A nucleotide-analogue-induced gain of function corrects the error-prone nature of human DNA polymerase iota

Journal of the American Chemical Society

Volumn 134, Issue 25, 2012, Pages 10698-10705

  Ketkar, Amit ^a   Zafar, Maroof K ^a   Banerjee, Surajit ^b   Marquez, Victor E ^c   Egli, Martin ^d   Eoff, Robert L ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b Department of Obstetrics Gynecology   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE RING; ANTI ORIENTATION; ANTI-CONFORMATIONS; BASE PAIRS; BASE-PAIRING; BASE-STACKING; DEOXYADENOSINE; DNA DAMAGES; DNA POLYMERASE; ERROR PRONES; GAIN-OF FUNCTION; GLYCOSYL; HUMAN DNA POLYMERASE; MODIFIED NUCLEOTIDES; MOLECULAR BASIS; TERNARY COMPLEX; TOLERANCE MECHANISMS; TORSION ANGLE; TRANSLESION; TRIPHOSPHATE;

HEXANE; NUCLEOTIDES; POLYMERS; SCAFFOLDS (BIOLOGY);

DNA;

DEOXYADENOSINE TRIPHOSPHATE; DNA POLYMERASE; MOLECULAR SCAFFOLD; NUCLEOTIDE DERIVATIVE; THYMIDINE;

ACCURACY; ARTICLE; BASE PAIRING; CRYSTAL STRUCTURE; ERROR; HUMAN; TORQUE;

DNA DAMAGE; DNA-DIRECTED DNA POLYMERASE; HUMANS; MODELS, MOLECULAR; NUCLEOTIDES;

EID: 84863434966     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja304176q     Document Type: Article

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