메뉴 건너뛰기




Volumn 162, Issue 2, 2003, Pages 691-702

CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR; RAG2 PROTEIN;

EID: 0037331279     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63863-1     Document Type: Article
Times cited : (268)

References (65)
  • 3
    • 0031781603 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Etiology and prevention
    • Fiocchi C: Inflammatory bowel disease: etiology and prevention. Gastroenterology 1998, 115:182-205
    • (1998) Gastroenterology , vol.115 , pp. 182-205
    • Fiocchi, C.1
  • 4
    • 0033955438 scopus 로고    scopus 로고
    • Recent developments in the immunology of inflammatory bowel disease
    • MacDonald TT, Montelone G, Pender SLF: Recent developments in the immunology of inflammatory bowel disease. Scand J Immunol 2000, 51:2-9
    • (2000) Scand J Immunol , vol.51 , pp. 2-9
    • MacDonald, T.T.1    Montelone, G.2    Pender, S.L.F.3
  • 9
    • 0035963326 scopus 로고    scopus 로고
    • T cells and tumors
    • Pardoll D: T cells and tumors. Nature 2001, 411:1010-1012
    • (2001) Nature , vol.411 , pp. 1010-1012
    • Pardoll, D.1
  • 10
    • 0029085294 scopus 로고
    • T cells in inflammatory bowel disease: Protective and pathogenic roles
    • Powrie F: T cells in inflammatory bowel disease: protective and pathogenic roles. Immunity 1995, 3:171-174
    • (1995) Immunity , vol.3 , pp. 171-174
    • Powrie, F.1
  • 11
    • 0030794060 scopus 로고    scopus 로고
    • Inflammatory bowel disease: An immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus
    • Cahill RJ, Foltz CJ, Fox JG, Dangler CA, Powrie F, Schauer DB: Inflammatory bowel disease: an immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus. Infect Immun 1997, 65:3126-3131
    • (1997) Infect Immun , vol.65 , pp. 3126-3131
    • Cahill, R.J.1    Foltz, C.J.2    Fox, J.G.3    Dangler, C.A.4    Powrie, F.5    Schauer, D.B.6
  • 12
    • 0032425062 scopus 로고    scopus 로고
    • Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism
    • Kuliberg MC, Ward JM, Gorelick PL, Caspar P, Hieny S, Cheever A, Jankovic D, Sher S: Helicobacter hepaticus triggers colitis in specific-pathogen-free interleukin-10 (IL-10)-deficient mice through an IL-12- and gamma interferon-dependent mechanism. Infect Immun 1998, 66:5157-5166
    • (1998) Infect Immun , vol.66 , pp. 5157-5166
    • Kuliberg, M.C.1    Ward, J.M.2    Gorelick, P.L.3    Caspar, P.4    Hieny, S.5    Cheever, A.6    Jankovic, D.7    Sher, S.8
  • 13
    • 0034972172 scopus 로고    scopus 로고
    • Helicobacter hepaticus-induced colitis in interleukin-10-deficient mice: Cytokine requirements for the induction and maintenance of intestinal inflammation
    • Kuliberg MC, Rothfucs AG, Jankovic D, Caspar P, Wynn TA, Gorelick PL, Cheever AW, Sher A: Helicobacter hepaticus-induced colitis in interleukin-10-deficient mice: cytokine requirements for the induction and maintenance of intestinal inflammation. Infect Immun 2001, 69:4232-4241
    • (2001) Infect Immun , vol.69 , pp. 4232-4241
    • Kuliberg, M.C.1    Rothfucs, A.G.2    Jankovic, D.3    Caspar, P.4    Wynn, T.A.5    Gorelick, P.L.6    Cheever, A.W.7    Sher, A.8
  • 14
  • 15
    • 0035866802 scopus 로고    scopus 로고
    • Intestinal microflora are necessary for development of spontaneous adenocarcinoma of the large intestine in T-cell receptor beta chain and p53 double-knockout mice
    • Kado S, Uchida K, Funabashi H, Iwata S, Nagata Y, Ando M, Onoue M, Matsuoka Y, Ohwaki M, Morotomi M: Intestinal microflora are necessary for development of spontaneous adenocarcinoma of the large intestine in T-cell receptor beta chain and p53 double-knockout mice. Cancer Res 2001, 61:2395-2398
    • (2001) Cancer Res , vol.61 , pp. 2395-2398
    • Kado, S.1    Uchida, K.2    Funabashi, H.3    Iwata, S.4    Nagata, Y.5    Ando, M.6    Onoue, M.7    Matsuoka, Y.8    Ohwaki, M.9    Morotomi, M.10
  • 18
    • 0033214776 scopus 로고    scopus 로고
    • Regulatory T cells and inflammatory bowel disease
    • Groux H, Powrie F: Regulatory T cells and inflammatory bowel disease. Immunol Today 1999, 20:442-445
    • (1999) Immunol Today , vol.20 , pp. 442-445
    • Groux, H.1    Powrie, F.2
  • 20
    • 0033565626 scopus 로고    scopus 로고
    • Transforming growth factor beta-1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis
    • Engle SJ, Hoying JB, Bolvin GP, Ormsby I, Gartside PS, Doetschman T: Transforming growth factor beta-1 suppresses nonmetastatic colon cancer at an early stage of tumorigenesis. Cancer Res 1999, 59:3379-3386
    • (1999) Cancer Res , vol.59 , pp. 3379-3386
    • Engle, S.J.1    Hoying, J.B.2    Bolvin, G.P.3    Ormsby, I.4    Gartside, P.S.5    Doetschman, T.6
  • 22
    • 0028179230 scopus 로고
    • Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity
    • Powrie F, Correa-Oliveira R, Mauze S, Coffman RL: Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity. J Exp Med 1994, 179:589-600
    • (1994) J Exp Med , vol.179 , pp. 589-600
    • Powrie, F.1    Correa-Oliveira, R.2    Mauze, S.3    Coffman, R.L.4
  • 24
    • 0035181616 scopus 로고    scopus 로고
    • Natural CD4+ CD25+ regulatory T cells: Their role in control of superantigen responses
    • Papiernik M: Natural CD4+ CD25+ regulatory T cells: their role in control of superantigen responses. Immunol Rev 2001, 182:180-189
    • (2001) Immunol Rev , vol.182 , pp. 180-189
    • Papiernik, M.1
  • 25
    • 0035062581 scopus 로고    scopus 로고
    • Human anergic/suppressive CD4+CD25+ T cells: A highly differentiated and apoptosis-prone population
    • Taams LS, Smith J, Rustin MH, Salmon M, Poulter LW, Akbar AN: Human anergic/suppressive CD4+CD25+ T cells: a highly differentiated and apoptosis-prone population. Eur J Immunol 2001, 31:1122-1131
    • (2001) Eur J Immunol , vol.31 , pp. 1122-1131
    • Taams, L.S.1    Smith, J.2    Rustin, M.H.3    Salmon, M.4    Poulter, L.W.5    Akbar, A.N.6
  • 26
    • 0035054606 scopus 로고    scopus 로고
    • Human CD4+CD25+ thymocytes and peripheral T cells have immune suppressive activity in vitro
    • Stephens LA, Mottet C, Mason D, Powrie F: Human CD4+CD25+ thymocytes and peripheral T cells have immune suppressive activity in vitro. Eur J Immunol 2001, 31:1247-1254
    • (2001) Eur J Immunol , vol.31 , pp. 1247-1254
    • Stephens, L.A.1    Mottet, C.2    Mason, D.3    Powrie, F.4
  • 27
    • 0034679567 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25+CD4+ regulatory cells that control intestinal inflammation
    • Read S, Malmstrom V, Powrie F: Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25+CD4+ regulatory cells that control intestinal inflammation. J Exp Med 2000, 192:295-302
    • (2000) J Exp Med , vol.192 , pp. 295-302
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 28
    • 0035554676 scopus 로고    scopus 로고
    • Regulatory cells in the control of immune pathology
    • Maloy K, Powrie F: Regulatory cells in the control of immune pathology. Nature Immunol 2001, 2:816-822
    • (2001) Nature Immunol , vol.2 , pp. 816-822
    • Maloy, K.1    Powrie, F.2
  • 29
    • 0036468866 scopus 로고    scopus 로고
    • Germline p53 mutation inhibits Helicobacter-induced premalignant lesions and invasive gastric carcinoma through downregulation of TH1 proinflammatory responses
    • Fox JG, Sheppard BJ, Dangler CA, Whary MT, Ihrig M, Wang TC: Germline p53 mutation inhibits Helicobacter-induced premalignant lesions and invasive gastric carcinoma through downregulation of TH1 proinflammatory responses. Cancer Res 2002, 62:696-702
    • (2002) Cancer Res , vol.62 , pp. 696-702
    • Fox, J.G.1    Sheppard, B.J.2    Dangler, C.A.3    Whary, M.T.4    Ihrig, M.5    Wang, T.C.6
  • 31
    • 0029781169 scopus 로고    scopus 로고
    • Persistent hepatitis and enterocolitis in germfree mice infected with Helicobacter hepaticus
    • Fox JG, Yan L, Shames B, Campbell J, Murphy JC: Persistent hepatitis and enterocolitis in germfree mice infected with Helicobacter hepaticus. Infect Immun 1996, 64:3673-3681
    • (1996) Infect Immun , vol.64 , pp. 3673-3681
    • Fox, J.G.1    Yan, L.2    Shames, B.3    Campbell, J.4    Murphy, J.C.5
  • 32
    • 0028864668 scopus 로고
    • Identification of widespread Helicobacter hepaticus infection in feces in commercial mouse colonies by culture and PCR assay
    • Shames B, Fox JG, Dewhirst F, Yan L, Shen Z, Taylor NS: Identification of widespread Helicobacter hepaticus infection in feces in commercial mouse colonies by culture and PCR assay. J Clin Microbiol 1995, 33:2968-2972
    • (1995) J Clin Microbiol , vol.33 , pp. 2968-2972
    • Shames, B.1    Fox, J.G.2    Dewhirst, F.3    Yan, L.4    Shen, Z.5    Taylor, N.S.6
  • 34
    • 0030837598 scopus 로고    scopus 로고
    • Failure of Lymphopoiesis after adoptive transfer of NF-kB deficient fetal liver cells
    • Horwitz BH, Scott ML, Cherry SR, Bronson RT, Baltimore D: Failure of Lymphopoiesis after adoptive transfer of NF-kB deficient fetal liver cells. Immunity 1997, 6:765-772
    • (1997) Immunity , vol.6 , pp. 765-772
    • Horwitz, B.H.1    Scott, M.L.2    Cherry, S.R.3    Bronson, R.T.4    Baltimore, D.5
  • 35
    • 0029813545 scopus 로고    scopus 로고
    • Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses
    • Berg DJ, Davidson N, Kuhn R, Muller W, Menon S, Holland G, Thompson-Snipes L, Leach MW, Rennick D: Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J Clin Invest 1996, 98:1010-1020
    • (1996) J Clin Invest , vol.98 , pp. 1010-1020
    • Berg, D.J.1    Davidson, N.2    Kuhn, R.3    Muller, W.4    Menon, S.5    Holland, G.6    Thompson-Snipes, L.7    Leach, M.W.8    Rennick, D.9
  • 38
    • 0033695108 scopus 로고    scopus 로고
    • Diagnostic criteria for gastrointestinal carcinomas in Japan and Western countries: Proposal for a new classification of gastrointestinal epithelial neoplasia
    • Schempler RJ, Kato Y, Stolte M: Diagnostic criteria for gastrointestinal carcinomas in Japan and Western countries: proposal for a new classification of gastrointestinal epithelial neoplasia. Gastroenterol Hepatol 2000, Oct 15:G49-G57
    • (2000) Gastroenterol Hepatol , vol.OCT 15
    • Schempler, R.J.1    Kato, Y.2    Stolte, M.3
  • 40
    • 0034951122 scopus 로고    scopus 로고
    • Fluorogenic PCR-based quantitative detection of a murine pathogen, Helicobacter hepaticus
    • Ge Z, White DA, Whary MT, Fox JG: Fluorogenic PCR-based quantitative detection of a murine pathogen, Helicobacter hepaticus. J Clin Microbiol 2001, 39:2598-2602
    • (2001) J Clin Microbiol , vol.39 , pp. 2598-2602
    • Ge, Z.1    White, D.A.2    Whary, M.T.3    Fox, J.G.4
  • 41
    • 0035200774 scopus 로고    scopus 로고
    • Long-term colonization levels of Helicobacter hepaticus in the cecum of hepatitis-prone A/JCr mice are significantly lower than those in hepatitis-resistant C57BL/6 mice
    • Whary MT, Cline J, King A, Ge Z, Shen Z, Sheppard B, Fox JG: Long-term colonization levels of Helicobacter hepaticus in the cecum of hepatitis-prone A/JCr mice are significantly lower than those in hepatitis-resistant C57BL/6 mice. Comp Med 2001, 51:413-417
    • (2001) Comp Med , vol.51 , pp. 413-417
    • Whary, M.T.1    Cline, J.2    King, A.3    Ge, Z.4    Shen, Z.5    Sheppard, B.6    Fox, J.G.7
  • 42
    • 0029873909 scopus 로고    scopus 로고
    • Inflammatory large bowel disease in immunodeficient mice naturally infected with Helicobacter hepaticus
    • Ward JM, Anver MR, Haines DC, Melhorn JM, Gorelick P, Yan L, Fox JG: Inflammatory large bowel disease in immunodeficient mice naturally infected with Helicobacter hepaticus. Lab Anim Sci 1996, 46:15-20
    • (1996) Lab Anim Sci , vol.46 , pp. 15-20
    • Ward, J.M.1    Anver, M.R.2    Haines, D.C.3    Melhorn, J.M.4    Gorelick, P.5    Yan, L.6    Fox, J.G.7
  • 43
    • 0032090186 scopus 로고    scopus 로고
    • Spontaneous inflammatory bowel disease in multiple mutant mouse lines: Association with colonization by Helicobacter hepaticus
    • Foltz CJ, Fox JG, Cahill R, Murphy JC, Yan L, Shames B, Schauer DB: Spontaneous inflammatory bowel disease in multiple mutant mouse lines: association with colonization by Helicobacter hepaticus. Helicobacter 1998, 3:69-78
    • (1998) Helicobacter , vol.3 , pp. 69-78
    • Foltz, C.J.1    Fox, J.G.2    Cahill, R.3    Murphy, J.C.4    Yan, L.5    Shames, B.6    Schauer, D.B.7
  • 45
    • 0029986919 scopus 로고    scopus 로고
    • Chronic proliferative hepatitis in A/JCr mice associated with persistent Helicobacter hepaticus infection: A model of Helicobacter-induced carcinogenesis
    • Fox JG, Li X, Yan L, Cahill RJ, Hurley R, Lewis R, Murphy JC: Chronic proliferative hepatitis in A/JCr mice associated with persistent Helicobacter hepaticus infection: a model of Helicobacter-induced carcinogenesis. Infect Immun 1996, 64:1548-1558
    • (1996) Infect Immun , vol.64 , pp. 1548-1558
    • Fox, J.G.1    Li, X.2    Yan, L.3    Cahill, R.J.4    Hurley, R.5    Lewis, R.6    Murphy, J.C.7
  • 47
    • 0032777440 scopus 로고    scopus 로고
    • Differential susceptibility of hepatic inflammation and proliferation in AXB recombinant inbred mice chronically infected with Helicobacter hepaticus
    • Ihrig M, Schrenzel M, Fox JG: Differential susceptibility of hepatic inflammation and proliferation in AXB recombinant inbred mice chronically infected with Helicobacter hepaticus. Am J Pathol 1999, 155:571-582
    • (1999) Am J Pathol , vol.155 , pp. 571-582
    • Ihrig, M.1    Schrenzel, M.2    Fox, J.G.3
  • 48
    • 0027065034 scopus 로고
    • Human gastric carcinogenesis: A multistep and multifactorial process. First American Cancer Society Award lecture on cancer epidemiology and prevention
    • Correa P: Human gastric carcinogenesis: a multistep and multifactorial process. First American Cancer Society Award lecture on cancer epidemiology and prevention. Cancer Res 1992, 52:6735-6740
    • (1992) Cancer Res , vol.52 , pp. 6735-6740
    • Correa, P.1
  • 50
    • 0029824918 scopus 로고    scopus 로고
    • The pattern of cell proliferation in neoplastic and nonneoplastic lesions of ulcerative colitis
    • Noffsinger AE, Miller MA, Cusi MV, Fenoglio-Preiser CM: The pattern of cell proliferation in neoplastic and nonneoplastic lesions of ulcerative colitis. Cancer 1996, 78:2307-2312
    • (1996) Cancer , vol.78 , pp. 2307-2312
    • Noffsinger, A.E.1    Miller, M.A.2    Cusi, M.V.3    Fenoglio-Preiser, C.M.4
  • 51
    • 0034052970 scopus 로고    scopus 로고
    • Dysplasia and cancer in the dextran sulfate sodium mouse colitis model. Relevance to colitis-associated neoplasia in the human: A study in histopathology, B-catenin and p53 expression and the role of inflammation
    • Cooper HS, Murthy S, Kido K, Yoshitake H, Flanigan A: Dysplasia and cancer in the dextran sulfate sodium mouse colitis model. Relevance to colitis-associated neoplasia in the human: a study in histopathology, B-catenin and p53 expression and the role of inflammation. Carcinogenesis 2000, 21:757-768
    • (2000) Carcinogenesis , vol.21 , pp. 757-768
    • Cooper, H.S.1    Murthy, S.2    Kido, K.3    Yoshitake, H.4    Flanigan, A.5
  • 53
    • 0033948508 scopus 로고    scopus 로고
    • Lessons from genetically engineered animal models XII. IL10-deficient mice and intestinal inflammation
    • Rennick DM, Fort MM: Lessons from genetically engineered animal models XII. IL10-deficient mice and intestinal inflammation. Am J Physiol 2000, 278:G829-G833
    • (2000) Am J Physiol , vol.278
    • Rennick, D.M.1    Fort, M.M.2
  • 54
    • 0031586331 scopus 로고    scopus 로고
    • Interleukin 10 inhibits tumor metastasis, down-regulates MHC class 1, and enhances NK lysis
    • Kundu N, Fulton MA: Interleukin 10 inhibits tumor metastasis, down-regulates MHC class 1, and enhances NK lysis. Cell Immunol 1997, 180:55-61
    • (1997) Cell Immunol , vol.180 , pp. 55-61
    • Kundu, N.1    Fulton, M.A.2
  • 57
    • 0028519015 scopus 로고
    • Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells
    • Powrie F, Leach W, Mauze S, Menon L, Caddle LB, Coffman RL: Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1994, 1:553-562
    • (1994) Immunity , vol.1 , pp. 553-562
    • Powrie, F.1    Leach, W.2    Mauze, S.3    Menon, L.4    Caddle, L.B.5    Coffman, R.L.6
  • 58
    • 0033559891 scopus 로고    scopus 로고
    • Colitis-inducing potency of CD4+ T cells in immunodeficient adoptive hosts depends upon their state of activation, IL12 responsiveness, and CD45RB phenotype
    • Claesson MH, Bregenholt S, Bonhagen K, Stefan T, Moller P, Grusby MJ, Leithauser F, Nissen MH, Reimann J: Colitis-inducing potency of CD4+ T cells in immunodeficient adoptive hosts depends upon their state of activation, IL12 responsiveness, and CD45RB phenotype. J Immunol 1999, 162:3702-3710
    • (1999) J Immunol , vol.162 , pp. 3702-3710
    • Claesson, M.H.1    Bregenholt, S.2    Bonhagen, K.3    Stefan, T.4    Moller, P.5    Grusby, M.J.6    Leithauser, F.7    Nissen, M.H.8    Reimann, J.9
  • 61
    • 0033523607 scopus 로고    scopus 로고
    • An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
    • Asseman C, Mauze S, Leach MW, Coffman RL, Powrie F: An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med 1999, 190:995-1004
    • (1999) J Exp Med , vol.190 , pp. 995-1004
    • Asseman, C.1    Mauze, S.2    Leach, M.W.3    Coffman, R.L.4    Powrie, F.5
  • 63
    • 0032526338 scopus 로고    scopus 로고
    • Molecular mechanisms of the induction of IL12 and its inhibition by IL10
    • Aste-Amezaga M, Ma X, Sartori A, Trinchieri G: Molecular mechanisms of the induction of IL12 and its inhibition by IL10. J Immunol 1998, 160:5936-5944
    • (1998) J Immunol , vol.160 , pp. 5936-5944
    • Aste-Amezaga, M.1    Ma, X.2    Sartori, A.3    Trinchieri, G.4
  • 64
    • 0032707898 scopus 로고    scopus 로고
    • Animal models of mucosal inflammation and their relation to human inflammatory bowel disease
    • Blumberg RS, Saubermann LJ, Strober W: Animal models of mucosal inflammation and their relation to human inflammatory bowel disease. Curr Opin Immunol 1999, 11:648-656
    • (1999) Curr Opin Immunol , vol.11 , pp. 648-656
    • Blumberg, R.S.1    Saubermann, L.J.2    Strober, W.3
  • 65
    • 0036134856 scopus 로고    scopus 로고
    • Cutting edge: IL10-producing CD4+ T cells mediate tumor rejection
    • Segal BM, Glass DD, Shevach EM: Cutting edge: IL10-producing CD4+ T cells mediate tumor rejection. J Immunol 2002, 168:1-4
    • (2002) J Immunol , vol.168 , pp. 1-4
    • Segal, B.M.1    Glass, D.D.2    Shevach, E.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.