The role of endocytosis in activating and regulating signal transduction

Cellular and Molecular Life Sciences

Volumn 69, Issue 11, 2012, Pages 1755-1771

  Andersson, Emma R ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Caveolin; Clathrin; Dynamin; EGF; Endocytosis; Eph; Ephrin; Notch; Primary cilium; Signaling; Wnt

Indexed keywords

BETA CATENIN; CAVEOLIN; CAVEOLIN 1; CAVEOLIN 3; CLATHRIN; CLATHRIN INDEPENDENT CARRIER; EPHRIN; FLOTILLIN 1; FLOTILLIN 2; NOTCH RECEPTOR; UNCLASSIFIED DRUG; WNT PROTEIN;

BINDING AFFINITY; CELL MEMBRANE; DOWN REGULATION; ENDOCYTOSIS; ENDOSOME; EUKARYOTIC FLAGELLUM; EXOCYTOSIS; GENE TARGETING; NONHUMAN; OLIGOMERIZATION; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION;

CELL COMMUNICATION; CLATHRIN-COATED VESICLES; ENDOCYTOSIS; LIGANDS; MODELS, BIOLOGICAL; RECEPTORS, EPH FAMILY; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 84862902356     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-011-0877-1     Document Type: Review

References (183)

1. GJ Doherty HT McMahon 2009 Mechanisms of endocytosis Annu Rev Biochem 78 857 902 19317650 1:CAS:528:DC%2BD1MXos1Ghu7s%3D
2. AV Vieira C Lamaze SL Schmid 1996 Control of EGF receptor signaling by clathrin-mediated endocytosis Science 274 2086 2089 8953040 1:CAS:528: DyaK2sXjtFKh (Pubitemid 27020702)
3. S Sigismund T Woelk C Puri E Maspero C Tacchetti P Transidico PP Di Fiore S Polo 2005 Clathrin-independent endocytosis of ubiquitinated cargos Proc Natl Acad Sci USA 102 2760 2765 15701692 1:CAS:528:DC%2BD2MXitVSks7k%3D (Pubitemid 40299866)
4. M Drab P Verkade M Elger M Kasper M Lohn B Lauterbach J Menne C Lindschau F Mende FC Luft, et al. 2001 Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice Science 293 2449 2452 11498544 1:CAS:528:DC%2BD3MXntlKjs7s%3D (Pubitemid 32917325)
5. F Galbiati JA Engelman D Volonte XL Zhang C Minetti M Li H Hou Jr B Kneitz W Edelmann MP Lisanti 2001 Caveolin-3 null mice show a loss of caveolae, changes in the microdomain distribution of the dystrophin-glycoprotein complex, and t-tubule abnormalities J Biol Chem 276 21425 21433 11259414 1:CAS:528:DC%2BD3MXksFGlurw%3D
6. Y Hagiwara T Sasaoka K Araishi M Imamura H Yorifuji I Nonaka E Ozawa T Kikuchi 2000 Caveolin-3 deficiency causes muscle degeneration in mice Hum Mol Genet 9 3047 3054 11115849 1:CAS:528:DC%2BD3MXjt1aj (Pubitemid 32000778)
7. B Razani JA Engelman XB Wang W Schubert XL Zhang CB Marks F Macaluso RG Russell M Li RG Pestell, et al. 2001 Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities J Biol Chem 276 38121 38138 11457855 1:CAS:528:DC%2BD3MXotFOrurk%3D
8. B Razani XB Wang JA Engelman M Battista G Lagaud XL Zhang B Kneitz H Hou Jr GJ Christ W Edelmann, et al. 2002 Caveolin-2-deficient mice show evidence of severe pulmonary dysfunction without disruption of caveolae Mol Cell Biol 22 2329 2344 11884617 1:CAS:528:DC%2BD38Xit1Kit7k%3D (Pubitemid 34224637)
9. CL Mattsson ER Andersson J Nedergaard 2010 Differential involvement of caveolin-1 in brown adipocyte signaling: impaired beta3-adrenergic, but unaffected LPA, PDGF and EGF receptor signaling Biochim Biophys Acta 1803 983 989 20381543 1:CAS:528:DC%2BC3cXntlaitbo%3D
10. GM Di Guglielmo C Le Roy AF Goodfellow JL Wrana 2003 Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover Nat Cell Biol 5 410 421 12717440 (Pubitemid 36592263)
11. BM Pearse 1976 Clathrin: a unique protein associated with intracellular transfer of membrane by coated vesicles Proc Natl Acad Sci USA 73 1255 1259 1063406 1:CAS:528:DyaE28XhslGmsrk%3D
12. T Kirchhausen 2000 Clathrin Annu Rev Biochem 69 699 727 10966473 1:CAS:528:DC%2BD3cXnt1ajur0%3D
13. A Reider B Wendland 2011 Endocytic adaptors-social networking at the plasma membrane J Cell Sci 124 1613 1622 21536832 1:CAS:528:DC%2BC3MXptFWqtLw%3D
14. BM Pearse MS Robinson 1984 Purification and properties of 100-kd proteins from coated vesicles and their reconstitution with clathrin EMBO J 3 1951 1957 6149117 1:CAS:528:DyaL2cXlsVKnsrw%3D
15. H Chen S Fre VI Slepnev MR Capua K Takei MH Butler PP Di Fiore P De Camilli 1998 Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis Nature 394 793 797 9723620 1:CAS:528: DyaK1cXlslemtrw%3D (Pubitemid 28391645)
16. T Itoh S Koshiba T Kigawa A Kikuchi S Yokoyama T Takenawa 2001 Role of the ENTH domain in phosphatidylinositol-4, 5-bisphosphate binding and endocytosis Science 291 1047 1051 11161217 1:CAS:528:DC%2BD3MXhtFGksL4%3D (Pubitemid 32157414)
17. E Overstreet E Fitch JA Fischer 2004 Fat facets and liquid facets promote delta endocytosis and delta signaling in the signaling cells Development 131 5355 5366 15469967 1:CAS:528:DC%2BD2cXhtVCjs7bL (Pubitemid 39567276)
18. EV Gurevich VV Gurevich 2006 Arrestins: ubiquitous regulators of cellular signaling pathways Genome Biol 7 236 17020596
19. SE Dho MB French SA Woods CJ McGlade 1999 Characterization of four mammalian Numb protein isoforms. Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain J Biol Chem 274 33097 33104 10551880 1:CAS:528:DyaK1MXntlygu7Y%3D (Pubitemid 129535352)
20. E Santolini C Puri AE Salcini MC Gagliani PG Pelicci C Tacchetti PP Di Fiore 2000 Numb is an endocytic protein J Cell Biol 151 1345 1352 11121447 1:CAS:528:DC%2BD3cXovFantbw%3D
21. R Ghossoub A Molla-Herman P Bastin A Benmerah 2011 The ciliary pocket: a once-forgotten membrane domain at the base of cilia Biol Cell 103 131 144 21275905
22. A Molla-Herman R Ghossoub T Blisnick A Meunier C Serres F Silbermann C Emmerson K Romeo P Bourdoncle A Schmitt, et al. 2010 The ciliary pocket: an endocytic membrane domain at the base of primary and motile cilia J Cell Sci 123 1785 1795 20427320 1:CAS:528:DC%2BC3cXotFGrsbY%3D
23. MC Field M Carrington 2009 The trypanosome flagellar pocket Nat Rev Microbiol 7 775 786 19806154 1:CAS:528:DC%2BD1MXht1ajtr7N
24. Q Hu L Milenkovic H Jin MP Scott MV Nachury ET Spiliotis WJ Nelson 2010 A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution Science 329 436 439 20558667 1:CAS:528: DC%2BC3cXptVWgtr4%3D
25. EJ Michaud BK Yoder 2006 The primary cilium in cell signaling and cancer Cancer Res 66 6463 6467 16818613 1:CAS:528:DC%2BD28XmsVamsbs%3D (Pubitemid 44085596)
26. Z Tang PE Scherer T Okamoto K Song C Chu DS Kohtz I Nishimoto HF Lodish MP Lisanti 1996 Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle J Biol Chem 271 2255 2261 8567687 1:CAS:528:DyaK28Xns1SjtQ%3D%3D (Pubitemid 26047818)
27. MM Hill M Bastiani R Luetterforst M Kirkham A Kirkham SJ Nixon P Walser D Abankwa VM Oorschot S Martin, et al. 2008 PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function Cell 132 113 124 18191225 1:CAS:528:DC%2BD1cXhtFehtbY%3D
28. L Liu PF Pilch 2008 A critical role of cavin (polymerase I and transcript release factor) in caveolae formation and organization J Biol Chem 283 4314 4322 18056712 1:CAS:528:DC%2BD1cXhs1Wgur8%3D
29. CG Hansen NA Bright G Howard BJ Nichols 2009 SDPR induces membrane curvature and functions in the formation of caveolae Nat Cell Biol 11 807 814 19525939 1:CAS:528:DC%2BD1MXnvF2rsLc%3D
30. KA McMahon H Zajicek WP Li MJ Peyton JD Minna VJ Hernandez K Luby-Phelps RG Anderson 2009 SRBC/cavin-3 is a caveolin adapter protein that regulates caveolae function EMBO J 28 1001 1015 19262564 1:CAS:528:DC%2BD1MXis1Churo%3D
31. P Oh DP McIntosh JE Schnitzer 1998 Dynamin at the neck of caveolae mediates their budding to form transport vesicles by GTP-driven fission from the plasma membrane of endothelium J Cell Biol 141 101 114 9531551 1:CAS:528:DyaK1cXis1ejsrg%3D (Pubitemid 28182644)
32. PU Le IR Nabi 2003 Distinct caveolae-mediated endocytic pathways target the Golgi apparatus and the endoplasmic reticulum J Cell Sci 116 1059 1071 12584249 1:CAS:528:DC%2BD3sXis1antrg%3D (Pubitemid 36395616)
33. RD Minshall C Tiruppathi SM Vogel WD Niles A Gilchrist HE Hamm AB Malik 2000 Endothelial cell-surface gp60 activates vesicle formation and trafficking via G(i)-coupled Src kinase signaling pathway J Cell Biol 150 1057 1070 10973995 1:CAS:528:DC%2BD3cXmtlegt7c%3D
34. RG Parton JC Molero M Floetenmeyer KM Green DE James 2002 Characterization of a distinct plasma membrane macrodomain in differentiated adipocytes J Biol Chem 277 46769 46778 12356772 1:CAS:528:DC%2BD38XovFKgtbw%3D (Pubitemid 35417680)
35. N Naslavsky R Weigert JG Donaldson 2003 Convergence of non-clathrin- and clathrin-derived endosomes involves Arf6 inactivation and changes in phosphoinositides Mol Biol Cell 14 417 431 12589044 1:CAS:528: DC%2BD3sXitFWmtb0%3D (Pubitemid 36237006)
36. L Pelkmans T Burli M Zerial A Helenius 2004 Caveolin-stabilized membrane domains as multifunctional transport and sorting devices in endocytic membrane traffic Cell 118 767 780 15369675 1:CAS:528:DC%2BD2cXnvFehtbg%3D (Pubitemid 39221735)
37. C Meyer D Zizioli S Lausmann EL Eskelinen J Hamann P Saftig K von Figura P Schu 2000 mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors EMBO J 19 2193 2203 10811610 1:CAS:528:DC%2BD3cXjvFOmurk%3D (Pubitemid 30259000)
38. T Mitsunari F Nakatsu N Shioda PE Love A Grinberg JS Bonifacino H Ohno 2005 Clathrin adaptor AP-2 is essential for early embryonal development Mol Cell Biol 25 9318 9323 16227583 1:CAS:528:DC%2BD2MXhtFOnsrnF (Pubitemid 41507833)
39. M Chinkers JA McKanna S Cohen 1979 Rapid induction of morphological changes in human carcinoma cells A-431 by epidermal growth factors J Cell Biol 83 260 265 315943 1:STN:280:DyaL3c%2Fnt1amsw%3D%3D (Pubitemid 10197049)
40. P Dowrick P Kenworthy B McCann R Warn 1993 Circular ruffle formation and closure lead to macropinocytosis in hepatocyte growth factor/scatter factor-treated cells Eur J Cell Biol 61 44 53 8223707 1:CAS:528: DyaK2cXpslWlsQ%3D%3D (Pubitemid 23221781)
41. K Mellstrom CH Heldin B Westermark 1988 Induction of circular membrane ruffling on human fibroblasts by platelet-derived growth factor Exp Cell Res 177 347 359 3391248 1:STN:280:DyaL1c3ntFGmsQ%3D%3D
42. K Mellstroom AS Hoglund M Nister CH Heldin B Westermark U Lindberg 1983 The effect of platelet-derived growth factor on morphology and motility of human glial cells J Muscle Res Cell Motil 4 589 609 6685736 1:STN:280: DyaL2c%2Fmt1antQ%3D%3D (Pubitemid 14244746)
43. B Peleg A Disanza G Scita N Gov 2011 Propagating cell-membrane waves driven by curved activators of actin polymerization PLoS One 6 e18635 21533032 1:CAS:528:DC%2BC3MXlsVagurk%3D
44. JD Orth MA McNiven 2006 Get off my back! Rapid receptor internalization through circular dorsal ruffles Cancer Res 66 11094 11096 17145849 1:CAS:528:DC%2BD28Xht1Kns7fP (Pubitemid 46009931)
45. AM Weaver AV Karginov AW Kinley SA Weed Y Li JT Parsons JA Cooper 2001 Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation Curr Biol 11 370 374 11267876 1:CAS:528:DC%2BD3MXitVOlu7w%3D (Pubitemid 32200742)
46. J Hasegawa E Tokuda T Tenno K Tsujita H Sawai H Hiroaki T Takenawa T Itoh 2011 SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide- binding domain J Cell Biol 193 901 916 21624956 1:CAS:528:DC%2BC3MXnt1Knt7k%3D
47. JA Legg G Bompard J Dawson HL Morris N Andrew L Cooper SA Johnston G Tramountanis LM Machesky 2007 N-WASP involvement in dorsal ruffle formation in mouse embryonic fibroblasts Mol Biol Cell 18 678 687 17182853 1:CAS:528:DC%2BD2sXhsFartrc%3D (Pubitemid 46213235)
48. M Huang L Satchell JB Duhadaway GC Prendergast LD Laury-Kleintop 2011 RhoB links PDGF signaling to cell migration by coordinating activation and localization of Cdc42 and Rac J Cell Biochem 112 1572 1584 21344485 1:CAS:528:DC%2BC3MXkvVakt7c%3D
49. OO Glebov NA Bright BJ Nichols 2006 Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells Nat Cell Biol 8 46 54 16341206 1:CAS:528:DC%2BD28Xmt1ei (Pubitemid 43064796)
50. S Affentranger S Martinelli J Hahn J Rossy V Niggli 2011 Dynamic reorganization of flotillins in chemokine-stimulated human T-lymphocytes BMC Cell Biol 12 28 21696602 1:CAS:528:DC%2BC3MXotF2mtrw%3D
51. MF Langhorst GP Solis S Hannbeck H Plattner CA Stuermer 2007 Linking membrane microdomains to the cytoskeleton: regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin FEBS Lett 581 4697 4703 17854803 1:CAS:528:DC%2BD2sXhtVOltr%2FF (Pubitemid 47418803)
52. M Kirkham SJ Nixon MT Howes L Abi-Rached DE Wakeham M Hanzal-Bayer C Ferguson MM Hill M Fernandez-Rojo DA Brown, et al. 2008 Evolutionary analysis and molecular dissection of caveola biogenesis J Cell Sci 121 2075 2086 18505796 1:CAS:528:DC%2BD1cXovFakt7g%3D (Pubitemid 352015205)
53. T Babuke M Ruonala M Meister M Amaddii C Genzler A Esposito R Tikkanen 2009 Hetero-oligomerization of reggie-1/flotillin-2 and reggie-2/flotillin-1 is required for their endocytosis Cell Signal 21 1287 1297 19318123 1:CAS:528:DC%2BD1MXmtVWjtbY%3D
54. DE Saslowsky JA Cho H Chinnapen RH Massol DJ Chinnapen JS Wagner HE De Luca W Kam BH Paw WI Lencer 2010 Intoxication of zebrafish and mammalian cells by cholera toxin depends on the flotillin/reggie proteins but not derlin-1 or -2 J Clin Invest 120 4399 4409 21041954 1:CAS:528:DC%2BC3cXhsFCntLvK
55. JR Henley EW Krueger BJ Oswald MA McNiven 1998 Dynamin-mediated internalization of caveolae J Cell Biol 141 85 99 9531550 1:CAS:528: DyaK1cXis1ejsrs%3D (Pubitemid 28182643)
56. JE Schnitzer P Oh DP McIntosh 1996 Role of GTP hydrolysis in fission of caveolae directly from plasma membranes Science 274 239 242 8824187 1:CAS:528:DyaK28XmtlWltrw%3D (Pubitemid 26353199)
57. ML Cremona HJ Matthies K Pau E Bowton N Speed BJ Lute M Anderson N Sen SD Robertson RA Vaughan, et al. 2011 Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT Nat Neurosci 14 469 477 21399631 1:CAS:528:DC%2BC3MXjtVGmt7o%3D
58. CA Stuermer 2011 Microdomain-forming proteins and the role of the reggies/flotillins during axon regeneration in zebrafish Biochim Biophys Acta 1812 415 422 21147218 1:CAS:528:DC%2BC3MXhtVegsb0%3D
59. S Cornfine M Himmel P Kopp K El Azzouzi C Wiesner M Kruger T Rudel S Linder 2011 The kinesin KIF9 and reggie/flotillin proteins regulate matrix degradation by macrophage podosomes Mol Biol Cell 22 202 215 21119006 1:CAS:528:DC%2BC3MXitVChsLo%3D
60. A Schneider L Rajendran M Honsho M Gralle G Donnert F Wouters SW Hell M Simons 2008 Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons J Neurosci 28 2874 2882 18337418 1:CAS:528:DC%2BD1cXjvVagu7s%3D (Pubitemid 351398889)
61. C Neumann-Giesen I Fernow M Amaddii R Tikkanen 2007 Role of EGF-induced tyrosine phosphorylation of reggie-1/flotillin-2 in cell spreading and signaling to the actin cytoskeleton J Cell Sci 120 395 406 17213334 1:CAS:528: DC%2BD2sXjtlSkurs%3D (Pubitemid 46332503)
62. VL Katanaev GP Solis G Hausmann S Buestorf N Katanayeva Y Schrock CA Stuermer K Basler 2008 Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of wingless and hedgehog in Drosophila EMBO J 27 509 521 18219274 1:CAS:528:DC%2BD1cXhs1KgtLw%3D (Pubitemid 351225681)
63. R Chadda MT Howes SJ Plowman JF Hancock RG Parton S Mayor 2007 Cholesterol-sensitive Cdc42 activation regulates actin polymerization for endocytosis via the GEEC pathway Traffic 8 702 717 17461795 1:CAS:528: DC%2BD2sXmt1OnsLs%3D (Pubitemid 46785152)
64. M Kirkham A Fujita R Chadda SJ Nixon TV Kurzchalia DK Sharma RE Pagano JF Hancock S Mayor RG Parton 2005 Ultrastructural identification of uncoated caveolin-independent early endocytic vehicles J Cell Biol 168 465 476 15668297 1:CAS:528:DC%2BD2MXhtVWktb8%3D (Pubitemid 40205068)
65. S Sabharanjak P Sharma RG Parton S Mayor 2002 GPI-anchored proteins are delivered to recycling endosomes via a distinct cdc42-regulated, clathrin-independent pinocytic pathway Dev Cell 2 411 423 11970892 1:CAS:528:DC%2BD38Xjt1ersbw%3D (Pubitemid 34436571)
66. MI Geli H Riezman 1996 Role of type I myosins in receptor-mediated endocytosis in yeast Science 272 533 535 8614799 1:CAS:528:DyaK28XisFOmsbk%3D (Pubitemid 26138193)
67. TP Rao M Kuhl 2010 An updated overview on Wnt signaling pathways: a prelude for more Circ Res 106 1798 1806 20576942 1:CAS:528:DC%2BC3cXnvFWnsb0%3D
68. R van Amerongen R Nusse 2009 Towards an integrated view of Wnt signaling in development Development 136 3205 3214 19736321
69. T Inoue HS Oz D Wiland S Gharib R Deshpande RJ Hill WS Katz PW Sternberg 2004 C. elegans LIN-18 is a Ryk ortholog and functions in parallel to LIN-17/frizzled in Wnt signaling Cell 118 795 806 15369677 1:CAS:528: DC%2BD2cXnvFehtbY%3D (Pubitemid 39221737)
70. W Lu V Yamamoto B Ortega D Baltimore 2004 Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth Cell 119 97 108 15454084 1:CAS:528:DC%2BD2cXotlyqu70%3D (Pubitemid 39349323)
71. I Oishi H Suzuki N Onishi R Takada S Kani B Ohkawara I Koshida K Suzuki G Yamada GC Schwabe, et al. 2003 The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway Genes Cells 8 645 654 12839624 1:CAS:528:DC%2BD3sXlvVOls7Y%3D (Pubitemid 36880848)
72. A Schambony D Wedlich 2007 Wnt-5A/Ror2 regulate expression of XPAPC through an alternative noncanonical signaling pathway Dev Cell 12 779 792 17488628 1:CAS:528:DC%2BD2sXlsVajtbw%3D (Pubitemid 46667742)
73. I Roszko A Sawada L Solnica-Krezel 2009 Regulation of convergence and extension movements during vertebrate gastrulation by the Wnt/PCP pathway Semin Cell Dev Biol 20 986 997 19761865 1:CAS:528:DC%2BD1MXhsVentr3K
74. C Gao YG Chen 2010 Dishevelled: the hub of Wnt signaling Cell Signal 22 717 727 20006983 1:CAS:528:DC%2BC3cXit1WqtL0%3D
75. L Dubois M Lecourtois C Alexandre E Hirst JP Vincent 2001 Regulated endocytic routing modulates wingless signaling in Drosophila embryos Cell 105 613 624 11389831 1:CAS:528:DC%2BD3MXktlSqtro%3D (Pubitemid 32524114)
76. ES Seto HJ Bellen 2006 Internalization is required for proper wingless signaling in Drosophila melanogaster J Cell Biol 173 95 106 16606693 1:CAS:528:DC%2BD28XjsFCgt7c%3D
77. JT Blitzer R Nusse 2006 A critical role for endocytosis in Wnt signaling BMC Cell Biol 7 28 16824228
78. W Chen LA Hu MV Semenov S Yanagawa A Kikuchi RJ Lefkowitz WE Miller 2001 beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins Proc Natl Acad Sci USA 98 14889 14894 11742073 1:CAS:528:DC%2BD38XptlOn (Pubitemid 34013940)
79. V Bryja D Gradl A Schambony E Arenas G Schulte 2007 Beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo Proc Natl Acad Sci USA 104 6690 6695 17426148 1:CAS:528:DC%2BD2sXkvFWjsLg%3D (Pubitemid 47175562)
80. H Yamamoto H Komekado A Kikuchi 2006 Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin Dev Cell 11 213 223 16890161 1:CAS:528:DC%2BD28XosVeksLg%3D (Pubitemid 44138502)
81. J Bilic YL Huang G Davidson T Zimmermann CM Cruciat M Bienz C Niehrs 2007 Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation Science 316 1619 1622 17569865 1:CAS:528:DC%2BD2sXmtl2jsLo%3D (Pubitemid 46982035)
82. Y Li W Lu TD King CC Liu GN Bijur G Bu 2010 Dkk1 stabilizes Wnt co-receptor LRP6: implication for Wnt ligand-induced LRP6 down-regulation PLoS One 5 e11014 20543981
83. GH Kim JH Her JK Han 2008 Ryk cooperates with frizzled 7 to promote Wnt11-mediated endocytosis and is essential for Xenopus laevis convergent extension movements J Cell Biol 182 1073 1082 18809723 1:CAS:528: DC%2BD1cXhtFKnurvF
84. GH Kim JK Han 2007 Essential role for beta-arrestin 2 in the regulation of Xenopus convergent extension movements EMBO J 26 2513 2526 17476309 1:CAS:528:DC%2BD2sXlt1KksLY%3D
85. W Chen D ten Berge J Brown S Ahn LA Hu WE Miller MG Caron LS Barak R Nusse RJ Lefkowitz 2003 Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4 Science 301 1391 1394 12958364 1:CAS:528:DC%2BD3sXmvFelur0%3D (Pubitemid 37075817)
86. A Yu JF Rual K Tamai Y Harada M Vidal X He T Kirchhausen 2007 Association of dishevelled with the clathrin AP-2 adaptor is required for frizzled endocytosis and planar cell polarity signaling Dev Cell 12 129 141 17199046 1:CAS:528:DC%2BD2sXpt1WitA%3D%3D (Pubitemid 46019421)
87. ER Andersson N Prakash L Cajanek E Minina V Bryja L Bryjova TP Yamaguchi AC Hall W Wurst E Arenas 2008 Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo PLoS One 3 e3517 18953410
88. A Sato H Yamamoto H Sakane H Koyama A Kikuchi 2010 Wnt5a regulates distinct signalling pathways by binding to Frizzled2 EMBO J 29 41 54 19910923 1:CAS:528:DC%2BD1MXhtlKmsL%2FI
89. ER Andersson R Sandberg U Lendahl 2011 Notch signaling: simplicity in design, versatility in function Development 138 3593 3612 21828089 1:CAS:528:DC%2BC3MXhtl2itLzJ
90. D Poulson 1937 Chromosomal deficiencies and the embryonic development of Drosophila melanogaster PNAS 23 133 137 16588136 1:STN:280: DC%2BD28zhvVKluw%3D%3D
91. MS Chen RA Obar CC Schroeder TW Austin CA Poodry SC Wadsworth RB Vallee 1991 Multiple forms of dynamin are encoded by shibire, a Drosophila gene involved in endocytosis Nature 351 583 586 1828536 1:CAS:528: DyaK38XnslGntQ%3D%3D (Pubitemid 21896646)
92. CA Poodry 1990 Shibire, a neurogenic mutant of Drosophila Dev Biol 138 464 472 2108067 1:STN:280:DyaK3c3gtFGltg%3D%3D
93. L Seugnet P Simpson M Haenlin 1997 Requirement for dynamin during Notch signaling in Drosophila neurogenesis Dev Biol 192 585 598 9441691 1:CAS:528:DyaK1cXkvVGmsw%3D%3D (Pubitemid 28066957)
94. AL Parks JR Stout SB Shepard KM Klueg AA Dos Santos TR Parody M Vaskova MA Muskavitch 2006 Structure-function analysis of delta trafficking, receptor binding and signaling in Drosophila Genetics 174 1947 1961 17028337 1:CAS:528:DC%2BD2sXhs1Wgtr4%3D (Pubitemid 46011585)
95. M Glittenberg C Pitsouli C Garvey C Delidakis S Bray 2006 Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis EMBO J 25 4697 4706 17006545 1:CAS:528:DC%2BD28XhtVyktLfO (Pubitemid 44607016)
96. K Haglund PP Di Fiore I Dikic 2003 Distinct monoubiquitin signals in receptor endocytosis Trends Biochem Sci 28 598 603 14607090 1:CAS:528: DC%2BD3sXos12ksr4%3D
97. GA Deblandre EC Lai C Kintner 2001 Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates notch signaling Dev Cell 1 795 806 11740941 1:CAS:528:DC%2BD3MXptFOnur4%3D (Pubitemid 33586134)
98. EC Lai GA Deblandre C Kintner GM Rubin 2001 Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta Dev Cell 1 783 794 11740940 1:CAS:528:DC%2BD3MXptFOntbc%3D (Pubitemid 33586133)
99. E Pavlopoulos C Pitsouli KM Klueg MA Muskavitch NK Moschonas C Delidakis 2001 Neuralized encodes a peripheral membrane protein involved in delta signaling and endocytosis Dev Cell 1 807 816 11740942 1:CAS:528: DC%2BD3MXptFOnur8%3D (Pubitemid 33586135)
100. E Yeh M Dermer C Commisso L Zhou CJ McGlade GL Boulianne 2001 Neuralized functions as an E3 ubiquitin ligase during Drosophila development Curr Biol 11 1675 1679 11696324 1:CAS:528:DC%2BD3MXot1Oktrc%3D (Pubitemid 33037778)
101. W Chen D Casey Corliss 2004 Three modules of zebrafish mind bomb work cooperatively to promote delta ubiquitination and endocytosis Dev Biol 267 361 373 15013799 1:CAS:528:DC%2BD2cXhvV2hsbg%3D (Pubitemid 38328578)
102. M Itoh CH Kim G Palardy T Oda YJ Jiang D Maust SY Yeo K Lorick GJ Wright L Ariza-McNaughton, et al. 2003 Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by delta Dev Cell 4 67 82 12530964 1:CAS:528:DC%2BD3sXntVyrtQ%3D%3D (Pubitemid 36109145)
103. E Overstreet X Chen B Wendland JA Fischer 2003 Either part of a Drosophila epsin protein, divided after the ENTH domain, functions in endocytosis of delta in the developing eye Curr Biol 13 854 860 12747835 1:CAS:528:DC%2BD3sXjvFamtrw%3D (Pubitemid 36573254)
104. X Tian D Hansen T Schedl JB Skeath 2004 Epsin potentiates Notch pathway activity in Drosophila and C. elegans Development 131 5807 5815 15539484 1:CAS:528:DC%2BD2MXnsleksQ%3D%3D (Pubitemid 40123898)
105. W Wang G Struhl 2004 Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch Development 131 5367 5380 15469974 1:CAS:528:DC%2BD2cXhtVCjs7bE (Pubitemid 39562180)
106. H Chen G Ko A Zatti G Di Giacomo L Liu E Raiteri E Perucco C Collesi W Min C Zeiss, et al. 2009 Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice Proc Natl Acad Sci USA 106 13838 13843 19666558 1:CAS:528:DC%2BD1MXhtFWksLnO
107. SL Windler D Bilder 2010 Endocytic internalization routes required for delta/notch signaling Curr Biol 20 538 543 20226669 1:CAS:528: DC%2BC3cXjslSjsrc%3D
108. R Le Borgne F Schweisguth 2003 Notch signaling: endocytosis makes delta signal better Curr Biol 13 R273 R275 12676105 1:CAS:528:DC%2BD3sXislChsLo%3D
109. B Gyorgy TG Szabo M Pasztoi Z Pal P Misjak B Aradi V Laszlo E Pallinger E Pap A Kittel, et al. 2011 Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles Cell Mol Life Sci 68 2667 2688 21560073 1:CAS:528:DC%2BC3MXpt1ahsbo%3D
110. H Sheldon E Heikamp H Turley R Dragovic P Thomas CE Oon R Leek M Edelmann B Kessler RC Sainson, et al. 2010 New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes Blood 116 2385 2394 20558614 1:CAS:528:DC%2BC3cXhtlWrtLjP
111. A Rajan AC Tien CM Haueter KL Schulze HJ Bellen 2009 The Arp2/3 complex and WASp are required for apical trafficking of delta into microvilli during cell fate specification of sensory organ precursors Nat Cell Biol 11 815 824 19543274 1:CAS:528:DC%2BD1MXnvF2rsb8%3D
112. G Emery A Hutterer D Berdnik B Mayer F Wirtz-Peitz MG Gaitan JA Knoblich 2005 Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system Cell 122 763 773 16137758 1:CAS:528: DC%2BD2MXhtVaqu73L (Pubitemid 41242640)
113. H Jafar-Nejad HK Andrews M Acar V Bayat F Wirtz-Peitz SQ Mehta JA Knoblich HJ Bellen 2005 Sec15, a component of the exocyst, promotes Notch signaling during the asymmetric division of Drosophila sensory organ precursors Dev Cell 9 351 363 16137928 1:CAS:528:DC%2BD2MXhtVert77I (Pubitemid 41235805)
114. SF Heuss D Ndiaye-Lobry EM Six A Israel F Logeat 2008 The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity Proc Natl Acad Sci USA 105 11212 11217 18676613 1:CAS:528: DC%2BD1cXhtVShtbbP
115. CA Parr-Sturgess DJ Rushton ET Parkin 2010 Ectodomain shedding of the Notch ligand Jagged1 is mediated by ADAM17, but is not a lipid-raft-associated event Biochem J 432 283 294 20819075 1:CAS:528:DC%2BC3cXhsVWmsb3M
116. EM Hansson F Lanner D Das A Mutvei U Marklund J Ericson F Farnebo G Stumm H Stenmark ER Andersson, et al. 2010 Control of Notch-ligand endocytosis by ligand-receptor interaction J Cell Sci 123 2931 2942 20720151 1:CAS:528:DC%2BC3cXhtlars7jP
117. JT Nichols A Miyamoto SL Olsen B D'Souza C Yao G Weinmaster 2007 DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur J Cell Biol 176 445 458 17296795 1:CAS:528: DC%2BD2sXhvFCqsbc%3D
118. AL Parks KM Klueg JR Stout MA Muskavitch 2000 Ligand endocytosis drives receptor dissociation and activation in the Notch pathway Development 127 1373 1385 10704384 1:CAS:528:DC%2BD3cXjtFWmsL4%3D (Pubitemid 30232589)
119. WR Gordon D Vardar-Ulu G Histen C Sanchez-Irizarry JC Aster SC Blacklow 2007 Structural basis for autoinhibition of Notch Nat Struct Mol Biol 14 295 300 17401372 1:CAS:528:DC%2BD2sXjslOmt7Y%3D (Pubitemid 46608349)
120. C Sanchez-Irizarry AC Carpenter AP Weng WS Pear JC Aster SC Blacklow 2004 Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats Mol Cell Biol 24 9265 9273 15485896 1:CAS:528:DC%2BD2MXltlyqtg%3D%3D (Pubitemid 39391665)
121. N Gupta-Rossi E Six O LeBail F Logeat P Chastagner A Olry A Israel C Brou 2004 Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor J Cell Biol 166 73 83 15240571 1:CAS:528: DC%2BD2cXlslWqtLs%3D (Pubitemid 38931918)
122. J Moretti P Chastagner S Gastaldello SF Heuss AM Dirac R Bernards MG Masucci A Israel C Brou 2010 The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation PLoS Biol 8 e1000545 21124883
123. M Cayouette M Raff 2002 Asymmetric segregation of Numb: a mechanism for neural specification from Drosophila to mammals Nat Neurosci 5 1265 1269 12447381 1:CAS:528:DC%2BD38XovFChsrk%3D (Pubitemid 35417760)
124. P Gonczy 2008 Mechanisms of asymmetric cell division: flies and worms pave the way Nat Rev Mol Cell Biol 9 355 366 18431399 (Pubitemid 351574196)
125. MA McGill SE Dho G Weinmaster CJ McGlade 2009 Numb regulates post-endocytic trafficking and degradation of Notch1 J Biol Chem 284 26427 26438 19567869 1:CAS:528:DC%2BD1MXhtFCgs73M
126. BJ Beres R George EJ Lougher M Barton BC Verrelli CJ McGlade JA Rawls J Wilson-Rawls 2011 Numb regulates Notch1, but not Notch3, during myogenesis Mech Dev 128 5-6 247 257 21356309 1:CAS:528:DC%2BC3MXotl2mt70%3D
127. RJ Diederich K Matsuno H Hing S Artavanis-Tsakonas 1994 Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway Development 120 473 481 8162848 1:CAS:528: DyaK2cXktlWntbw%3D (Pubitemid 24071190)
128. K Hori M Fostier M Ito TJ Fuwa MJ Go H Okano M Baron K Matsuno 2004 Drosophila deltex mediates suppressor of hairless-independent and late-endosomal activation of Notch signaling Development 131 5527 5537 15496440 1:CAS:528:DC%2BD2cXhtFSgs77F (Pubitemid 39625197)
129. K Matsuno RJ Diederich MJ Go CM Blaumueller S Artavanis-Tsakonas 1995 Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats Development 121 2633 2644 7671825 1:CAS:528:DyaK2MXnsFSgsL0%3D
130. M Wilkin P Tongngok N Gensch S Clemence M Motoki K Yamada K Hori M Taniguchi-Kanai E Franklin K Matsuno, et al. 2008 Drosophila HOPS and AP-3 complex genes are required for a Deltex-regulated activation of notch in the endosomal trafficking pathway Dev Cell 15 762 772 19000840 1:CAS:528: DC%2BD1cXhsVSms7jJ
131. K Yamada TJ Fuwa T Ayukawa T Tanaka A Nakamura MB Wilkin M Baron K Matsuno 2011 Roles of Drosophila deltex in Notch receptor endocytic trafficking and activation Genes Cells 16 261 272 21299753 1:CAS:528:DC%2BC3MXjsVWnsr8%3D
132. TJ Fuwa K Hori T Sasamura J Higgs M Baron K Matsuno 2006 The first deltex null mutant indicates tissue-specific deltex-dependent Notch signaling in Drosophila Mol Genet Genomics 275 251 263 16395579 1:CAS:528: DC%2BD28XitFOhu7o%3D (Pubitemid 43357662)
133. K Matsuno M Ito K Hori F Miyashita S Suzuki N Kishi S Artavanis-Tsakonas H Okano 2002 Involvement of a proline-rich motif and RING-H2 finger of deltex in the regulation of Notch signaling Development 129 1049 1059 11861487 1:CAS:528:DC%2BD38XitFygt74%3D (Pubitemid 34874128)
134. A Mukherjee A Veraksa A Bauer C Rosse J Camonis S Artavanis-Tsakonas 2005 Regulation of Notch signalling by non-visual beta-arrestin Nat Cell Biol 7 1191 1201 16284625
135. N Sestan S Artavanis-Tsakonas P Rakic 1999 Contact-dependent inhibition of cortical neurite growth mediated by Notch signaling Science 286 741 746 10531053 1:CAS:528:DyaK1MXntFWit7w%3D
136. E Jorissen B De Strooper 2010 Gamma-secretase and the intramembrane proteolysis of Notch Curr Top Dev Biol 92 201 230 20816396 1:CAS:528: DC%2BC3cXht12jtLvE
137. C Kaether S Schmitt M Willem C Haass 2006 Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface Traffic 7 408 415 16536739 1:CAS:528:DC%2BD28Xjs1OltL8%3D (Pubitemid 43372750)
138. EB Sorensen SD Conner 2010 Gamma-secretase-dependent cleavage initiates Notch signaling from the plasma membrane Traffic 11 1234 1245 20573067 1:CAS:528:DC%2BC3cXhtFSltLrK
139. L Tarassishin YI Yin B Bassit YM Li 2004 Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct Proc Natl Acad Sci USA 101 17050 17055 15563588 1:CAS:528:DC%2BD2cXhtFagu7jF (Pubitemid 39627772)
140. T Vaccari H Lu R Kanwar ME Fortini D Bilder 2008 Endosomal entry regulates Notch receptor activation in Drosophila melanogaster J Cell Biol 180 755 762 18299346 1:CAS:528:DC%2BD1cXis12iur0%3D (Pubitemid 351397775)
141. S Tagami M Okochi K Yanagida A Ikuta A Fukumori N Matsumoto Y Ishizuka-Katsura T Nakayama N Itoh J Jiang, et al. 2008 Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1 Mol Cell Biol 28 165 176 17967888 1:CAS:528:DC%2BD1cXktValsQ%3D%3D
142. A Kapoor WM Hsu BJ Wang GH Wu TY Lin SJ Lee CT Yen SM Liang YF Liao 2010 Caveolin-1 regulates gamma-secretase-mediated AbetaPP processing by modulating spatial distribution of gamma-secretase in membrane J Alzheimers Dis 22 423 442 20847442 1:CAS:528:DC%2BC3cXhsVektLvM
143. P Osenkowski W Ye R Wang MS Wolfe DJ Selkoe 2008 Direct and potent regulation of gamma-secretase by its lipid microenvironment J Biol Chem 283 22529 22540 18539594 1:CAS:528:DC%2BD1cXpsVKmsL0%3D
144. EJ Ezratty N Stokes S Chai AS Shah SE Williams E Fuchs 2011 A role for the primary cilium in Notch signaling and epidermal differentiation during skin development Cell 145 1129 1141 21703454 1:CAS:528:DC%2BC3MXotVarsrc%3D
145. KA Ahmed J Xiang 2011 Mechanisms of cellular communication through intercellular protein transfer J Cell Mol Med 15 1458 1473 20070437 1:CAS:528:DC%2BC3MXptFWgsb4%3D
146. ME Pitulescu RH Adams 2010 Eph/ephrin molecules-a hub for signaling and endocytosis Genes Dev 24 2480 2492 21078817 1:CAS:528:DC%2BC3cXhsFSgurfL
147. RL Cagan H Kramer AC Hart SL Zipursky 1992 The bride of sevenless and sevenless interaction: internalization of a transmembrane ligand Cell 69 393 399 1316239 1:CAS:528:DyaK38XktVCmtrs%3D
148. S Kusakari H Ohnishi FJ Jin Y Kaneko T Murata Y Murata H Okazawa T Matozaki 2008 Trans-endocytosis of CD47 and SHPS-1 and its role in regulation of the CD47-SHPS-1 system J Cell Sci 121 1213 1223 18349073 1:CAS:528: DC%2BD1cXmtFaltbY%3D (Pubitemid 351753505)
149. EB Pasquale 2008 Eph-ephrin bidirectional signaling in physiology and disease Cell 133 38 52 18394988 1:CAS:528:DC%2BD1cXkslOlu7o%3D (Pubitemid 351442996)
150. S Thakar G Chenaux M Henkemeyer 2011 Critical roles for EphB and ephrin-B bidirectional signalling in retinocollicular mapping Nat Commun 2 431 21847105
151. D del Alamo H Rouault F Schweisguth 2011 Mechanism and significance of cis-inhibition in Notch signalling Curr Biol 21 R40 R47 21215938
152. RF Carvalho M Beutler KJ Marler B Knoll E Becker-Barroso R Heintzmann T Ng U Drescher 2006 Silencing of EphA3 through a cis interaction with ephrinA5 Nat Neurosci 9 322 330 16491080 1:CAS:528:DC%2BD28Xhsleltr0%3D (Pubitemid 43290961)
153. Y Yin Y Yamashita H Noda T Okafuji MJ Go H Tanaka 2004 EphA receptor tyrosine kinases interact with co-expressed ephrin-A ligands in cis Neurosci Res 48 285 296 15154674 1:CAS:528:DC%2BD2cXhtFCitLg%3D (Pubitemid 38220946)
154. M Parker R Roberts M Enriquez X Zhao T Takahashi D Pat Cerretti T Daniel J Chen 2004 Reverse endocytosis of transmembrane ephrin-B ligands via a clathrin-mediated pathway Biochem Biophys Res Commun 323 17 23 15351694 1:CAS:528:DC%2BD2cXntlOisLs%3D (Pubitemid 39200642)
155. K Bruckner J Pablo Labrador P Scheiffele A Herb PH Seeburg R Klein 1999 EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains Neuron 22 511 524 10197531 1:CAS:528:DyaK1MXit1emtro%3D (Pubitemid 29159850)
156. MM Vihanto C Vindis V Djonov DP Cerretti U Huynh-Do 2006 Caveolin-1 is required for signaling and membrane targeting of EphB1 receptor tyrosine kinase J Cell Sci 119 2299 2309 16723736 1:CAS:528:DC%2BD28Xms1Gis74%3D (Pubitemid 43960319)
157. S Yoo J Shin S Park 2010 EphA8-ephrinA5 signaling and clathrin-mediated endocytosis is regulated by Tiam-1, a Rac-specific guanine nucleotide exchange factor Mol Cells 29 603 609 20496116 1:CAS:528:DC%2BC3cXptFKrtbo%3D
158. F Irie M Okuno EB Pasquale Y Yamaguchi 2005 EphrinB-EphB signalling regulates clathrin-mediated endocytosis through tyrosine phosphorylation of synaptojanin 1 Nat Cell Biol 7 501 509 15821731 1:CAS:528:DC%2BD2MXjsl2msbg%3D (Pubitemid 40637410)
159. D Bouvier ME Tremblay M Riad AT Corera D Gingras KE Horn M Fotouhi M Girard KK Murai TE Kennedy, et al. 2010 EphA4 is localized in clathrin-coated and synaptic vesicles in adult mouse brain J Neurochem 113 153 165 20067584 1:CAS:528:DC%2BC3cXktVSks74%3D
160. JL Carpentier F Sawano D Geiger P Gorden A Perrelet L Orci 1989 Potassium depletion and hypertonic medium reduce "non-coated" and clathrin-coated pit formation, as well as endocytosis through these two gates J Cell Physiol 138 519 526 2466853 1:CAS:528:DyaL1MXhslSluro%3D (Pubitemid 19083770)
161. D Vercauteren RE Vandenbroucke AT Jones J Rejman J Demeester SC De Smedt NN Sanders K Braeckmans 2010 The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls Mol Ther 18 561 569 20010917 1:CAS:528:DC%2BD1MXhsFKjsr%2FK
162. S Ellis H Mellor 2000 Regulation of endocytic traffic by rho family GTPases Trends Cell Biol 10 85 88 10675900 1:CAS:528:DC%2BD3cXht1KrsLs%3D (Pubitemid 30110689)
163. DJ Marston S Dickinson CD Nobes 2003 Rac-dependent trans-endocytosis of ephrinBs regulates Eph-ephrin contact repulsion Nat Cell Biol 5 879 888 12973357 1:CAS:528:DC%2BD3sXns1OjtrY%3D (Pubitemid 37220693)
164. CW Cowan YR Shao M Sahin SM Shamah MZ Lin PL Greer S Gao EC Griffith JS Brugge ME Greenberg 2005 Vav family GEFs link activated Ephs to endocytosis and axon guidance Neuron 46 205 217 15848800 1:CAS:528:DC%2BD2MXktFeqsbc%3D (Pubitemid 40545777)
165. SG Hunter G Zhuang D Brantley-Sieders W Swat CW Cowan J Chen 2006 Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis Mol Cell Biol 26 4830 4842 16782872 1:CAS:528:DC%2BD28XmsVSltb4%3D (Pubitemid 43955801)
166. K Deininger M Eder ER Kramer W Zieglgansberger HU Dodt K Dornmair J Colicelli R Klein 2008 The Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neurons Proc Natl Acad Sci USA 105 12539 12544 18723684 1:CAS:528:DC%2BD1cXhtVKqur%2FP
167. SM Shamah MZ Lin JL Goldberg S Estrach M Sahin L Hu M Bazalakova RL Neve G Corfas A Debant, et al. 2001 EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin Cell 105 233 244 11336673 1:CAS:528:DC%2BD3MXjtFOktL4%3D (Pubitemid 32429513)
168. N Hiramoto-Yamaki S Takeuchi S Ueda K Harada S Fujimoto M Negishi H Katoh 2010 Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism J Cell Biol 190 461 477 20679435 1:CAS:528:DC%2BC3cXhtVCrs7zF
169. M Sahin PL Greer MZ Lin H Poucher J Eberhart S Schmidt TM Wright SM Shamah S O'Connell CW Cowan, et al. 2005 Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse Neuron 46 191 204 15848799 1:CAS:528:DC%2BD2MXktFeqsbY%3D (Pubitemid 40545776)
170. C Lamaze TH Chuang LJ Terlecky GM Bokoch SL Schmid 1996 Regulation of receptor-mediated endocytosis by Rho and Rac Nature 382 177 179 8700210 1:CAS:528:DyaK28XktlSkurg%3D (Pubitemid 26242886)
171. C Lamaze LM Fujimoto HL Yin SL Schmid 1997 The actin cytoskeleton is required for receptor-mediated endocytosis in mammalian cells J Biol Chem 272 20332 20335 9252336 1:CAS:528:DyaK2sXlsFKhsbk%3D (Pubitemid 27355580)
172. M Zimmer A Palmer J Kohler R Klein 2003 EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion Nat Cell Biol 5 869 878 12973358 1:CAS:528:DC%2BD3sXns1Ojtrc%3D (Pubitemid 37220692)
173. A Georgakopoulos C Litterst E Ghersi L Baki C Xu G Serban NK Robakis 2006 Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling EMBO J 25 1242 1252 16511561 1:CAS:528: DC%2BD28Xis1Grsrw%3D
174. E Inoue M Deguchi-Tawarada A Togawa C Matsui K Arita S Katahira-Tayama T Sato E Yamauchi Y Oda Y Takai 2009 Synaptic activity prompts gamma-secretase-mediated cleavage of EphA4 and dendritic spine formation J Cell Biol 185 551 564 19414612 1:CAS:528:DC%2BD1MXlvFSru70%3D
175. PW Janes N Saha WA Barton MV Kolev SH Wimmer-Kleikamp E Nievergall CP Blobel JP Himanen M Lackmann DB Nikolov 2005 Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans Cell 123 291 304 16239146 1:CAS:528:DC%2BD2MXhtFOqsbbF (Pubitemid 41457218)
176. PW Janes SH Wimmer-Kleikamp AS Frangakis K Treble B Griesshaber O Sabet M Grabenbauer AY Ting P Saftig PI Bastiaens, et al. 2009 Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10 PLoS Biol 7 e1000215 19823572
177. C Litterst A Georgakopoulos J Shioi E Ghersi T Wisniewski R Wang A Ludwig NK Robakis 2007 Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor J Biol Chem 282 16155 16163 17428795 1:CAS:528:DC%2BD2sXlvVajsbk%3D (Pubitemid 47100347)
178. T Tomita S Tanaka Y Morohashi T Iwatsubo 2006 Presenilin-dependent intramembrane cleavage of ephrin-B1 Mol Neurodegener 1 2 16930449
179. JK Song E Giniger 2011 Noncanonical Notch function in motor axon guidance is mediated by Rac GTPase and the GEF1 domain of Trio Dev Dyn 240 324 332 21246649
180. K Schlessinger A Hall N Tolwinski 2009 Wnt signaling pathways meet Rho GTPases Genes Dev 23 265 277 19204114 1:CAS:528:DC%2BD1MXit1Kgt7Y%3D
181. H Steiner R Fluhrer C Haass 2008 Intramembrane proteolysis by gamma-secretase J Biol Chem 283 29627 29631 18650432 1:CAS:528: DC%2BD1cXht1ynt7rI
182. A Zolkiewska 2008 ADAM proteases: ligand processing and modulation of the Notch pathway Cell Mol Life Sci 65 2056 2068 18344021 1:CAS:528: DC%2BD1cXotVyktLs%3D
183. MJ LaVoie DJ Selkoe 2003 The Notch ligands, jagged and delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments J Biol Chem 278 34427 34437 12826675 1:CAS:528:DC%2BD3sXmvVCqtr8%3D (Pubitemid 37553289)