A common mechanism of action of the selective serotonin reuptake inhibitors citalopram and fluoxetine: Reversal of chronic psychosocial stress-induced increase in CRE/CREB-directed gene transcription in transgenic reporter gene mice

European Journal of Pharmacology

Volumn 633, Issue 1-3, 2010, Pages 33-38

  Böer, Ulrike ^a   Noll, Christine ^a   Cierny, Irmgard ^a   Krause, Doris ^a   Hiemke, Christoph ^b   Knepel, Willhart ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Citalopram; CRE (cAMP response element) CREB (cAMP response element binding) directed transcription; Fluoxetine; Psychosocial stress; Transgenic reporter gene mice

Indexed keywords

CITALOPRAM; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DNA; FLUOXETINE; LUCIFERASE; SERINE; SEROTONIN UPTAKE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN HOMOGENATE; BRAIN REGION; CONTROLLED STUDY; CYCLIC AMP RESPONSIVE ELEMENT; DEPRESSION; DRUG DETERMINATION; DRUG MECHANISM; GENE EXPRESSION; GENETIC TRANSCRIPTION; HIPPOCAMPUS; HYPOTHALAMUS; MALE; MENTAL STRESS; MOUSE; NONHUMAN; PONS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REPORTER GENE; WESTERN BLOTTING;

ANIMALS; BRAIN; CITALOPRAM; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DRUG ADMINISTRATION SCHEDULE; FLUOXETINE; GENE EXPRESSION REGULATION; GENES, REPORTER; MICE; MICE, TRANSGENIC; PHOSPHORYLATION; SEROTONIN UPTAKE INHIBITORS; STRESS, PSYCHOLOGICAL; TRANSCRIPTION, GENETIC;

EID: 77949914686     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.01.016     Document Type: Article

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