메뉴 건너뛰기




Volumn 63, Issue , 2012, Pages 207-256

Human Pluripotent Stem Cells for Modeling Toxicity

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE; BUFURALOL; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CYTOCHROME P450 1A1; DEXAMETHASONE; HEPATOCYTE NUCLEAR FACTOR 3BETA; MICRORNA; MYOCYTE ENHANCER FACTOR 2; OCTAMER TRANSCRIPTION FACTOR 4; ONCOSTATIN M; RETINOIC ACID; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR NKX2.5; TRANSCRIPTION FACTOR SOX17; TRASTUZUMAB; TYROSINE AMINOTRANSFERASE; VERAPAMIL; XENOBIOTIC AGENT;

EID: 84863770073     PISSN: 10543589     EISSN: 15578925     Source Type: Book Series    
DOI: 10.1016/B978-0-12-398339-8.00006-9     Document Type: Chapter
Times cited : (23)

References (279)
  • 1
    • 45549093674 scopus 로고    scopus 로고
    • Testing potential developmental toxicants with a cytotoxicity assay based on human embryonic stem cells
    • Adler S., Lindqvist J., Uddenberg K., Hyllner J., Strehl R. Testing potential developmental toxicants with a cytotoxicity assay based on human embryonic stem cells. Alternatives to Laboratory Animals 2008, 36(2):129-140.
    • (2008) Alternatives to Laboratory Animals , vol.36 , Issue.2 , pp. 129-140
    • Adler, S.1    Lindqvist, J.2    Uddenberg, K.3    Hyllner, J.4    Strehl, R.5
  • 2
    • 37249044261 scopus 로고    scopus 로고
    • First steps in establishing a developmental toxicity test method based on human embryonic stem cells
    • Adler S., Pellizzer C., Hareng L., Hartung T., Bremer S. First steps in establishing a developmental toxicity test method based on human embryonic stem cells. Toxicology In Vitro 2008, 22(1):200-211.
    • (2008) Toxicology In Vitro , vol.22 , Issue.1 , pp. 200-211
    • Adler, S.1    Pellizzer, C.2    Hareng, L.3    Hartung, T.4    Bremer, S.5
  • 3
    • 47949092668 scopus 로고    scopus 로고
    • Efficient differentiation of functional hepatocytes from human embryonic stem cells
    • Agarwal S., Holton K.L., Lanza R. Efficient differentiation of functional hepatocytes from human embryonic stem cells. Stem Cells 2008, 26(5):1117-1127.
    • (2008) Stem Cells , vol.26 , Issue.5 , pp. 1117-1127
    • Agarwal, S.1    Holton, K.L.2    Lanza, R.3
  • 5
    • 35549006752 scopus 로고    scopus 로고
    • Transgenic enrichment of cardiomyocytes from human embryonic stem cells
    • Anderson D., Self T., Mellor I.R., Goh G., Hill S.J., Denning C. Transgenic enrichment of cardiomyocytes from human embryonic stem cells. Molecular Theraphy 2007, 15(11):2027-2036.
    • (2007) Molecular Theraphy , vol.15 , Issue.11 , pp. 2027-2036
    • Anderson, D.1    Self, T.2    Mellor, I.R.3    Goh, G.4    Hill, S.J.5    Denning, C.6
  • 6
    • 77957373096 scopus 로고    scopus 로고
    • Assaying cardiac biomarkers for toxicity testing using biosensing and cardiomyocytes derived from human embryonic stem cells
    • Andersson H., Steel D., Asp J., Dahlenborg K., Jonsson M., Jeppsson A., et al. Assaying cardiac biomarkers for toxicity testing using biosensing and cardiomyocytes derived from human embryonic stem cells. Journal of Biotechnology 2010, 150(1):175-181.
    • (2010) Journal of Biotechnology , vol.150 , Issue.1 , pp. 175-181
    • Andersson, H.1    Steel, D.2    Asp, J.3    Dahlenborg, K.4    Jonsson, M.5    Jeppsson, A.6
  • 7
    • 18744376412 scopus 로고    scopus 로고
    • Drug-induced liver injury: an analysis of 461 incidences submitted to the spanish registry over a 10-year period
    • Andrade R.J., Lucena M.I., Fernández M.C., Pelaez G., Pachkoria K., García-Ruiz E., et al. Drug-induced liver injury: an analysis of 461 incidences submitted to the spanish registry over a 10-year period. Gastroenterology 2005, 129(2):512-521.
    • (2005) Gastroenterology , vol.129 , Issue.2 , pp. 512-521
    • Andrade, R.J.1    Lucena, M.I.2    Fernández, M.C.3    Pelaez, G.4    Pachkoria, K.5    García-Ruiz, E.6
  • 8
    • 79953881831 scopus 로고    scopus 로고
    • Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency
    • Anokye-Danso F., Trivedi C.M., Juhr D., Gupta M., Cui Z., Tian Y., et al. Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell 2011, 8(4):376-388.
    • (2011) Cell Stem Cell , vol.8 , Issue.4 , pp. 376-388
    • Anokye-Danso, F.1    Trivedi, C.M.2    Juhr, D.3    Gupta, M.4    Cui, Z.5    Tian, Y.6
  • 9
    • 79955482429 scopus 로고    scopus 로고
    • Opportunities for use of human iPS cells in predictive toxicology
    • Anson B.D., Kolaja K.L., Kamp T.J. Opportunities for use of human iPS cells in predictive toxicology. Clinical Pharmacology & Therapeutics 2011, 89(5):754-758.
    • (2011) Clinical Pharmacology & Therapeutics , vol.89 , Issue.5 , pp. 754-758
    • Anson, B.D.1    Kolaja, K.L.2    Kamp, T.J.3
  • 10
    • 69949117306 scopus 로고    scopus 로고
    • Simultaneous expression of plural forms of human cytochrome P450 at desired ratios in HepG2 cells: adenovirus-mediated tool for cytochrome P450 reconstitution
    • Aoyama K., Yoshinari K., Kim H.J., Nagata K., Yamazoe Y. Simultaneous expression of plural forms of human cytochrome P450 at desired ratios in HepG2 cells: adenovirus-mediated tool for cytochrome P450 reconstitution. Drug Metabolism and Pharmacokinetics 2009, 24(3):209-217.
    • (2009) Drug Metabolism and Pharmacokinetics , vol.24 , Issue.3 , pp. 209-217
    • Aoyama, K.1    Yoshinari, K.2    Kim, H.J.3    Nagata, K.4    Yamazoe, Y.5
  • 11
    • 80054796325 scopus 로고    scopus 로고
    • Embryotoxicity of lead (II) acetate and aroclor 1254 using a new end point of the embryonic stem cell test
    • Baek D.H., Park S.H., Park J.H., Choi Y., Park K.D., Kang J.W., et al. Embryotoxicity of lead (II) acetate and aroclor 1254 using a new end point of the embryonic stem cell test. International Journal of Toxicology 2011, 30(5):498-509.
    • (2011) International Journal of Toxicology , vol.30 , Issue.5 , pp. 498-509
    • Baek, D.H.1    Park, S.H.2    Park, J.H.3    Choi, Y.4    Park, K.D.5    Kang, J.W.6
  • 12
    • 72849122971 scopus 로고    scopus 로고
    • Patenting human pluripotent cells: balancing commercial, academic and ethical interests
    • Bahadur G., Morrison M. Patenting human pluripotent cells: balancing commercial, academic and ethical interests. Human Reproduction 2010, 25(1):14-21.
    • (2010) Human Reproduction , vol.25 , Issue.1 , pp. 14-21
    • Bahadur, G.1    Morrison, M.2
  • 13
    • 14744281936 scopus 로고    scopus 로고
    • Establishment and in vitro differentiation of a new embryonic stem cell line from human blastocyst
    • Baharvand H., Ashtiani S.K., Valojerdi M.R., Shahverdi A., Taee A., Sabour D. Establishment and in vitro differentiation of a new embryonic stem cell line from human blastocyst. Differentiation 2004, 72(5):224-229.
    • (2004) Differentiation , vol.72 , Issue.5 , pp. 224-229
    • Baharvand, H.1    Ashtiani, S.K.2    Valojerdi, M.R.3    Shahverdi, A.4    Taee, A.5    Sabour, D.6
  • 15
    • 79952756154 scopus 로고    scopus 로고
    • Role of biotransformation in drug-induced toxicity: Influence of intra- and inter-species differences in drug metabolism
    • Baillie T.A., Rettie A.E. Role of biotransformation in drug-induced toxicity: Influence of intra- and inter-species differences in drug metabolism. Drug Metabolism and Pharmacokinetics 2011, 26(1):15-29.
    • (2011) Drug Metabolism and Pharmacokinetics , vol.26 , Issue.1 , pp. 15-29
    • Baillie, T.A.1    Rettie, A.E.2
  • 16
    • 79959992876 scopus 로고    scopus 로고
    • Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells
    • Bar-Nur O., Russ H.A., Efrat S., Benvenisty N. Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells. Cell Stem Cell 2011, 9(1):17-23.
    • (2011) Cell Stem Cell , vol.9 , Issue.1 , pp. 17-23
    • Bar-Nur, O.1    Russ, H.A.2    Efrat, S.3    Benvenisty, N.4
  • 17
    • 79961160557 scopus 로고    scopus 로고
    • Inducing iPSCs to Escape the dish
    • Barrilleaux B., Knoepfler P.S. Inducing iPSCs to Escape the dish. Cell Stem Cell 2011, 9(2):103-111.
    • (2011) Cell Stem Cell , vol.9 , Issue.2 , pp. 103-111
    • Barrilleaux, B.1    Knoepfler, P.S.2
  • 18
    • 60449098836 scopus 로고    scopus 로고
    • Differentiation and transplantation of human embryonic stem cell-derived hepatocytes
    • e994
    • Basma H., Soto-Gutiérrez A., Yannam G.R., Liu L., Ito R., Yamamoto T., et al. Differentiation and transplantation of human embryonic stem cell-derived hepatocytes. Gastroenterology 2009, 136(3):990-999. e994.
    • (2009) Gastroenterology , vol.136 , Issue.3 , pp. 990-999
    • Basma, H.1    Soto-Gutiérrez, A.2    Yannam, G.R.3    Liu, L.4    Ito, R.5    Yamamoto, T.6
  • 19
    • 77953286668 scopus 로고    scopus 로고
    • Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening
    • Baxter M.A., Rowe C., Alder J., Harrison S., Hanley K.P., Park B.K., et al. Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening. Stem Cell Research 2010, 5(1):4-22.
    • (2010) Stem Cell Research , vol.5 , Issue.1 , pp. 4-22
    • Baxter, M.A.1    Rowe, C.2    Alder, J.3    Harrison, S.4    Hanley, K.P.5    Park, B.K.6
  • 20
    • 33748621304 scopus 로고    scopus 로고
    • Genome-wide transcriptional profiling of human embryonic stem cells differentiating to cardiomyocytes
    • Beqqali A., Kloots J., Ward-van Oostwaard D., Mummery C., Passier R. Genome-wide transcriptional profiling of human embryonic stem cells differentiating to cardiomyocytes. Stem Cells 2006, 24(8):1956-1967.
    • (2006) Stem Cells , vol.24 , Issue.8 , pp. 1956-1967
    • Beqqali, A.1    Kloots, J.2    Ward-van Oostwaard, D.3    Mummery, C.4    Passier, R.5
  • 21
    • 0034976974 scopus 로고    scopus 로고
    • Liver tissue engineering: a role for co-culture systems in modifying hepatocyte function and viability
    • Bhandari R.N., Riccalton L.A., Lewis A.L., Fry J.R., Hammond A.H., Tendler S.J., et al. Liver tissue engineering: a role for co-culture systems in modifying hepatocyte function and viability. Tissue Engineering 2001, 7(3):345-357.
    • (2001) Tissue Engineering , vol.7 , Issue.3 , pp. 345-357
    • Bhandari, R.N.1    Riccalton, L.A.2    Lewis, A.L.3    Fry, J.R.4    Hammond, A.H.5    Tendler, S.J.6
  • 22
    • 0015817744 scopus 로고
    • Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture
    • Biedler J.L., Helson L., Spengler B.A. Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture. Cancer Research 1973, 33(11):2643-2652.
    • (1973) Cancer Research , vol.33 , Issue.11 , pp. 2643-2652
    • Biedler, J.L.1    Helson, L.2    Spengler, B.A.3
  • 23
    • 9344256686 scopus 로고    scopus 로고
    • In vitro differentiation and in vivo mineralization of osteogenic cells derived from human embryonic stem cells
    • Bielby R.C., Boccaccini A.R., Polak J.M., Buttery L.D. In vitro differentiation and in vivo mineralization of osteogenic cells derived from human embryonic stem cells. Tissue Engineering 2004, 10(9, 10):1518-1525.
    • (2004) Tissue Engineering , vol.10 , Issue.9-10 , pp. 1518-1525
    • Bielby, R.C.1    Boccaccini, A.R.2    Polak, J.M.3    Buttery, L.D.4
  • 24
    • 0032856081 scopus 로고    scopus 로고
    • The relative semi-quantification of mrna expression as a useful toxicological endpoint for the identification of embryotoxic/teratogenic substances
    • Bigot K., de Lange J., Archer G., Clothier R., Bremer S. The relative semi-quantification of mrna expression as a useful toxicological endpoint for the identification of embryotoxic/teratogenic substances. Toxicology In Vitro 1999, 13(4, 5):619-623.
    • (1999) Toxicology In Vitro , vol.13 , Issue.4-5 , pp. 619-623
    • Bigot, K.1    de Lange, J.2    Archer, G.3    Clothier, R.4    Bremer, S.5
  • 27
    • 76749151845 scopus 로고    scopus 로고
    • Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes
    • Braam S.R., Tertoolen L., van de Stolpe A., Meyer T., Passier R., Mummery C.L. Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes. Stem Cell Research 2010, 4(2):107-116.
    • (2010) Stem Cell Research , vol.4 , Issue.2 , pp. 107-116
    • Braam, S.R.1    Tertoolen, L.2    van de Stolpe, A.3    Meyer, T.4    Passier, R.5    Mummery, C.L.6
  • 28
    • 49249113004 scopus 로고    scopus 로고
    • Development of a high-throughput screening assay for chemical effects on proliferation and viability of immortalized human neural progenitor cells
    • Breier J.M., Radio N.M., Mundy W.R., Shafer T.J. Development of a high-throughput screening assay for chemical effects on proliferation and viability of immortalized human neural progenitor cells. Toxicological Sciences 2008, 105(1):119-133.
    • (2008) Toxicological Sciences , vol.105 , Issue.1 , pp. 119-133
    • Breier, J.M.1    Radio, N.M.2    Mundy, W.R.3    Shafer, T.J.4
  • 29
    • 74149094915 scopus 로고    scopus 로고
    • Hepatocyte-like cells derived from human embryonic stem cells specifically via definitive endoderm and a progenitor stage
    • Brolén G., Sivertsson L., Björquist P., Eriksson G., Ek M., Semb H., et al. Hepatocyte-like cells derived from human embryonic stem cells specifically via definitive endoderm and a progenitor stage. Journal of Biotechnology 2010, 145(3):284-294.
    • (2010) Journal of Biotechnology , vol.145 , Issue.3 , pp. 284-294
    • Brolén, G.1    Sivertsson, L.2    Björquist, P.3    Eriksson, G.4    Ek, M.5    Semb, H.6
  • 30
    • 34147124971 scopus 로고    scopus 로고
    • Improved human embryonic stem cell embryoid body homogeneity and cardiomyocyte differentiation from a novel V-96 plate aggregation system highlights interline variability
    • Burridge P.W., Anderson D., Priddle H., Barbadillo Munoz M.D., Chamberlain S., Allegrucci C., et al. Improved human embryonic stem cell embryoid body homogeneity and cardiomyocyte differentiation from a novel V-96 plate aggregation system highlights interline variability. Stem Cells 2007, 25(4):929-938.
    • (2007) Stem Cells , vol.25 , Issue.4 , pp. 929-938
    • Burridge, P.W.1    Anderson, D.2    Priddle, H.3    Barbadillo Munoz, M.D.4    Chamberlain, S.5    Allegrucci, C.6
  • 31
    • 79954543387 scopus 로고    scopus 로고
    • A universal system for highly efficient cardiac differentiation of human induced pluripotent stem cells that eliminates interline variability
    • Burridge P.W., Thompson S., Millrod M.A., Weinberg S., Yuan X., Peters A., et al. A universal system for highly efficient cardiac differentiation of human induced pluripotent stem cells that eliminates interline variability. PLoS One 2011, 6(4):e18293.
    • (2011) PLoS One , vol.6 , Issue.4
    • Burridge, P.W.1    Thompson, S.2    Millrod, M.A.3    Weinberg, S.4    Yuan, X.5    Peters, A.6
  • 32
    • 23844506916 scopus 로고    scopus 로고
    • Human cord blood-derived neural stem cell line - possible implementation in studying neurotoxicity
    • Buzanska L., Habich A., Jurga M., Sypecka J., Domanska-Janik K. Human cord blood-derived neural stem cell line - possible implementation in studying neurotoxicity. Toxicology In Vitro 2005, 19(7):991-999.
    • (2005) Toxicology In Vitro , vol.19 , Issue.7 , pp. 991-999
    • Buzanska, L.1    Habich, A.2    Jurga, M.3    Sypecka, J.4    Domanska-Janik, K.5
  • 33
    • 70350241654 scopus 로고    scopus 로고
    • A human stem cell-based model for identifying adverse effects of organic and inorganic chemicals on the developing nervous system
    • Buzanska L., Sypecka J., Nerini-Molteni S., Compagnoni A., Hogberg H.T., del Torchio R., et al. A human stem cell-based model for identifying adverse effects of organic and inorganic chemicals on the developing nervous system. Stem Cells 2009, 27(10):2591-2601.
    • (2009) Stem Cells , vol.27 , Issue.10 , pp. 2591-2601
    • Buzanska, L.1    Sypecka, J.2    Nerini-Molteni, S.3    Compagnoni, A.4    Hogberg, H.T.5    del Torchio, R.6
  • 34
    • 34248634898 scopus 로고    scopus 로고
    • Directed differentiation of human embryonic stem cells into functional hepatic cells
    • Cai J., Zhao Y., Liu Y., Ye F., Song Z., Qin H., et al. Directed differentiation of human embryonic stem cells into functional hepatic cells. Hepatology 2007, 45(5):1229-1239.
    • (2007) Hepatology , vol.45 , Issue.5 , pp. 1229-1239
    • Cai, J.1    Zhao, Y.2    Liu, Y.3    Ye, F.4    Song, Z.5    Qin, H.6
  • 35
    • 0035023474 scopus 로고    scopus 로고
    • Growth factors regulate the survival and fate of cells derived from human neurospheres
    • Caldwell M.A., He X., Wilkie N., Pollack S., Marshall G., Wafford K.A., et al. Growth factors regulate the survival and fate of cells derived from human neurospheres. Nature Biotechnology 2001, 19(5):475-479.
    • (2001) Nature Biotechnology , vol.19 , Issue.5 , pp. 475-479
    • Caldwell, M.A.1    He, X.2    Wilkie, N.3    Pollack, S.4    Marshall, G.5    Wafford, K.A.6
  • 36
    • 84872213869 scopus 로고    scopus 로고
    • Distinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in human neural progenitor cells
    • Callihan P., Zitomer N.C., Stoeling M.V., Kennedy P.C., Lynch K.R., Riley R.T., et al. Distinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in human neural progenitor cells. Neuropharmacology 2011.
    • (2011) Neuropharmacology
    • Callihan, P.1    Zitomer, N.C.2    Stoeling, M.V.3    Kennedy, P.C.4    Lynch, K.R.5    Riley, R.T.6
  • 37
    • 77953443251 scopus 로고    scopus 로고
    • Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome
    • Carvajal-Vergara X., Sevilla A., D'Souza S.L., Ang Y.S., Schaniel C., Lee D.F., et al. Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature 2010, 465(7299):808-812.
    • (2010) Nature , vol.465 , Issue.7299 , pp. 808-812
    • Carvajal-Vergara, X.1    Sevilla, A.2    D'Souza, S.L.3    Ang, Y.S.4    Schaniel, C.5    Lee, D.F.6
  • 40
    • 77149175609 scopus 로고    scopus 로고
    • Assessment of embryotoxicity of compounds in cosmetics by the embryonic stem cell test
    • Chen R., Chen J., Cheng S., Qin J., Li W., Zhang L., et al. Assessment of embryotoxicity of compounds in cosmetics by the embryonic stem cell test. Toxicology Mechanisms and Methods 2010, 20(3):112-118.
    • (2010) Toxicology Mechanisms and Methods , vol.20 , Issue.3 , pp. 112-118
    • Chen, R.1    Chen, J.2    Cheng, S.3    Qin, J.4    Li, W.5    Zhang, L.6
  • 41
    • 84862876378 scopus 로고    scopus 로고
    • Rapid generation of mature hepatocyte-like cells from human induced pluripotent stem cells by an efficient three-step protocol
    • Chen Y.-F., Tseng C.-Y., Wang H.-W., Kuo H.-C., Yang V.W., Lee O.K. Rapid generation of mature hepatocyte-like cells from human induced pluripotent stem cells by an efficient three-step protocol. Hepatology 2011.
    • (2011) Hepatology
    • Chen, Y.-F.1    Tseng, C.-Y.2    Wang, H.-W.3    Kuo, H.-C.4    Yang, V.W.5    Lee, O.K.6
  • 42
    • 55049086868 scopus 로고    scopus 로고
    • Isolation and transcriptional profiling of purified hepatic cells derived from human embryonic stem cells
    • Chiao E., Elazar M., Xing Y., Xiong A., Kmet M., Millan M.T., et al. Isolation and transcriptional profiling of purified hepatic cells derived from human embryonic stem cells. Stem Cells 2008, 26(8):2032-2041.
    • (2008) Stem Cells , vol.26 , Issue.8 , pp. 2032-2041
    • Chiao, E.1    Elazar, M.2    Xing, Y.3    Xiong, A.4    Kmet, M.5    Millan, M.T.6
  • 43
    • 33344458106 scopus 로고    scopus 로고
    • Herceptin and the heart - a molecular modifier of cardiac failure
    • Chien K.R. Herceptin and the heart - a molecular modifier of cardiac failure. New England Journal of Medicins 2006, 354(8):789-790.
    • (2006) New England Journal of Medicins , vol.354 , Issue.8 , pp. 789-790
    • Chien, K.R.1
  • 44
    • 55549098894 scopus 로고    scopus 로고
    • Bmp2 signaling regulates the hepatic versus pancreatic fate decision
    • Chung W.S., Shin C.H., Stainier D.Y.R. Bmp2 signaling regulates the hepatic versus pancreatic fate decision. Developmental Cell 2008, 15(5):738-748.
    • (2008) Developmental Cell , vol.15 , Issue.5 , pp. 738-748
    • Chung, W.S.1    Shin, C.H.2    Stainier, D.Y.R.3
  • 46
    • 81855211078 scopus 로고    scopus 로고
    • Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure
    • Colleoni S., Galli C., Gaspar J.A., Meganathan K., Jagtap S., Hescheler J., et al. Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicological Sciences 2011, 124(2):370-377.
    • (2011) Toxicological Sciences , vol.124 , Issue.2 , pp. 370-377
    • Colleoni, S.1    Galli, C.2    Gaspar, J.A.3    Meganathan, K.4    Jagtap, S.5    Hescheler, J.6
  • 48
    • 70349976819 scopus 로고    scopus 로고
    • Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties
    • Coulouarn C., Factor V.M., Andersen J.B., Durkin M.E., Thorgeirsson S.S. Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties. Oncogene 2009, 28(40):3526-3536.
    • (2009) Oncogene , vol.28 , Issue.40 , pp. 3526-3536
    • Coulouarn, C.1    Factor, V.M.2    Andersen, J.B.3    Durkin, M.E.4    Thorgeirsson, S.S.5
  • 52
    • 79955604503 scopus 로고    scopus 로고
    • Comparison of the mouse embryonic stem cell test, the rat whole embryo culture and the zebrafish embryotoxicity test as alternative methods for developmental toxicity testing of six 1,2,4-triazoles
    • de Jong E., Barenys M., Hermsen S.A., Verhoef A., Ossendorp B.C., Bessems J.G., et al. Comparison of the mouse embryonic stem cell test, the rat whole embryo culture and the zebrafish embryotoxicity test as alternative methods for developmental toxicity testing of six 1,2,4-triazoles. Toxicology and Applied Pharmacology 2011, 253(2):103-111.
    • (2011) Toxicology and Applied Pharmacology , vol.253 , Issue.2 , pp. 103-111
    • de Jong, E.1    Barenys, M.2    Hermsen, S.A.3    Verhoef, A.4    Ossendorp, B.C.5    Bessems, J.G.6
  • 53
    • 51749104176 scopus 로고    scopus 로고
    • Optimisation of the cell cultivation methods in the embryonic stem cell test results in an increased differentiation potential of the cells into strong beating myocard cells
    • De Smedt A., Steemans M., De Boeck M., Peters A.K., van der Leede B.J., Van Goethem F., et al. Optimisation of the cell cultivation methods in the embryonic stem cell test results in an increased differentiation potential of the cells into strong beating myocard cells. Toxicology In Vitro 2008, 22(7):1789-1796.
    • (2008) Toxicology In Vitro , vol.22 , Issue.7 , pp. 1789-1796
    • De Smedt, A.1    Steemans, M.2    De Boeck, M.3    Peters, A.K.4    van der Leede, B.J.5    Van Goethem, F.6
  • 55
    • 77955937897 scopus 로고    scopus 로고
    • Evaluating the utility of cardiomyocytes from human pluripotent stem cells for drug screening
    • Dick E., Rajamohan D., Ronksley J., Denning C. Evaluating the utility of cardiomyocytes from human pluripotent stem cells for drug screening. Biochemical Society Transactions 2010, 38(4):1037-1045.
    • (2010) Biochemical Society Transactions , vol.38 , Issue.4 , pp. 1037-1045
    • Dick, E.1    Rajamohan, D.2    Ronksley, J.3    Denning, C.4
  • 56
    • 55249107586 scopus 로고    scopus 로고
    • Biochemical markers for prediction of chemotherapy-induced cardiotoxicity: systematic review of the literature and recommendations for use
    • Dolci A., Dominici R., Cardinale D., Sandri M.T., Panteghini M. Biochemical markers for prediction of chemotherapy-induced cardiotoxicity: systematic review of the literature and recommendations for use. American Journal of Clinical Pathology 2008, 130(5):688-695.
    • (2008) American Journal of Clinical Pathology , vol.130 , Issue.5 , pp. 688-695
    • Dolci, A.1    Dominici, R.2    Cardinale, D.3    Sandri, M.T.4    Panteghini, M.5
  • 57
    • 37349037630 scopus 로고    scopus 로고
    • Differentiation and enrichment of hepatocyte-like cells from human embryonic stem cells in vitro and in vivo
    • Duan Y., Catana A., Meng Y., Yamamoto N., He S., Gupta S., et al. Differentiation and enrichment of hepatocyte-like cells from human embryonic stem cells in vitro and in vivo. Stem Cells 2007, 25(12):3058-3068.
    • (2007) Stem Cells , vol.25 , Issue.12 , pp. 3058-3068
    • Duan, Y.1    Catana, A.2    Meng, Y.3    Yamamoto, N.4    He, S.5    Gupta, S.6
  • 58
    • 77950994754 scopus 로고    scopus 로고
    • Differentiation and characterization of metabolically functioning hepatocytes from human embryonic stem cells
    • Duan Y., Ma X., Zou W.E.I., Wang C., Bahbahan I.S., Ahuja T.P., et al. Differentiation and characterization of metabolically functioning hepatocytes from human embryonic stem cells. Stem Cells 2010, 28(4):674-686.
    • (2010) Stem Cells , vol.28 , Issue.4 , pp. 674-686
    • Duan, Y.1    Ma, X.2    Zou, W.E.I.3    Wang, C.4    Bahbahan, I.S.5    Ahuja, T.P.6
  • 59
    • 0036707624 scopus 로고    scopus 로고
    • Effects of dexamethasone on aryl (SULT1A1)- and hydroxysteroid (SULT2A1)-sulfotransferase gene expression in primary cultured human hepatocytes
    • Duanmu Z., Locke D., Smigelski J., Wu W., Dahn M.S., Falany C.N., et al. Effects of dexamethasone on aryl (SULT1A1)- and hydroxysteroid (SULT2A1)-sulfotransferase gene expression in primary cultured human hepatocytes. Drug Metabolism and Disposition 2002, 30(9):997-1004.
    • (2002) Drug Metabolism and Disposition , vol.30 , Issue.9 , pp. 997-1004
    • Duanmu, Z.1    Locke, D.2    Smigelski, J.3    Wu, W.4    Dahn, M.S.5    Falany, C.N.6
  • 62
    • 84863767970 scopus 로고    scopus 로고
    • EC1907
    • EC1907/2006.
    • (2006)
  • 63
    • 76749111450 scopus 로고    scopus 로고
    • Use of two validated in vitro tests to assess the embryotoxic potential of mycophenolic acid
    • Eckardt K., Stahlmann R. Use of two validated in vitro tests to assess the embryotoxic potential of mycophenolic acid. Archives in Toxicology 2010, 84(1):37-43.
    • (2010) Archives in Toxicology , vol.84 , Issue.1 , pp. 37-43
    • Eckardt, K.1    Stahlmann, R.2
  • 64
    • 0034619028 scopus 로고    scopus 로고
    • Adverse drug reactions: definitions, diagnosis, and management
    • Edwards I.R., Aronson J.K. Adverse drug reactions: definitions, diagnosis, and management. Lancet 2000, 356(9237):1255-1259.
    • (2000) Lancet , vol.356 , Issue.9237 , pp. 1255-1259
    • Edwards, I.R.1    Aronson, J.K.2
  • 66
    • 33747312640 scopus 로고    scopus 로고
    • Molecular mechanisms underlying the dedifferentiation process of isolated hepatocytes and their cultures
    • Elaut G., Henkens T., Papeleu P., Snykers S., Vinken M., Vanhaecke T., et al. Molecular mechanisms underlying the dedifferentiation process of isolated hepatocytes and their cultures. Current Drug Metabolism 2006, 7(6):629-660.
    • (2006) Current Drug Metabolism , vol.7 , Issue.6 , pp. 629-660
    • Elaut, G.1    Henkens, T.2    Papeleu, P.3    Snykers, S.4    Vinken, M.5    Vanhaecke, T.6
  • 69
    • 78650526759 scopus 로고    scopus 로고
    • Differences in NMDA receptor expression during human development determine the response of neurons to HIV-tat-mediated neurotoxicity
    • Eugenin E.A., King J.E., Hazleton J.E., Major E.O., Bennett M.V., Zukin R.S., et al. Differences in NMDA receptor expression during human development determine the response of neurons to HIV-tat-mediated neurotoxicity. Neurotoxicological Research 2011, 19(1):138-148.
    • (2011) Neurotoxicological Research , vol.19 , Issue.1 , pp. 138-148
    • Eugenin, E.A.1    King, J.E.2    Hazleton, J.E.3    Major, E.O.4    Bennett, M.V.5    Zukin, R.S.6
  • 70
    • 0041326652 scopus 로고    scopus 로고
    • Induction of hepatic differentiation in embryonic stem cells by co-culture with embryonic cardiac mesoderm
    • Fair J.H., Cairns B.A., LaPaglia M., Wang J., Meyer A.A., Kim H., et al. Induction of hepatic differentiation in embryonic stem cells by co-culture with embryonic cardiac mesoderm. Surgery 2003, 134(2):189-196.
    • (2003) Surgery , vol.134 , Issue.2 , pp. 189-196
    • Fair, J.H.1    Cairns, B.A.2    LaPaglia, M.3    Wang, J.4    Meyer, A.A.5    Kim, H.6
  • 71
    • 0034007745 scopus 로고    scopus 로고
    • Liver regeneration
    • Fausto N. Liver regeneration. Journal of Hepatology 2000, 32(1 Suppl.):19-31.
    • (2000) Journal of Hepatology , vol.32 , Issue.1 SUPPL. , pp. 19-31
    • Fausto, N.1
  • 72
    • 0038471102 scopus 로고    scopus 로고
    • The impact of drug-induced QT interval prolongation on drug discovery and development
    • Fermini B., Fossa A.A. The impact of drug-induced QT interval prolongation on drug discovery and development. Nature Reviews Drug Discovery 2003, 2(6):439-447.
    • (2003) Nature Reviews Drug Discovery , vol.2 , Issue.6 , pp. 439-447
    • Fermini, B.1    Fossa, A.A.2
  • 73
    • 66449091911 scopus 로고    scopus 로고
    • Testing costs and testing capacity according to the REACH requirements - results of a survey of independent and corporate GLP laboratories in the EU and Switzerland
    • Fleischer M. Testing costs and testing capacity according to the REACH requirements - results of a survey of independent and corporate GLP laboratories in the EU and Switzerland. Journal of Business Chemistry 2007, 4(3):96-114.
    • (2007) Journal of Business Chemistry , vol.4 , Issue.3 , pp. 96-114
    • Fleischer, M.1
  • 74
    • 33745106680 scopus 로고    scopus 로고
    • Whole embryo culture: an important tool in developmental toxicology today
    • Flick B., Klug S. Whole embryo culture: an important tool in developmental toxicology today. Current Pharmaceutical Design 2006, 12(12):1467-1488.
    • (2006) Current Pharmaceutical Design , vol.12 , Issue.12 , pp. 1467-1488
    • Flick, B.1    Klug, S.2
  • 75
    • 0021288290 scopus 로고
    • Differentiation of rat embryo cells in culture: response following acute maternal exposure to teratogens and non-teratogens
    • Flint O.P., Orton T.C., Ferguson R.A. Differentiation of rat embryo cells in culture: response following acute maternal exposure to teratogens and non-teratogens. J Appl Toxicol 1984, 4(2):109-116.
    • (1984) J Appl Toxicol , vol.4 , Issue.2 , pp. 109-116
    • Flint, O.P.1    Orton, T.C.2    Ferguson, R.A.3
  • 76
    • 22144449590 scopus 로고    scopus 로고
    • Polychlorinated biphenyls disturb differentiation of normal human neural progenitor cells: clue for involvement of thyroid hormone receptors
    • Fritsche E., Cline J.E., Nguyen N.H., Scanlan T.S., Abel J. Polychlorinated biphenyls disturb differentiation of normal human neural progenitor cells: clue for involvement of thyroid hormone receptors. Environmental Health Perspectives 2005, 113(7):871-876.
    • (2005) Environmental Health Perspectives , vol.113 , Issue.7 , pp. 871-876
    • Fritsche, E.1    Cline, J.E.2    Nguyen, N.H.3    Scanlan, T.S.4    Abel, J.5
  • 77
    • 79952121986 scopus 로고    scopus 로고
    • The role of circadian timing system on drug metabolism and detoxification
    • Gachon F., Firsov D. The role of circadian timing system on drug metabolism and detoxification. Expert Opinion on Drug Metabolism & Toxicology 2011, 7(2):147-158.
    • (2011) Expert Opinion on Drug Metabolism & Toxicology , vol.7 , Issue.2 , pp. 147-158
    • Gachon, F.1    Firsov, D.2
  • 78
    • 0033949393 scopus 로고    scopus 로고
    • Development of prediction models for three in vitro embryotoxicity tests in an ECVAM validation study
    • Genschow E., Scholz G., Brown N., Piersma A., Brady M., Clemann N., et al. Development of prediction models for three in vitro embryotoxicity tests in an ECVAM validation study. In Vitro and Molecular Toxicology 2000, 13(1):51-66.
    • (2000) In Vitro and Molecular Toxicology , vol.13 , Issue.1 , pp. 51-66
    • Genschow, E.1    Scholz, G.2    Brown, N.3    Piersma, A.4    Brady, M.5    Clemann, N.6
  • 79
    • 0036098620 scopus 로고    scopus 로고
    • The ECVAM international validation study on in vitro embryotoxicity tests: results of the definitive phase and evaluation of prediction models. European Centre for the Validation of Alternative Methods
    • Genschow E., Spielmann H., Scholz G., Seiler A., Brown N., Piersma A., et al. The ECVAM international validation study on in vitro embryotoxicity tests: results of the definitive phase and evaluation of prediction models. European Centre for the Validation of Alternative Methods. Alternatives to Laboratory Animals 2002, 30(2):151-176.
    • (2002) Alternatives to Laboratory Animals , vol.30 , Issue.2 , pp. 151-176
    • Genschow, E.1    Spielmann, H.2    Scholz, G.3    Seiler, A.4    Brown, N.5    Piersma, A.6
  • 80
    • 8744223170 scopus 로고    scopus 로고
    • Validation of the embryonic stem cell test in the international ECVAM validation study on three in vitro embryotoxicity tests
    • Genschow E., Spielmann H., Scholz G., Pohl I., Seiler A., Clemann N., et al. Validation of the embryonic stem cell test in the international ECVAM validation study on three in vitro embryotoxicity tests. Alternatives to Laboratory Animals 2004, 32(3):209-244.
    • (2004) Alternatives to Laboratory Animals , vol.32 , Issue.3 , pp. 209-244
    • Genschow, E.1    Spielmann, H.2    Scholz, G.3    Pohl, I.4    Seiler, A.5    Clemann, N.6
  • 81
    • 77957347780 scopus 로고    scopus 로고
    • Generation of liver disease-specific induced pluripotent stem cells along with efficient differentiation to functional hepatocyte-like cells
    • Ghodsizadeh A., Taei A., Totonchi M., Seifinejad A., Gourabi H., Pournasr B., et al. Generation of liver disease-specific induced pluripotent stem cells along with efficient differentiation to functional hepatocyte-like cells. Stem Cell Reviews and Reports 2010, 6(4):622-632.
    • (2010) Stem Cell Reviews and Reports , vol.6 , Issue.4 , pp. 622-632
    • Ghodsizadeh, A.1    Taei, A.2    Totonchi, M.3    Seifinejad, A.4    Gourabi, H.5    Pournasr, B.6
  • 82
    • 84863736752 scopus 로고    scopus 로고
    • Prescription-acquired acetaminophen use and potential overuse patterns: 2001-2008
    • Gokhale M., Martin B.C. Prescription-acquired acetaminophen use and potential overuse patterns: 2001-2008. Pharmacoepidemiology and Drug Safety 2011.
    • (2011) Pharmacoepidemiology and Drug Safety
    • Gokhale, M.1    Martin, B.C.2
  • 85
    • 79952899995 scopus 로고    scopus 로고
    • Methods for making induced pluripotent stem cells: Reprogramming à la carte
    • González F., Boué S., Belmonte J.C.I. Methods for making induced pluripotent stem cells: Reprogramming à la carte. Nature Reviews Genetics 2011, 12(4):231-242.
    • (2011) Nature Reviews Genetics , vol.12 , Issue.4 , pp. 231-242
    • González, F.1    Boué, S.2    Belmonte, J.C.I.3
  • 86
    • 33750882952 scopus 로고    scopus 로고
    • BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm
    • Gouon-Evans V., Boussemart L., Gadue P., Nierhoff D., Koehler C.I., Kubo A., et al. BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm. Nature Biotechnology 2006, 24(11):1402-1411.
    • (2006) Nature Biotechnology , vol.24 , Issue.11 , pp. 1402-1411
    • Gouon-Evans, V.1    Boussemart, L.2    Gadue, P.3    Nierhoff, D.4    Koehler, C.I.5    Kubo, A.6
  • 87
    • 42149094990 scopus 로고    scopus 로고
    • Enhanced cardiomyogenesis of human embryonic stem cells by a small molecular inhibitor of p38 MAPK
    • Graichen R., Xu X., Braam S.R., Balakrishnan T., Norfiza S., Sieh S., et al. Enhanced cardiomyogenesis of human embryonic stem cells by a small molecular inhibitor of p38 MAPK. Differentiation 2008, 76(4):357-370.
    • (2008) Differentiation , vol.76 , Issue.4 , pp. 357-370
    • Graichen, R.1    Xu, X.2    Braam, S.R.3    Balakrishnan, T.4    Norfiza, S.5    Sieh, S.6
  • 88
    • 13844254521 scopus 로고    scopus 로고
    • Comparison of Matrigel and gelatin substrata for feeder-free culture of undifferentiated mouse embryonic stem cells for toxicity testing
    • Greenlee A.R., Kronenwetter-Koepel T.A., Kaiser S.J., Liu K. Comparison of Matrigel and gelatin substrata for feeder-free culture of undifferentiated mouse embryonic stem cells for toxicity testing. Toxicology In Vitro 2005, 19(3):389-397.
    • (2005) Toxicology In Vitro , vol.19 , Issue.3 , pp. 389-397
    • Greenlee, A.R.1    Kronenwetter-Koepel, T.A.2    Kaiser, S.J.3    Liu, K.4
  • 91
    • 78049375674 scopus 로고    scopus 로고
    • General review on in vitro hepatocyte models and their applications
    • Guguen-Guillouzo C., Guillouzo A. General review on in vitro hepatocyte models and their applications. Methods in Molecular Biology 2010, 640:1-40.
    • (2010) Methods in Molecular Biology , vol.640 , pp. 1-40
    • Guguen-Guillouzo, C.1    Guillouzo, A.2
  • 92
    • 80052487012 scopus 로고    scopus 로고
    • Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes
    • Guo L., Abrams R.M., Babiarz J.E., Cohen J.D., Kameoka S., Sanders M.J., et al. Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes. Toxicological Sciences 2011, 123(1):281-289.
    • (2011) Toxicological Sciences , vol.123 , Issue.1 , pp. 281-289
    • Guo, L.1    Abrams, R.M.2    Babiarz, J.E.3    Cohen, J.D.4    Kameoka, S.5    Sanders, M.J.6
  • 93
    • 77950920903 scopus 로고    scopus 로고
    • Transcriptome-wide Identification of RNA-binding protein and MicroRNA target sites by PAR-CLIP
    • Hafner M., Landthaler M., Burger L., Khorshid M., Hausser J., Berninger P., et al. Transcriptome-wide Identification of RNA-binding protein and MicroRNA target sites by PAR-CLIP. Cell 2010, 141(1):129-141.
    • (2010) Cell , vol.141 , Issue.1 , pp. 129-141
    • Hafner, M.1    Landthaler, M.2    Burger, L.3    Khorshid, M.4    Hausser, J.5    Berninger, P.6
  • 94
    • 0035907098 scopus 로고    scopus 로고
    • Hepatic maturation in differentiating embryonic stem cells in vitro
    • Hamazaki T., Iiboshi Y., Oka M., Papst P.J., Meacham A.M., Zon L.I., et al. Hepatic maturation in differentiating embryonic stem cells in vitro. FEBS Letters 2001, 497(1):15-19.
    • (2001) FEBS Letters , vol.497 , Issue.1 , pp. 15-19
    • Hamazaki, T.1    Iiboshi, Y.2    Oka, M.3    Papst, P.J.4    Meacham, A.M.5    Zon, L.I.6
  • 95
    • 70349612311 scopus 로고    scopus 로고
    • Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons
    • Han Y., Miller A., Mangada J., Liu Y., Swistowski A., Zhan M., et al. Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One 2009, 4(9):e7155.
    • (2009) PLoS One , vol.4 , Issue.9
    • Han, Y.1    Miller, A.2    Mangada, J.3    Liu, Y.4    Swistowski, A.5    Zhan, M.6
  • 97
    • 21744435739 scopus 로고    scopus 로고
    • The integrated project ReProTect: a novel approach in reproductive toxicity hazard assessment
    • Hareng L., Pellizzer C., Bremer S., Schwarz M., Hartung T. The integrated project ReProTect: a novel approach in reproductive toxicity hazard assessment. Reproductive Toxicology 2005, 20(3):441-452.
    • (2005) Reproductive Toxicology , vol.20 , Issue.3 , pp. 441-452
    • Hareng, L.1    Pellizzer, C.2    Bremer, S.3    Schwarz, M.4    Hartung, T.5
  • 98
    • 77952673694 scopus 로고    scopus 로고
    • Quantitative assessment of neurite outgrowth in human embryonic stem cell-derived hN2 cells using automated high-content image analysis
    • Harrill J.A., Freudenrich T.M., Machacek D.W., Stice S.L., Mundy W.R. Quantitative assessment of neurite outgrowth in human embryonic stem cell-derived hN2 cells using automated high-content image analysis. Neurotoxicology 2010, 31(3):277-290.
    • (2010) Neurotoxicology , vol.31 , Issue.3 , pp. 277-290
    • Harrill, J.A.1    Freudenrich, T.M.2    Machacek, D.W.3    Stice, S.L.4    Mundy, W.R.5
  • 99
    • 69349104947 scopus 로고    scopus 로고
    • Chemical regulators have overreached
    • Hartung T., Rovida C. Chemical regulators have overreached. Nature 2009, 460(7259):1080-1081.
    • (2009) Nature , vol.460 , Issue.7259 , pp. 1080-1081
    • Hartung, T.1    Rovida, C.2
  • 102
    • 0038300672 scopus 로고    scopus 로고
    • Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization
    • He J.Q., Ma Y., Lee Y., Thomson J.A., Kamp T.J. Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization. Circulation Research 2003, 93(1):32-39.
    • (2003) Circulation Research , vol.93 , Issue.1 , pp. 32-39
    • He, J.Q.1    Ma, Y.2    Lee, Y.3    Thomson, J.A.4    Kamp, T.J.5
  • 103
    • 77954087354 scopus 로고    scopus 로고
    • Metabolic activation capacity by primary hepatocytes expands the applicability of the embryonic stem cell test as alternative to experimental animal testing
    • Hettwer M., Reis-Fernandes M.A., Iken M., Ott M., Steinberg P., Nau H. Metabolic activation capacity by primary hepatocytes expands the applicability of the embryonic stem cell test as alternative to experimental animal testing. Reproductive Toxicology 2010, 30(1):113-120.
    • (2010) Reproductive Toxicology , vol.30 , Issue.1 , pp. 113-120
    • Hettwer, M.1    Reis-Fernandes, M.A.2    Iken, M.3    Ott, M.4    Steinberg, P.5    Nau, H.6
  • 104
    • 9944253258 scopus 로고    scopus 로고
    • Animal testing and alternative approaches for the human health risk assessment under the proposed new European chemicals regulation
    • Hofer T., Gerner I., Gundert-Remy U., Liebsch M., Schulte A., Spielmann H., et al. Animal testing and alternative approaches for the human health risk assessment under the proposed new European chemicals regulation. Archives in Toxicology 2004, 78(10):549-564.
    • (2004) Archives in Toxicology , vol.78 , Issue.10 , pp. 549-564
    • Hofer, T.1    Gerner, I.2    Gundert-Remy, U.3    Liebsch, M.4    Schulte, A.5    Spielmann, H.6
  • 105
    • 0027394918 scopus 로고
    • To do tissue culture in two or three dimensions? That is the question
    • Hoffman R.M. To do tissue culture in two or three dimensions? That is the question. Stem Cells 1993, 11(2):105-111.
    • (1993) Stem Cells , vol.11 , Issue.2 , pp. 105-111
    • Hoffman, R.M.1
  • 106
    • 81455149481 scopus 로고    scopus 로고
    • Electrophysiological characterization of cardiomyocytes derived from human induced pluripotent stem cells
    • Honda M., Kiyokawa J., Tabo M., Inoue T. Electrophysiological characterization of cardiomyocytes derived from human induced pluripotent stem cells. Journal of Pharmacological Sciences 2011.
    • (2011) Journal of Pharmacological Sciences
    • Honda, M.1    Kiyokawa, J.2    Tabo, M.3    Inoue, T.4
  • 107
    • 55749104227 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2
    • Huangfu D., Osafune K., Maehr R., Guo W., Eijkelenboom A., Chen S., et al. Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nature Biotechnology 2008, 26(11):1269-1275.
    • (2008) Nature Biotechnology , vol.26 , Issue.11 , pp. 1269-1275
    • Huangfu, D.1    Osafune, K.2    Maehr, R.3    Guo, W.4    Eijkelenboom, A.5    Chen, S.6
  • 108
    • 33646829077 scopus 로고    scopus 로고
    • In vitro embryotoxicity testing of metals for dental use by differentiation of embryonic stem cell test
    • Imai K., Nakamura M. In vitro embryotoxicity testing of metals for dental use by differentiation of embryonic stem cell test. Congenital Anomaly (Kyoto) 2006, 46(1):34-38.
    • (2006) Congenital Anomaly (Kyoto) , vol.46 , Issue.1 , pp. 34-38
    • Imai, K.1    Nakamura, M.2
  • 109
    • 36148976077 scopus 로고    scopus 로고
    • Influence of cytochrome P450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects
    • Ingelman-Sundberg M., Sim S.C., Gomez A., Rodriguez-Antona C. Influence of cytochrome P450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects. Pharmacology and Therapeutics 2007, 116(3):496-526.
    • (2007) Pharmacology and Therapeutics , vol.116 , Issue.3 , pp. 496-526
    • Ingelman-Sundberg, M.1    Sim, S.C.2    Gomez, A.3    Rodriguez-Antona, C.4
  • 111
    • 0029043995 scopus 로고
    • Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins
    • Itoh K., Igarashi K., Hayashi N., Nishizawa M., Yamamoto M. Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins. Molecular and Cellular Biology 1995, 15(8):4184-4193.
    • (1995) Molecular and Cellular Biology , vol.15 , Issue.8 , pp. 4184-4193
    • Itoh, K.1    Igarashi, K.2    Hayashi, N.3    Nishizawa, M.4    Yamamoto, M.5
  • 112
    • 0031577292 scopus 로고    scopus 로고
    • An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
    • Itoh K., Chiba T., Takahashi S., Ishii T., Igarashi K., Katoh Y., et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochemical and Biophysical Research Communications 1997, 236(2):313-322.
    • (1997) Biochemical and Biophysical Research Communications , vol.236 , Issue.2 , pp. 313-322
    • Itoh, K.1    Chiba, T.2    Takahashi, S.3    Ishii, T.4    Igarashi, K.5    Katoh, Y.6
  • 113
    • 0034136393 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers
    • Itskovitz-Eldor J., Schuldiner M., Karsenti D., Eden A., Yanuka O., Amit M., et al. Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers. Molecular Medicine 2000, 6(2):88-95.
    • (2000) Molecular Medicine , vol.6 , Issue.2 , pp. 88-95
    • Itskovitz-Eldor, J.1    Schuldiner, M.2    Karsenti, D.3    Eden, A.4    Yanuka, O.5    Amit, M.6
  • 114
    • 79953056240 scopus 로고    scopus 로고
    • Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation
    • Jagtap S., Meganathan K., Gaspar J., Wagh V., Winkler J., Hescheler J., et al. Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. British Journal of Pharmacology 2011, 162(8):1743-1756.
    • (2011) British Journal of Pharmacology , vol.162 , Issue.8 , pp. 1743-1756
    • Jagtap, S.1    Meganathan, K.2    Gaspar, J.3    Wagh, V.4    Winkler, J.5    Hescheler, J.6
  • 115
    • 0032171581 scopus 로고    scopus 로고
    • Lithium - early development, toxicity, and renal function
    • Johnson G. Lithium - early development, toxicity, and renal function. Neuropsychopharmacology 1998, 19(3):200-205.
    • (1998) Neuropsychopharmacology , vol.19 , Issue.3 , pp. 200-205
    • Johnson, G.1
  • 116
    • 79959820846 scopus 로고    scopus 로고
    • Comparative analysis of human embryonic stem cell and induced pluripotent stem cell-derived hepatocyte-like cells reveals current drawbacks and possible strategies for improved differentiation
    • Jozefczuk J., Prigione A., Chavez L., Adjaye J. Comparative analysis of human embryonic stem cell and induced pluripotent stem cell-derived hepatocyte-like cells reveals current drawbacks and possible strategies for improved differentiation. Stem Cells and Development 2011, 20(7):1259-1275.
    • (2011) Stem Cells and Development , vol.20 , Issue.7 , pp. 1259-1275
    • Jozefczuk, J.1    Prigione, A.2    Chavez, L.3    Adjaye, J.4
  • 117
    • 0035831059 scopus 로고    scopus 로고
    • Oncostatin M and hepatocyte growth factor induce hepatic maturation via distinct signaling pathways
    • Kamiya A., Kinoshita T., Miyajima A. Oncostatin M and hepatocyte growth factor induce hepatic maturation via distinct signaling pathways. FEBS Letters 2001, 492(1, 2):90-94.
    • (2001) FEBS Letters , vol.492 , Issue.1-2 , pp. 90-94
    • Kamiya, A.1    Kinoshita, T.2    Miyajima, A.3
  • 118
    • 0035513932 scopus 로고    scopus 로고
    • Effects and neuro-toxic mechanisms of 2, 2', 4, 4', 5, 5'-hexachlorobiphenyl and endosulfan in neuronal stem cells
    • Kang K.S., Park J.E., Ryu D.Y., Lee Y.S. Effects and neuro-toxic mechanisms of 2, 2', 4, 4', 5, 5'-hexachlorobiphenyl and endosulfan in neuronal stem cells. Journal of Veterinary Medical Science 2001, 63(11):1183-1190.
    • (2001) Journal of Veterinary Medical Science , vol.63 , Issue.11 , pp. 1183-1190
    • Kang, K.S.1    Park, J.E.2    Ryu, D.Y.3    Lee, Y.S.4
  • 119
    • 0347091717 scopus 로고    scopus 로고
    • Growth factors and nonparenchymal cell conditioned media induce mitogenic responses in stable long-term adult rat hepatocyte cultures
    • Kang Y.H., Berthiaume F., Nath B.D., Yarmush M.L. Growth factors and nonparenchymal cell conditioned media induce mitogenic responses in stable long-term adult rat hepatocyte cultures. Experimental Cell Research 2004, 293(2):239-247.
    • (2004) Experimental Cell Research , vol.293 , Issue.2 , pp. 239-247
    • Kang, Y.H.1    Berthiaume, F.2    Nath, B.D.3    Yarmush, M.L.4
  • 121
    • 0034904645 scopus 로고    scopus 로고
    • Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes
    • Kehat I., Kenyagin-Karsenti D., Snir M., Segev H., Amit M., Gepstein A., et al. Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. Journal of Clinical Investigations 2001, 108(3):407-414.
    • (2001) Journal of Clinical Investigations , vol.108 , Issue.3 , pp. 407-414
    • Kehat, I.1    Kenyagin-Karsenti, D.2    Snir, M.3    Segev, H.4    Amit, M.5    Gepstein, A.6
  • 122
    • 48149086386 scopus 로고    scopus 로고
    • Preclinical assessment of cardiac toxicity
    • Kettenhofen R., Bohlen H. Preclinical assessment of cardiac toxicity. Drug Discovery Today 2008, 13(15, 16):702-707.
    • (2008) Drug Discovery Today , vol.13 , Issue.15-16 , pp. 702-707
    • Kettenhofen, R.1    Bohlen, H.2
  • 123
    • 38049011979 scopus 로고    scopus 로고
    • Microscale culture of human liver cells for drug development
    • Khetani S.R., Bhatia S.N. Microscale culture of human liver cells for drug development. Nature Biotechnology 2008, 26(1):120-126.
    • (2008) Nature Biotechnology , vol.26 , Issue.1 , pp. 120-126
    • Khetani, S.R.1    Bhatia, S.N.2
  • 124
    • 34347343984 scopus 로고    scopus 로고
    • Patterned co-culture of primary hepatocytes and fibroblasts using polyelectrolyte multilayer templates
    • Kidambi S., Sheng L., Yarmush M.L., Toner M., Lee I., Chan C. Patterned co-culture of primary hepatocytes and fibroblasts using polyelectrolyte multilayer templates. Macromolecular Bioscience 2007, 7(3):344-353.
    • (2007) Macromolecular Bioscience , vol.7 , Issue.3 , pp. 344-353
    • Kidambi, S.1    Sheng, L.2    Yarmush, M.L.3    Toner, M.4    Lee, I.5    Chan, C.6
  • 125
    • 79251512982 scopus 로고    scopus 로고
    • Expression profiles of miRNAs in human embryonic stem cells during hepatocyte differentiation
    • Kim N., Kim H., Jung I., Kim Y., Kim D., Han Y.-M. Expression profiles of miRNAs in human embryonic stem cells during hepatocyte differentiation. Hepatology Research 2011, 41(2):170-183.
    • (2011) Hepatology Research , vol.41 , Issue.2 , pp. 170-183
    • Kim, N.1    Kim, H.2    Jung, I.3    Kim, Y.4    Kim, D.5    Han, Y.-M.6
  • 127
    • 2342424743 scopus 로고    scopus 로고
    • Development of definitive endoderm from embryonic stem cells in culture
    • Kubo A., Shinozaki K., Shannon J.M., Kouskoff V., Kennedy M., Woo S., et al. Development of definitive endoderm from embryonic stem cells in culture. Development 2004, 131(7):1651-1662.
    • (2004) Development , vol.131 , Issue.7 , pp. 1651-1662
    • Kubo, A.1    Shinozaki, K.2    Shannon, J.M.3    Kouskoff, V.4    Kennedy, M.5    Woo, S.6
  • 129
    • 0035955374 scopus 로고    scopus 로고
    • Identification of novel genes coding for small expressed RNAs
    • Lagos-Quintana M., Rauhut R., Lendeckel W., Tuschl T. Identification of novel genes coding for small expressed RNAs. Science 2001, 294(5543):853-858.
    • (2001) Science , vol.294 , Issue.5543 , pp. 853-858
    • Lagos-Quintana, M.1    Rauhut, R.2    Lendeckel, W.3    Tuschl, T.4
  • 131
    • 77957553807 scopus 로고    scopus 로고
    • Similarly derived and cultured hESC lines show variation in their developmental potential towards neuronal cells in long-term culture
    • Lappalainen R.S., Salomaki M., Yla-Outinen L., Heikkila T.J., Hyttinen J.A., Pihlajamaki H., et al. Similarly derived and cultured hESC lines show variation in their developmental potential towards neuronal cells in long-term culture. Regenerative Medicine 2010, 5(5):749-762.
    • (2010) Regenerative Medicine , vol.5 , Issue.5 , pp. 749-762
    • Lappalainen, R.S.1    Salomaki, M.2    Yla-Outinen, L.3    Heikkila, T.J.4    Hyttinen, J.A.5    Pihlajamaki, H.6
  • 132
    • 84872210008 scopus 로고    scopus 로고
    • A feedback loop between the liver-enriched transcription factor network and Mir-122 controls hepatocyte differentiation
    • Laudadio I., Manfroid I., Achouri Y., Schmidt D., Wilson M.D., Cordi S., et al. A feedback loop between the liver-enriched transcription factor network and Mir-122 controls hepatocyte differentiation. Gastroenterology 2011.
    • (2011) Gastroenterology
    • Laudadio, I.1    Manfroid, I.2    Achouri, Y.3    Schmidt, D.4    Wilson, M.D.5    Cordi, S.6
  • 133
    • 78650971216 scopus 로고    scopus 로고
    • Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture
    • Laurent L.C., Ulitsky I., Slavin I., Tran H., Schork A., Morey R., et al. Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. Cell Stem Cell 2011, 8(1):106-118.
    • (2011) Cell Stem Cell , vol.8 , Issue.1 , pp. 106-118
    • Laurent, L.C.1    Ulitsky, I.2    Slavin, I.3    Tran, H.4    Schork, A.5    Morey, R.6
  • 134
    • 27944455549 scopus 로고    scopus 로고
    • Study of hepatocyte differentiation using embryonic stem cells
    • Lavon N., Benvenisty N. Study of hepatocyte differentiation using embryonic stem cells. Journal of Cellular Biochemistry 2005, 96(6):1193-1202.
    • (2005) Journal of Cellular Biochemistry , vol.96 , Issue.6 , pp. 1193-1202
    • Lavon, N.1    Benvenisty, N.2
  • 135
    • 9644282186 scopus 로고    scopus 로고
    • Differentiation and isolation of hepatic-like cells from human embryonic stem cells
    • Lavon N., Yanuka O., Benvenisty N. Differentiation and isolation of hepatic-like cells from human embryonic stem cells. Differentiation 2004, 72(5):230-238.
    • (2004) Differentiation , vol.72 , Issue.5 , pp. 230-238
    • Lavon, N.1    Yanuka, O.2    Benvenisty, N.3
  • 137
    • 0041317597 scopus 로고    scopus 로고
    • Acute liver failure in the United States
    • Lee W.M. Acute liver failure in the United States. Seminal Liver Disease 2003, 23(03):217,226.
    • (2003) Seminal Liver Disease , vol.23 , Issue.3 , pp. 217-226
    • Lee, W.M.1
  • 138
    • 33745198904 scopus 로고    scopus 로고
    • Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 (hENT1): implications for interspecies differences in mitochondrial toxicity of fialuridine
    • Lee E.W., Lai Y., Zhang H., Unadkat J.D. Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1 (hENT1): implications for interspecies differences in mitochondrial toxicity of fialuridine. Journal of Biological Chemistry 2006, 281(24):16,700-16,706.
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.24 , pp. 16700-16706
    • Lee, E.W.1    Lai, Y.2    Zhang, H.3    Unadkat, J.D.4
  • 139
    • 77949363964 scopus 로고    scopus 로고
    • The continuing evolution of torsades de pointes liability testing methods: is there an end in sight?
    • Lee N., Authier S., Pugsley M.K., Curtis M.J. The continuing evolution of torsades de pointes liability testing methods: is there an end in sight?. Toxicology and Applied Pharmacology 2010, 243(2):146-153.
    • (2010) Toxicology and Applied Pharmacology , vol.243 , Issue.2 , pp. 146-153
    • Lee, N.1    Authier, S.2    Pugsley, M.K.3    Curtis, M.J.4
  • 142
    • 79955755007 scopus 로고    scopus 로고
    • MicroRNA cluster 302-367 enhances somatic cell reprogramming by accelerating a mesenchymal-to-epithelial transition
    • Liao B., Bao X., Liu L., Feng S., Zovoilis A., Liu W., et al. MicroRNA cluster 302-367 enhances somatic cell reprogramming by accelerating a mesenchymal-to-epithelial transition. Journal of Biological Chemistry 2011, 286(19):17,359-17,364.
    • (2011) Journal of Biological Chemistry , vol.286 , Issue.19 , pp. 17359-17364
    • Liao, B.1    Bao, X.2    Liu, L.3    Feng, S.4    Zovoilis, A.5    Liu, W.6
  • 143
    • 84863745268 scopus 로고    scopus 로고
    • Deciphering the mechanism behind iPSC generation
    • Lin S.-L. Deciphering the mechanism behind iPSC generation. Stem Cells 2011.
    • (2011) Stem Cells
    • Lin, S.-L.1
  • 144
    • 79952200696 scopus 로고    scopus 로고
    • Methods for culturing mouse and human embryonic stem cells
    • Lin S., Talbot P. Methods for culturing mouse and human embryonic stem cells. Methods in Molecular Biology 2011, 690:31-56.
    • (2011) Methods in Molecular Biology , vol.690 , pp. 31-56
    • Lin, S.1    Talbot, P.2
  • 145
    • 78650196632 scopus 로고    scopus 로고
    • Regulation of somatic cell reprogramming through inducible mir-302 expression
    • Lin S.L., Chang D.C., Lin C.H., Ying S.Y., Leu D., Wu D.T.S. Regulation of somatic cell reprogramming through inducible mir-302 expression. Nucleic Acids Research 2011, 39(3):1054-1065.
    • (2011) Nucleic Acids Research , vol.39 , Issue.3 , pp. 1054-1065
    • Lin, S.L.1    Chang, D.C.2    Lin, C.H.3    Ying, S.Y.4    Leu, D.5    Wu, D.T.S.6
  • 146
    • 79952264847 scopus 로고    scopus 로고
    • Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells
    • Lister R., Pelizzola M., Kida Y.S., Hawkins R.D., Nery J.R., Hon G., et al. Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature 2011, 471(7336):68-73.
    • (2011) Nature , vol.471 , Issue.7336 , pp. 68-73
    • Lister, R.1    Pelizzola, M.2    Kida, Y.S.3    Hawkins, R.D.4    Nery, J.R.5    Hon, G.6
  • 147
    • 2942607445 scopus 로고    scopus 로고
    • The changing view of acrylamide neurotoxicity
    • LoPachin R.M. The changing view of acrylamide neurotoxicity. Neurotoxicology 2004, 25(4):617-630.
    • (2004) Neurotoxicology , vol.25 , Issue.4 , pp. 617-630
    • LoPachin, R.M.1
  • 148
    • 0035906902 scopus 로고    scopus 로고
    • Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets
    • Lumelsky N., Blondel O., Laeng P., Velasco I., Ravin R., McKay R. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 2001, 292(5520):1389-1394.
    • (2001) Science , vol.292 , Issue.5520 , pp. 1389-1394
    • Lumelsky, N.1    Blondel, O.2    Laeng, P.3    Velasco, I.4    Ravin, R.5    McKay, R.6
  • 151
    • 80053900492 scopus 로고    scopus 로고
    • Direct lineage conversion of terminally differentiated hepatocytes to functional neurons
    • Marro S., Pang Z.P., Yang N., Tsai M.C., Qu K., Chang H.Y., et al. Direct lineage conversion of terminally differentiated hepatocytes to functional neurons. Cell Stem Cell 2011, 9(4):374-382.
    • (2011) Cell Stem Cell , vol.9 , Issue.4 , pp. 374-382
    • Marro, S.1    Pang, Z.P.2    Yang, N.3    Tsai, M.C.4    Qu, K.5    Chang, H.Y.6
  • 152
    • 69849088915 scopus 로고    scopus 로고
    • A review of the implementation of the embryonic stem cell test (EST). The report and recommendations of an ECVAM/ReProTect Workshop
    • Marx-Stoelting P., Adriaens E., Ahr H.J., Bremer S., Garthoff B., Gelbke H.P., et al. A review of the implementation of the embryonic stem cell test (EST). The report and recommendations of an ECVAM/ReProTect Workshop. Alternatives to Laboratory Animals 2009, 37(3):313-328.
    • (2009) Alternatives to Laboratory Animals , vol.37 , Issue.3 , pp. 313-328
    • Marx-Stoelting, P.1    Adriaens, E.2    Ahr, H.J.3    Bremer, S.4    Garthoff, B.5    Gelbke, H.P.6
  • 153
    • 79954523845 scopus 로고    scopus 로고
    • Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation
    • Matsa E., Rajamohan D., Dick E., Young L., Mellor I., Staniforth A., et al. Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation. European Heart Journal 2011, 32(8):952-962.
    • (2011) European Heart Journal , vol.32 , Issue.8 , pp. 952-962
    • Matsa, E.1    Rajamohan, D.2    Dick, E.3    Young, L.4    Mellor, I.5    Staniforth, A.6
  • 154
    • 33845996144 scopus 로고    scopus 로고
    • Activin A efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed
    • McLean A.B., D'Amour K.A., Jones K.L., Krishnamoorthy M., Kulik M.J., Reynolds D.M., et al. Activin A efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells 2007, 25(1):29-38.
    • (2007) Stem Cells , vol.25 , Issue.1 , pp. 29-38
    • McLean, A.B.1    D'Amour, K.A.2    Jones, K.L.3    Krishnamoorthy, M.4    Kulik, M.J.5    Reynolds, D.M.6
  • 156
    • 10244235353 scopus 로고    scopus 로고
    • QT-screen: high-throughput cardiac safety pharmacology by extracellular electrophysiology on primary cardiac myocytes
    • Meyer T., Leisgen C., Gonser B., Gunther E. QT-screen: high-throughput cardiac safety pharmacology by extracellular electrophysiology on primary cardiac myocytes. Assay and Drug Development Technologies 2004, 2(5):507-514.
    • (2004) Assay and Drug Development Technologies , vol.2 , Issue.5 , pp. 507-514
    • Meyer, T.1    Leisgen, C.2    Gonser, B.3    Gunther, E.4
  • 157
    • 33644903202 scopus 로고    scopus 로고
    • Influence of retinoic acid and lithium on proliferation and dopaminergic potential of human NT2 cells
    • Misiuta I.E., Saporta S., Sanberg P.R., Zigova T., Willing A.E. Influence of retinoic acid and lithium on proliferation and dopaminergic potential of human NT2 cells. Journal of Neuroscience Research 2006, 83(4):668-679.
    • (2006) Journal of Neuroscience Research , vol.83 , Issue.4 , pp. 668-679
    • Misiuta, I.E.1    Saporta, S.2    Sanberg, P.R.3    Zigova, T.4    Willing, A.E.5
  • 159
    • 79957855262 scopus 로고    scopus 로고
    • Reprogramming of mouse and human cells to pluripotency using mature microRNAs
    • Miyoshi N., Ishii H., Nagano H., Haraguchi N., Dewi D.L., Kano Y., et al. Reprogramming of mouse and human cells to pluripotency using mature microRNAs. Cell Stem Cell 2011, 8(6):633-638.
    • (2011) Cell Stem Cell , vol.8 , Issue.6 , pp. 633-638
    • Miyoshi, N.1    Ishii, H.2    Nagano, H.3    Haraguchi, N.4    Dewi, D.L.5    Kano, Y.6
  • 160
    • 65249151353 scopus 로고    scopus 로고
    • Differentiation of monkey embryonic stem cells into hepatocytes and mRNA expression of cytochrome P450 enzymes responsible for drug metabolism: Comparison of embryoid body formation conditions and matrices
    • Momose Y., Matsunaga T., Murai K., Takezawa T., Ohmori S. Differentiation of monkey embryonic stem cells into hepatocytes and mRNA expression of cytochrome P450 enzymes responsible for drug metabolism: Comparison of embryoid body formation conditions and matrices. Biological and Pharmaceutical Bulletin 2009, 32(4):619-626.
    • (2009) Biological and Pharmaceutical Bulletin , vol.32 , Issue.4 , pp. 619-626
    • Momose, Y.1    Matsunaga, T.2    Murai, K.3    Takezawa, T.4    Ohmori, S.5
  • 161
    • 67649873120 scopus 로고    scopus 로고
    • Expedited growth factor-mediated specification of human embryonic stem cells toward the hepatic lineage
    • Moore R.N., Moghe P.V. Expedited growth factor-mediated specification of human embryonic stem cells toward the hepatic lineage. Stem Cell Research 2009, 3(1):51-62.
    • (2009) Stem Cell Research , vol.3 , Issue.1 , pp. 51-62
    • Moore, R.N.1    Moghe, P.V.2
  • 162
    • 77952306707 scopus 로고    scopus 로고
    • Mouse and human induced pluripotent stem cells as a source for multipotent Isl1+ cardiovascular progenitors
    • Moretti A., Bellin M., Jung C.B., Thies T.M., Takashima Y., Bernshausen A., et al. Mouse and human induced pluripotent stem cells as a source for multipotent Isl1+ cardiovascular progenitors. FASEB Journal 2010, 24(3):700-711.
    • (2010) FASEB Journal , vol.24 , Issue.3 , pp. 700-711
    • Moretti, A.1    Bellin, M.2    Jung, C.B.3    Thies, T.M.4    Takashima, Y.5    Bernshausen, A.6
  • 163
    • 74049120877 scopus 로고    scopus 로고
    • Sorting cardiomyocytes: a simple solution after all?
    • Mummery C. Sorting cardiomyocytes: a simple solution after all?. Nature Methods 2010, 7(1):40-42.
    • (2010) Nature Methods , vol.7 , Issue.1 , pp. 40-42
    • Mummery, C.1
  • 164
    • 0038210217 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells
    • Mummery C., Ward-van Oostwaard D., Doevendans P., Spijker R., van den Brink S., Hassink R., et al. Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells. Circulation 2003, 107(21):2733-2740.
    • (2003) Circulation , vol.107 , Issue.21 , pp. 2733-2740
    • Mummery, C.1    Ward-van Oostwaard, D.2    Doevendans, P.3    Spijker, R.4    van den Brink, S.5    Hassink, R.6
  • 165
    • 53449095205 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells to cardiomyocytes by coculture with endoderm in serum-free medium
    • Chapter 1, Unit 1F 2
    • Mummery C.L., Ward D., Passier R. Differentiation of human embryonic stem cells to cardiomyocytes by coculture with endoderm in serum-free medium. Current Protocols in Stem Cell Biology 2007, Chapter 1, Unit 1F 2.
    • (2007) Current Protocols in Stem Cell Biology
    • Mummery, C.L.1    Ward, D.2    Passier, R.3
  • 166
    • 58249095955 scopus 로고    scopus 로고
    • Directed induction of anterior and posterior primitive streak by Wnt from embryonic stem cells cultured in a chemically defined serum-free medium
    • Nakanishi M., Kurisaki A., Hayashi Y., Warashina M., Ishiura S., Kusuda-Furue M., et al. Directed induction of anterior and posterior primitive streak by Wnt from embryonic stem cells cultured in a chemically defined serum-free medium. FASEB Journal 2009, 23(1):114-122.
    • (2009) FASEB Journal , vol.23 , Issue.1 , pp. 114-122
    • Nakanishi, M.1    Kurisaki, A.2    Hayashi, Y.3    Warashina, M.4    Ishiura, S.5    Kusuda-Furue, M.6
  • 167
    • 46249104284 scopus 로고    scopus 로고
    • Methylmercury increases N-methyl-d-aspartate receptors on human SH-SY 5Y neuroblastoma cells leading to neurotoxicity
    • Ndountse L.T., Chan H.M. Methylmercury increases N-methyl-d-aspartate receptors on human SH-SY 5Y neuroblastoma cells leading to neurotoxicity. Toxicology 2008, 249(2, 3):251-255.
    • (2008) Toxicology , vol.249 , Issue.2-3 , pp. 251-255
    • Ndountse, L.T.1    Chan, H.M.2
  • 169
    • 84872204763 scopus 로고    scopus 로고
    • OECD. Guidelines for the testing of chemicals.
    • OECD. Guidelines for the testing of chemicals.
  • 170
    • 85027958626 scopus 로고    scopus 로고
    • Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells
    • Ohi Y., Qin H., Hong C., Blouin L., Polo J.M., Guo T., et al. Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells. Nature Cell Biology 2011, 13(5):541-549.
    • (2011) Nature Cell Biology , vol.13 , Issue.5 , pp. 541-549
    • Ohi, Y.1    Qin, H.2    Hong, C.3    Blouin, L.4    Polo, J.M.5    Guo, T.6
  • 172
    • 77955272554 scopus 로고    scopus 로고
    • Proteome profiling of mouse embryonic stem cells to define markers for cell differentiation and embryotoxicity
    • Osman A.M., van Dartel D.A., Zwart E., Blokland M., Pennings J.L., Piersma A.H. Proteome profiling of mouse embryonic stem cells to define markers for cell differentiation and embryotoxicity. Reproductive Toxicology 2010, 30(2):322-332.
    • (2010) Reproductive Toxicology , vol.30 , Issue.2 , pp. 322-332
    • Osman, A.M.1    van Dartel, D.A.2    Zwart, E.3    Blokland, M.4    Pennings, J.L.5    Piersma, A.H.6
  • 174
    • 0029885913 scopus 로고    scopus 로고
    • Relevance of induction of human drug-metabolizing enzymes: pharmacological and toxicological implications
    • Park B.K., Kitteringham N.R., Pirmohamed M., Tucker G.T. Relevance of induction of human drug-metabolizing enzymes: pharmacological and toxicological implications. British Journal of Clinical Pharmacology 1996, 41(6):477-491.
    • (1996) British Journal of Clinical Pharmacology , vol.41 , Issue.6 , pp. 477-491
    • Park, B.K.1    Kitteringham, N.R.2    Pirmohamed, M.3    Tucker, G.T.4
  • 176
    • 75949094213 scopus 로고    scopus 로고
    • Acrylamide induces cell death in neural progenitor cells and impairs hippocampal neurogenesis
    • Park H.R., Kim M.S., Kim S.J., Park M., Kong K.H., Kim H.S., et al. Acrylamide induces cell death in neural progenitor cells and impairs hippocampal neurogenesis. Toxicological Letters 2010, 193(1):86-93.
    • (2010) Toxicological Letters , vol.193 , Issue.1 , pp. 86-93
    • Park, H.R.1    Kim, M.S.2    Kim, S.J.3    Park, M.4    Kong, K.H.5    Kim, H.S.6
  • 177
    • 66149153524 scopus 로고    scopus 로고
    • Lineage restriction and differentiation of human embryonic stem cells into hepatic progenitors and zone 1 hepatocytes
    • Pei H., Yang Y., Xi J., Bai Z., Yue W., Nan X., et al. Lineage restriction and differentiation of human embryonic stem cells into hepatic progenitors and zone 1 hepatocytes. Tissue Engineering - Part C: Methods 2009, 15(1):95-104.
    • (2009) Tissue Engineering - Part C: Methods , vol.15 , Issue.1 , pp. 95-104
    • Pei, H.1    Yang, Y.2    Xi, J.3    Bai, Z.4    Yue, W.5    Nan, X.6
  • 178
    • 1642409267 scopus 로고    scopus 로고
    • Monitoring of teratogenic effects in vitro by analysing a selected gene expression pattern
    • Pellizzer C., Adler S., Corvi R., Hartung T., Bremer S. Monitoring of teratogenic effects in vitro by analysing a selected gene expression pattern. Toxicology In Vitro 2004, 18(3):325-335.
    • (2004) Toxicology In Vitro , vol.18 , Issue.3 , pp. 325-335
    • Pellizzer, C.1    Adler, S.2    Corvi, R.3    Hartung, T.4    Bremer, S.5
  • 179
    • 78751484566 scopus 로고    scopus 로고
    • Ultrastructural and molecular analyzes of insulin-producing cells induced from human hepatoma cells
    • Peran M., Sanchez-Ferrero A., Tosh D., Marchal J.A., Lopez E., Alvarez P., et al. Ultrastructural and molecular analyzes of insulin-producing cells induced from human hepatoma cells. Cytotherapy 2011, 13(2):193-200.
    • (2011) Cytotherapy , vol.13 , Issue.2 , pp. 193-200
    • Peran, M.1    Sanchez-Ferrero, A.2    Tosh, D.3    Marchal, J.A.4    Lopez, E.5    Alvarez, P.6
  • 180
    • 84954358518 scopus 로고    scopus 로고
    • Automated analysis of contractility in the embryonic stem cell test, a novel approach to assess embryotoxicity
    • Peters A.K., Wouwer G.V., Weyn B., Verheyen G.R., Vanparys P., Gompel J.V. Automated analysis of contractility in the embryonic stem cell test, a novel approach to assess embryotoxicity. Toxicology In Vitro 2008, 22(8):1948-1956.
    • (2008) Toxicology In Vitro , vol.22 , Issue.8 , pp. 1948-1956
    • Peters, A.K.1    Wouwer, G.V.2    Weyn, B.3    Verheyen, G.R.4    Vanparys, P.5    Gompel, J.V.6
  • 181
    • 80255131336 scopus 로고    scopus 로고
    • MiRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2
    • Pfaff N., Fiedler J., Holzmann A., Schambach A., Moritz T., Cantz T., et al. miRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2. EMBO Reports 2011, 12(11):1153-1159.
    • (2011) EMBO Reports , vol.12 , Issue.11 , pp. 1153-1159
    • Pfaff, N.1    Fiedler, J.2    Holzmann, A.3    Schambach, A.4    Moritz, T.5    Cantz, T.6
  • 182
    • 0035965343 scopus 로고    scopus 로고
    • Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
    • Phiel C.J., Zhang F., Huang E.Y., Guenther M.G., Lazar M.A., Klein P.S. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. Journal of Biological Chemistry 2001, 276(39):36,734-36,741.
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.39 , pp. 36734-36741
    • Phiel, C.J.1    Zhang, F.2    Huang, E.Y.3    Guenther, M.G.4    Lazar, M.A.5    Klein, P.S.6
  • 183
    • 72849144528 scopus 로고    scopus 로고
    • Clone- and gene-specific aberrations of parental imprinting in human induced pluripotent stem cells
    • Pick M., Stelzer Y., Bar-Nur O., Mayshar Y., Eden A., Benvenisty N. Clone- and gene-specific aberrations of parental imprinting in human induced pluripotent stem cells. Stem Cells 2009, 27(11):2686-2690.
    • (2009) Stem Cells , vol.27 , Issue.11 , pp. 2686-2690
    • Pick, M.1    Stelzer, Y.2    Bar-Nur, O.3    Mayshar, Y.4    Eden, A.5    Benvenisty, N.6
  • 184
    • 33646262295 scopus 로고    scopus 로고
    • Alternative methods for developmental toxicity testing
    • Piersma A.H. Alternative methods for developmental toxicity testing. Basic & Clinical Pharmacology & Toxicology 2006, 98(5):427-431.
    • (2006) Basic & Clinical Pharmacology & Toxicology , vol.98 , Issue.5 , pp. 427-431
    • Piersma, A.H.1
  • 185
    • 8744293605 scopus 로고    scopus 로고
    • Validation of the postimplantation rat whole-embryo culture test in the international ECVAM validation study on three in vitro embryotoxicity tests
    • Piersma A.H., Genschow E., Verhoef A., Spanjersberg M.Q., Brown N.A., Brady M., et al. Validation of the postimplantation rat whole-embryo culture test in the international ECVAM validation study on three in vitro embryotoxicity tests. Alternatives to Laboratory Animals 2004, 32(3):275-307.
    • (2004) Alternatives to Laboratory Animals , vol.32 , Issue.3 , pp. 275-307
    • Piersma, A.H.1    Genschow, E.2    Verhoef, A.3    Spanjersberg, M.Q.4    Brown, N.A.5    Brady, M.6
  • 186
    • 3042723720 scopus 로고    scopus 로고
    • Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients
    • Pirmohamed M., James S., Meakin S., Green C., Scott A.K., Walley T.J., et al. Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients. BMJ 2004, 329(7456):15-19.
    • (2004) BMJ , vol.329 , Issue.7456 , pp. 15-19
    • Pirmohamed, M.1    James, S.2    Meakin, S.3    Green, C.4    Scott, A.K.5    Walley, T.J.6
  • 187
    • 11844305963 scopus 로고    scopus 로고
    • Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IκB kinase 2, TPCA-1 (2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell proliferation
    • Podolin P.L., Callahan J.F., Bolognese B.J., Li Y.H., Carlson K., Davis T.G., et al. Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IκB kinase 2, TPCA-1 (2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell proliferation. Journal of Pharmacology and Experimental Therapeutics 2005, 312(1):373-381.
    • (2005) Journal of Pharmacology and Experimental Therapeutics , vol.312 , Issue.1 , pp. 373-381
    • Podolin, P.L.1    Callahan, J.F.2    Bolognese, B.J.3    Li, Y.H.4    Carlson, K.5    Davis, T.G.6
  • 188
    • 78650752402 scopus 로고    scopus 로고
    • Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells
    • Polo J.M., Liu S., Figueroa M.E., Kulalert W., Eminli S., Tan K.Y., et al. Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells. Nature Biotechnology 2010, 28(8):848-855.
    • (2010) Nature Biotechnology , vol.28 , Issue.8 , pp. 848-855
    • Polo, J.M.1    Liu, S.2    Figueroa, M.E.3    Kulalert, W.4    Eminli, S.5    Tan, K.Y.6
  • 189
    • 0035136803 scopus 로고    scopus 로고
    • Drug biotransformation by human hepatocytes. In vitro/in vivo metabolism by cells from the same donor
    • Ponsoda X., Pareja E., Gómez-Lechón M.J., Fabra R., Carrasco E., Trullenque R., et al. Drug biotransformation by human hepatocytes. In vitro/in vivo metabolism by cells from the same donor. Journal of Hepatology 2001, 34(1):19-25.
    • (2001) Journal of Hepatology , vol.34 , Issue.1 , pp. 19-25
    • Ponsoda, X.1    Pareja, E.2    Gómez-Lechón, M.J.3    Fabra, R.4    Carrasco, E.5    Trullenque, R.6
  • 190
    • 34547620338 scopus 로고    scopus 로고
    • Embryonic stem cells as a source of models for drug discovery
    • Pouton C.W., Haynes J.M. Embryonic stem cells as a source of models for drug discovery. Nature Reviews Drug Discovery 2007, 6(8):605-616.
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.8 , pp. 605-616
    • Pouton, C.W.1    Haynes, J.M.2
  • 193
    • 81855199725 scopus 로고    scopus 로고
    • Tissue distribution and gender-divergent expression of 78 cytochrome P450 mRNAs in mice
    • Renaud H.J., Cui J.Y., Khan M., Klaassen C.D. Tissue distribution and gender-divergent expression of 78 cytochrome P450 mRNAs in mice. Toxicological Sciences 2011, 124(2):261-277.
    • (2011) Toxicological Sciences , vol.124 , Issue.2 , pp. 261-277
    • Renaud, H.J.1    Cui, J.Y.2    Khan, M.3    Klaassen, C.D.4
  • 194
    • 80053476385 scopus 로고    scopus 로고
    • Shortening and improving the embryonic stem cell test through the use of gene biomarkers of differentiation
    • Romero A.C., Vilanova E., Sogorb M.A. Shortening and improving the embryonic stem cell test through the use of gene biomarkers of differentiation. Journal of Toxicology 2011, 2011:286,034.
    • (2011) Journal of Toxicology , vol.2011 , pp. 286034
    • Romero, A.C.1    Vilanova, E.2    Sogorb, M.A.3
  • 195
    • 0028557342 scopus 로고
    • Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction
    • Roskelley C.D., Desprez P.Y., Bissell M.J. Extracellular matrix-dependent tissue-specific gene expression in mammary epithelial cells requires both physical and biochemical signal transduction. Proceedings of the National Academy of Sciences of the United States of America 1994, 91(26):12,378-12,382.
    • (1994) Proceedings of the National Academy of Sciences of the United States of America , vol.91 , Issue.26 , pp. 12378-12382
    • Roskelley, C.D.1    Desprez, P.Y.2    Bissell, M.J.3
  • 196
    • 77249143567 scopus 로고    scopus 로고
    • Intrinsic versus idiosyncratic drug-induced hepatotoxicity - two villains or one?
    • Roth R.A., Ganey P.E. Intrinsic versus idiosyncratic drug-induced hepatotoxicity - two villains or one?. Journal of Pharmacology and Experimental Therapeutics 2010, 332(3):692-697.
    • (2010) Journal of Pharmacology and Experimental Therapeutics , vol.332 , Issue.3 , pp. 692-697
    • Roth, R.A.1    Ganey, P.E.2
  • 197
    • 65549167805 scopus 로고    scopus 로고
    • Cardiomyocyte enrichment from human embryonic stem cell cultures by selection of ALCAM surface expression
    • Rust W., Balakrishnan T., Zweigerdt R. Cardiomyocyte enrichment from human embryonic stem cell cultures by selection of ALCAM surface expression. Regenerative Medicine 2009, 4(2):225-237.
    • (2009) Regenerative Medicine , vol.4 , Issue.2 , pp. 225-237
    • Rust, W.1    Balakrishnan, T.2    Zweigerdt, R.3
  • 199
    • 84863745273 scopus 로고    scopus 로고
    • Role of CYP2E1-mediated metabolism in the acute and vestibular toxicities of nineteen nitriles in the mouse
    • Saldana-Ruiz S., Soler-Martin C., Llorens J. Role of CYP2E1-mediated metabolism in the acute and vestibular toxicities of nineteen nitriles in the mouse. Toxicological Letters 2011.
    • (2011) Toxicological Letters
    • Saldana-Ruiz, S.1    Soler-Martin, C.2    Llorens, J.3
  • 200
    • 80053102926 scopus 로고    scopus 로고
    • Human hepatocytes and endothelial cells in organotypic membrane systems
    • Salerno S., Campana C., Morelli S., Drioli E., De Bartolo L. Human hepatocytes and endothelial cells in organotypic membrane systems. Biomaterials 2011, 32(34):8848-8859.
    • (2011) Biomaterials , vol.32 , Issue.34 , pp. 8848-8859
    • Salerno, S.1    Campana, C.2    Morelli, S.3    Drioli, E.4    De Bartolo, L.5
  • 202
    • 34247580093 scopus 로고    scopus 로고
    • Developmental changes in cardiomyocytes differentiated from human embryonic stem cells: a molecular and electrophysiological approach
    • Sartiani L., Bettiol E., Stillitano F., Mugelli A., Cerbai E., Jaconi M.E. Developmental changes in cardiomyocytes differentiated from human embryonic stem cells: a molecular and electrophysiological approach. Stem Cells 2007, 25(5):1136-1144.
    • (2007) Stem Cells , vol.25 , Issue.5 , pp. 1136-1144
    • Sartiani, L.1    Bettiol, E.2    Stillitano, F.3    Mugelli, A.4    Cerbai, E.5    Jaconi, M.E.6
  • 203
    • 4644235479 scopus 로고    scopus 로고
    • Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyocytes
    • Satin J., Kehat I., Caspi O., Huber I., Arbel G., Itzhaki I., et al. Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyocytes. Journal of Physiology 2004, 559(Pt 2):479-496.
    • (2004) Journal of Physiology , vol.559 , Issue.PART 2 , pp. 479-496
    • Satin, J.1    Kehat, I.2    Caspi, O.3    Huber, I.4    Arbel, G.5    Itzhaki, I.6
  • 204
    • 54249111025 scopus 로고    scopus 로고
    • Calcium handling in human embryonic stem cell-derived cardiomyocytes
    • Satin J., Itzhaki I., Rapoport S., Schroder E.A., Izu L., Arbel G., et al. Calcium handling in human embryonic stem cell-derived cardiomyocytes. Stem Cells 2008, 26(8):1961-1972.
    • (2008) Stem Cells , vol.26 , Issue.8 , pp. 1961-1972
    • Satin, J.1    Itzhaki, I.2    Rapoport, S.3    Schroder, E.A.4    Izu, L.5    Arbel, G.6
  • 205
    • 0035064452 scopus 로고    scopus 로고
    • Lithium influences differentiation and tissue-specific gene expression of mouse embryonic stem (ES) cells in vitro
    • Schmidt M.M., Guan K., Wobus A.M. Lithium influences differentiation and tissue-specific gene expression of mouse embryonic stem (ES) cells in vitro. International Journal of Developmental Biology 2001, 45(2):421-429.
    • (2001) International Journal of Developmental Biology , vol.45 , Issue.2 , pp. 421-429
    • Schmidt, M.M.1    Guan, K.2    Wobus, A.M.3
  • 208
    • 79959877538 scopus 로고    scopus 로고
    • The validated embryonic stem cell test to predict embryotoxicity in vitro
    • Seiler A.E., Spielmann H. The validated embryonic stem cell test to predict embryotoxicity in vitro. Nature Protocols 2011, 6(7):961-978.
    • (2011) Nature Protocols , vol.6 , Issue.7 , pp. 961-978
    • Seiler, A.E.1    Spielmann, H.2
  • 209
    • 78049354200 scopus 로고    scopus 로고
    • Transdifferentiation of pancreatic cells to hepatocytes
    • Shen C.N., Tosh D. Transdifferentiation of pancreatic cells to hepatocytes. Methods in Molecular Biology 2010, 640:273-280.
    • (2010) Methods in Molecular Biology , vol.640 , pp. 273-280
    • Shen, C.N.1    Tosh, D.2
  • 210
    • 2442534076 scopus 로고    scopus 로고
    • Differentiation of human and mouse embryonic stem cells along a hepatocyte lineage
    • Shirahashi H., Wu J., Yamamoto N., Catana A., Wege H., Wager B., et al. Differentiation of human and mouse embryonic stem cells along a hepatocyte lineage. Cell Transplantation 2004, 13(3):197-211.
    • (2004) Cell Transplantation , vol.13 , Issue.3 , pp. 197-211
    • Shirahashi, H.1    Wu, J.2    Yamamoto, N.3    Catana, A.4    Wege, H.5    Wager, B.6
  • 211
    • 48949120846 scopus 로고    scopus 로고
    • Differentiation of mouse and human embryonic stem cells into hepatic lineages
    • Shiraki N., Umeda K., Sakashita N., Takeya M., Kume K., Kume S. Differentiation of mouse and human embryonic stem cells into hepatic lineages. Genes to Cells 2008, 13(7):731-746.
    • (2008) Genes to Cells , vol.13 , Issue.7 , pp. 731-746
    • Shiraki, N.1    Umeda, K.2    Sakashita, N.3    Takeya, M.4    Kume, K.5    Kume, S.6
  • 212
    • 73449100783 scopus 로고    scopus 로고
    • Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells
    • Si-Tayeb K., Noto F.K., Nagaoka M., Li J., Battle M.A., Duris C., et al. Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells. Hepatology 2010, 51(1):297-305.
    • (2010) Hepatology , vol.51 , Issue.1 , pp. 297-305
    • Si-Tayeb, K.1    Noto, F.K.2    Nagaoka, M.3    Li, J.4    Battle, M.A.5    Duris, C.6
  • 213
    • 84872205282 scopus 로고    scopus 로고
    • Influence of CYP2C9, GSTM1, GSTT1 and NAT2 genetic polymorphisms on DNA damage in workers occupationally exposed to organophosphate pesticides
    • Singh S., Kumar V., Singh P., Banerjee B.D., Rautela R.S., Grover S.S., et al. Influence of CYP2C9, GSTM1, GSTT1 and NAT2 genetic polymorphisms on DNA damage in workers occupationally exposed to organophosphate pesticides. Mutation Research 2011.
    • (2011) Mutation Research
    • Singh, S.1    Kumar, V.2    Singh, P.3    Banerjee, B.D.4    Rautela, R.S.5    Grover, S.S.6
  • 217
    • 65249118823 scopus 로고    scopus 로고
    • In vitro differentiation of embryonic and adult stem cells into hepatocytes: state of the art
    • Snykers S., De Kock J., Rogiers V., Vanhaecke T. In vitro differentiation of embryonic and adult stem cells into hepatocytes: state of the art. Stem Cells 2009, 27(3):577-605.
    • (2009) Stem Cells , vol.27 , Issue.3 , pp. 577-605
    • Snykers, S.1    De Kock, J.2    Rogiers, V.3    Vanhaecke, T.4
  • 219
    • 70449534874 scopus 로고    scopus 로고
    • Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells
    • Song Z., Cai J., Liu Y., Zhao D., Yong J., Duo S., et al. Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells. Cell Research 2009, 19(11):1233-1242.
    • (2009) Cell Research , vol.19 , Issue.11 , pp. 1233-1242
    • Song, Z.1    Cai, J.2    Liu, Y.3    Zhao, D.4    Yong, J.5    Duo, S.6
  • 221
    • 34347221578 scopus 로고    scopus 로고
    • Differentiation of mouse embryonic stem cells to hepatocyte-like cells by co-culture with human liver nonparenchymal cell lines
    • Soto-Gutierrez A., Navarro-Alvarez N., Zhao D., Rivas-Carrillo J.D., Lebkowski J., Tanaka N., et al. Differentiation of mouse embryonic stem cells to hepatocyte-like cells by co-culture with human liver nonparenchymal cell lines. Nature Protocols 2007, 2(2):347-356.
    • (2007) Nature Protocols , vol.2 , Issue.2 , pp. 347-356
    • Soto-Gutierrez, A.1    Navarro-Alvarez, N.2    Zhao, D.3    Rivas-Carrillo, J.D.4    Lebkowski, J.5    Tanaka, N.6
  • 222
    • 24644513538 scopus 로고    scopus 로고
    • Predicting the risk of developmental toxicity from in vitro assays
    • Spielmann H. Predicting the risk of developmental toxicity from in vitro assays. Toxicology and Applied Pharmacology 2005, 207(2 Suppl.):375-380.
    • (2005) Toxicology and Applied Pharmacology , vol.207 , Issue.2 SUPPL. , pp. 375-380
    • Spielmann, H.1
  • 223
    • 33748523021 scopus 로고    scopus 로고
    • REACH testing requirements must not be driven by reproductive toxicity testing
    • Spielmann H., Vogel R. REACH testing requirements must not be driven by reproductive toxicity testing. Alternative to Laboratory Animals 2006, 34(4):365-366.
    • (2006) Alternative to Laboratory Animals , vol.34 , Issue.4 , pp. 365-366
    • Spielmann, H.1    Vogel, R.2
  • 224
    • 0030917962 scopus 로고    scopus 로고
    • The embryonic stem cells test (EST), an in vitro embryotoxicity test using two permanent mouse cell lines: 3T3 fibroblasts and embyronic stem cells
    • Spielmann H., Pohl I., Doring B., Liebsch M., Moldenhauer F. The embryonic stem cells test (EST), an in vitro embryotoxicity test using two permanent mouse cell lines: 3T3 fibroblasts and embyronic stem cells. In Vitro Toxicology 1997, 10:119-127.
    • (1997) In Vitro Toxicology , vol.10 , pp. 119-127
    • Spielmann, H.1    Pohl, I.2    Doring, B.3    Liebsch, M.4    Moldenhauer, F.5
  • 225
    • 77952425747 scopus 로고    scopus 로고
    • Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells
    • Stadtfeld M., Apostolou E., Akutsu H., Fukuda A., Follett P., Natesan S., et al. Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells. Nature 2010, 465(7295):175-181.
    • (2010) Nature , vol.465 , Issue.7295 , pp. 175-181
    • Stadtfeld, M.1    Apostolou, E.2    Akutsu, H.3    Fukuda, A.4    Follett, P.5    Natesan, S.6
  • 226
    • 60249094665 scopus 로고    scopus 로고
    • Hazard assessment of methylmercury toxicity to neuronal induction in embryogenesis using human embryonic stem cells
    • Stummann T.C., Hareng L., Bremer S. Hazard assessment of methylmercury toxicity to neuronal induction in embryogenesis using human embryonic stem cells. Toxicology 2009, 257(3):117-126.
    • (2009) Toxicology , vol.257 , Issue.3 , pp. 117-126
    • Stummann, T.C.1    Hareng, L.2    Bremer, S.3
  • 227
    • 79955780736 scopus 로고    scopus 로고
    • Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells
    • Subramanyam D., Lamouille S., Judson R.L., Liu J.Y., Bucay N., Derynck R., et al. Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nature Biotechnology 2011, 29(5):443-448.
    • (2011) Nature Biotechnology , vol.29 , Issue.5 , pp. 443-448
    • Subramanyam, D.1    Lamouille, S.2    Judson, R.L.3    Liu, J.Y.4    Bucay, N.5    Derynck, R.6
  • 228
    • 81255167161 scopus 로고    scopus 로고
    • Dialkyl phosphates as biomarkers of organophosphates: the current divide between epidemiology and clinical toxicology
    • Sudakin D.L., Stone D.L. Dialkyl phosphates as biomarkers of organophosphates: the current divide between epidemiology and clinical toxicology. Clinical Toxicology (Philadelphia) 2011, 49(9):771-781.
    • (2011) Clinical Toxicology (Philadelphia) , vol.49 , Issue.9 , pp. 771-781
    • Sudakin, D.L.1    Stone, D.L.2
  • 229
    • 73449100456 scopus 로고    scopus 로고
    • Generation of functional human hepatic endoderm from human induced pluripotent stem cells
    • Sullivan G.J., Hay D.C., Park I.-H., Fletcher J., Hannoun Z., Payne C.M., et al. Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology 2010, 51(1):329-335.
    • (2010) Hepatology , vol.51 , Issue.1 , pp. 329-335
    • Sullivan, G.J.1    Hay, D.C.2    Park, I.-H.3    Fletcher, J.4    Hannoun, Z.5    Payne, C.M.6
  • 230
    • 80053513897 scopus 로고    scopus 로고
    • Analysis of altered gene expression specific to embryotoxic chemical treatment during embryonic stem cell differentiation into myocardiac and neural cells
    • Suzuki N., Ando S., Sumida K., Horie N., Saito K. Analysis of altered gene expression specific to embryotoxic chemical treatment during embryonic stem cell differentiation into myocardiac and neural cells. Journal of Toxicological Sciences 2011, 36(5):569-585.
    • (2011) Journal of Toxicological Sciences , vol.36 , Issue.5 , pp. 569-585
    • Suzuki, N.1    Ando, S.2    Sumida, K.3    Horie, N.4    Saito, K.5
  • 232
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126(4):663-676.
    • (2006) Cell , vol.126 , Issue.4 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 233
    • 33847697379 scopus 로고    scopus 로고
    • Retained introns increase putative microRNA targets within 3' UTRs of human mRNA
    • Tan S., Guo J., Huang Q., Chen X., Li-Ling J., Li Q., et al. Retained introns increase putative microRNA targets within 3' UTRs of human mRNA. FEBS Letters 2007, 581(6):1081-1086.
    • (2007) FEBS Letters , vol.581 , Issue.6 , pp. 1081-1086
    • Tan, S.1    Guo, J.2    Huang, Q.3    Chen, X.4    Li-Ling, J.5    Li, Q.6
  • 234
    • 4344567112 scopus 로고    scopus 로고
    • Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors
    • Tanimizu N., Miyajima A. Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors. Journal of Cell Science 2004, 117(15):3165-3174.
    • (2004) Journal of Cell Science , vol.117 , Issue.15 , pp. 3165-3174
    • Tanimizu, N.1    Miyajima, A.2
  • 235
    • 84866742396 scopus 로고    scopus 로고
    • The effects of metallothionein 2A polymorphism on lead metabolism: are pregnant women with a heterozygote genotype for metallothionein 2A polymorphism and their newborns at risk of having higher blood lead levels?
    • Tekin D., Kayaalti Z., Soylemezoglu T. The effects of metallothionein 2A polymorphism on lead metabolism: are pregnant women with a heterozygote genotype for metallothionein 2A polymorphism and their newborns at risk of having higher blood lead levels?. International Archives of Occupational and Environmental Health 2011.
    • (2011) International Archives of Occupational and Environmental Health
    • Tekin, D.1    Kayaalti, Z.2    Soylemezoglu, T.3
  • 236
    • 34548492056 scopus 로고    scopus 로고
    • Comparison of guinea-pig ventricular myocytes and dog Purkinje fibres for in vitro assessment of drug-induced delayed repolarization
    • Terrar D.A., Wilson C.M., Graham S.G., Bryant S.M., Heath B.M. Comparison of guinea-pig ventricular myocytes and dog Purkinje fibres for in vitro assessment of drug-induced delayed repolarization. Journal of Pharmacological and Toxicological Methods 2007, 56(2):171-185.
    • (2007) Journal of Pharmacological and Toxicological Methods , vol.56 , Issue.2 , pp. 171-185
    • Terrar, D.A.1    Wilson, C.M.2    Graham, S.G.3    Bryant, S.M.4    Heath, B.M.5
  • 237
    • 84872219068 scopus 로고    scopus 로고
    • The International Conference on Harmonisation. (2011). Safety Guidelines. Available from: (retrieved 26 October).
    • The International Conference on Harmonisation. (2011). Safety Guidelines. Available from: (retrieved 26 October 2011). http://www.ich.org/products/guidelines/safety/article/safety-guidelines.html.
    • (2011)
  • 239
    • 79952696864 scopus 로고    scopus 로고
    • The effects of Boehmeria nivea (L.) Gaud. on embryonic development: in vivo and in vitro studies
    • Tian X.Y., Xu M., Deng B., Leung K.S., Cheng K.F., Zhao Z.Z., et al. The effects of Boehmeria nivea (L.) Gaud. on embryonic development: in vivo and in vitro studies. Journal of Ethnopharmacology 2011, 134(2):393-398.
    • (2011) Journal of Ethnopharmacology , vol.134 , Issue.2 , pp. 393-398
    • Tian, X.Y.1    Xu, M.2    Deng, B.3    Leung, K.S.4    Cheng, K.F.5    Zhao, Z.Z.6
  • 241
    • 6044267892 scopus 로고    scopus 로고
    • Failing the public health-rofecoxib, Merck, and the FDA
    • Topol E.J. Failing the public health-rofecoxib, Merck, and the FDA. New England Journal of Medicine 2004, 351(17):1707-1709.
    • (2004) New England Journal of Medicine , vol.351 , Issue.17 , pp. 1707-1709
    • Topol, E.J.1
  • 242
    • 77951480489 scopus 로고    scopus 로고
    • Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development
    • Touboul T., Hannan N.R.F., Corbineau S., Martinez A., Martinet C., Branchereau S., et al. Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development. Hepatology 2010, 51(5):1754-1765.
    • (2010) Hepatology , vol.51 , Issue.5 , pp. 1754-1765
    • Touboul, T.1    Hannan, N.R.F.2    Corbineau, S.3    Martinez, A.4    Martinet, C.5    Branchereau, S.6
  • 243
    • 45349084219 scopus 로고    scopus 로고
    • Reproducible, ultra high-throughput formation of multicellular organization from single cell suspension-derived human embryonic stem cell aggregates
    • Ungrin M.D., Joshi C., Nica A., Bauwens C., Zandstra P.W. Reproducible, ultra high-throughput formation of multicellular organization from single cell suspension-derived human embryonic stem cell aggregates. PLoS One 2008, 3(2):e1565.
    • (2008) PLoS One , vol.3 , Issue.2
    • Ungrin, M.D.1    Joshi, C.2    Nica, A.3    Bauwens, C.4    Zandstra, P.W.5
  • 245
    • 67650635159 scopus 로고    scopus 로고
    • Disentangling cellular proliferation and differentiation in the embryonic stem cell test, and its impact on the experimental protocol
    • van Dartel D.A., Zeijen N.J., de la Fonteyne L.J., van Schooten F.J., Piersma A.H. Disentangling cellular proliferation and differentiation in the embryonic stem cell test, and its impact on the experimental protocol. Reproductive Toxicology 2009, 28(2):254-261.
    • (2009) Reproductive Toxicology , vol.28 , Issue.2 , pp. 254-261
    • van Dartel, D.A.1    Zeijen, N.J.2    de la Fonteyne, L.J.3    van Schooten, F.J.4    Piersma, A.H.5
  • 246
    • 78650538006 scopus 로고    scopus 로고
    • Evaluation of developmental toxicant identification using gene expression profiling in embryonic stem cell differentiation cultures
    • van Dartel D.A., Pennings J.L., de la Fonteyne L.J., Brauers K.J., Claessen S., van Delft J.H., et al. Evaluation of developmental toxicant identification using gene expression profiling in embryonic stem cell differentiation cultures. Toxicological Sciences 2011, 119(1):126-134.
    • (2011) Toxicological Sciences , vol.119 , Issue.1 , pp. 126-134
    • van Dartel, D.A.1    Pennings, J.L.2    de la Fonteyne, L.J.3    Brauers, K.J.4    Claessen, S.5    van Delft, J.H.6
  • 248
    • 77949862634 scopus 로고    scopus 로고
    • Identification of cell surface proteins for antibody-based selection of human embryonic stem cell-derived cardiomyocytes
    • Van Hoof D., Dormeyer W., Braam S.R., Passier R., Monshouwer-Kloots J., Ward-van Oostwaard D., et al. Identification of cell surface proteins for antibody-based selection of human embryonic stem cell-derived cardiomyocytes. J Proteome Res 2010, 9(3):1610-1618.
    • (2010) J Proteome Res , vol.9 , Issue.3 , pp. 1610-1618
    • Van Hoof, D.1    Dormeyer, W.2    Braam, S.R.3    Passier, R.4    Monshouwer-Kloots, J.5    Ward-van Oostwaard, D.6
  • 249
    • 0032994516 scopus 로고    scopus 로고
    • Isolation and cloning of multipotential stem cells from the embryonic human CNS and establishment of transplantable human neural stem cell lines by epigenetic stimulation
    • Vescovi A.L., Parati E.A., Gritti A., Poulin P., Ferrario M., Wanke E., et al. Isolation and cloning of multipotential stem cells from the embryonic human CNS and establishment of transplantable human neural stem cell lines by epigenetic stimulation. Experimental Neurology 1999, 156(1):71-83.
    • (1999) Experimental Neurology , vol.156 , Issue.1 , pp. 71-83
    • Vescovi, A.L.1    Parati, E.A.2    Gritti, A.3    Poulin, P.4    Ferrario, M.5    Wanke, E.6
  • 250
    • 80054726357 scopus 로고    scopus 로고
    • Direct lineage conversions: unnatural but useful?
    • Vierbuchen T., Wernig M. Direct lineage conversions: unnatural but useful?. Nature Biotechnology 2011, 29(10):892-907.
    • (2011) Nature Biotechnology , vol.29 , Issue.10 , pp. 892-907
    • Vierbuchen, T.1    Wernig, M.2
  • 251
    • 77649162059 scopus 로고    scopus 로고
    • Direct conversion of fibroblasts to functional neurons by defined factors
    • Vierbuchen T., Ostermeier A., Pang Z.P., Kokubu Y., Sudhof T.C., Wernig M. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 2010, 463(7284):1035-1041.
    • (2010) Nature , vol.463 , Issue.7284 , pp. 1035-1041
    • Vierbuchen, T.1    Ostermeier, A.2    Pang, Z.P.3    Kokubu, Y.4    Sudhof, T.C.5    Wernig, M.6
  • 252
    • 0029998039 scopus 로고    scopus 로고
    • Embryonic stem cells differentiate in vitro to endothelial cells through successive maturation steps
    • Vittet D., Prandini M.H., Berthier R., Schweitzer A., Martin-Sisteron H., Uzan G., et al. Embryonic stem cells differentiate in vitro to endothelial cells through successive maturation steps. Blood 1996, 88(9):3424-3431.
    • (1996) Blood , vol.88 , Issue.9 , pp. 3424-3431
    • Vittet, D.1    Prandini, M.H.2    Berthier, R.3    Schweitzer, A.4    Martin-Sisteron, H.5    Uzan, G.6
  • 253
    • 0018228644 scopus 로고
    • Human biochemical genetics of plasma dopamine-beta-hydroxylase and erythrocyte catechol-o-methyltransferase
    • Weinshilboum R.M. Human biochemical genetics of plasma dopamine-beta-hydroxylase and erythrocyte catechol-o-methyltransferase. Human genetics Supplement 1978, 1:101-112.
    • (1978) Human genetics Supplement , vol.1 , pp. 101-112
    • Weinshilboum, R.M.1
  • 255
    • 15544383394 scopus 로고    scopus 로고
    • Embryonic stem cells: prospects for developmental biology and cell therapy
    • Wobus A.M., Boheler K.R. Embryonic stem cells: prospects for developmental biology and cell therapy. Physiological Reviews 2005, 85(2):635-678.
    • (2005) Physiological Reviews , vol.85 , Issue.2 , pp. 635-678
    • Wobus, A.M.1    Boheler, K.R.2
  • 256
    • 79954447513 scopus 로고    scopus 로고
    • Present state and future perspectives of using pluripotent stem cells in toxicology research
    • Wobus A., Löser P. Present state and future perspectives of using pluripotent stem cells in toxicology research. Archives of Toxicology 2011, 85(2):79-117.
    • (2011) Archives of Toxicology , vol.85 , Issue.2 , pp. 79-117
    • Wobus, A.1    Löser, P.2
  • 257
    • 79954447513 scopus 로고    scopus 로고
    • Present state and future perspectives of using pluripotent stem cells in toxicology research
    • Wobus A.M., Loser P. Present state and future perspectives of using pluripotent stem cells in toxicology research. Archives in Toxicology 2011, 85(2):79-117.
    • (2011) Archives in Toxicology , vol.85 , Issue.2 , pp. 79-117
    • Wobus, A.M.1    Loser, P.2
  • 258
    • 0036134448 scopus 로고    scopus 로고
    • Embryonic stem cells as a model to study cardiac, skeletal muscle, and vascular smooth muscle cell differentiation
    • Wobus A.M., Guan K., Yang H.T., Boheler K.R. Embryonic stem cells as a model to study cardiac, skeletal muscle, and vascular smooth muscle cell differentiation. Methods in Molecular Biology 2002, 185:127-156.
    • (2002) Methods in Molecular Biology , vol.185 , pp. 127-156
    • Wobus, A.M.1    Guan, K.2    Yang, H.T.3    Boheler, K.R.4
  • 259
    • 0037144701 scopus 로고    scopus 로고
    • Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells
    • Xu C., Police S., Rao N., Carpenter M.K. Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells. Circulation Research 2002, 91(6):501-508.
    • (2002) Circulation Research , vol.91 , Issue.6 , pp. 501-508
    • Xu, C.1    Police, S.2    Rao, N.3    Carpenter, M.K.4
  • 260
    • 33751002976 scopus 로고    scopus 로고
    • Cardiac bodies: a novel culture method for enrichment of cardiomyocytes derived from human embryonic stem cells
    • Xu C., Police S., Hassanipour M., Gold J.D. Cardiac bodies: a novel culture method for enrichment of cardiomyocytes derived from human embryonic stem cells. Stem Cells and Development 2006, 15(5):631-639.
    • (2006) Stem Cells and Development , vol.15 , Issue.5 , pp. 631-639
    • Xu, C.1    Police, S.2    Hassanipour, M.3    Gold, J.D.4
  • 261
    • 54249098708 scopus 로고    scopus 로고
    • Chemically defined medium supporting cardiomyocyte differentiation of human embryonic stem cells
    • Xu X.Q., Graichen R., Soo S.Y., Balakrishnan T., Rahmat S.N., Sieh S., et al. Chemically defined medium supporting cardiomyocyte differentiation of human embryonic stem cells. Differentiation 2008, 76(9):958-970.
    • (2008) Differentiation , vol.76 , Issue.9 , pp. 958-970
    • Xu, X.Q.1    Graichen, R.2    Soo, S.Y.3    Balakrishnan, T.4    Rahmat, S.N.5    Sieh, S.6
  • 262
    • 47249107353 scopus 로고    scopus 로고
    • Highly enriched cardiomyocytes from human embryonic stem cells
    • Xu X.Q., Zweigerdt R., Soo S.Y., Ngoh Z.X., Tham S.C., Wang S.T., et al. Highly enriched cardiomyocytes from human embryonic stem cells. Cytotherapy 2008, 10(4):376-389.
    • (2008) Cytotherapy , vol.10 , Issue.4 , pp. 376-389
    • Xu, X.Q.1    Zweigerdt, R.2    Soo, S.Y.3    Ngoh, Z.X.4    Tham, S.C.5    Wang, S.T.6
  • 263
    • 77958000068 scopus 로고    scopus 로고
    • Effects of low level of methylmercury on proliferation of cortical progenitor cells
    • Xu M., Yan C., Tian Y., Yuan X., Shen X. Effects of low level of methylmercury on proliferation of cortical progenitor cells. Brain Research 2010, 1359:272-280.
    • (2010) Brain Research , vol.1359 , pp. 272-280
    • Xu, M.1    Yan, C.2    Tian, Y.3    Yuan, X.4    Shen, X.5
  • 264
    • 44349175948 scopus 로고    scopus 로고
    • Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population
    • Yang L., Soonpaa M.H., Adler E.D., Roepke T.K., Kattman S.J., Kennedy M., et al. Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature 2008, 453(7194):524-528.
    • (2008) Nature , vol.453 , Issue.7194 , pp. 524-528
    • Yang, L.1    Soonpaa, M.H.2    Adler, E.D.3    Roepke, T.K.4    Kattman, S.J.5    Kennedy, M.6
  • 265
    • 0026778383 scopus 로고
    • Mechanism of action of hydroxyurea
    • Yarbro J.W. Mechanism of action of hydroxyurea. Seminars in Oncology 1992, 19(3 Suppl. 9):1-10.
    • (1992) Seminars in Oncology , vol.19 , Issue.3 SUPPL. 9 , pp. 1-10
    • Yarbro, J.W.1
  • 266
    • 81855211099 scopus 로고    scopus 로고
    • Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity
    • Yildirimman R., Brolen G., Vilardell M., Eriksson G., Synnergren J., Gmuender H., et al. Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity. Toxicological Sciences 2011, 124(2):278-290.
    • (2011) Toxicological Sciences , vol.124 , Issue.2 , pp. 278-290
    • Yildirimman, R.1    Brolen, G.2    Vilardell, M.3    Eriksson, G.4    Synnergren, J.5    Gmuender, H.6
  • 268
  • 270
    • 80054987997 scopus 로고    scopus 로고
    • Targeted gene correction of [agr]1-antitrypsin deficiency in induced pluripotent stem cells
    • Yusa K., Rashid S.T., Strick-Marchand H., Varela I., Liu P.-Q., Paschon D.E., et al. Targeted gene correction of [agr]1-antitrypsin deficiency in induced pluripotent stem cells. Nature 2011, 478(7369):391-394.
    • (2011) Nature , vol.478 , Issue.7369 , pp. 391-394
    • Yusa, K.1    Rashid, S.T.2    Strick-Marchand, H.3    Varela, I.4    Liu, P.-Q.5    Paschon, D.E.6
  • 271
    • 33751114134 scopus 로고    scopus 로고
    • An in vitro model of human dopaminergic neurons derived from embryonic stem cells: MPP+ toxicity and GDNF neuroprotection
    • Zeng X., Chen J., Deng X., Liu Y., Rao M.S., Cadet J.L., et al. An in vitro model of human dopaminergic neurons derived from embryonic stem cells: MPP+ toxicity and GDNF neuroprotection. Neuropsychopharmacology 2006, 31(12):2708-2715.
    • (2006) Neuropsychopharmacology , vol.31 , Issue.12 , pp. 2708-2715
    • Zeng, X.1    Chen, J.2    Deng, X.3    Liu, Y.4    Rao, M.S.5    Cadet, J.L.6
  • 272
    • 70350222219 scopus 로고    scopus 로고
    • Lack of ABCG2 expression and side population properties in human pluripotent stem cells
    • Zeng H., Park J.W., Guo M., Lin G., Crandall L., Compton T., et al. Lack of ABCG2 expression and side population properties in human pluripotent stem cells. Stem Cells 2009, 27(10):2435-2445.
    • (2009) Stem Cells , vol.27 , Issue.10 , pp. 2435-2445
    • Zeng, H.1    Park, J.W.2    Guo, M.3    Lin, G.4    Crandall, L.5    Compton, T.6
  • 273
    • 58249084043 scopus 로고    scopus 로고
    • Small but influential: the role of microRNAs on gene regulatory network and 3'UTR evolution
    • Zhang R., Su B. Small but influential: the role of microRNAs on gene regulatory network and 3'UTR evolution. Journal of Genetics and Genomics 2009, 36(1):1-6.
    • (2009) Journal of Genetics and Genomics , vol.36 , Issue.1 , pp. 1-6
    • Zhang, R.1    Su, B.2
  • 274
    • 0035200623 scopus 로고    scopus 로고
    • In vitro differentiation of transplantable neural precursors from human embryonic stem cells
    • Zhang S.C., Wernig M., Duncan I.D., Brustle O., Thomson J.A. In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nature Biotechnology 2001, 19(12):1129-1133.
    • (2001) Nature Biotechnology , vol.19 , Issue.12 , pp. 1129-1133
    • Zhang, S.C.1    Wernig, M.2    Duncan, I.D.3    Brustle, O.4    Thomson, J.A.5
  • 276
    • 68149145797 scopus 로고    scopus 로고
    • Derivation and characterization of hepatic progenitor cells from human embryonic stem cells
    • Zhao D., Chen S., Cai J., Guo Y., Song Z., Che J., et al. Derivation and characterization of hepatic progenitor cells from human embryonic stem cells. PLoS ONE 2009, 4(7).
    • (2009) PLoS ONE , vol.4 , Issue.7
    • Zhao, D.1    Chen, S.2    Cai, J.3    Guo, Y.4    Song, Z.5    Che, J.6
  • 277
    • 84862832855 scopus 로고    scopus 로고
    • Early embryonic sensitivity to cyclophosphamide in cardiac differentiation from human embryonic stem cells
    • Zhu M.X., Zhao J.Y., Chen G.A., Guan L. Early embryonic sensitivity to cyclophosphamide in cardiac differentiation from human embryonic stem cells. Cell Biology International 2011, 35(9):927-938.
    • (2011) Cell Biology International , vol.35 , Issue.9 , pp. 927-938
    • Zhu, M.X.1    Zhao, J.Y.2    Chen, G.A.3    Guan, L.4
  • 278
    • 79951678616 scopus 로고    scopus 로고
    • Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing
    • Zimmer B., Kuegler P.B., Baudis B., Genewsky A., Tanavde V., Koh W., et al. Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing. Cell Death & Differentiation 2011, 18(3):383-395.
    • (2011) Cell Death & Differentiation , vol.18 , Issue.3 , pp. 383-395
    • Zimmer, B.1    Kuegler, P.B.2    Baudis, B.3    Genewsky, A.4    Tanavde, V.5    Koh, W.6
  • 279
    • 33750933369 scopus 로고    scopus 로고
    • Contribution of non-parenchymal cells to the performance of micropatterned hepatocytes
    • Zinchenko Y.S., Culberson C.R., Coger R.N. Contribution of non-parenchymal cells to the performance of micropatterned hepatocytes. Tissue Engineering 2006, 12(8):2241-2251.
    • (2006) Tissue Engineering , vol.12 , Issue.8 , pp. 2241-2251
    • Zinchenko, Y.S.1    Culberson, C.R.2    Coger, R.N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.