Up and downregulation of p16 Ink4a expression in BRAF-mutated polyps/adenomas indicates a senescence barrier in the serrated route to colon cancer

Modern Pathology

Volumn 24, Issue 7, 2011, Pages 1015-1022

  Kriegl, Lydia ^a   Neumann, Jens ^a   Vieth, Michael ^b   Greten, Florian R ^c   Reu, Simone ^a   Jung, Andreas ^a   Kirchner, Thomas ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b INSTITUTE OF PATHOLOGY   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

BRAF mutation; hypermethylation; Ki67; p16Ink4a; serrated route

Indexed keywords

B RAF KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; KI 67 ANTIGEN;

ADENOMA; ARTICLE; CANCER GROWTH; COLON ADENOMA; COLON CANCER; DOWN REGULATION; GENE EXPRESSION; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN METHYLATION; SENESCENCE; UPREGULATION;

ADENOMA; ADENOMATOUS POLYPS; ADULT; AGED; AGED, 80 AND OVER; CELL AGING; CELL TRANSFORMATION, NEOPLASTIC; COLONIC NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA METHYLATION; DNA MUTATIONAL ANALYSIS; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P16; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; MUTATION; PRECANCEROUS CONDITIONS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS B-RAF; UP-REGULATION;

EID: 79960009775     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2011.43     Document Type: Article

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