Conformationally restricted nucleosides. The reaction of adenosine deaminase with substrates built on a bicyclo[3.1.0]hexane template

Nucleosides and Nucleotides

Volumn 18, Issue 4-5, 1999, Pages 521-530

  Marquez, Victor E ^a   Russ, Pamela ^a   Alonso, Randolph ^a   Siddiqui, Maqbool A ^a   Shin, Kye Jung ^a   George, Clifford ^b   Nicklaus, Marc C ^a   Dai, Fang ^a   Ford Jr , Harry ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NAVAL RESEARCH LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DEAMINASE; NUCLEOSIDE;

COMPLEX FORMATION; CONFERENCE PAPER; DEAMINATION; ENZYME BINDING; ENZYME KINETICS; ENZYME MECHANISM; ENZYME STRUCTURE; PROTEIN CONFORMATION; STRUCTURE ANALYSIS;

ADA;

EID: 0032989645     PISSN: 07328311     EISSN: None     Source Type: Journal    
DOI: 10.1080/15257779908041487     Document Type: Conference Paper

References (17)

1. Plavec, J.; Thibaudeau, C.; Chattopadhyaya, J. Pure & Appl. Chem. 1994, 68, 2137-2144.
2. Altona, C.; Sundaranlingam, M. J Am. Chem. Soc ., 1972, 94, 8205.
3. For a comprehensive review of these concepts see: Saenger, W. 1984. Principles of Nucleic Acid Structure. Springer-Verlag, New York.
4. Nicklaus, M. C.; Wang, S.; Driscoll, J. S.; Milne, G. W. A. Bioorg. Med. Chem. 1995, 3, 411-428.
5. Marquez, V. E.; Siddiqui, M. A.; Ezzitouni, A.; Russ, P.; Wang, J.; Wagner, R. W.; Matteucci, M. D. J. Med. Chem. 1996, 39, 3739-3747.
6. Marquez, V. E.; Ezzitouni, A.; Russ, P.; Siddiqui, M. A.; Ford, Jr., H.; Feldman, R. J.; Mitsuya, H.; George, C.; Barchi, Jr., J. J. J. Am. Chem. Soc. 1998, 120, 2780-2789.
7. Wolfenden, R.; Kaufman, J.; Macon, J. B. Biochemistry 1969, 8, 2412-2415.
8. Wang, Z.; Quiocho, F. A. Biochemistry 1998, 37, 8314-8324.
9. Jones, W.; Kurz, L. C.; Wolfenden, R. Biochemistry 1989, 28, 1242-1247.
10. Siddiqui, M. A.; Ford, H., Jr.; George, C.; Marquez, V. E. Nucleoside Nucleotides 1996, 15, 235-250.
11. Ezzitouni, A.; Marquez, V. E. J. Chem. Soc., Perkin Tans. 1, 1997, 1073-1078.
12. Marquez, V. E. et al. unpublished
13. Rodriguez, J. B.; Marquez, V. E.; Nicklaus, M. C.; Mitsuya, H.; Barchi, Jr., J. J. J. Med. Chem. 1994, 37, 3389-3399.
14. These calculations took ca. 18,000 hours of CPU time on a DEC 2100 AlphaServer 4/275 equipped with four 275 MHz Alpha 21064 CPUs.
15. Lim, B. B.; Marquez, V. E.; Dobyns, K. A.; Cooney, D. A.; De Clercq, E. Nucleosides Nucleotides 1992, 11, 1123-1135.
16. Thibaudeau, C.; Kumar, A.; Bekiroglu, S.; Matsuda, A.; Marquez, V. E.; Chattopadhyaya, J. J. Org. Chem. 1998, 63, 5447-5462.
17. Erion, M. D.; Reddy, M. R. J. Am. Chem. Soc. 1998, 120, 3295-3304.