Clone- and gene-specific aberrations of parental imprinting in human induced pluripotent stem cells

Stem Cells

Volumn 27, Issue 11, 2009, Pages 2686-2690

  Pick, Marjorie ^a   Stelzer, Yonatan ^a   Bar Nur, Ori ^a   Mayshar, Yoav ^a   Eden, Amir ^a   Benvenisty, Nissim ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Embryonic stem cells; Imprinting; Induced pluripotency; iPS

Indexed keywords

COMPLEMENTARY DNA; DNA; RNA H19;

ALLELE; ARTICLE; CELL COUNT; CELL LINE; CHROMOSOME ABERRATION; CLONE; DEMETHYLATION; DNA METHYLATION; DNA MICROARRAY; DNA POLYMORPHISM; DNA SEQUENCE; FIBROBLAST CULTURE; GENE EXPRESSION; GENETIC DISORDER; GENETIC VARIABILITY; GENOME IMPRINTING; HUMAN; HUMAN CELL; PARENT; PLURIPOTENT STEM CELL; PROMOTER REGION; REGENERATIVE MEDICINE; SINGLE NUCLEOTIDE POLYMORPHISM; STABLE EXPRESSION;

DNA METHYLATION; EMBRYONIC STEM CELLS; GENOMIC IMPRINTING; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MODELS, GENETIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS, GENETIC;

IPS;

EID: 72849144528     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.205     Document Type: Article

References (19)

1. Cerrato F, Sparago A, Verde G et al. Different mechanisms cause imprinting defects at the IGF2/H19 locus in Beckwith-Wiedemann syndrome and Wilms' tumour. Hum Mol Genet 2008;17:1427-1435.
2. Adewumi O, Aflatoonian B, Ahrlund-Richter L et al. Characterization of human embryonic stem cell lines by the International Stem Cell Initiative. Nat Biotechnol 2007;25:803-816.
3. Rugg-Gunn PJ, Ferguson-Smith AC, Pedersen RA. Status of genomic imprinting in human embryonic stem cells as revealed by a large cohort of independently derived and maintained lines. Hum Mol Genet 2007;16:R243-R251.
4. Rugg-Gunn PJ, Ferguson-Smith AC, Pedersen RA. Epigenetic status of human embryonic stem cells. Nat Genet 2005;37:585-587. (Pubitemid 40770411)
5. Takahashi K, Tanabe K, Ohnuki M et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007;131:861-872. (Pubitemid 350138099)
6. Yu J, Vodyanik MA, Smuga-Otto K et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007;318:1917-1920.
7. Wernig M, Meissner A, Foreman R et al. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 2007;448:318-324.
8. Daley GQ, Lensch MW, Jaenisch R et al. Broader implications of defining standards for the pluripotency of iPSCs. Cell Stem Cell 2009;4:200-201.
9. Humpherys D, Eggan K, Akutsu H et al. Epigenetic instability in ES cells and cloned mice. Science 2001;293:95-97. (Pubitemid 32625502)
10. Maherali N, Ahfeldt T, Rigamonti A et al. A high-efficiency system for the generation and study of human induced pluripotent stem cells. Cell Stem Cell 2008;3:340-345.
11. Masaki H, Ishikawa T, Takahashi S et al. Heterogeneity of pluripotent marker gene expression in colonies generated in human iPS cell induction culture. Stem Cell Res 2007;1:105-115. (Pubitemid 351726532)
12. Park IH, Zhao R, West JA et al. Reprogramming of human somatic cells to pluripotency with defined factors. Nature 2008;451:141-146.
13. Lowry WE, Richter L, Yachechko R et al. Generation of human induced pluripotent stem cells from dermal fibroblasts. Proc Natl Acad Sci U S A 2008;105:2883-2888. (Pubitemid 351723638)
14. Ebert AD, Yu J, Rose FF Jr et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 2009;457:277-280.
15. Yu J, Hu K, Smuga-Otto K et al. Human induced pluripotent stem cells free of vector and transgene sequences. Science 2009;324:797-801.
16. Feng W, Marquez RT, Lu Z et al. Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation. Cancer 2008;112:1489-1502.
17. Pedersen IS, Dervan PA, Broderick D et al. Frequent loss of imprinting of PEG1/MEST in invasive breast cancer. Cancer Res 1999;59:5449-5451. (Pubitemid 29526454)
18. Fukuzawa R, Heathcott RW, Morison IM et al. Imprinting, expression, and localisation of DLK1 in Wilms tumours. J Clin Pathol 2005;58:145-150. (Pubitemid 40193798)
19. Astuti D, Latif F, Wagner K et al. Epigenetic alteration at the DLK1-GTL2 imprinted domain in human neoplasia: Analysis of neuroblastoma, phaeochromocytoma and Wilms' tumour. Br J Cancer 2005;92:1574-1580. (Pubitemid 40705027)