In vitro embryotoxicity assessment with dental restorative materials

Journal of Dentistry

Volumn 33, Issue 1, 2005, Pages 49-55

  Schwengberg, S ^a   Bohlen, H ^a   Kleinsasser, N ^b   Kehe, K ^c   Seiss, M ^d   Walther, U I ^d   Hickel, R ^e   Reichl, F X ^d,e  

^a Pluriomics BV   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c Sanitatsakademie der Bundeswehr   (Germany)

^d UNIVERSITY OF MUNICH   (Germany)

^e Goethestr 70 80336 Munich Germany ^*  (Germany)

Author keywords

Dental materials; Embryotoxicity; Mouse embryonic stem cells; Teratogenesis

Indexed keywords

2,3 EPOXY 2 METHYLPROPIONIC ACID; 2,3 EPOXY 2 METHYLPROPIONIC ACID METHYL ESTER; BISPHENOL A BIS(2 HYDROXYPROPYL) ETHER DIMETHACRYLATE; GREEN FLUORESCENT PROTEIN; METHACRYLIC ACID; METHACRYLIC ACID DERIVATIVE; MYOSIN HEAVY CHAIN ALPHA; POLYMACON; PROPIONIC ACID DERIVATIVE; RESIN; TRIETHYLENE GLYCOL DIMETHACRYLATE; UNCLASSIFIED DRUG; URETHANE DIMETHACRYLATE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; EMBRYONIC STEM CELL; EMBRYOTOXICITY; FLUORESCENCE; HEART MUSCLE CELL; IN VITRO STUDY; MOUSE; NONHUMAN; TOOTH FILLING;

ANIMALS; BISPHENOL A-GLYCIDYL METHACRYLATE; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; COMPOSITE RESINS; DENTAL RESTORATION, PERMANENT; EMBRYO; EPOXY COMPOUNDS; HEART; MATERIALS TESTING; METHACRYLATES; MICE; POLYETHYLENE GLYCOLS; POLYMETHACRYLIC ACIDS; POLYURETHANES; PROPIONIC ACIDS; STEM CELLS; TOXICITY TESTS;

EID: 11844262075     PISSN: 03005712     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jdent.2004.08.001     Document Type: Article

References (29)

1. N. Nakabayashi, and K. Takarada Effect of HEMA on bonding to dentine Dental Materials 8 1992 125 130
2. T.M. Gerzina, K. Picker, A. Hood, and W. Hume Toxicity and quantitative analysis of TEGDMA and composite resin eluates Journal of Dental Research 70 suppl 1991 424
3. C.T. Hanks, S.E. Strawn, J.C. Wataha, and R.G. Craig Cytotoxic effects of resin components on cultured mammalian fibroblasts Journal of Dental Research 70 11 1991 1450 1455
4. M. Jontell, C.T. Hanks, J. Bratel, and G. Bergenholtz Effects of unpolymerized resin components on the function of accessory cells derived from the rat incisor pulp Journal of Dental Research 74 5 1995 1162 1167
5. H. Schweikl, G. Schmalz, and K. Rackebrandt The mutagenic activity of unpolymerized resin monomers in Salmonella typhimurium and V79 cells Mutation Research 415 1-2 1998 119 130
6. H. Schweikl, and G. Schmalz Triethyleneglycoldimethacrylate induces large deletions in the hprt gene of V79 cells Mutation Research 438 1 1999 71 78
7. F.X. Reichl, J. Durner, H. Mückter, B. Elsenhans, W. Forth, K.H. Kunzelmann, R. Hickel, W. Spahl, W.R. Hume, and G.W. Moes Effect of dental materials on gluconeogenesis in rat kidney tubules Archives of Toxicology 73 1999 381 386
8. F.X. Reichl, U. Walther, J. Durner, K. Kehe, R. Hickel, K.H. Kunzelmann, W. Spahl, W.R. Hume, H. Benschop, and W. Forth Cytotoxicity of dental composite components and mercury compounds in lung cells Dental Materials 17 2001 95 101
9. 2 with components of dental restorative materials on gluconeogenesis in rat kidney tubules Biomaterials 24 11 2003 1909 1916
10. F.X. Reichl Toxikologie zahnärztlicher Restaurationsmaterialien Zahnärztliche Mitteilungen, Deutscher Ärzte-Verlag, Köln 93 7 2003 74 80
11. F.X. Reichl, J. Durner, K.H. Kunzelmann, R. Hickel, W. Spahl, W.R. Hume, G.W. Moes, K. Kehe, U. Walther, and W. Forth Biological clearance of TEGDMA in guinea pigs Archives of Toxicology 75 2001 22 27
12. F.X. Reichl, J. Durner, J. Manhart, W. Spahl, K. Gempel, K. Kehe, B. Liebl, U.I. Walther, W.R. Hume, and R. Hickel Biological clearance of HEMA in guinea pigs Biomaterials 23 2002 2135 2141
13. F.X. Reichl, J. Durner, R. Hickel, K.H. Kunzelmann, A. Jewett, M.Y. Wang, W. Spahl, H. Kreppel, G.W. Moes, K. Kehe, U. Walther, W. Forth, and W.R. Hume Distribution and excretion of TEGDMA in guinea pigs and mice Journal of Dental Research 80 5 2001 1412 1415
14. F.X. Reichl, J. Durner, R. Hickel, W. Spahl, K. Kehe, U. Walther, K. Gempel, B. Liebl, K.H. Kunzelmann, and W. Hume Uptake, clearance and metabolism of TEGDMA in guinea pig Dental Materials 18 2002 581 589
15. F.X. Reichl, J. Durner, K. Kehe, J. Manhart, M. Folwaczny, N. Kleinsasser, W. Hume, and R. Hickel Toxicokinetic of HEMA in guinea pigs Journal of Dentistry 30 2002 353 358
16. G. Scholz, I. Pohl, E. Genschow, M. Klemm, and H. Spielmann Embryotoxicity screening using embryonic stem cells in vitro: correlation to in vivo teratogenicity Cells Tissues Organs 165 1999 203 211
17. T.C. Doetschman, H. Eistetter, M. Katz, W. Schmidt, and R. Kemler The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium Journal of Embryology and Experimental Morphology 87 1985 27 45
18. S. Bremer, A.P. Worth, M. Paprarella, K. Bigot, E. Kolossov, B.K. Fleischmann, J. Hescheler, and M. Balls Establishment of an in vitro reporter gene assay for developmental cardiac toxicity Toxicology In Vitro 15 2001 215 223
19. N. Brown Selection of test chemicals for the ecvam international validation study on in vitro embryotoxicity tests. european centre for the validation of alternative methods Alternatives to Laboratory Animals 30 2002 177 198
20. H.R. Yao, and D.E. Richardson Epoxidation of alkenes with bicarbonate-activated hydrogen peroxide Journal of American Chemical Society 122 13 2000 3220 3221
21. M. Klemm, E. Genschow, I. Pohl, C. Barrabas, M. Liebsch, and H. Spielmann Permanent embryonic germ cell lines of BALB/cJ mice-an in vitro alternative for in vivo germ cell mutagenicity tests Toxicol In Vitro 15 4-5 2001 447 453
22. H.T. Forst Probleme des multiplen Testens und Schätzens in der Arznei-mittelforschung Arzneim Forsch/Drug Research 35 1985 563 569
23. C.D. Klaassen Heavy metals and heavy-metal antagonists J.G. Hardman L.E. Limbird P.B. Molinoff R.W. Ruddon A. Goodman Gilman Goodman and Gilman's. The pharmacological basis of therapeutics 1998 McGraw-Hill New York 1649 1671
24. M. Seiss, K. Kehe, C. Haffner, K. El-Mahdy, R. Hickel, S. Nitz, U.I. Walther, J. Manhard, and F.X. Reichl Intermediates from metabolized dental restorative materials Naunyn Schmiedebergs's Archives of Pharmacology 369 1 2004 428 R107
25. Durner J. Untersuchungen zur Zytotoxizität in vitro und zur Toxikokinetik in vivo der Komposit-Komonomere TEGDMA und HEMA. Dissertation an der Ludwig-Maximilians-Universität München; 2000.
26. N.H. Kleinsasser, B.C. Wallner, A. Ulrich, U.A. Harréus, T. Kleinjung, M. Folwaczny, R. Hickel, K. Kehe, and F.X. Reichl Genotoxicity and cytotoxicity of dental materials in human lymphocytes as assessed by the single cell microgel electrophoresis (comet) assay Journal of Dentistry 32 2004 229 234
27. D.Y. Xie, W. Zhang, L.F. Cao, W.Q. Sun, Z.S. Li, Q. Gao, Y.L. Wu, H.F. Yang, and J. Zuo Studies on the genotoxicity of glycidyl methacrylate Biomedical and Environmental Sciences 3 1990 281 289
28. J. Heil, G. Reifferscheid, P. Waldmann, G. Leyhausen, and W. Geurtsen Genotoxicity of dental materials Mutation Research 368 1996 181 194
29. Organisation for Economic Co-operation and Development. Report of the OECD Ad Hoc Working Group on Reproduction and Developmental Toxicity. Copenhagen, Denmark; 1995.