ABC transporters and immunity: Mechanism of self-defense

Biochemistry

Volumn 51, Issue 25, 2012, Pages 4981-4989

  Hinz, Andreas ^a   Tampé, Robert ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ANTIGEN PROCESSING; ATP BINDING; ATP-BINDING CASSETTE TRANSPORTERS; CYTOSOLS; ENDOPLASMIC RETICULUM; INFECTED CELLS; MAJOR HISTOCOMPATIBILITY COMPLEX CLASS; MECHANISTIC ASPECTS; MOLECULAR ARCHITECTURE; MOLECULAR TOOLS; NUCLEOTIDE-BINDING DOMAIN; PEPTIDE BINDING; TRANS-MEMBRANE DOMAINS;

ACTIVATION ANALYSIS; ANTIGENS; CELL MEMBRANES; HYDROLYSIS; MACHINERY; PEPTIDES;

LOADING;

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING 1;

ENDOPLASMIC RETICULUM; HUMAN; IMMUNITY; MEMBRANE TRANSPORT; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; REVIEW;

ANIMALS; ANTIGEN PRESENTATION; ATP-BINDING CASSETTE TRANSPORTERS; HUMANS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN TRANSPORT; T-LYMPHOCYTES, CYTOTOXIC;

EID: 84862893497     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300128f     Document Type: Review

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101. Ahn, K., Gruhler, A., Galocha, B., Jones, T. R., Wiertz, E. J., Ploegh, H. L., Peterson, P. A., Yang, Y., and Früh, K. (1997) The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP Immunity 6, 613-621 (Pubitemid 27239352)
102. Hewitt, E. W., Gupta, S. S., and Lehner, P. J. (2001) The human cytomegalovirus gene product US6 inhibits ATP binding by TAP EMBO J. 20, 387-396 (Pubitemid 32126975)
103. Kyritsis, C., Gorbulev, S., Hutschenreiter, S., Pawlitschko, K., Abele, R., and Tampé, R. (2001) Molecular mechanism and structural aspects of transporter associated with antigen processing inhibition by the cytomegalovirus protein US6 J. Biol. Chem. 276, 48031-48039
104. Halenius, A., Momburg, F., Reinhard, H., Bauer, D., Lobigs, M., and Hengel, H. (2006) Physical and functional interactions of the cytomegalovirus US6 glycoprotein with the transporter associated with antigen processing J. Biol. Chem. 281, 5383-5390 (Pubitemid 43847632)
105. Koppers-Lalic, D., Reits, E. A., Ressing, M. E., Lipinska, A. D., Abele, R., Koch, J., Marcondes Rezende, M., Admiraal, P., van Leeuwen, D., Bienkowska-Szewczyk, K., Mettenleiter, T. C., Rijsewijk, F. A., Tampé, R., Neefjes, J., and Wiertz, E. J. (2005) Varicelloviruses avoid T cell recognition by UL49.5-mediated inactivation of the transporter associated with antigen processing Proc. Natl. Acad. Sci. U.S.A. 102, 5144-5149
106. Loch, S., Klauschies, F., Schölz, C., Verweij, M. C., Wiertz, E. J., Koch, J., and Tampé, R. (2008) Signaling of a varicelloviral factor across the endoplasmic reticulum membrane induces destruction of the peptide-loading complex and immune evasion J. Biol. Chem. 283, 13428-13436
107. Verweij, M. C., Koppers-Lalic, D., Loch, S., Klauschies, F., de la Salle, H., Quinten, E., Lehner, P. J., Mulder, A., Knittler, M. R., Tampé, R., Koch, J., Ressing, M. E., and Wiertz, E. J. (2008) The varicellovirus UL49.5 protein blocks the transporter associated with antigen processing (TAP) by inhibiting essential conformational transitions in the 6+6 transmembrane TAP core complex J. Immunol. 181, 4894-4907
108. Lipinska, A. D., Koppers-Lalic, D., Rychlowski, M., Admiraal, P., Rijsewijk, F. A., Bienkowska-Szewczyk, K., and Wiertz, E. J. (2006) Bovine herpesvirus 1 UL49.5 protein inhibits the transporter associated with antigen processing despite complex formation with glycoprotein M J. Virol. 80, 5822-5832 (Pubitemid 43849160)
109. Koppers-Lalic, D., Verweij, M. C., Lipinska, A. D., Wang, Y., Quinten, E., Reits, E. A., Koch, J., Loch, S., Marcondes Rezende, M., Daus, F., Bienkowska-Szewczyk, K., Osterrieder, N., Mettenleiter, T. C., Heemskerk, M. H., Tampe, R., Neefjes, J. J., Chowdhury, S. I., Ressing, M. E., Rijsewijk, F. A., and Wiertz, E. J. (2008) Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP PLoS Pathog. 4, e1000080
110. Ressing, M. E., Keating, S. E., van Leeuwen, D., Koppers-Lalic, D., Pappworth, I. Y., Wiertz, E. J., and Rowe, M. (2005) Impaired transporter associated with antigen processing-dependent peptide transport during productive EBV infection J. Immunol. 174, 6829-6838 (Pubitemid 40705646)
111. Horst, D., van Leeuwen, D., Croft, N. P., Garstka, M. A., Hislop, A. D., Kremmer, E., Rickinson, A. B., Wiertz, E. J., and Ressing, M. E. (2009) Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation J. Immunol. 182, 2313-2324
112. Croft, N. P., Shannon-Lowe, C., Bell, A. I., Horst, D., Kremmer, E., Ressing, M. E., Wiertz, E. J., Middeldorp, J. M., Rowe, M., Rickinson, A. B., and Hislop, A. D. (2009) Stage-specific inhibition of MHC class I presentation by the Epstein-Barr virus BNLF2a protein during virus lytic cycle PLoS Pathog. 5, e1000490
113. Wycisk, A. I., Lin, J., Loch, S., Hobohm, K., Funke, J., Wieneke, R., Koch, J., Skach, W. R., Mayerhofer, P. U., and Tampe, R. (2011) Epstein-Barr viral BNLF2a protein hijacks the tail-anchored protein insertion machinery to block antigen processing by the transport complex TAP J. Biol. Chem. 286, 41402-41412
114. Schölz, C., Parcej, D., Ejsing, C. S., Robenek, H., Urbatsch, I. L., and Tampé, R. (2011) Specific lipids modulate the transporter associated with antigen processing (TAP) J. Biol. Chem. 286, 13346-13356