메뉴 건너뛰기




Volumn 25, Issue 5, 2007, Pages 1136-1144

Developmental changes in cardiomyocytes differentiated from human embryonic stem cells: A molecular and electrophysiological approach

Author keywords

Cardiac differentiation; Embryonic stem cells; Ion channel subunits; Ion current; Maturation; Multicellular recordings

Indexed keywords

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL ISOLATION; CELL MATURATION; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EMBRYONIC STEM CELL; HEART MUSCLE CELL; MOUSE; NONHUMAN; POTASSIUM CURRENT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 34247580093     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2006-0466     Document Type: Article
Times cited : (326)

References (43)
  • 1
    • 0032491416 scopus 로고    scopus 로고
    • Embryonic stem cell lines derived from human blastocysts
    • Thomson JA, Itskovitz-Eldor J, Shapiro SS et al. Embryonic stem cell lines derived from human blastocysts. Science 1998;282:1145-1147.
    • (1998) Science , vol.282 , pp. 1145-1147
    • Thomson, J.A.1    Itskovitz-Eldor, J.2    Shapiro, S.S.3
  • 2
    • 0034904645 scopus 로고    scopus 로고
    • Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes
    • Kehat I, Kenyagin-Karsenti D, Snir M et al. Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J Clin Invest 2001;108:407-414.
    • (2001) J Clin Invest , vol.108 , pp. 407-414
    • Kehat, I.1    Kenyagin-Karsenti, D.2    Snir, M.3
  • 3
    • 1542298998 scopus 로고    scopus 로고
    • Derivation, propagation and differentiation of human embryonic stem cells
    • Conley BJ, Young JC, Trounson AO et al. Derivation, propagation and differentiation of human embryonic stem cells. Int J Biochem Cell Biol 2004;36:555-567.
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 555-567
    • Conley, B.J.1    Young, J.C.2    Trounson, A.O.3
  • 4
    • 0345303845 scopus 로고    scopus 로고
    • Assessment of the ultrastructural and proliferative properties of human embryonic stem cell-derived cardiomyocytes
    • Snir M, Kehat I, Gepstein A et al. Assessment of the ultrastructural and proliferative properties of human embryonic stem cell-derived cardiomyocytes. Am J Physiol Heart Circ Physiol 2003;285:H2355-H2363.
    • (2003) Am J Physiol Heart Circ Physiol , vol.285
    • Snir, M.1    Kehat, I.2    Gepstein, A.3
  • 5
    • 0037144701 scopus 로고    scopus 로고
    • Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells
    • Xu C, Police S, Rao N et al. Characterization and enrichment of cardiomyocytes derived from human embryonic stem cells. Circ Res 2002;91:501-508.
    • (2002) Circ Res , vol.91 , pp. 501-508
    • Xu, C.1    Police, S.2    Rao, N.3
  • 6
    • 0038300672 scopus 로고    scopus 로고
    • Human embryonic stem cells develop into multiple types of cardiac myocytes: Action potential characterization
    • He JQ, Ma Y, Lee Y et al. Human embryonic stem cells develop into multiple types of cardiac myocytes: Action potential characterization. Circ Res 2003;93:32-39.
    • (2003) Circ Res , vol.93 , pp. 32-39
    • He, J.Q.1    Ma, Y.2    Lee, Y.3
  • 7
    • 0037131206 scopus 로고    scopus 로고
    • High-resolution electrophysiological assessment of human embryonic stem cell-derived cardiomyocytes: A novel in vitro model for the study of conduction
    • Kehat I, Gepstein A, Spira A et al. High-resolution electrophysiological assessment of human embryonic stem cell-derived cardiomyocytes: A novel in vitro model for the study of conduction. Circ Res 2002;91:659-661.
    • (2002) Circ Res , vol.91 , pp. 659-661
    • Kehat, I.1    Gepstein, A.2    Spira, A.3
  • 8
    • 0038210217 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells to cardiomyocytes: Role of coculture with visceral endoderm-like cells
    • Mummery C, Ward-van Oostwaard D, Doevendans P et al. Differentiation of human embryonic stem cells to cardiomyocytes: Role of coculture with visceral endoderm-like cells. Circulation 2003;107:2733-2740.
    • (2003) Circulation , vol.107 , pp. 2733-2740
    • Mummery, C.1    Ward-van Oostwaard, D.2    Doevendans, P.3
  • 9
    • 4444267925 scopus 로고    scopus 로고
    • Beta-adrenergic and muscarinic modulation of human embryonic stem cell-derived cardiomyocytes
    • Reppel M, Boettinger C, Hescheler J. Beta-adrenergic and muscarinic modulation of human embryonic stem cell-derived cardiomyocytes. Cell Physiol Biochem 2004;14:187-196.
    • (2004) Cell Physiol Biochem , vol.14 , pp. 187-196
    • Reppel, M.1    Boettinger, C.2    Hescheler, J.3
  • 10
    • 0030248109 scopus 로고    scopus 로고
    • Modulated expression of transient outward current in cultured neonatal rat ventricular myocytes: Comparison with development in situ
    • Guo W, Kamiya K, Toyama J. Modulated expression of transient outward current in cultured neonatal rat ventricular myocytes: comparison with development in situ. Cardiovasc Res 1996;32:524-533.
    • (1996) Cardiovasc Res , vol.32 , pp. 524-533
    • Guo, W.1    Kamiya, K.2    Toyama, J.3
  • 11
    • 0142026953 scopus 로고    scopus 로고
    • Developmental changes in IKr and IKs contribute to age-related expression of dofetilide effects on repolarization and proarrhythmia
    • Obreztchikova MN, Sosunov EA, Plotnikov A et al. Developmental changes in IKr and IKs contribute to age-related expression of dofetilide effects on repolarization and proarrhythmia. Cardiovasc Res 2003;59:339-350.
    • (2003) Cardiovasc Res , vol.59 , pp. 339-350
    • Obreztchikova, M.N.1    Sosunov, E.A.2    Plotnikov, A.3
  • 12
    • 0030951493 scopus 로고    scopus 로고
    • Thyroid hormone regulates postnatal expression of transient K+ channel isoforms in rat ventricle
    • Shimoni Y, Fiset C, Clark RB et al. Thyroid hormone regulates postnatal expression of transient K+ channel isoforms in rat ventricle. J Physiol 1997;500:65-73.
    • (1997) J Physiol , vol.500 , pp. 65-73
    • Shimoni, Y.1    Fiset, C.2    Clark, R.B.3
  • 13
    • 4644235479 scopus 로고    scopus 로고
    • Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyocytes
    • Satin J, Kehat I, Caspi O et al. Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyocytes. J Physiol 2004;559:479-496.
    • (2004) J Physiol , vol.559 , pp. 479-496
    • Satin, J.1    Kehat, I.2    Caspi, O.3
  • 14
    • 3242784826 scopus 로고    scopus 로고
    • Atrial natriuretic peptide modulates the hyperpolarization-activated current (If) in human atrial myocytes
    • Lonardo G, Cerbai E, Casini S et al. Atrial natriuretic peptide modulates the hyperpolarization-activated current (If) in human atrial myocytes. Cardiovasc Res 2004;63:528-536.
    • (2004) Cardiovasc Res , vol.63 , pp. 528-536
    • Lonardo, G.1    Cerbai, E.2    Casini, S.3
  • 15
    • 1642580523 scopus 로고    scopus 로고
    • Prenatal exposure to carbon monoxide affects postnatal cellular electrophysiological maturation of the rat heart: A potential substrate for arrhythmogenesis in infancy
    • Sartiani L, Cerbai E, Lonardo G et al. Prenatal exposure to carbon monoxide affects postnatal cellular electrophysiological maturation of the rat heart: A potential substrate for arrhythmogenesis in infancy. Circulation 2004;109:419-423.
    • (2004) Circulation , vol.109 , pp. 419-423
    • Sartiani, L.1    Cerbai, E.2    Lonardo, G.3
  • 16
    • 0031041032 scopus 로고    scopus 로고
    • Characterization of the hyperpolarization-activated current, I(f), in ventricular myocytes from human failing heart
    • Cerbai E, Pino R, Porciatti F et al. Characterization of the hyperpolarization-activated current, I(f), in ventricular myocytes from human failing heart. Circulation 1997;95:568-571.
    • (1997) Circulation , vol.95 , pp. 568-571
    • Cerbai, E.1    Pino, R.2    Porciatti, F.3
  • 17
    • 0028232549 scopus 로고
    • Electrophysiological basis for the enhanced cardiac arrhythmogenic effect of isoprenaline in aged spontaneously hypertensive rats
    • Barbieri M, Varani K, Cerbai E et al. Electrophysiological basis for the enhanced cardiac arrhythmogenic effect of isoprenaline in aged spontaneously hypertensive rats. J Mol Cell Cardiol 1994;26:849-860.
    • (1994) J Mol Cell Cardiol , vol.26 , pp. 849-860
    • Barbieri, M.1    Varani, K.2    Cerbai, E.3
  • 18
    • 0026451082 scopus 로고
    • Age-related appearance of outward currents may contribute to developmental differences in ventricular repolarization
    • Jeck CD, Boyden PA. Age-related appearance of outward currents may contribute to developmental differences in ventricular repolarization. Circ Res 1992;71:1390-1403.
    • (1992) Circ Res , vol.71 , pp. 1390-1403
    • Jeck, C.D.1    Boyden, P.A.2
  • 19
    • 0031711111 scopus 로고    scopus 로고
    • Regulation of voltage-gated K+ channel expression in the developing mammalian myocardium
    • Nerbonne JM. Regulation of voltage-gated K+ channel expression in the developing mammalian myocardium. J Neurobiol 1998;37:37-59.
    • (1998) J Neurobiol , vol.37 , pp. 37-59
    • Nerbonne, J.M.1
  • 20
    • 0037474225 scopus 로고    scopus 로고
    • Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells
    • Crociani O, Guasti L, Balzi M et al. Cell cycle-dependent expression of HERG1 and HERG1B isoforms in tumor cells. J Biol Chem 2003;278:2947-2955.
    • (2003) J Biol Chem , vol.278 , pp. 2947-2955
    • Crociani, O.1    Guasti, L.2    Balzi, M.3
  • 21
    • 7244226352 scopus 로고    scopus 로고
    • Cardiac IKr channels minimally comprise hERG 1a and 1b subunits
    • Jones EM, Roti Roti EC, Wang J et al. Cardiac IKr channels minimally comprise hERG 1a and 1b subunits. J Biol Chem 2004;279:44690-44694.
    • (2004) J Biol Chem , vol.279 , pp. 44690-44694
    • Jones, E.M.1    Roti Roti, E.C.2    Wang, J.3
  • 22
    • 0032216690 scopus 로고    scopus 로고
    • Effect of 5-HT4 receptor stimulation on the pacemaker current I(f) in human isolated atrial myocytes
    • Pino R, Cerbai E, Calamai G et al. Effect of 5-HT4 receptor stimulation on the pacemaker current I(f) in human isolated atrial myocytes. Cardiovasc Res 1998;40:516-522.
    • (1998) Cardiovasc Res , vol.40 , pp. 516-522
    • Pino, R.1    Cerbai, E.2    Calamai, G.3
  • 23
    • 0036021103 scopus 로고    scopus 로고
    • Cardiac HCN channels: Structure, function, and modulation
    • Biel M, Schneider A, Wahl C. Cardiac HCN channels: Structure, function, and modulation. Trends Cardiovasc Med 2002;12:206-212.
    • (2002) Trends Cardiovasc Med , vol.12 , pp. 206-212
    • Biel, M.1    Schneider, A.2    Wahl, C.3
  • 24
    • 0036462416 scopus 로고    scopus 로고
    • From funny current to HCN channels: 20 years of excitation
    • Accili EA, Proenza C, Baruscotti M et al. From funny current to HCN channels: 20 years of excitation. News Physiol Sci 2002;17:32-37.
    • (2002) News Physiol Sci , vol.17 , pp. 32-37
    • Accili, E.A.1    Proenza, C.2    Baruscotti, M.3
  • 25
    • 0032707530 scopus 로고    scopus 로고
    • Adrenergic and muscarinic receptors in the human heart
    • Brodde OE, Michel MC. Adrenergic and muscarinic receptors in the human heart. Pharmacol Rev 1999;51:651-690.
    • (1999) Pharmacol Rev , vol.51 , pp. 651-690
    • Brodde, O.E.1    Michel, M.C.2
  • 26
    • 0038030960 scopus 로고    scopus 로고
    • Cardiac specific differentiation of mouse embryonic stem cells
    • Sachinidis A, Fleischmann BK, Kolossov E et al. Cardiac specific differentiation of mouse embryonic stem cells. Cardiovasc Res 2003;58:278-291.
    • (2003) Cardiovasc Res , vol.58 , pp. 278-291
    • Sachinidis, A.1    Fleischmann, B.K.2    Kolossov, E.3
  • 27
    • 33644851751 scopus 로고    scopus 로고
    • Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism
    • Anderson CL, Delisle BP, Anson BD et al. Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism. Circulation 2006;113:365-373.
    • (2006) Circulation , vol.113 , pp. 365-373
    • Anderson, C.L.1    Delisle, B.P.2    Anson, B.D.3
  • 28
    • 0036588462 scopus 로고    scopus 로고
    • Rapidly and slowly activating components of delayed rectifier K(+) current in guinea-pig sino-atrial node pacemaker cells
    • Matsuura H, Ehara T, Ding WG. Rapidly and slowly activating components of delayed rectifier K(+) current in guinea-pig sino-atrial node pacemaker cells. J Physiol 2002;540:815-830.
    • (2002) J Physiol , vol.540 , pp. 815-830
    • Matsuura, H.1    Ehara, T.2    Ding, W.G.3
  • 29
    • 0030670273 scopus 로고    scopus 로고
    • Two isoforms of the mouse ether-a-go-go-related gene coassemble to form channels with properties similar to the rapidly activating component of the cardiac delayed rectifier K+ current
    • London B, Trudeau MC, Newton KP et al. Two isoforms of the mouse ether-a-go-go-related gene coassemble to form channels with properties similar to the rapidly activating component of the cardiac delayed rectifier K+ current. Circ Res 1997;81:870-878.
    • (1997) Circ Res , vol.81 , pp. 870-878
    • London, B.1    Trudeau, M.C.2    Newton, K.P.3
  • 30
    • 0029766520 scopus 로고    scopus 로고
    • Changes in action potentials and ion currents in long-term cultured neonatal rat ventricular cells
    • Guo W, Kamiya K, Cheng J et al. Changes in action potentials and ion currents in long-term cultured neonatal rat ventricular cells. Am J Physiol 1996;271:C93-C102.
    • (1996) Am J Physiol , vol.271
    • Guo, W.1    Kamiya, K.2    Cheng, J.3
  • 31
    • 85047696118 scopus 로고    scopus 로고
    • Outwards currents in embryonic stem cell-derived cardiomyocytes
    • Gryschenko O, Lu ZJ, Fleischmann BK et al. Outwards currents in embryonic stem cell-derived cardiomyocytes. Pflugers Arch 2000;439:798-807.
    • (2000) Pflugers Arch , vol.439 , pp. 798-807
    • Gryschenko, O.1    Lu, Z.J.2    Fleischmann, B.K.3
  • 32
    • 0030049208 scopus 로고    scopus 로고
    • Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle
    • Näbauer M, Beuckelmann DJ, Uberfuhr P et al. Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle. Circulation 1996;93:168-177.
    • (1996) Circulation , vol.93 , pp. 168-177
    • Näbauer, M.1    Beuckelmann, D.J.2    Uberfuhr, P.3
  • 33
    • 28444449787 scopus 로고    scopus 로고
    • Electrophysiological properties of pluripotent human and mouse embryonic stem cells
    • Wang K, Xue T, Tsang SY et al. Electrophysiological properties of pluripotent human and mouse embryonic stem cells. STEM CELLS 2005;23:1526-1534.
    • (2005) STEM CELLS , vol.23 , pp. 1526-1534
    • Wang, K.1    Xue, T.2    Tsang, S.Y.3
  • 34
    • 0036350593 scopus 로고    scopus 로고
    • Differential distribution of Kir2.1 and Kir2.3 subunits in canine atrium and ventricle
    • Melnyk P, Zhang L, Shrier A et al. Differential distribution of Kir2.1 and Kir2.3 subunits in canine atrium and ventricle. Am J Physiol Heart Circ Physiol 2002;283:H1123-H1133.
    • (2002) Am J Physiol Heart Circ Physiol , vol.283
    • Melnyk, P.1    Zhang, L.2    Shrier, A.3
  • 35
    • 0038116653 scopus 로고    scopus 로고
    • Molecular dissection of the inward rectifier potassium current (IK1) in rabbit cardiomyocytes: Evidence for heteromeric co-assembly of Kir2.1 and Kir2.2
    • Zobel C, Cho HC, Nguyen TT et al. Molecular dissection of the inward rectifier potassium current (IK1) in rabbit cardiomyocytes: Evidence for heteromeric co-assembly of Kir2.1 and Kir2.2. J Physiol 2003;550:365-372.
    • (2003) J Physiol , vol.550 , pp. 365-372
    • Zobel, C.1    Cho, H.C.2    Nguyen, T.T.3
  • 36
    • 0037459001 scopus 로고    scopus 로고
    • Mechanism of pacemaking in I(K1)-downregulated myocytes
    • Silva J, Rudy Y. Mechanism of pacemaking in I(K1)-downregulated myocytes. Circ Res 2003;92:261-263.
    • (2003) Circ Res , vol.92 , pp. 261-263
    • Silva, J.1    Rudy, Y.2
  • 37
    • 0034818628 scopus 로고    scopus 로고
    • Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues
    • Moosmang S, Stieber J, Zong X et al. Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues. Eur J Biochem 2001;268:1646-1652.
    • (2001) Eur J Biochem , vol.268 , pp. 1646-1652
    • Moosmang, S.1    Stieber, J.2    Zong, X.3
  • 38
    • 0032895801 scopus 로고    scopus 로고
    • Modulation of the pacemaker current If by beta-adrenoceptor subtypes in ventricular myocytes isolated from hypertensive and normotensive rats
    • Cerbai E, Pino R, Rodriguez ML et al. Modulation of the pacemaker current If by beta-adrenoceptor subtypes in ventricular myocytes isolated from hypertensive and normotensive rats. Cardiovasc Res 1999;42:121-129.
    • (1999) Cardiovasc Res , vol.42 , pp. 121-129
    • Cerbai, E.1    Pino, R.2    Rodriguez, M.L.3
  • 39
    • 18244380294 scopus 로고    scopus 로고
    • Initiation of embryonic cardiac pacemaker activity by inositol 1,4,5-trisphosphate-dependent calcium signaling
    • Méry A, Aimond F, Menard C et al. Initiation of embryonic cardiac pacemaker activity by inositol 1,4,5-trisphosphate-dependent calcium signaling. Mol Biol Cell 2005;16:2414-2423.
    • (2005) Mol Biol Cell , vol.16 , pp. 2414-2423
    • Méry, A.1    Aimond, F.2    Menard, C.3
  • 40
    • 0037834607 scopus 로고    scopus 로고
    • Heteromeric HCN1-HCN4 channels: A comparison with native pacemaker channels from the rabbit sinoatrial node
    • Altomare C, Terragni B, Brioschi C et al. Heteromeric HCN1-HCN4 channels: A comparison with native pacemaker channels from the rabbit sinoatrial node. J Physiol 2003;549:347-359.
    • (2003) J Physiol , vol.549 , pp. 347-359
    • Altomare, C.1    Terragni, B.2    Brioschi, C.3
  • 41
    • 29244482937 scopus 로고    scopus 로고
    • Molecular basis of funny current (If) in normal and failing human heart
    • Lonardo G, Stillitano F, Zicha S et al. Molecular basis of funny current (If) in normal and failing human heart. Circulation 2004;110(suppl):129a-130a.
    • (2004) Circulation , vol.110 , Issue.SUPPL.
    • Lonardo, G.1    Stillitano, F.2    Zicha, S.3
  • 42
    • 0037975497 scopus 로고    scopus 로고
    • Functional role of inward rectifier current in heart probed by Kir2.1 overexpression and dominant-negative suppression
    • Miake J, Marban E, Nuss HB. Functional role of inward rectifier current in heart probed by Kir2.1 overexpression and dominant-negative suppression. J Clin Invest 2003;111:1529-1536.
    • (2003) J Clin Invest , vol.111 , pp. 1529-1536
    • Miake, J.1    Marban, E.2    Nuss, H.B.3
  • 43
    • 23844467580 scopus 로고    scopus 로고
    • Telomere-independent cellular senescence in human fetal cardiomyocytes
    • Ball AJ, Levine F. Telomere-independent cellular senescence in human fetal cardiomyocytes. Aging Cell 2005;4:21-30.
    • (2005) Aging Cell , vol.4 , pp. 21-30
    • Ball, A.J.1    Levine, F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.