메뉴 건너뛰기




Volumn 22, Issue 2, 2010, Pages 423-442

Caveolin-1 Regulates γ-Secretase-Mediated AβPP Processing by Modulating Spatial Distribution of γ-Secretase in Membrane

Author keywords

Amyloid ; amyloid precursor protein; caveolin 1; clathrin; lipid raft; secretase

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; CAVEOLIN 1; GAMMA SECRETASE; JANUS KINASE; NOTCH RECEPTOR;

EID: 78650848737     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2010-100531     Document Type: Article
Times cited : (25)

References (53)
  • 1
    • 33749177143 scopus 로고    scopus 로고
    • A hundred years of Alzheimer's disease research
    • Hardy J (2006) A hundred years of Alzheimer's disease research. Neuron 52, 3-13.
    • (2006) Neuron , vol.52 , pp. 3-13
    • Hardy, J.1
  • 2
    • 33750705653 scopus 로고    scopus 로고
    • A century of Alzheimer's disease
    • Goedert M, Spillantini MG (2006) A century of Alzheimer's disease. Science 314, 777-781.
    • (2006) Science , vol.314 , pp. 777-781
    • Goedert, M.1    Spillantini, M.G.2
  • 3
    • 33750731675 scopus 로고    scopus 로고
    • 100 years and counting: Prospects for defeating Alzheimer's disease
    • Roberson ED, Mucke L (2006) 100 years and counting: prospects for defeating Alzheimer's disease. Science 314, 781784.
    • (2006) Science , vol.314 , pp. 781784
    • Roberson, E.D.1    Mucke, L.2
  • 5
    • 0037431082 scopus 로고    scopus 로고
    • Aph-1, Pen-2, and Nicastrin with Pre-senilin generate an active gamma-Secretase complex
    • De Strooper B (2003) Aph-1, Pen-2, and Nicastrin with Pre-senilin generate an active gamma-Secretase complex. Neuron 38, 9-12.
    • (2003) Neuron , vol.38 , pp. 9-12
    • De Strooper, B.1
  • 6
    • 40949159198 scopus 로고    scopus 로고
    • Building gamma-secretase: The bits and pieces
    • Spasic D, Annaert W (2008) Building gamma-secretase: the bits and pieces. J Cell Sci 121, 413-420.
    • (2008) J Cell Sci , vol.121 , pp. 413-420
    • Spasic, D.1    Annaert, W.2
  • 10
    • 0035928732 scopus 로고    scopus 로고
    • Compartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts
    • Riddell DR, Christie G, Hussain I, Dingwall C (2001) Comartmentalization of beta-secretase (Asp2) into low-buoyant density, noncaveolar lipid rafts. CurrBiol 11, 1288-1293.
    • (2001) CurrBiol , vol.11 , pp. 1288-1293
    • Riddell, D.R.1    Christie, G.2    Hussain, I.3    Dingwall, C.4
  • 11
    • 0037421206 scopus 로고    scopus 로고
    • Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts
    • Ehehalt R, Keller P, Haass C, Thiele C, Simons K (2003) Amy-loidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts. JCellBiol 160, 113-123.
    • (2003) J Cell Biol , vol.160 , pp. 113-123
    • Ehehalt, R.1    Keller, P.2    Haass, C.3    Thiele, C.4    Simons, K.5
  • 12
    • 27744501797 scopus 로고    scopus 로고
    • Lipids as modulators of proteolytic activity of BACE: Involvement of cholesterol, glycosph-ingolipids, and anionic phospholipids in vitro
    • Kalvodova L, Kahya N, Schwille P, Ehehalt R, Verkade P, Drechsel D, Simons K (2005) Lipids as modulators of proteolytic activity of BACE: involvement of cholesterol, glycosph-ingolipids, and anionic phospholipids in vitro. J Biol Chem 280, 36815-36823.
    • (2005) J Biol Chem , vol.280 , pp. 36815-36823
    • Kalvodova, L.1    Kahya, N.2    Schwille, P.3    Ehehalt, R.4    Verkade, P.5    Drechsel, D.6    Simons, K.7
  • 13
    • 0345669752 scopus 로고    scopus 로고
    • Alzheimer's disease: The cholesterol connection
    • Puglielli L, Tanzi RE, Kovacs DM (2003) Alzheimer's disease: the cholesterol connection. Nat Neurosci 6, 345-351.
    • (2003) Nat Neurosci , vol.6 , pp. 345-351
    • Puglielli, L.1    Tanzi, R.E.2    Kovacs, D.M.3
  • 16
    • 37649017003 scopus 로고    scopus 로고
    • PTRF triggers a cave in
    • Chadda R, Mayor S (2008) PTRF triggers a cave in. Cell 132, 23-24.
    • (2008) Cell , vol.132 , pp. 23-24
    • Chadda, R.1    Mayor, S.2
  • 18
    • 49549094763 scopus 로고    scopus 로고
    • Caveolin-1: An ambiguous partner in cell signalling and cancer
    • Quest AF, Gutierrez-Pajares JL, Torres VA (2008) Caveolin-1: an ambiguous partner in cell signalling and cancer. J Cell Mol Med 12, 1130-1150.
    • (2008) J Cell Mol Med , vol.12 , pp. 1130-1150
    • Quest, A.F.1    Gutierrez-Pajares, J.L.2    Torres, V.A.3
  • 19
    • 33744529908 scopus 로고    scopus 로고
    • Caveolin-1 controls cell proliferation and cell death by suppressing expression of the inhibitor of apoptosis protein survivin
    • Torres VA, Tapia JC, Rodriguez DA, Parraga M, Lisboa P, Montoya M, Leyton L, Quest AF (2006) Caveolin-1 controls cell proliferation and cell death by suppressing expression of the inhibitor of apoptosis protein survivin. J Cell Sci 119, 1812-1823.
    • (2006) J Cell Sci , vol.119 , pp. 1812-1823
    • Torres, V.A.1    Tapia, J.C.2    Rodriguez, D.A.3    Parraga, M.4    Lisboa, P.5    Montoya, M.6    Leyton, L.7    Quest, A.F.8
  • 20
    • 2542580859 scopus 로고    scopus 로고
    • Increased caveolin-1 expression in Alzheimer's disease brain
    • Gaudreault SB, Dea D, Poirier J (2004) Increased caveolin-1 expression in Alzheimer's disease brain. Neurobiol Aging 25, 753-759.
    • (2004) Neurobiol Aging , vol.25 , pp. 753-759
    • Gaudreault, S.B.1    Dea, D.2    Poirier, J.3
  • 21
    • 0032562615 scopus 로고    scopus 로고
    • Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein
    • Ikezu T, Trapp BD, Song KS, Schlegel A, Lisanti MP, Okamo-to T (1998) Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein. J Biol Chem 273, 10485-10495.
    • (1998) J Biol Chem , vol.273 , pp. 10485-10495
    • Ikezu, T.1    Trapp, B.D.2    Song, K.S.3    Schlegel, A.4    Lisanti, M.P.5    Okamoto, T.6
  • 23
    • 17644421882 scopus 로고    scopus 로고
    • Rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the beta-amyloid precursor protein
    • Cam JA, Zerbinatti CV, Li Y, Bu G (2005) Rapid endocytosis of the low density lipoprotein receptor-related protein modulates cell surface distribution and processing of the beta-amyloid precursor protein. J Biol Chem 280, 15464-15470.
    • (2005) J Biol Chem , vol.280 , pp. 15464-15470
    • Cam, J.A.1    Zerbinatti, C.V.2    Li, Y.3    Bu, G.4
  • 24
    • 34547670388 scopus 로고    scopus 로고
    • ApoER2 expression increases Abeta production while decreasing amyloid precursor protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity
    • Fuentealba RA, Barria MI, Lee J, Cam J, Araya C, Escud-ero CA, Inestrosa NC, Bronfman FC, Bu G, Marzolo MP (2007) ApoER2 expression increases Abeta production while decreasing amyloid precursor protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity. Mol Neurodegener 2, 14.
    • (2007) Mol Neurodegener , vol.2 , pp. 14
    • Fuentealba, R.A.1    Barria, M.I.2    Lee, J.3    Cam, J.4    Araya, C.5    Escudero, C.A.6    Inestrosa, N.C.7    Bronfman, F.C.8    Bu, G.9    Marzolo, M.P.10
  • 25
    • 0345803941 scopus 로고    scopus 로고
    • Inhibition of receptor-mediated endocytosis demonstrates generation of amyloid beta-protein at the cell surface
    • Chyung JH, Selkoe DJ (2003) Inhibition of receptor-mediated endocytosis demonstrates generation of amyloid beta-protein at the cell surface. J Biol Chem 278, 51035-51043.
    • (2003) J Biol Chem , vol.278 , pp. 51035-51043
    • Chyung, J.H.1    Selkoe, D.J.2
  • 26
    • 45549102847 scopus 로고    scopus 로고
    • Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes
    • Lee J, Retamal C, Cuitino L, Caruano-Yzermans A, Shin JE, van Kerkhof P, Marzolo MP, Bu G (2008) Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes. J Biol Chem 283, 11501-11508.
    • (2008) J Biol Chem , vol.283 , pp. 11501-11508
    • Lee, J.1    Retamal, C.2    Cuitino, L.3    Caruano-Yzermans, A.4    Shin, J.E.5    Van Kerkhof, P.6    Marzolo, M.P.7    Bu, G.8
  • 27
    • 0033198295 scopus 로고    scopus 로고
    • Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein
    • Homayouni R, Rice DS, Sheldon M, Curran T (1999) Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein J Neurosci 19, 7507-7515.
    • (1999) J Neurosci , vol.19 , pp. 7507-7515
    • Homayouni, R.1    Rice, D.S.2    Sheldon, M.3    Curran, T.4
  • 28
    • 40549088942 scopus 로고    scopus 로고
    • The FE65 proteins and Alzheimer's disease
    • McLoughlin DM, Miller CC (2008) The FE65 proteins and Alzheimer's disease. J Neurosci Res 86, 744-754.
    • (2008) J Neurosci Res , vol.86 , pp. 744-754
    • McLoughlin, D.M.1    Miller, C.C.2
  • 30
    • 0031717925 scopus 로고    scopus 로고
    • Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor protein
    • Russo T, Faraonio R, Minopoli G, De Candia P, De Renzis S, Zambrano N (1998). Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor protein. FEBS Lett 434, 1-7.
    • (1998) FEBS Lett , vol.434 , pp. 1-7
    • Russo, T.1    Faraonio, R.2    Minopoli, G.3    De Candia, P.4    De Renzis, S.5    Zambrano, N.6
  • 31
    • 57649221135 scopus 로고    scopus 로고
    • Amyloid precursor protein trafficking, processing, and function
    • Thinakaran G, Koo EH (2008) Amyloid precursor protein trafficking, processing, and function. J Biol Chem 283, 29615-29619.
    • (2008) J Biol Chem , vol.283 , pp. 29615-29619
    • Thinakaran, G.1    Koo, E.H.2
  • 32
    • 33644849690 scopus 로고    scopus 로고
    • Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments
    • Vetrivel KS, Thinakaran G (2006) Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments. Neurology 66, S69-73.
    • (2006) Neurology , vol.66
    • Vetrivel, K.S.1    Thinakaran, G.2
  • 33
    • 0027389118 scopus 로고
    • Identification ofthe Alzheimer beta/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells
    • Nordstedt C, Caporaso GL, Thyberg J, Gandy SE, Greengard P (1993) Identification ofthe Alzheimer beta/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells. JBiol Chem 268, 608-612.
    • (1993) J Biol Chem , vol.268 , pp. 608-612
    • Nordstedt, C.1    Caporaso, G.L.2    Thyberg, J.3    Gandy, S.E.4    Greengard, P.5
  • 35
    • 33845542144 scopus 로고    scopus 로고
    • Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation
    • Ni Y, Zhao X, Bao G, Zou L, Teng L, Wang Z, Song M, Xiong J, Bai Y, Pei G (2006) Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation. Nat Med 12, 1390-1396.
    • (2006) Nat Med , vol.12 , pp. 1390-1396
    • Ni, Y.1    Zhao, X.2    Bao, G.3    Zou, L.4    Teng, L.5    Wang, Z.6    Song, M.7    Xiong, J.8    Bai, Y.9    Pei, G.10
  • 36
    • 34547114456 scopus 로고    scopus 로고
    • Pathways ofclathrin-independent endocytosis
    • Mayor S, Pagano RE (2007) Pathways ofclathrin-independent endocytosis. Nat Rev Mol Cell Biol 8, 603-612.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 603-612
    • Mayor, S.1    Pagano, R.E.2
  • 37
    • 17044427901 scopus 로고    scopus 로고
    • A high-throughput screen to identify inhibitors of amyloid beta-protein precursor processing
    • Bakshi P, Liao YF, Gao J, Ni J, Stein R, Yeh LA, Wolfe MS (2005) A high-throughput screen to identify inhibitors of amyloid beta-protein precursor processing. J Biomol Screen 10, 1-12.
    • (2005) J Biomol Screen , vol.10 , pp. 1-12
    • Bakshi, P.1    Liao, Y.F.2    Gao, J.3    Ni, J.4    Stein, R.5    Yeh, L.A.6    Wolfe, M.S.7
  • 38
    • 10344238086 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway
    • Liao YF, Wang BJ, Cheng HT, Kuo LH, Wolfe MS (2004) Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway. JBiol Chem 279, 49523-49532.
    • (2004) JBiol Chem , vol.279 , pp. 49523-49532
    • Liao, Y.F.1    Wang, B.J.2    Cheng, H.T.3    Kuo, L.H.4    Wolfe, M.S.5
  • 39
    • 33846449879 scopus 로고    scopus 로고
    • Unnatural amino acid-substituted (hydroxyethyl)urea peptidomimetics inhibit gamma-secretase and promote the neuronal differentiation of neuroblastoma cells
    • Liao YF, Wang BJ, Hsu WM, Lee H, Liao CY, Wu SY, Cheng HT, Hu MK (2007) Unnatural amino acid-substituted (hydroxyethyl)urea peptidomimetics inhibit gamma-secretase and promote the neuronal differentiation of neuroblastoma cells. MolPharmacol 71, 588-601.
    • (2007) MolPharmacol , vol.71 , pp. 588-601
    • Liao, Y.F.1    Wang, B.J.2    Hsu, W.M.3    Lee, H.4    Liao, C.Y.5    Wu, S.Y.6    Cheng, H.T.7    Hu, M.K.8
  • 40
    • 57349183115 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin
    • Kuo LH, Hu MK, Hsu WM, Tung YT, Wang BJ, Tsai WW, Yen CT, Liao YF (2008) Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin. Mol Biol Cell 19, 4201-4212.
    • (2008) Mol Biol Cell , vol.19 , pp. 4201-4212
    • Kuo, L.H.1    Hu, M.K.2    Hsu, W.M.3    Tung, Y.T.4    Wang, B.J.5    Tsai, W.W.6    Yen, C.T.7    Liao, Y.F.8
  • 44
    • 0034970989 scopus 로고    scopus 로고
    • Localization of apolipoprotein e receptor 2 to caveolae in the plasma membrane
    • Riddell DR, Sun XM, Stannard AK, Soutar AK, Owen JS (2001) Localization of apolipoprotein E receptor 2 to caveolae in the plasma membrane. J Lipid Res 42, 998-1002.
    • (2001) J Lipid Res , vol.42 , pp. 998-1002
    • Riddell, D.R.1    Sun, X.M.2    Stannard, A.K.3    Soutar, A.K.4    Owen, J.S.5
  • 46
    • 0034723418 scopus 로고    scopus 로고
    • Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network
    • Skovronsky DM, Moore DB, Milla ME, Doms RW, Lee VM (2000) Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network. J Biol Chem 275, 2568-2575.
    • (2000) J Biol Chem , vol.275 , pp. 2568-2575
    • Skovronsky, D.M.1    Moore, D.B.2    Milla, M.E.3    Doms, R.W.4    Lee, V.M.5
  • 47
    • 4644224284 scopus 로고    scopus 로고
    • Role of caveolae and caveolins in health and disease
    • Cohen AW, Hnasko R, Schubert W, Lisanti MP (2004) Role of caveolae and caveolins in health and disease. Physiol Rev 84, 1341-1379.
    • (2004) Physiol Rev , vol.84 , pp. 1341-1379
    • Cohen, A.W.1    Hnasko, R.2    Schubert, W.3    Lisanti, M.P.4
  • 48
    • 0037134014 scopus 로고    scopus 로고
    • Local actin polymerization and dynamin recruitment in SV40-induced inter-nalization ofcaveolae
    • Pelkmans L, Puntener D, Helenius A (2002) Local actin polymerization and dynamin recruitment in SV40-induced inter-nalization ofcaveolae. Science 296, 535-539.
    • (2002) Science , vol.296 , pp. 535-539
    • Pelkmans, L.1    Puntener, D.2    Helenius, A.3
  • 49
    • 33645292025 scopus 로고    scopus 로고
    • Membrane microdomains, caveolae, and caveolar endocytosis of sphingolipids
    • Cheng ZJ, Singh RD, Marks DL, Pagano RE (2006) Membrane microdomains, caveolae, and caveolar endocytosis of sphingolipids. MolMembr Biol 23, 101-110.
    • (2006) MolMembr Biol , vol.23 , pp. 101-110
    • Cheng, Z.J.1    Singh, R.D.2    Marks, D.L.3    Pagano, R.E.4
  • 50
    • 41149124594 scopus 로고    scopus 로고
    • Caveolae as organizers of pharmacologically relevant signal transduction molecules
    • Patel HH, Murray F, Insel PA (2008) Caveolae as organizers of pharmacologically relevant signal transduction molecules. Annu Rev Pharmacol Toxicol 48, 359-391.
    • (2008) Annu Rev Pharmacol Toxicol , vol.48 , pp. 359-391
    • Patel, H.H.1    Murray, F.2    Insel, P.A.3
  • 51
    • 47749147258 scopus 로고    scopus 로고
    • Hydrogen peroxide promotes Abeta production through JNK-dependent activation ofgamma-secretase
    • Shen C, Chen Y, Liu H, Zhang K, Zhang T, Lin A, Jing N (2008) Hydrogen peroxide promotes Abeta production through JNK-dependent activation ofgamma-secretase. J Biol Chem 283, 17721-17730.
    • (2008) J Biol Chem , vol.283 , pp. 17721-17730
    • Shen, C.1    Chen, Y.2    Liu, H.3    Zhang, K.4    Zhang, T.5    Lin, A.6    Jing, N.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.