The active domain of the herpes simplex virus protein ICP47: A potent inhibitor of the transporter associated with antigen processing (TAP)

Journal of Molecular Biology

Volumn 272, Issue 4, 1997, Pages 484-492

  Neumann, Lars ^a   Kraas, Wolfgang ^b   Uebel, Stephan ^a   Jung, Günther ^b   Tampé, Robert ^a,c  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

ABC transporter; Membrane protein; Multi protein complex; Vaccination; Virus persistence

Indexed keywords

ABC TRANSPORTER; IMMUNOSTIMULATING AGENT; VIRUS PROTEIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANTIGEN PRESENTATION; ANTIGEN RECOGNITION; ARTICLE; CARBOXY TERMINAL SEQUENCE; DELETION MUTANT; HERPES SIMPLEX VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE;

HERPES; HUMAN HERPESVIRUS 1; HUMAN HERPESVIRUS 2; SIMPLEXVIRUS;

EID: 0031551581     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1997.1282     Document Type: Article

References (29)

1. Ahn, K., Meyer, T. H., Uebel, S., Sempé, P., Djaballah, H., Yang, Y., Peterson, P. A., Früh, K. & Tampé, R. (1996). Molecular mechanism and species-specificity of TAP inhibition by herpes-simplex virus protein ICP47. EMBO J. 15, 3247-3255.
2. Androlewicz, M. J. & Cresswell, P. (1994). Human transporters associated with antigen processing possess a promiscuous peptide-binding site. Immunity, 1, 7-14.
3. Androlewicz, M. J., Anderson, K. S. & Cresswell, P. (1993). Evidence that transporter associated with antigen processing translocate a major histocompatibility complex class I-binding peptide into the endoplasmic reticulum in an ATP-dependent manner. Proc. Natl Acad. Sci. USA, 90, 9130-9134.
4. Beinert, D., Neumann, L., Uebel, S. & Tampé, R. (1997). Structure of the TAP-inhibitior ICP47 induced by membrane association. Biochemistry, 36, 4694-4700.
5. Cresswell, P. & Howard, J. C. (1997). Antigen recognition. Curr. Opin. Immunol. 9, 71-74.
6. Früh, K., Ahn, K., Djaballah, H., Semp, P., van Endert, P. M., Tampé, R., Peterson, P. A. & Yang, Y. (1995). A viral inhibitor of peptide transporters for antigen presentation. Nature, 375, 415-418.
7. 2-terminal 35 residues. J. Exp. Med. 185, 1565-1572.
8. Higgins, C. F. (1992). ABC transporters: from microorganisms to man. Annu. Rev. Cell Biol, 8, 67-113.
9. Hill, A. & Ploegh, H. (1995). Getting the inside-out-the transporter associated with antigen-processing (TAP) and the presentation of viral-antigen. Proc. Natl Acad. Sci. USA, 92, 341-343.
10. Hill, A., Jugovic, P., York, I., Russ, G., Bennink, J., Yewdell, J., Ploegh, H. & Johnson, D. (1995). Herpes simplex virus turns off the TAP to evade host immunity. Nature, 375, 411-415.
11. Jung, G. & Beck-Sickinger, A. G. (1992). Multiple peptide synthesis methods and their applications. Angew. Chem. 104, 375-391.
12. Kelly, A. P., Powis, S. H., Kerr, L.-A., Mockridge, I., Elliott, T., Bastin, J., Uchanska-Ziegler, B., Ziegler, A., Trowsdale, J. & Townsend, A. (1992). Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex. Nature, 355, 641-644.
13. Kleijmeer, M., Kelly, A., Geuze, H. J., Slot, J. W., Townsend, A. & Trowsdale, J. (1992). Location of MHC-encoded transporters in the endoplasmic reticulum and cis-golgi. Nature, 357, 342-344.
14. Koopmann, J. O., Hämmerling, G. J. & Momburg, F. (1997). Generation, intracellular-transport and loading of peptides associated with MHC class-I molecules. Curr. Opin. Immunol. 9, 80-88.
15. McGeoch, D. J., Dolan, A., Donald, S. & Rixon, F. J. (1985). Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1. J. Mol. Biol. 181, 1-13.
16. Meyer, T. H., van Endert, P. M., Uebel, S., Ehring, B. & Tampé, R. (1994). Functional expression and purification of the ABC transporter complex-associated with antigen-processing (TAP) in insect cells. FEBS Letters, 351, 443-447.
17. Müller, K. M., Ebensperger, C. & Tampé, R. (1994). Nucleotide binding to the hydrophilic C-terminal domain of the transporter associated with antigen processing (TAP). J. Biol. Chem. 269, 14032-14037.
18. Neefjes, J. J., Momburg, F. & Hammerling, G. J. (1993). Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter. Science, 261, 769-771.
19. Schwyzer, R. (1995). 100 years lock-and-key concept: are peptide keys shaped and guided to their receptors by the target cell membrane? Biopolymers, 37, 5-16.
20. Shepherd, J. C., Schumacher, T. N., Ashton-Rickardt, P. G., Imaeda, S., Ploegh, H. L., Janeway, C. A. J. & Tonegawa, S. (1993). TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective. Cell, 74, 577-584.
21. Tampé, R., Urlinger, S., Pawlitschko, K. & Uebel, S. (1997). The transporter associated with antigen processing (TAP). In Unusual Secretory Pathways: From Bacteria to Man (Kuchler, K., Rubartelli, A. & Holland, B., eds), pp. 115-136, Springer, New York.
22. Tomazin, R., Hill, A. B., Jugovic, P., York, I., van Endert, P., Ploegh, H. L., Andrews, D. W. & Johnson, D. C. (1996). Stable binding of the herpes simplex virus ICP47 protein to the peptide-binding-site of TAP. EMBO J. 15, 3256-3266.
23. Townsend, A. & Bodmer, H. (1989). Antigen recognition by class I-resticed T lymphocytes. Annu. Rev. Immunol. 7, 601-624.
24. Uebel, S., Meyer, T. H., Kraas, W., Kienle, S., Jung, G., Wiesmüller, K. H. & Tampé, R. (1995). Requirements for peptide-binding to the human transporter associated with antigen-processing revealed by peptide scans and complex peptide libraries. J. Biol. Chem. 270, 18512-18516.
25. Uebel, S., Kraas, W., Kienle, S., Wiesmüller, K.-H., Jung, G. & Tampé, R. (1997). Recognition principle of the TAP-transporter disclosed by combinatorial peptide libraries. Proc. Natl. Acad. Sci. USA, 94, 8976-8981.
26. van Endert, P. M., Tampé, R., Meyer, T. H., Tisch, R., Bach, J. F. & McDevitt, H. O. (1994). A sequential model for peptide-binding and transport by the transporters associated with antigen processing. Immunity, 1, 491-500.
27. van Endert, P. M., Riganelli, D., Greco, G., Fleischhauer, K., Sidney, J., Sette, A. & Bach, J. F. (1995). The peptide-binding motif for the human transporter associated with antigen-processing. J. Exp. Med. 182, 1883-1895.
28. Whitton, J. L. & Clements, J. B. (1984). The junctions between the repetitive and the short unique sequences of the herpes simplex virus genome are determined by the polypeptide-coding regions of two spliced immediate-early mRNAs. J. Gen. Virol. 65, 451-466.
29. York, I. A., Roop, C., Andrews, D. W., Riddell, S. R., Graham, F. L. & Johnson, D. C. (1994). A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes. Cell, 77, 525-35.