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Volumn 4, Issue 1, 2011, Pages 22-30

Helicobacter hepaticus infection in mice: Models for understanding lower bowel inflammation and cancer

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLETHAL DISTENDING TOXIN; GAMMA INTERFERON; HYAB PROTEIN; INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 6; KATA PROTEIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; UREASE; VIRULENCE FACTOR;

EID: 78650828652     PISSN: 19330219     EISSN: None     Source Type: Journal    
DOI: 10.1038/mi.2010.61     Document Type: Review
Times cited : (160)

References (97)
  • 1
    • 0028325311 scopus 로고
    • Helicobacter hepaticus sp. nov., A microaerophilic bacterium isolated from livers and intestinal mucosal scrapings from mice
    • Fox, J. G. et al. Helicobacter hepaticus sp. nov., a microaerophilic bacterium isolated from livers and intestinal mucosal scrapings from mice. J. Clin. Microbiol. 32, 1238-1245 (1994).
    • (1994) J. Clin. Microbiol. , vol.32 , pp. 1238-1245
    • Fox, J.G.1
  • 2
    • 0028093372 scopus 로고
    • Chronic active hepatitis and associated liver tumors in mice caused by a persistent bacterial infection with a novel Helicobacter species
    • Ward, J. M. et al. Chronic active hepatitis and associated liver tumors in mice caused by a persistent bacterial infection with a novel Helicobacter species. J. Natl Cancer. Inst. 86, 1222-1227 (1994).
    • (1994) J. Natl Cancer. Inst. , vol.86 , pp. 1222-1227
    • Ward, J.M.1
  • 3
    • 0029986919 scopus 로고    scopus 로고
    • Chronic proliferative hepatitis in A/JCr mice associated with persistent Helicobacter hepaticus infection: A model of Helicobacter-induced carcinogenesis
    • Fox, J. G. et al. Chronic proliferative hepatitis in A/JCr mice associated with persistent Helicobacter hepaticus infection: A model of Helicobacter-induced carcinogenesis. Infect. Immun. 64, 1548-1558 (1996).
    • (1996) Infect. Immun. , vol.64 , pp. 1548-1558
    • Fox, J.G.1
  • 4
    • 77951830706 scopus 로고    scopus 로고
    • Helicobacter pullorum outbreak in C57BL/6NTac and C3H/HeNTac barrier-maintained mice
    • Boutin, S. R. et al. Helicobacter pullorum outbreak in C57BL/6NTac and C3H/HeNTac barrier-maintained mice. J. Clin. Microbiol. 48, 1908-1910 (2010).
    • (2010) J. Clin. Microbiol. , vol.48 , pp. 1908-1910
    • Boutin, S.R.1
  • 5
    • 0028864668 scopus 로고
    • Identifi cation of widespread Helicobacter hepaticus infection in feces in commercial mouse colonies by culture and PCR assay
    • Shames, B. et al. Identifi cation of widespread Helicobacter hepaticus infection in feces in commercial mouse colonies by culture and PCR assay. J. Clin. Microbiol. 33, 2968-2972 (1995).
    • (1995) J. Clin. Microbiol. , vol.33 , pp. 2968-2972
    • Shames, B.1
  • 6
    • 34547645764 scopus 로고    scopus 로고
    • Enterohepatic Helicobacter species are prevalent in mice from commercial and academic institutions in Asia, Europe, and North America
    • Taylor, N. S., Xu, S., Nambiar, P., Dewhirst, F. E. & Fox, J. G. Enterohepatic Helicobacter species are prevalent in mice from commercial and academic institutions in Asia, Europe, and North America. J. Clin. Microbiol. 45, 2166-2172 (2007).
    • (2007) J. Clin. Microbiol. , vol.45 , pp. 2166-2172
    • Taylor, N.S.1    Xu, S.2    Nambiar, P.3    Dewhirst, F.E.4    Fox, J.G.5
  • 7
    • 0029813545 scopus 로고    scopus 로고
    • Enterocolitis and colon cancer in interleukin-10-defi cient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses
    • Berg, D. J. et al. Enterocolitis and colon cancer in interleukin-10-defi cient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J. Clin. Invest. 98, 1010-1020 (1996).
    • (1996) J. Clin. Invest. , vol.98 , pp. 1010-1020
    • Berg, D.J.1
  • 8
    • 0029873909 scopus 로고    scopus 로고
    • Infl ammatory large bowel disease in immunodefi cient mice naturally infected with Helicobacter hepaticus
    • Ward, J. M. et al. Infl ammatory large bowel disease in immunodefi cient mice naturally infected with Helicobacter hepaticus. Lab. Anim. Sci. 46, 15-20 (1996).
    • (1996) Lab. Anim. Sci. , vol.46 , pp. 15-20
    • Ward, J.M.1
  • 9
    • 0032090186 scopus 로고    scopus 로고
    • Spontaneous infl ammatory bowel disease in multiple mutant mouse lines: Association with colonization by Helicobacter hepaticus
    • Foltz, C. J. et al. Spontaneous infl ammatory bowel disease in multiple mutant mouse lines: Association with colonization by Helicobacter hepaticus. Helicobacter 3, 69-78 (1998).
    • (1998) Helicobacter , vol.3 , pp. 69-78
    • Foltz, C.J.1
  • 10
    • 0030794060 scopus 로고    scopus 로고
    • Infl ammatory bowel disease: An immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus
    • Cahill, R. J. et al. Infl ammatory bowel disease: An immunity-mediated condition triggered by bacterial infection with Helicobacter hepaticus. Infect Immun 65, 3126-3131 (1997).
    • (1997) Infect Immun , vol.65 , pp. 3126-3131
    • Cahill, R.J.1
  • 11
    • 0027517545 scopus 로고
    • Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal infl ammation in C. B-17 scid mice
    • Powrie, F., Leach, M. W., Mauze, S., Caddle, L. B. & Coffman, R. L. Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal infl ammation in C. B-17 scid mice. Int. Immunol. 5, 1461-1471 (1993).
    • (1993) Int. Immunol. , vol.5 , pp. 1461-1471
    • Powrie, F.1    Leach, M.W.2    Mauze, S.3    Caddle, L.B.4    Coffman, R.L.5
  • 12
    • 0028519015 scopus 로고
    • Inhibition of Th1 responses prevents infl ammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells
    • Powrie, F. et al. Inhibition of Th1 responses prevents infl ammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1, 553-562 (1994).
    • (1994) Immunity , vol.1 , pp. 553-562
    • Powrie, F.1
  • 13
    • 0032425062 scopus 로고    scopus 로고
    • Helicobacter hepaticus triggers colitis in specifi cpathogen- free interleukin-10 (IL-10)-defi cient mice through an IL-12- and gamma interferon-dependent mechanism
    • Kullberg, M. C. et al. Helicobacter hepaticus triggers colitis in specifi cpathogen- free interleukin-10 (IL-10)-defi cient mice through an IL-12- and gamma interferon-dependent mechanism. Infect. Immun. 66, 5157-5166 (1998).
    • (1998) Infect. Immun. , vol.66 , pp. 5157-5166
    • Kullberg, M.C.1
  • 14
    • 0034828657 scopus 로고    scopus 로고
    • Helicobacter-induced infl ammatory bowel disease in IL-10- and T cell-defi cient mice
    • Burich, A. et al. Helicobacter-induced infl ammatory bowel disease in IL-10- and T cell-defi cient mice. Am. J. Physiol. Gastrointest. Liver Physiol. 281, G764-778 (2001).
    • (2001) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.281
    • Burich, A.1
  • 15
    • 78650814147 scopus 로고    scopus 로고
    • Susceptibility of three strains of Rag2-defi cient mice to Helicobacter hepaticus induced colitis and colorectal cancer
    • Erdman, S. E., Poutahidis, T., Rogers, A. B., Tomszaki, M., Horwitz, B. & Fox, J. G. Susceptibility of three strains of Rag2-defi cient mice to Helicobacter hepaticus induced colitis and colorectal cancer. Gastroenterology 124 (Suppl 1), A340 (2003).
    • (2003) Gastroenterology , vol.124 , Issue.SUPPL. 1
    • Erdman, S.E.1    Poutahidis, T.2    Rogers, A.B.3    Tomszaki, M.4    Horwitz, B.5    Fox, J.G.6
  • 16
    • 0027521572 scopus 로고
    • Interleukin- 10-defi cient mice develop chronic enterocolitis
    • Kuhn, R., Lohler, J., Rennick, D., Rajewsky, K. & Muller, W. Interleukin- 10-defi cient mice develop chronic enterocolitis. Cell 75, 263-274 (1993).
    • (1993) Cell , vol.75 , pp. 263-274
    • Kuhn, R.1    Lohler, J.2    Rennick, D.3    Rajewsky, K.4    Muller, W.5
  • 17
    • 0033860659 scopus 로고    scopus 로고
    • Helicobacter hepaticus does not induce or potentiate colitis in interleukin-10-defi cient mice
    • Dieleman, L. A. et al. Helicobacter hepaticus does not induce or potentiate colitis in interleukin-10-defi cient mice. Infect. Immun. 68, 5107-5113 (2000).
    • (2000) Infect. Immun. , vol.68 , pp. 5107-5113
    • Dieleman, L.A.1
  • 18
    • 0034972172 scopus 로고    scopus 로고
    • Helicobacter hepaticus -induced colitis in interleukin- 10-defi cient mice: Cytokine requirements for the induction and maintenance of intestinal infl ammation
    • Kullberg, M. C. et al. Helicobacter hepaticus -induced colitis in interleukin- 10-defi cient mice: Cytokine requirements for the induction and maintenance of intestinal infl ammation. Infect. Immun. 69, 4232-4241 (2001).
    • (2001) Infect. Immun. , vol.69 , pp. 4232-4241
    • Kullberg, M.C.1
  • 19
    • 33750530394 scopus 로고    scopus 로고
    • IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis
    • Kullberg, M. C. et al. IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. J. Exp. Med. 203, 2485-2494 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 2485-2494
    • Kullberg, M.C.1
  • 20
    • 59849114998 scopus 로고    scopus 로고
    • ROR gamma-expressing Th17 cells induce murine chronic intestinal infl ammation via redundant effects of IL-17A and IL-17F
    • Leppkes, M. et al. ROR gamma-expressing Th17 cells induce murine chronic intestinal infl ammation via redundant effects of IL-17A and IL-17F. Gastroenterology 136, 257-267 (2009).
    • (2009) Gastroenterology , vol.136 , pp. 257-267
    • Leppkes, M.1
  • 21
    • 65749091607 scopus 로고    scopus 로고
    • A protective function for interleukin 17A in T cell-mediated intestinal infl ammation
    • O'Connor, W. Jr et al. A protective function for interleukin 17A in T cell-mediated intestinal infl ammation. Nat. Immunol. 1, 603-609 (2009).
    • (2009) Nat. Immunol. , vol.1 , pp. 603-609
    • O'Connor Jr., W.1
  • 22
    • 57449090428 scopus 로고    scopus 로고
    • Innate and adaptive interleukin-22 protects mice from infl ammatory bowel disease
    • Zenewicz, L. A. et al. Innate and adaptive interleukin-22 protects mice from infl ammatory bowel disease. Immunity 29, 947-957 (2008).
    • (2008) Immunity , vol.29 , pp. 947-957
    • Zenewicz, L.A.1
  • 23
    • 38849141814 scopus 로고    scopus 로고
    • IL-22 ameliorates intestinal infl ammation in a mouse model of ulcerative colitis
    • Sugimoto, K. et al. IL-22 ameliorates intestinal infl ammation in a mouse model of ulcerative colitis. J. Clin. Invest. 118, 534-544 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 534-544
    • Sugimoto, K.1
  • 24
    • 0141731259 scopus 로고    scopus 로고
    • CD4(+)CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice
    • Erdman, S. E. et al. CD4(+)CD25(+) regulatory lymphocytes require interleukin 10 to interrupt colon carcinogenesis in mice. Cancer Res. 63, 6042-6050 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 6042-6050
    • Erdman, S.E.1
  • 25
    • 0037243827 scopus 로고    scopus 로고
    • CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms
    • Maloy, K. J. et al. CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms. J. Exp. Med. 197, 111-119 (2003).
    • (2003) J. Exp. Med. , vol.197 , pp. 111-119
    • Maloy, K.J.1
  • 26
    • 0042847143 scopus 로고    scopus 로고
    • NF-kappa B is required within the innate immune system to inhibit microfl ora-induced colitis and expression of IL-12 p40
    • Tomczak, M. F. et al. NF-kappa B is required within the innate immune system to inhibit microfl ora-induced colitis and expression of IL-12 p40. J. Immunol. 171, 1484-1492 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 1484-1492
    • Tomczak, M.F.1
  • 27
    • 0032533480 scopus 로고    scopus 로고
    • IL-7 defi ciency prevents development of a non- T cell non-B cell-mediated colitis
    • von Freeden-Jeffry, U. et al. IL-7 defi ciency prevents development of a non- T cell non-B cell-mediated colitis. J. Immunol. 161, 5673-5680 (1998).
    • (1998) J. Immunol. , vol.161 , pp. 5673-5680
    • Von Freeden-Jeffry, U.1
  • 28
    • 0037331279 scopus 로고    scopus 로고
    • CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-defi cient mice
    • Erdman, S. E. et al. CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-defi cient mice. Am. J. Pathol. 162, 691-702 (2003).
    • (2003) Am. J. Pathol. , vol.162 , pp. 691-702
    • Erdman, S.E.1
  • 29
    • 33750505009 scopus 로고    scopus 로고
    • Interleukin-23 drives innate and T cell-mediated intestinal infl ammation
    • Hue, S. et al. Interleukin-23 drives innate and T cell-mediated intestinal infl ammation. J. Exp. Med. 203, 2473-2483 (2006).
    • (2006) J. Exp. Med. , vol.203 , pp. 2473-2483
    • Hue, S.1
  • 30
    • 77951878587 scopus 로고    scopus 로고
    • Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology
    • Buonocore, S. et al. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature 464, 1371-1375 (2010).
    • (2010) Nature , vol.464 , pp. 1371-1375
    • Buonocore, S.1
  • 31
    • 3042720708 scopus 로고    scopus 로고
    • Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells
    • Eberl, G. & Littman, D. R. Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells. Science 305, 248-251 (2004).
    • (2004) Science , vol.305 , pp. 248-251
    • Eberl, G.1    Littman, D.R.2
  • 32
    • 0346496018 scopus 로고    scopus 로고
    • An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells
    • Eberl, G. et al. An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat. Immunol. 5, 64-73 (2004).
    • (2004) Nat. Immunol. , vol.5 , pp. 64-73
    • Eberl, G.1
  • 33
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORgammat directs the differentiation program of proinfl ammatory IL-17+ T helper cells
    • Ivanov, I.I. et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinfl ammatory IL-17+ T helper cells. Cell 126, 1121-1133 (2006).
    • (2006) Cell , vol.126 , pp. 1121-1133
    • Ivanov, I.I.1
  • 34
    • 0031984960 scopus 로고    scopus 로고
    • Essential role of IL-7 receptor alpha in the formation of Peyer's patch anlage
    • Adachi, S. et al. Essential role of IL-7 receptor alpha in the formation of Peyer's patch anlage. Int. Immunol. 10, 1-6 (1998).
    • (1998) Int. Immunol. , vol.10 , pp. 1-6
    • Adachi, S.1
  • 35
    • 14744270856 scopus 로고    scopus 로고
    • Cure of innate intestinal immune pathology by CD4+CD25+ regulatory T cells
    • Maloy, K. J., Antonelli, L. R., Lefevre, M. & Powrie, F. Cure of innate intestinal immune pathology by CD4+CD25+ regulatory T cells. Immunol. Lett. 97, 189-192 (2005).
    • (2005) Immunol. Lett. , vol.97 , pp. 189-192
    • Maloy, K.J.1    Antonelli, L.R.2    Lefevre, M.3    Powrie, F.4
  • 36
    • 0037136284 scopus 로고    scopus 로고
    • Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus -induced colitis
    • Kullberg, M. C. et al. Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus -induced colitis. J. Exp. Med. 196, 505-515 (2002).
    • (2002) J. Exp. Med. , vol.196 , pp. 505-515
    • Kullberg, M.C.1
  • 37
    • 36949006791 scopus 로고    scopus 로고
    • Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma
    • Poutahidis, T. et al. Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma. Carcinogenesis 28, 2614-2623 (2007).
    • (2007) Carcinogenesis , vol.28 , pp. 2614-2623
    • Poutahidis, T.1
  • 38
    • 30744448978 scopus 로고    scopus 로고
    • Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kappaB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus
    • Tomczak, M. F. et al. Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kappaB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus. J. Immunol. 176, 1244-1251 (2006).
    • (2006) J. Immunol. , vol.176 , pp. 1244-1251
    • Tomczak, M.F.1
  • 39
    • 50949094396 scopus 로고    scopus 로고
    • C-Rel is essential for the development of innate and T cellinduced colitis
    • Wang, Y. et al. c-Rel is essential for the development of innate and T cellinduced colitis. J. Immunol. 180, 8118-8125 (2008).
    • (2008) J. Immunol. , vol.180 , pp. 8118-8125
    • Wang, Y.1
  • 40
    • 33750838717 scopus 로고    scopus 로고
    • Inhibition of Helicobacter hepaticus -induced colitis by IL-10 requires the p50/p105 subunit of NF-kappa B
    • Tomczak, M. F. et al. Inhibition of Helicobacter hepaticus -induced colitis by IL-10 requires the p50/p105 subunit of NF-kappa B. J. Immunol. 177, 7332-7339 (2006).
    • (2006) J. Immunol. , vol.177 , pp. 7332-7339
    • Tomczak, M.F.1
  • 41
    • 5044240576 scopus 로고    scopus 로고
    • Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via tolllike receptor 2 but not toll-like receptor 4
    • Mandell, L. et al. Intact gram-negative Helicobacter pylori, Helicobacter felis, and Helicobacter hepaticus bacteria activate innate immunity via tolllike receptor 2 but not toll-like receptor 4. Infect. Immun. 72, 6446-6454 (2004).
    • (2004) Infect. Immun. , vol.72 , pp. 6446-6454
    • Mandell, L.1
  • 42
    • 75149118945 scopus 로고    scopus 로고
    • TLR2-independent induction and regulation of chronic intestinal infl ammation
    • Boulard, O., Asquith, M. J., Powrie, F. & Maloy, K. J. TLR2-independent induction and regulation of chronic intestinal infl ammation. Eur. J. Immunol. 40, 516-524 (2009).
    • (2009) Eur. J. Immunol. , vol.40 , pp. 516-524
    • Boulard, O.1    Asquith, M.J.2    Powrie, F.3    Maloy, K.J.4
  • 43
    • 77955346494 scopus 로고    scopus 로고
    • Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of infl ammatory bowel disease
    • Asquith, M. J., Boulard, O., Powrie, F. & Maloy, K. J. Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of infl ammatory bowel disease. Gastroenterology 139, 519-529 (2010).
    • (2010) Gastroenterology , vol.139 , pp. 519-529
    • Asquith, M.J.1    Boulard, O.2    Powrie, F.3    Maloy, K.J.4
  • 44
  • 45
    • 77954607064 scopus 로고    scopus 로고
    • A pathobiont of the microbiota balances host colonization and intestinal infl ammation
    • Chow, J. & Mazmanian, S. K. A pathobiont of the microbiota balances host colonization and intestinal infl ammation. Cell Host Microbe 7, 265-276 (2010).
    • (2010) Cell Host Microbe , vol.7 , pp. 265-276
    • Chow, J.1    Mazmanian, S.K.2
  • 46
    • 65549116380 scopus 로고    scopus 로고
    • A commensal Helicobacter sp. of the rodent intestinal fl ora activates TLR2 and NOD1 responses in epithelial cells
    • Chaouche-Drider, N. et al. A commensal Helicobacter sp. of the rodent intestinal fl ora activates TLR2 and NOD1 responses in epithelial cells. PLoS One 4, e5396 (2009).
    • (2009) PLoS One , vol.4
    • Chaouche-Drider, N.1
  • 47
    • 34249905600 scopus 로고    scopus 로고
    • Inhibitory effect of enterohepatic Helicobacter hepaticus on innate immune responses of mouse intestinal epithelial cells
    • Sterzenbach, T. et al. Inhibitory effect of enterohepatic Helicobacter hepaticus on innate immune responses of mouse intestinal epithelial cells. Infect. Immun. 75, 2717-2728 (2007).
    • (2007) Infect. Immun. , vol.75 , pp. 2717-2728
    • Sterzenbach, T.1
  • 48
    • 70349468054 scopus 로고    scopus 로고
    • Nod2 is required for the regulation of commensal microbiota in the intestine
    • Petnicki-Ocwieja, T. et al. Nod2 is required for the regulation of commensal microbiota in the intestine. Proc. Natl Acad. Sci. USA 106, 15813-15818 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 15813-15818
    • Petnicki-Ocwieja, T.1
  • 49
    • 42949091932 scopus 로고    scopus 로고
    • Genetic susceptibility to chronic hepatitis is inherited codominantly in Helicobacter hepaticus -infected AB6F1 and B6AF1 hybrid male mice, and progression to hepatocellular carcinoma is linked to hepatic expression of lipogenic genes and immune function-associated networks
    • Garcia, A. et al. Genetic susceptibility to chronic hepatitis is inherited codominantly in Helicobacter hepaticus -infected AB6F1 and B6AF1 hybrid male mice, and progression to hepatocellular carcinoma is linked to hepatic expression of lipogenic genes and immune function-associated networks. Infect. Immun. 76, 1866-1876 (2008).
    • (2008) Infect. Immun. , vol.76 , pp. 1866-1876
    • Garcia, A.1
  • 50
    • 0032777440 scopus 로고    scopus 로고
    • Differential susceptibility to hepatic infl ammation and proliferation in AXB recombinant inbred mice chronically infected with Helicobacter hepaticus
    • Ihrig, M., Schrenzel, M. D. & Fox, J. G. Differential susceptibility to hepatic infl ammation and proliferation in AXB recombinant inbred mice chronically infected with Helicobacter hepaticus. Am. J. Pathol. 155, 571-582 (1999).
    • (1999) Am. J. Pathol. , vol.155 , pp. 571-582
    • Ihrig, M.1    Schrenzel, M.D.2    Fox, J.G.3
  • 51
    • 0027988869 scopus 로고
    • Chronic active hepatitis in mice caused by Helicobacter hepaticus
    • Ward, J. M., Anver, M. R., Haines, D. C. & Benveniste, R. E. Chronic active hepatitis in mice caused by Helicobacter hepaticus. Am. J. Pathol. 145, 959-968 (1994).
    • (1994) Am. J. Pathol. , vol.145 , pp. 959-968
    • Ward, J.M.1    Anver, M.R.2    Haines, D.C.3    Benveniste, R.E.4
  • 52
    • 73449143207 scopus 로고    scopus 로고
    • Gut microbes defi ne liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens
    • Fox, J. G. et al. Gut microbes defi ne liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens. Gut 59, 88-97 (2010).
    • (2010) Gut , vol.59 , pp. 88-97
    • Fox, J.G.1
  • 53
    • 0037112436 scopus 로고    scopus 로고
    • Elimination of colon cancer in germ-free transforming growth factor beta 1-defi cient mice
    • Engle, S. J. et al. Elimination of colon cancer in germ-free transforming growth factor beta 1-defi cient mice. Cancer Res. 62, 6362-6366 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 6362-6366
    • Engle, S.J.1
  • 54
    • 0037370137 scopus 로고    scopus 로고
    • Pathology of mouse models of intestinal cancer: Consensus report and recommendations
    • Boivin, G. P. et al. Pathology of mouse models of intestinal cancer: Consensus report and recommendations. Gastroenterology 124, 762-777 (2003).
    • (2003) Gastroenterology , vol.124 , pp. 762-777
    • Boivin, G.P.1
  • 55
    • 0021017589 scopus 로고
    • Dysplasia in infl ammatory bowel disease: Standardized classifi cation with provisional clinical applications
    • Riddell, R. H. et al. Dysplasia in infl ammatory bowel disease: Standardized classifi cation with provisional clinical applications. Hum. Pathol. 14, 931-968 (1983).
    • (1983) Hum. Pathol. , vol.14 , pp. 931-968
    • Riddell, R.H.1
  • 56
    • 59049099999 scopus 로고    scopus 로고
    • Nitric oxide and TNF-alpha trigger colonic infl ammation and carcinogenesis in Helicobacter hepaticus -infected, Rag2-defi cient mice
    • Erdman, S. E. et al. Nitric oxide and TNF-alpha trigger colonic infl ammation and carcinogenesis in Helicobacter hepaticus -infected, Rag2-defi cient mice. Proc. Natl Acad. Sci. USA 106, 1027-1032 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 1027-1032
    • Erdman, S.E.1
  • 57
    • 33747481384 scopus 로고    scopus 로고
    • Innate immune infl ammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice
    • Rao, V. P. et al. Innate immune infl ammatory response against enteric bacteria Helicobacter hepaticus induces mammary adenocarcinoma in mice. Cancer Res. 66, 7395-7400 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 7395-7400
    • Rao, V.P.1
  • 58
    • 0025015168 scopus 로고
    • A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse
    • Moser, A. R., Pitot, H. C. & Dove, W. F. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 247, 322-324 (1990).
    • (1990) Science , vol.247 , pp. 322-324
    • Moser, A.R.1    Pitot, H.C.2    Dove, W.F.3
  • 59
    • 20144375359 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ mice
    • Erdman, S. E. et al. CD4+CD25+ regulatory lymphocytes induce regression of intestinal tumors in ApcMin/+ mice. Cancer Res. 65, 3998-4004 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 3998-4004
    • Erdman, S.E.1
  • 60
    • 31544451792 scopus 로고    scopus 로고
    • Proinfl ammatory CD4+ CD45RB(hi) lymphocytes promote mammary and intestinal carcinogenesis in Apc (Min/+) mice
    • Rao, V. P. et al. Proinfl ammatory CD4+ CD45RB(hi) lymphocytes promote mammary and intestinal carcinogenesis in Apc (Min/+) mice. Cancer Res. 66, 57-61 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 57-61
    • Rao, V.P.1
  • 61
    • 0035879772 scopus 로고    scopus 로고
    • Bacterial infection promotes colon tumorigenesis in Apc (Min/+) mice
    • Newman, J. V., Kosaka, T., Sheppard, B. J., Fox, J. G. & Schauer, D. B. Bacterial infection promotes colon tumorigenesis in Apc (Min/+) mice. J. Infect. Dis. 184, 227-230 (2001).
    • (2001) J. Infect. Dis. , vol.184 , pp. 227-230
    • Newman, J.V.1    Kosaka, T.2    Sheppard, B.J.3    Fox, J.G.4    Schauer, D.B.5
  • 62
    • 69949120571 scopus 로고    scopus 로고
    • A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17T cell responses
    • Wu, S. et al. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17T cell responses. Nat. Med. 15, 1016-1022 (2009).
    • (2009) Nat. Med. , vol.15 , pp. 1016-1022
    • Wu, S.1
  • 63
    • 77449142400 scopus 로고    scopus 로고
    • Unifying roles for regulatory T cells and infl ammation in cancer
    • Erdman, S. E. et al. Unifying roles for regulatory T cells and infl ammation in cancer. Int. J. Cancer 126, 1651-1665 (2010).
    • (2010) Int. J. Cancer , vol.126 , pp. 1651-1665
    • Erdman, S.E.1
  • 64
    • 33847041537 scopus 로고    scopus 로고
    • Breast cancer: Should gastrointestinal bacteria be on our radar screen?
    • Rao, V. P., Poutahidis, T., Fox, J. G. & Erdman, S. E. Breast cancer: Should gastrointestinal bacteria be on our radar screen? Cancer Res. 67, 847-850 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 847-850
    • Rao, V.P.1    Poutahidis, T.2    Fox, J.G.3    Erdman, S.E.4
  • 65
    • 0038610618 scopus 로고    scopus 로고
    • The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus
    • Suerbaum, S. et al. The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus. Proc. Natl Acad. Sci. USA 100, 7901-7906 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 7901-7906
    • Suerbaum, S.1
  • 66
    • 33845222309 scopus 로고    scopus 로고
    • The contribution of cytolethal distending toxin to bacterial pathogenesis
    • Smith, J. L. & Bayles, D. O. The contribution of cytolethal distending toxin to bacterial pathogenesis. Crit. Rev. Microbiol. 32, 227-248 (2006).
    • (2006) Crit. Rev. Microbiol. , vol.32 , pp. 227-248
    • Smith, J.L.1    Bayles, D.O.2
  • 67
    • 47549092184 scopus 로고    scopus 로고
    • In vivo virulence properties of bacterial cytolethal-distending toxin
    • Ge, Z., Schauer, D. B. & Fox, J. G. In vivo virulence properties of bacterial cytolethal-distending toxin. Cell Microbiol. 10, 1599-1607 (2008).
    • (2008) Cell Microbiol. , vol.10 , pp. 1599-1607
    • Ge, Z.1    Schauer, D.B.2    Fox, J.G.3
  • 68
    • 0034081113 scopus 로고    scopus 로고
    • Identifi cation of cdtB homologues and cytolethal distending toxin activity in enterohepatic Helicobacter spp
    • Chien, C. C. et al. Identifi cation of cdtB homologues and cytolethal distending toxin activity in enterohepatic Helicobacter spp. J. Med. Microbiol. 49, 525-534 (2000).
    • (2000) J. Med. Microbiol. , vol.49 , pp. 525-534
    • Chien, C.C.1
  • 69
    • 0347319588 scopus 로고    scopus 로고
    • Cytolethal distending toxin: A potential virulence factor for Helicobacter cinaedi
    • Taylor, N. S., Ge, Z., Shen, Z., Dewhirst, F. E. & Fox, J. G. Cytolethal distending toxin: A potential virulence factor for Helicobacter cinaedi. J. Infect. Dis. 188, 1892-1897 (2003).
    • (2003) J. Infect. Dis. , vol.188 , pp. 1892-1897
    • Taylor, N.S.1    Ge, Z.2    Shen, Z.3    Dewhirst, F.E.4    Fox, J.G.5
  • 70
    • 0033836386 scopus 로고    scopus 로고
    • Cytolethal distending toxin in avian and human isolates of Helicobacter pullorum
    • Young, V. B. et al. Cytolethal distending toxin in avian and human isolates of Helicobacter pullorum. J. Infect. Dis. 182, 620-623 (2000).
    • (2000) J. Infect. Dis. , vol.182 , pp. 620-623
    • Young, V.B.1
  • 71
    • 19744378055 scopus 로고    scopus 로고
    • Cytolethal distending toxin is essential for Helicobacter hepaticus colonization in outbred Swiss Webster mice
    • Ge, Z. et al. Cytolethal distending toxin is essential for Helicobacter hepaticus colonization in outbred Swiss Webster mice. Infect. Immun. 73, 3559-3567 (2005).
    • (2005) Infect. Immun. , vol.73 , pp. 3559-3567
    • Ge, Z.1
  • 72
    • 33746585280 scopus 로고    scopus 로고
    • Modulation of host immune responses by the cytolethal distending toxin of Helicobacter hepaticus
    • Pratt, J. S., Sachen, K. L., Wood, H. D., Eaton, K. A. & Young, V. B. Modulation of host immune responses by the cytolethal distending toxin of Helicobacter hepaticus. Infect. Immun. 74, 4496-4504 (2006).
    • (2006) Infect. Immun. , vol.74 , pp. 4496-4504
    • Pratt, J.S.1    Sachen, K.L.2    Wood, H.D.3    Eaton, K.A.4    Young, V.B.5
  • 73
    • 2142758715 scopus 로고    scopus 로고
    • In vitro and in vivo characterization of Helicobacter hepaticus cytolethal distending toxin mutants
    • Young, V. B. et al. In vitro and in vivo characterization of Helicobacter hepaticus cytolethal distending toxin mutants. Infect. Immun. 72, 2521-2527 (2004).
    • (2004) Infect. Immun. , vol.72 , pp. 2521-2527
    • Young, V.B.1
  • 74
    • 66549121984 scopus 로고    scopus 로고
    • Cytolethal distending toxin promotes Helicobacter cinaedi-associated typhlocolitis in interleukin-10-defi cient mice
    • Shen, Z. et al. Cytolethal distending toxin promotes Helicobacter cinaedi-associated typhlocolitis in interleukin-10-defi cient mice. Infect. Immun. 77, 2508-2516 (2009).
    • (2009) Infect. Immun. , vol.77 , pp. 2508-2516
    • Shen, Z.1
  • 75
    • 77749233744 scopus 로고    scopus 로고
    • Myc is required for activation of the ATM-dependent checkpoints in response to DNA damage
    • Guerra, L. et al. Myc is required for activation of the ATM-dependent checkpoints in response to DNA damage. PLoS One 5, e8924 (2010).
    • (2010) PLoS One , vol.5
    • Guerra, L.1
  • 76
    • 77749246230 scopus 로고    scopus 로고
    • Helicobacter hepaticus cytolethal distending toxin causes cell death in intestinal epithelial cells via mitochondrial apoptotic pathway
    • Liyanage, N. P. et al. Helicobacter hepaticus cytolethal distending toxin causes cell death in intestinal epithelial cells via mitochondrial apoptotic pathway. Helicobacter 15, 98-107 (2010).
    • (2010) Helicobacter , vol.15 , pp. 98-107
    • Liyanage, N.P.1
  • 77
    • 33749565756 scopus 로고    scopus 로고
    • Pathogenicity islands: A molecular toolbox for bacterial virulence
    • Gal-Mor, O. & Finlay, B. B. Pathogenicity islands: A molecular toolbox for bacterial virulence. Cell Microbiol. 8, 1707-1719 (2006).
    • (2006) Cell Microbiol. , vol.8 , pp. 1707-1719
    • Gal-Mor, O.1    Finlay, B.B.2
  • 78
    • 28444445594 scopus 로고    scopus 로고
    • Different Helicobacter hepaticus strains with variable genomic content induce various degrees of hepatitis
    • Boutin, S. R. et al. Different Helicobacter hepaticus strains with variable genomic content induce various degrees of hepatitis. Infect. Immun. 73, 8449-8452 (2005).
    • (2005) Infect. Immun. , vol.73 , pp. 8449-8452
    • Boutin, S.R.1
  • 79
    • 45849148064 scopus 로고    scopus 로고
    • Helicobacter hepaticus HHGI1 is a pathogenicity island associated with typhlocolitis in B6.129- IL10 tm1Cgn mice
    • Ge, Z. et al. Helicobacter hepaticus HHGI1 is a pathogenicity island associated with typhlocolitis in B6.129- IL10 tm1Cgn mice. Microbes. Infect. 10, 726-733 (2008).
    • (2008) Microbes. Infect. , vol.10 , pp. 726-733
    • Ge, Z.1
  • 80
    • 0034039960 scopus 로고    scopus 로고
    • Bacterial ureases in infectious diseases
    • Burne, R. A. & Chen, Y. Y. Bacterial ureases in infectious diseases. Microbes Infect. 2, 533-542 (2000).
    • (2000) Microbes Infect. , vol.2 , pp. 533-542
    • Burne, R.A.1    Chen, Y.Y.2
  • 81
    • 44649092624 scopus 로고    scopus 로고
    • Helicobacter hepaticus urease is not required for intestinal colonization but promotes hepatic infl ammation in male A/JCr mice
    • Ge, Z. et al. Helicobacter hepaticus urease is not required for intestinal colonization but promotes hepatic infl ammation in male A/JCr mice. Microb. Pathog. 45, 18-24 (2008).
    • (2008) Microb. Pathog. , vol.45 , pp. 18-24
    • Ge, Z.1
  • 82
    • 29244447384 scopus 로고    scopus 로고
    • Differential regulation of urease activity in Helicobacter hepaticus and Helicobacter pylori
    • Belzer, C. et al. Differential regulation of urease activity in Helicobacter hepaticus and Helicobacter pylori. Microbiology 151, 3989-3995 (2005).
    • (2005) Microbiology , vol.151 , pp. 3989-3995
    • Belzer, C.1
  • 83
    • 33846816947 scopus 로고    scopus 로고
    • Iron-responsive repression of urease expression in Helicobacter hepaticus is mediated by the transcriptional regulator Fur
    • Belzer, C., van Schendel, B. A., Kuipers, E. J., Kusters, J. G. & van Vliet, A. H. Iron-responsive repression of urease expression in Helicobacter hepaticus is mediated by the transcriptional regulator Fur. Infect. Immun. 75, 745-752 (2007).
    • (2007) Infect. Immun. , vol.75 , pp. 745-752
    • Belzer, C.1    Van Schendel, B.A.2    Kuipers, E.J.3    Kusters, J.G.4    Van Vliet, A.H.5
  • 84
    • 34247230489 scopus 로고    scopus 로고
    • Helicobacter hepaticus catalase shares surfacepredicted epitopes with mammalian catalases
    • Alyamani, E. J. et al. Helicobacter hepaticus catalase shares surfacepredicted epitopes with mammalian catalases. Microbiology 153, 1006-1016 (2007).
    • (2007) Microbiology , vol.153 , pp. 1006-1016
    • Alyamani, E.J.1
  • 85
    • 34247250292 scopus 로고    scopus 로고
    • A Helicobacter hepaticus catalase mutant is hypersensitive to oxidative stress and suffers increased DNA damage
    • Hong, Y., Wang, G. & Maier, R. J. A Helicobacter hepaticus catalase mutant is hypersensitive to oxidative stress and suffers increased DNA damage. J. Med. Microbiol. 56, 557-562 (2007).
    • (2007) J. Med. Microbiol. , vol.56 , pp. 557-562
    • Hong, Y.1    Wang, G.2    Maier, R.J.3
  • 86
    • 23944475683 scopus 로고    scopus 로고
    • Helicobacter hepaticus hydrogenase mutants are defi cient in hydrogen-supported amino acid uptake and in causing liver lesions in A/J mice
    • Mehta, N. S., Benoit, S., Mysore, J. V., Sousa, R. S. & Maier, R. J. Helicobacter hepaticus hydrogenase mutants are defi cient in hydrogen-supported amino acid uptake and in causing liver lesions in A/J mice. Infect. Immun. 73, 5311-5318 (2005).
    • (2005) Infect. Immun. , vol.73 , pp. 5311-5318
    • Mehta, N.S.1    Benoit, S.2    Mysore, J.V.3    Sousa, R.S.4    Maier, R.J.5
  • 87
    • 52649112717 scopus 로고    scopus 로고
    • Role of the Helicobacter hepaticus fl agellar sigma factor FliA in gene regulation and murine colonization
    • Sterzenbach, T. et al. Role of the Helicobacter hepaticus fl agellar sigma factor FliA in gene regulation and murine colonization. J. Bacteriol. 190, 6398-6408 (2008).
    • (2008) J. Bacteriol. , vol.190 , pp. 6398-6408
    • Sterzenbach, T.1
  • 88
    • 0034503471 scopus 로고    scopus 로고
    • Helicobacter hepaticus infection triggers infl ammatory bowel disease in T cell receptor alpha\beta mutant mice
    • Chin, E. Y., Dangler, C. A., Fox, J. G. & Schauer, D. B. Helicobacter hepaticus infection triggers infl ammatory bowel disease in T cell receptor alpha\beta mutant mice. Comp. Med. 50, 586-594 (2000).
    • (2000) Comp. Med. , vol.50 , pp. 586-594
    • Chin, E.Y.1    Dangler, C.A.2    Fox, J.G.3    Schauer, D.B.4
  • 89
    • 0030735193 scopus 로고    scopus 로고
    • Helicobacter bilis- Induced infl ammatory bowel disease in scid mice with defi ned fl ora
    • Shomer, N. H., Dangler, C. A., Schrenzel, M. D. & Fox, J. G. Helicobacter bilis- induced infl ammatory bowel disease in scid mice with defi ned fl ora. Infect. Immun. 65, 4858-4864 (1997).
    • (1997) Infect. Immun. , vol.65 , pp. 4858-4864
    • Shomer, N.H.1    Dangler, C.A.2    Schrenzel, M.D.3    Fox, J.G.4
  • 90
    • 0031772881 scopus 로고    scopus 로고
    • Helicobacter bilis / Helicobacter rodentium co-infection associated with diarrhea in a colony of scid mice
    • Shomer, N. H., Dangler, C. A., Marini, R. P. & Fox, J. G. Helicobacter bilis / Helicobacter rodentium co-infection associated with diarrhea in a colony of scid mice. Lab. Anim. Sci. 48, 455-459 (1998).
    • (1998) Lab. Anim. Sci. , vol.48 , pp. 455-459
    • Shomer, N.H.1    Dangler, C.A.2    Marini, R.P.3    Fox, J.G.4
  • 91
    • 0029781169 scopus 로고    scopus 로고
    • Persistent hepatitis and enterocolitis in germfree mice infected with Helicobacter hepaticus
    • Fox, J. G. et al. Persistent hepatitis and enterocolitis in germfree mice infected with Helicobacter hepaticus. Infect. Immun. 64, 3673-3681 (1996).
    • (1996) Infect. Immun. , vol.64 , pp. 3673-3681
    • Fox, J.G.1
  • 93
    • 0036169116 scopus 로고    scopus 로고
    • Helicobacter bilis infection accelerates and H. hepaticus infection delays the development of colitis in multiple drug resistance-defi cient (mdr1a-/ -) mice
    • Maggio-Price, L. et al. Helicobacter bilis infection accelerates and H. hepaticus infection delays the development of colitis in multiple drug resistance-defi cient (mdr1a-/ -) mice. Am. J. Pathol. 160, 739-751 (2002).
    • (2002) Am. J. Pathol. , vol.160 , pp. 739-751
    • Maggio-Price, L.1
  • 94
    • 31544465904 scopus 로고    scopus 로고
    • Helicobacter infection is required for infl ammation and colon cancer in SMAD3-defi cient mice
    • Maggio-Price, L. et al. Helicobacter infection is required for infl ammation and colon cancer in SMAD3-defi cient mice. Cancer Res. 66, 828-838 (2006).
    • (2006) Cancer Res. , vol.66 , pp. 828-838
    • Maggio-Price, L.1
  • 95
    • 0033041980 scopus 로고    scopus 로고
    • A novel urease-negative Helicobacter species associated with colitis and typhlitis in IL-10-defi cient mice
    • Fox, J. G. et al. A novel urease-negative Helicobacter species associated with colitis and typhlitis in IL-10-defi cient mice. Infect. Immun. 67, 1757-1762 (1999).
    • (1999) Infect. Immun. , vol.67 , pp. 1757-1762
    • Fox, J.G.1
  • 96
    • 0034759480 scopus 로고    scopus 로고
    • Helicobacter typhlonius sp. nov., A novel murine urease-negative Helicobacter species
    • Franklin, C. L. et al. Helicobacter typhlonius sp. nov., a novel murine urease-negative Helicobacter species. J. Clin. Microbiol. 39, 3920-3926 (2001).
    • (2001) J. Clin. Microbiol. , vol.39 , pp. 3920-3926
    • Franklin, C.L.1
  • 97
    • 33845503040 scopus 로고    scopus 로고
    • Rapid onset of ulcerative typhlocolitis in B6. 129P2- IL10 tm1Cgn (IL-10-/ -) mice infected with Helicobacter trogontum is associated with decreased colonization by altered Schaedler β s fl ora
    • Whary, M. T. et al. Rapid onset of ulcerative typhlocolitis in B6. 129P2- IL10 tm1Cgn (IL-10-/ -) mice infected with Helicobacter trogontum is associated with decreased colonization by altered Schaedler β s fl ora. Infect. Immun. 74, 6615-6623 (2006).
    • (2006) Infect. Immun. , vol.74 , pp. 6615-6623
    • Whary, M.T.1


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