The nucleoside analogue D-carba T blocks HIV-1 reverse transcription

Journal of Medicinal Chemistry

Volumn 52, Issue 17, 2009, Pages 5356-5364

  Boyer, Paul L ^a   Vu, B Christie ^a   Ambrose, Zandrea ^a,d   Julias, John G ^b,e   Warnecke, Svenja ^c   Liao, Chenzhong ^a   Meier, Chris ^c   Marquez, Victor E ^a   Hughes, Stephen H ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c UNIVERSITY OF HAMBURG   (Germany)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e BOOZ ALLEN HAMILTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [3 HYDROXY 4 (HYDROXYMETHYL)CYCLOPENTYL] 5 METHYLPYRIMIDINE 2,4(1H,3H) DIONE; CARBOCYCLIC NUCLEOSIDE; NUCLEOSIDE ANALOG; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS VECTOR; ZIDOVUDINE;

ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CHEMICAL REACTION; CONTROLLED STUDY; CYTOTOXICITY; DNA SYNTHESIS INHIBITION; DRUG CONFORMATION; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; EXCISION; GENE MUTATION; HOST CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MOLECULAR MODEL;

ANTI-HIV AGENTS; BASE SEQUENCE; CELL LINE, TUMOR; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PYRIMIDINE NUCLEOSIDES; REVERSE TRANSCRIPTASE INHIBITORS; THYMIDINE; VIRUS REPLICATION;

EID: 69949102329     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm801176e     Document Type: Article

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