Structure and activity of Y-class DNA polymerase DPO4 from Sulfolobus solfataricus with templates containing the hydrophobic thymine analog 2,4-difluorotoluene

Journal of Biological Chemistry

Volumn 282, Issue 50, 2007, Pages 36421-36433

  Irimia, Adriana ^a   Eoff, Robert L ^a   Pallan, Pradeep S ^a   Guengerich, F Peter ^a   Egli, Martin ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4-DIFLUOROTOLUENE (DFT) ANALOG; DNA POLYMERASES; PRIMER BASE; THYMINE;

CRYSTAL STRUCTURE; ELECTROSTATICS; ENZYME ACTIVITY; HYDROGEN BONDS; KINETIC THEORY; NUCLEOTIDES;

DNA;

2,4 DIFLUOROTOLUENE; DEOXYADENOSINE TRIPHOSPHATE; DNA POLYMERASE; DNA POLYMERASE DPO4; DOUBLE STRANDED DNA; THYMINE DERIVATIVE; TOLUENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BASE MISPAIRING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME STRUCTURE; FRAMESHIFT MUTATION; HYDROGEN BOND; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; STEADY STATE; STRUCTURE ACTIVITY RELATION; SULFOLOBUS SOLFATARICUS;

BACTERIAL PROTEINS; CRYSTALLOGRAPHY, X-RAY; DNA POLYMERASE BETA; DNA, BACTERIAL; HYDROPHOBICITY; KINETICS; NUCLEOTIDES; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; SULFOLOBUS SOLFATARICUS; THYMINE; TOLUENE;

SULFOLOBUS SOLFATARICUS;

EID: 37549025441     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M707267200     Document Type: Article

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