Correlation between hippocampal BDNF mRNA expression and memory performance in senescent rats

Brain Research

Volumn 915, Issue 2, 2001, Pages 227-233

  Schaaf, Marcel J M ^b   Workel, Judith O ^a   Lesscher, Heidi M ^a   Vreugdenhil, Erno ^a   Oitzl, Melly S ^a   Ron de Kloet, E ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Aging; Hippocampus; Learning; Neurotrophin; Nuerotrophic factor; Water maze

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; MESSENGER RNA;

AMNESIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; COGNITION; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION FUNCTION; DENTATE GYRUS; DISEASE ASSOCIATION; HIPPOCAMPUS; LEARNING; MALE; MAZE TEST; MENTAL TASK; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; RAT; SENESCENCE; SOCIAL ISOLATION; SPATIAL MEMORY; TASK PERFORMANCE; TRAINING;

AGING; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; FEMALE; GENE EXPRESSION REGULATION; HIPPOCAMPUS; IN SITU HYBRIDIZATION; MALE; MATERNAL DEPRIVATION; MAZE LEARNING; MEMORY; RATS; RATS, INBRED BN; RNA, MESSENGER;

EID: 0035850812     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02855-4     Document Type: Article

References (41)

1. Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat
2. An age comparison of the rates of acquisition and forgetting of spatial information in relation to long-term enhancement of hippocampal synapses
3. Multistability of cognitive maps in the hippocampus of old rats
4. NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults
5. Age-dependent alterations in hippocampal synaptic plasticity: Relation to memory disorders
6. Increased expression of brain-derived neurotrophic factor mRNA in rat hippocampus is associated with improved spatial memory and enriched environment
7. Spatial learning and motor deficits in aged rats
8. Animal models of normal aging: Relationship between cognitive decline and markers in hippocampal circuitry
9. Rapid and selective induction of BDNF expression in the hippocampus during contextual learning
10. Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain
11. Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats
12. Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus
13. Neurotrophins and time: Different roles for TrkB signaling in hippocampal long-term potentiation
14. Learning upregulates brain-derived neurotrophic factor messenger ribonucleic acid: A mechanism to facilitate encoding and circuit maintenance?
15. Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor
16. Virus-mediated gene transfer into hippocampal CA1 region restores long-term potentiation in brain-derived neurotrophic factor mutant mice
17. A role for BDNF in the late-phase of hippocampal long-term potentiation
18. Hippocampal neurobiological mechanisms of age-related memory dysfunction
19. Differential effects of protein synthesis inhibition on the activity-dependent expression of BDNF transcripts: Evidence for immediate-early gene responses from specific promoters
20. Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors
21. Neurotrophins and brain insults
22. Learning deficit in BDNF mutant mice
23. The effects of growth factors on the survival and differentiation of cultured dentate gyrus neurons
24. Brain-derived neurotrophic factor antisense oligonucleotide impairs memory retention and inhibits long-term potentiation in rats
25. Individual differences in aging: Behavioral and neurobiological correlates
26. Place navigation impaired in rats with hippocampal lesions
27. Deprivation of endogenous brain-derived neurotrophic factor results in impairment of spatial learning and memory in adult rats
28. Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain
29. Place units in the hippocampus of the freely moving rat
30. The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat
31. Maternal deprivation affects behavior from youth to senescence: Amplification of individual differences in spatial learning and memory in senescent Brown Norway rats
32. Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice
33. Widespread expression of BDNF but not NT3 by target areas of basal forebrain cholinergic neurons
34. Individual differences in the cognitive and neurobiological consequences of normal aging
35. Corticosterone regulates expression of BDNF and trkB but not NT-3 and trkC mRNA in the rat hippocampus
36. Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone
37. Corticosterone effects on BDNF mRNA expression in the rat hippocampus during water maze training
38. Identification of a signaling pathway involved in calcium regulation of BDNF expression
39. Multiple promoters direct tissue-specific expression of the rat BDNF gene
40. Dynamics of the hippocampal ensemble code for space
41. The Brown Norway rat displays enhanced stress-induced ACTH reactivity at day 18 after 24-h maternal deprivation at day 3