin, M. Chesney, S. Cohen, and B. Natelson Stress-induced immunomodulation: Implications for infectious diseases? JAMA: The Journal of the American Medical Association 281 1999 2268 2270 (Pubitemid 29289805)
53. C.K. Glass, K. Saijo, B. Winner, M.C. Marchetto, and F.H. Gage Mechanisms underlying inflammation in neurodegeneration Cell 140 2010 918 934
54. J.P. Godbout, and R. Glaser Stress-induced immune dysregulation: Implications for wound healing, infectious disease and cancer Journal of Neuroimmune Pharmacology 1 2006 421 427 (Pubitemid 44786675)
55. T. Greco, and G. Fiskum Neuroprotection through stimulation of mitochondrial antioxidant protein expression Journal of Alzheimer's Disease 20 Suppl. 2 2010 S427 S437
56. B. Halliwell Oxidative stress and neurodegeneration: Where are we now? Journal of Neurochemistry 97 2006 1634 1658 (Pubitemid 43873658)
57. G.E. Hermann, R.C. Rogers, J.C. Bresnahan, and M.S. Beattie Tumor necrosis factor-alpha induces cFOS and strongly potentiates glutamate-mediated cell death in the rat spinal cord Neurobiology of Disease 8 2001 590 599 (Pubitemid 32758663)
58. S.J. Hopkins, and N.J. Rothwell Cytokines and the nervous system. I: Expression and recognition Trends in Neurosciences 18 1995 83 88
59. R. Hou, and D.S. Baldwin A neuroimmunological perspective on anxiety disorders Human Psychopharmacology 27 2012 6 14 doi: 10.1002/hup.1259. [Epub ahead of print]
60. L. Hovatta, J. Juhila, and J. Donner Oxidative stress in anxiety and comorbid disorders Neuroscience Research 68 2011 261 275
61. L. Hovatta, R.S. Tennant, R. Helton, R.A. Marr, O. Singer, and J.M. Redwine Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice Nature 438 2005 662 666 (Pubitemid 41740575)
62. M.B. Howren, D.M. Lamkin, and J. Suls Associations of depression with C-reactive protein, IL-1, and IL-6: A meta-analysis Psychosomatic Medicine 71 2009 171 186
63. M. Irwin, and J.C. Gillin Impaired natural killer cell activity among depressed patients Psychiatry Research 20 1987 181 182
64. C.F. Jehn, D. Kuehnhardt, A. Bartholomae, S. Pfeiffer, M. Krebs, and A.C. Regierer Biomarkers of depression in cancer patients Cancer 107 2006 2723 2729 (Pubitemid 44845629)
65. F.C. Kaiser, G.C. Palmer, A.V. Wallace, R.D. Carr, L. Fraser-Rae, and C. Hallam Antianxiety properties of the angiotensin II antagonist, DUP 753, in the rat using the elevated plus-maze Neuroreport 3 1992 922 924
66. C.A. Kassed, and M. Herkenham NF-kappaB p50-deficient mice show reduced anxiety-like behaviors in tests of exploratory drive and anxiety Behavioural Brain Research 154 2004 577 584 (Pubitemid 39094009)
67. M.J. Kim, S.J. Oh, S.H. Park, H.J. Kang, M.H. Won, and T.C. Kang Neuronal loss in primary long-term cortical culture involves neurodegeneration-like cell death via calpain and p35 processing, but not developmental apoptosis or aging Experimental & Molecular Medicine 39 2007 14 26
68. K.B. Koh, and Y. Lee Reduced anxiety level by therapeutic interventions and cell-mediated immunity in panic disorder patients Psychotherapy and Psychosomatics 73 2004 286 292 (Pubitemid 39060997)
69. Z. Kronfol, and D.G. Remick Impaired lymphocyte function in depressive illness Life Sciences 33 1983 241 247 (Pubitemid 13056867)
70. Z. Kronfol, and D.G. Remick Cytokines and the brain: Implications for clinical psychiatry The American Journal of Psychiatry 157 2000 683 694 (Pubitemid 30249643)
71. A. Kumar, B. Kumari, and P. Kumar Protective effects of selective and non-selective cyclooxygenase inhibitors in an animal model of chronic stress Neuroscience Bulletin 26 2010 17 27
72. B. Kumari, A. Kumar, and A. Dhir Protective effect of non-selective and selective COX-2-inhibitors in acute immobilization stress-induced behavioral and biochemical alterations Pharmacological Reports 59 2007 699 707 (Pubitemid 351586561)
73. Y. Kustova, Y. Sei, H.C. Morse Jr., and A.S. Basile The influence of a targeted deletion of the IFNgamma gene on emotional behaviors Brain, Behavior, and Immunity 12 1998 308 324 (Pubitemid 29224833)
74. H. Lassmann, W. Brück, and C. Lucchinetti Heterogeneity of multiple sclerosis pathogenesis: Implications for diagnosis and therapy Trends in Molecular Medicine 7 2001 115 121 (Pubitemid 32201673)
75. B.E. Leonard, and A. Myint The psychoneuroimmunology of depression Human Psychopharmacology 24 2009 165 175
76. K.P. Lesch Mouse anxiety: The power of knockout The Pharmacogenomics Journal 1 2001 187 192
77. H.C. Liou, and D. Baltimore Regulation of the NF-kappa B/rel transcription factor and I kappa B inhibitor system Current Opinion in Cell Biology 5 1993 477 487
78. J.M. Loftis, M. Huckans, and B.J. Morasco Neuroimmune mechanisms of cytokine-induced depression: Current theories and novel treatment strategies Neurobiology of Disease 37 2010 519 533
79. L. Longhi, K.E. Saatman, R. Raghupathi, H.L. Laurer, P.M. Lenz-linger, and P. Riess A review and rationale for the use of genetically engineered animals in the study of traumatic brain injury Journal of Cerebral Blood Flow and Metabolism 21 2001 1241 1258 (Pubitemid 33130937)
80. B.E. Lonze, and D.D. Ginty Function and regulation of CREB family transcription factors in the nervous system Neuron 35 2002 605 623 (Pubitemid 35229980)
81. J.F. Lopez, H. Akil, and S.J. Watson Neural circuits mediating stress Biological Psychiatry 46 1999 1461 1471
82. S.M. Lucas, N.J. Rothwell, and R.M. Gibson The role of inflammation in CNS injury and disease British Journal of Pharmacology 147 Suppl 1 2006 S232 S240
83. S.K. Lutgendorf, D.M. Lamkin, K. DeGeest, B. Anderson, M. Dao, and S. McGinn Depressed and anxious mood and T-cell cytokine expressing populations in ovarian cancer patients Brain, Behavior, and Immunity 22 2008 890 900
84. R.B. Maccioni, L.E. Rojo, J.A. Fernandez, and R.O. Kuljis The role of neuroimmunomodulation in Alzheimer's disease Annals of the New York Academy of Sciences 1153 2009 240 246
85. M. Maes, E. Bosmans, E. Suy, C. Vandervorst, C. De Jonckheere, and J. Raus Immune disturbances during major depression: Upregulated expression of interleukin-2 receptors Neuropsychobiology 24 1990 115 120
86. M. Maes, E. Bosmans, E. Suy, C. Vandervorst, C. De Jonckheere, and J. Raus Depression-related disturbances in mitogen-induced lymphocyte responses and interleukin-1 beta and soluble interleukin-2 receptor production Acta Psychiatrica Scandinavica 84 1991 379 386
87. M. Maes, M. Kubera, E. Obuchowiczwa, L. Goehler, and J. Brzeszcz Depression's multiple comorbidities explained by (neuro)inflammatory and oxidative & nitrosative stress pathways Neuroendocrinology Letters 32 2011 7 24
88. M. Maes, S. Scharpe, E. Bosmans, M. Vandewoude, E. Suy, and W. Uyttenbroeck Disturbances in acute phase plasma proteins during melancholia: Additional evidence for the presence of an inflammatory process during that illness Progress in Neuro-Psychopharmacology & Biological Psychiatry 16 1992 501 515
89. M. Maes, S. Scharpé, H.Y. Meltzer, E. Bosmans, E. Suy, and J. Calabrese Relationships between interleukin-6 activity, acute phase proteins, and function of the hypothalamic-pituitary-adrenal axis in severe depression Psychiatry Research 49 1993 11 27 (Pubitemid 23329244)
90. M. Maes, C. Song, A. Lin, R. De Jongh, A. Van Gastel, and G. Kenis Leukocytosis, monocytosis and neutrophilia: Hallmarks of severe depression Journal of Psychiatric Research 26 1992 125 134
91. M. Maes, C. Song, A. Lin, R. De Jongh, A. Van Gastel, and G. Kenis The effects of psychological stress on humans: Increased production of pro-inflammatory cytokines and a Th1-like response in stress-induced anxiety Cytokine 10 1998 313 318 (Pubitemid 28227076)
92. T. Mantamadiotis, T. Lemberger, S.C. Bleckmann, H. Kern, O. Kretz, and Martin Villalba Disruption of CREB function in brain leads to neurodegeneration Nature Genetics 31 2002 47 54
93. J.A. Martiney, C. Cuff, M. Litwak, J. Berman, and C.F. Brosnan Cytokine-induced inflammation in the central nervous system revisited Neurochemical Research 23 1998 349 359 (Pubitemid 28109880)
94. K. Martinowich, H. Manji, and B. Lu New insights into BDNF function in depression and anxiety Nature Neuroscience 10 2007 1089 1093 (Pubitemid 47339961)
95. A. Masood, A. Nadeem, S.J. Mustafa, and J.M. O'Donnell Reversal of oxidative stress-induced anxiety by inhibition of phosphodiesterase-2 in mice The Journal of Pharmacology and Experimental Therapeutics 326 2008 369 379
96. M.P. Mattson, and S. Camandola NF-kappaB in neuronal plasticity and neurodegenerative disorders The Journal of Clinical Investigation 107 2001 247 254 (Pubitemid 32162153)
97. B.S. McEwen Structural plasticity of the adult brain: How animal models help us understand brain changes in depression and systemic disorders related to depression Dialogues in Clinical Neuroscience 6 2004 119 133 (Pubitemid 38886186)
98. B.S. McEwen, and J.C. Wingfield The concept of allostasis in biology and biomedicine Hormones and Behavior 43 2003 2 15 (Pubitemid 36293268)
99. J. Menard, and D. Treit Effects of centrally administered anxiolytic compounds in animal models of anxiety Neuroscience and Biobehavioral Reviews 23 1999 591 613 (Pubitemid 29086927)
100. J.E. Merrill, and E.N. Benveniste Cytokines in inflammatory brain lesions: Helpful and harmful Trends in Neurosciences 19 1996 331 338 (Pubitemid 26349062)
101. C.A. Meyers, M. Albitar, and E. Estey Cognitive impairment, fatigue, and cytokine levels in patients with acute myelogenous leukemia or myelodysplastic syndrome Cancer 104 2005 788 793 (Pubitemid 41113679)
102. M. Mhatre, R.A. Floyd, and K. Hensley Oxidative stress and neuroinflammation in Alzheimer's disease and amyotrophic lateral sclerosis: Common links and potential therapeutic targets Journal of Alzheimer's Disease 6 2004 147 157 (Pubitemid 38560250)
103. A.H. Miller, V. Maletic, and C.L. Raison Inflammation and its discontents: The role of cytokines in the pathophysiology of major depression Biological Psychiatry 65 2009 732 741
104. A. Munck, and P.M. Guyre Glucocorticoids and immune function R. Ader, D.L. Felten, N. Cohen, Psychoneuroimmunology 1991 Academic Press San Diego, CA 447 474
105. D.L. Musselman, D.H. Lawson, J.F. Gumnick, A.K. Manatunga, S. Penna, and R.S. Goodkin Paroxetine for the prevention of depression induced by high-dose interferon alfa The New England Journal of Medicine 344 2001 961 966 (Pubitemid 32240314)
106. H. Neumann The immunological microenvironment in the CNS: Implications on neuronal cell death and survival Journal of Neural Transmission. Supplementum 59 2000 59 68 (Pubitemid 30479407)
107. F. Ng, M. Berk, O. Dean, and A.I. Bush Oxidative stress in psychiatric disorders: Evidence base and therapeutic implications The International Journal of Neuropsychopharmacology 11 2008 851 876
108. M.D. Nguyen, J.P. Julien, and S. Rivest Innate immunity: The missing link in neuroprotection and neurodegeneration? Nature Reviews. Neuroscience 3 2002 216 227 (Pubitemid 135706591)
109. A. O'Donovan, B.M. Hughes, G.M. Slavich, L. Lynch, M.T. Cronin, and C. O'Farrelly Clinical anxiety, cortisol and interleukin-6: Evidence for specificity in emotion-biology relationships Brain, Behavior, and Immunity 24 2010 1074 1077
110. S.C. Pandey Anxiety and alcohol abuse disorders: A common role for CREB and its target, the neuropeptide Y gene Trends in Pharmacological Sciences 24 2003 456 460 (Pubitemid 37088170)
111. V.H. Perry, S.J. Bolton, D.C. Anthony, and S. Betmouni The contribution of inflammation to acute and chronic neurodegeneration Research in Immunology 149 1998 721 725 (Pubitemid 29487170)
112. I. Peruga, S. Hartwig, J. Thöne, B. Hovemann, R. Gold, and G. Juckel Inflammation modulates anxiety in an animal model of multiple sclerosis Behavioural Brain Research 220 2011 20 29
113. C. Pitsavos, D.B. Panagiotakos, C. Papageorgiou, E. Tsetsekou, C. Soldatos, and C. Stefanadis Anxiety in relation to inflammation and coagulation markers, among healthy adults: The ATTICA study Atherosclerosis 185 2006 320 326
114. L. Probert, K. Akassoglou, M. Pasparakis, G. Kontogeorgos, and G. Kollias Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha Proceedings of the National Academy of Sciences of the United States of America 92 1995 11294 11298
115. S. Raha, and B.H. Robinson Mitochondria, oxygen free radicals, and apoptosis American Journal of Medical Genetics 106 2001 62 70
116. C.L. Raison, A.S. Borisov, S.D. Broadwell, L. Capuron, B.J. Woolwine, and I.M. Jacobson Depression during pegylated interferon-alpha plus ribavirin therapy: Prevalence and prediction The Journal of Clinical Psychiatry 66 2005 41 48
117. C.L. Raison, L. Capuron, and A.H. Miller Cytokines sing the blues: Inflammation and the pathogenesis of depression Trends in Immunology 27 2006 24 31 (Pubitemid 43083561)
118. H. Rammal, J. Bouayed, C. Younos, and R. Soulimani Evidence that oxidative stress is linked to anxiety-related behaviour in mice Brain, Behavior, and Immunity 22 2008 1156 1159
119. R.M. Ransohoff, and V.H. Perry Microglial physiology: Unique stimuli, specialized responses Annual Review of Immunology 27 2009 119 145
120. A. Reichenberg, R. Yirmiya, A. Schuld, T. Kraus, M. Haack, and A. Morag Cytokine-associated emotional and cognitive disturbances in humans Archives of General Psychiatry 58 2001 445 452 (Pubitemid 32411324)
121. K. Rezai-Zadeh, D. Gate, and T. Town CNS infiltration of peripheral immune cells: D-Day for neurodegenerative disease? Journal of Neuroimmune Pharmacology 4 2009 462 475
122. J.M. Saavedra, I. Armando, C. Bregonzio, A. Juorio, M. Macova, and J. Pavel A centrally acting, anxiolytic angiotensin II AT1 receptor antagonist prevents the isolation stress-induced decrease in cortical CRF1 receptor and benzodiazepine binding Neuropsychopharmacology 31 2006 1123 1134 (Pubitemid 43971830)
123. J.M. Saavedra, E. Sánchez-Lemus, and J. Benicky Blockade of brain angiotensin II AT1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: Therapeutic implications Psychoneuroendocrinology 36 2011 1 18
124. B. Sakic, H. Szechtman, H. Talangbayan, S.D. Denburg, R.M. Carbotte, and J.A. Denburg Disturbed emotionality in autoimmune MRL-lpr mice Physiology & Behavior 56 1994 609 617 (Pubitemid 24269588)
125. S. Salim, M. Asghar, G. Chugh, M. Taneja, Z. Xia, and K. Saha Oxidative stress: A potential recipe for anxiety, hypertension and insulin resistance Brain Research 1359 2010 178 185
126. S. Salim, M. Asghar, M. Taneja, I. Hovatta, G. Chugh, and C. Vollert Potential contribution of oxidative stress and inflammation to anxiety and hypertension Brain Research 1404 2011 63 71
127. S. Salim, N. Sarraj, M. Taneja, K. Saha, M.V. Tejada-Simon, and C. Chugh Moderate treadmill exercise prevents oxidative stress-induced anxiety-like behavior in rats Behavioural Brain Research 208 2010 545 552
128. R.M. Sapolsky, L.M. Romero, and A.U. Munck How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions Endocrine Reviews 21 2000 55 89 (Pubitemid 32266068)
129. C. Savoia, and E.L. Schiffrin Vascular inflammation in hypertension and diabetes: Molecular mechanisms and therapeutic interventions Clinical Science (London, England) 112 2007 375 384 (Pubitemid 46587452)
130. L.M. Sayre, G. Perry, and M.A. Smith Oxidative stress and neurotoxicity Chemical Research in Toxicology 21 2008 172 188 (Pubitemid 351219718)
131. M.J. Schaaf, J.O. Workel, E. Vreugdenhil, M.S. Oitzl, and E.R. de Kloet Correlation between hippocampal BDNF mRNA expression and memory performance in senescent rats Brain Research 915 2001 227 233 (Pubitemid 32947038)
132. N. Schneiderman, G. Ironson, and S.D. Siegel Stress and health: Psychological, behavioral, and biological determinants Annual Review of Clinical Psychology 1 2005 607 628 (Pubitemid 43843964)
133. L.M. Schrott, and L.S. Crnic Increased anxiety behaviors in autoimmune mice Behavioral Neuroscience 110 1996 492 502 (Pubitemid 26227096)
134. A. Shekhar, P.L. Johnson, T.J. Sajdyk, S.D. Fitz, S.R. Keim, and P.E. Kelley Angiotensin-II is a putative neurotransmitter in lactate-induced panic-like responses in rats with disruption of GABAergic inhibition in the dorsomedial hypothalamus The Journal of Neuroscience 26 2006 9205 9215 (Pubitemid 44359847)
135. L.M. Shin, S.L. Rauch, and R.K. Pitman Amygdala, medial prefrontal cortex, and hippocampal function in PTSD Annals of the New York Academy of Sciences 1071 2006 67 79 (Pubitemid 44126721)
136. S.D. Shumway, M. Maki, and S. Miyamoto The PEST domain of IkappaBalpha is necessary and sufficient for in vitro degradation by mu-calpain The Journal of Biological Chemistry 274 1999 30874 30881 (Pubitemid 129576835)
137. C.G. Souza, J.D. Moreira, I.R. Siqueira, A.G. Pereira, D.K. Rieger, and D.O. Souza Highly palatable diet consumption increases protein oxidation in rat frontal cortex and anxiety-like behavior Life Sciences 81 2007 198 203 (Pubitemid 46976978)
138. E.M. Sternberg Neural-immune interactions in health and disease The Journal of Clinical Investigation 100 1997 2641 2647 (Pubitemid 28007529)
139. G. Stoll, S. Jander, and M. Schroeter Cytokines in CNS disorders: Neurotoxicity versus neuroprotection Journal of Neural Transmission. Supplementum 59 2000 81 89 (Pubitemid 30479409)
140. W.J. Streit, S.A. Walter, and N.A. Pennell Reactive microgliosis Progress in Neurobiology 57 1999 563 581 (Pubitemid 29148415)
141. B. Takkouche, C. Regueira, and J.J. Gestal-Otero A cohort study of stress and the common cold Epidemiology 12 2001 345 349 (Pubitemid 32336399)
142. P.J. Thornalley Glyoxalase I - Structure, function and a critical role in the enzymatic defence against glycation Biochemical Society Transactions 31 2003 1343 1348 (Pubitemid 38030973)
143. P.J. Thornalley Dicarbonyl intermediates in the maillard reaction Annals of the New York Academy of Sciences 1043 2005 111 117 (Pubitemid 41123896)
144. B. Tremper-Wells, and M.L. Vallano Nuclear calpain regulates Ca2+-dependent signaling via proteolysis of nuclear Ca2 +/calmodulin-dependent protein kinase type IV in cultured neurons The Journal of Biological Chemistry 280 2005 2165 2175
145. B. Viviani, S. Bartesaghi, E. Corsini, C.L. Galli, and M. Marinovich Cytokines role in neurodegenerative events Toxicology Letters 149 2004 85 89 (Pubitemid 38469824)
146. B. Viviani, and M. Boraso Cytokines and neuronal channels: A molecular basis for age-related decline of neuronal function? Experimental Gerontology 46 2011 199 206
147. B. Viviani, F. Gardoni, and M. Marinovich Cytokines and neuronal ion channels in health and disease International Review of Neurobiology 82 2007 247 263
148. T. Wakita, F. Shintani, G. Yagi, M. Asai, and S. Nozawa Combination of inflammatory cytokines increases nitrite and nitrate levels in the paraventricular nucleus of conscious rats Brain Research 905 2001 12 20 (Pubitemid 32553833)
149. B.G. Xiao, and H. Link Immune regulation within the central nervous system Journal of the Neurological Sciences 157 1998 1 12 (Pubitemid 28179529)
150. F.L. Zhou, W.G. Zhang, Y.C. Wei, K.L. Xu, L.Y. Hui, and X.S. Wang Impact of comorbid anxiety and depression on quality of life and cellular immunity changes in patients with digestive tract cancers World Journal of Gastroenterology 11 2005 2313 2318
151. E.P. Zorrilla, L. Luborsky, J.R. McKay, R. Rosenthal, A. Houldin, and A. Tax The relationship of depression and stressors to immunological assays: A meta-analytic review Brain, Behavior, and Immunity 15 2001 199 226 (Pubitemid 33070955)
152. E.P. Zorrilla, E. Redei, and R.J. DeRubeis Reduced cytokine levels and T-cell function in healthy males: Relation to individual differences in subclinical anxiety Brain, Behavior, and Immunity 8 1994 293 312