Specificity of the proteasome and the TAP transporter

Current Opinion in Immunology

Volumn 11, Issue 2, 1999, Pages 203-208

  Uebel, Stephan ^a   Tampé, Robert ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROTEASOME;

ANTIGEN BINDING; ANTIGEN PRESENTATION; CYTOTOXIC T LYMPHOCYTE; ENDOPLASMIC RETICULUM; ENZYME SPECIFICITY; HUMAN; NONHUMAN; PROTEIN TRANSPORT; REVIEW;

EID: 0033118158     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(99)80034-X     Document Type: Article

References (38)

1. Koopmann JO, Hämmerling GJ, Momburg F: Generation, intracellular-transport and loading of peptides associated with MHC class-I molecules. Curr Opin Immunol 1997, 9:80-88.
2. Pamer E, Cresswell P: Mechanisms of MHC class I-restricted antigen processing. Annu Rev Immunol 1998, 16:323-358.
3. Rammensee H-G, Friede T, Stevanovic S: MHC ligands and peptide motifs: First listing. Immunogenetics 1995, 41:178-228.
4. Uebel S, Tampé R: Processing and selection of antigens by the MHC-encoded peptide transporter TAP. In Symposium in Immunology, Vol 5. Edited by Eibl MM, Huber C, Peter HH, Wahn U. New York: Springer; 1997:155-164.
5. Baumeister W, Walz J, Zühl F, Seemüller E: The proteasome - Paradigm of a self-compartmentalizing protease. Cell 1998, 92:367-380.
6. Goldberg AL, Gaczynska M, Grant E, Michalek M, Rock KL: Functions of the proteasome in antigen presentation. Cold Spring Harb Symp Quant Biol 1995, 60:479-490.
7. Tanaka K, Kasahara M: The MHC class-I ligand-generating system - Roles of immunoproteasomes and the interferon-gamma-inducible proteasome activator PA28. Immunol Rev 1998, 163:161-176.
8. Groll M, Ditzel L, Lowe J, Stock D, Bochtler M, Bartunik HD, Huber R: Structure of 20S proteasome from yeast at 2.4 Å resolution. Nature 1997, 386:463-471.
9. Ehring B, Meyer TH, Eckerskorn C, Lottspeich F, Tampé R: Effects of major-histocompatibility-complex-encoded subunits on the peptidase and proteolytic activities of human 20S proteasomes - Cleavage of proteins and antigenic peptides. Eur J Biochem 1996, 235:404-415.
10. Bogyo M, Shin S, Mcmaster JS, Ploegh HL: Substrate-binding and sequence preference of the proteasome revealed by active-site-directed affinity probes. Chem Biol 1998, 5:307-320.
11. Nussbaum AK, Dick TP, Keilholz W, Schirle M, Stevanovic S, Dietz K, Heinemeyer W, Groll M, Wolf DH, Huber R et al.: Cleavage motifs of the yeast 20S proteasome beta-subunits deduced from digests of enolase-1. Proc Natl Acad Sci USA 1998, 95:12504-12509. A 45 kDa protein from yeast was degraded in vitro by purified wild-type and mutant yeast 20S proteasomes. Analysis of the cleavage products at different times revealed a processive degradation mechanism and a length distribution of fragments with an average length of approximately 8 amino acids. A detailed analysis of the cleavages also allowed the identification of certain amino acid characteristics in positions flanking the P1 residue.
12. Dick TP, Nussbaum AK, Deeg M, Heinemeyer W, Groll M, Schirle M, Keilholz W, Stevanovic S, Wolf DH, Huber R et al.: Contribution of proteasomal beta-subunits to the cleavage of peptide-substrates analyzed with yeast mutants. J Biol Chem 1998, 273:25637-25646. This study relates to [11••]; using wild-type and mutated yeast 20S proteasomes, the specificities and contributions of the different β subunits to the degradation of fluorogenic substrates containing MHC class I ligands were analyzed. A correlation between the contribution of the different subunits to the cleavage of long peptide substrates was found.
13. Dick TP, Ruppert T, Groettrup M, Kloetzel PM, Kuehn L, Koszinowski UH, Stevanovic S, Schild H, Rammensee HG: Coordinated dual cleavages induced by the proteasome regulator PA28 lead to dominant MHC ligands. Cell 1996, 86:253-262.
14. Shimbara N, Ogawa K, Hidaka Y, Nakajima H, Yamasaki N, Niwa S, Tanahashi N, Tanaka K: Contribution of proline residue for efficient production of MHC class-I ligands by proteasomes. J Biol Chem 1998, 273:23062-23071.
15. Sharipo A, Imreh M, Leonchiks A, Imreh S, Masucci MG: A minimal glycine-alanine repeat prevents the interaction of ubiquitinated i-kappa-b-alpha with the proteasome - A new mechanism for selective-inhibition of proteolysis. Nat Med 1998, 4:939-944.
16. Niedermann G, Grimm R, Geier E, Maurer M, Realini C, Gartmann C, Soll J, Omura S, Rechsteiner MC, Baumeister W, Eichmann K: Potential immunocompetence of proteolytic fragments produced by proteasomes before evolution of the vertebrate immune-system. J Exp Med 1997, 186:209-220.
17. Anton LC, Snyder HL, Bennink JR, Vinitsky A, Orlowski M, Porgador A, Yewdell JW: Dissociation of proteasomal degradation of biosynthesized viral-proteins from generation of MHC class I-associated antigenic peptides. J Immunol 1998, 160:4859-4868.
18. Kisselev AF, Akopian TN, Goldberg AL: Range of sizes of peptide products generated during degradation of different proteins by archaeal proteasomes. J Biol Chem 199B, 273:1982-1989.
19. Wenzel T, Eckerskorn C, Lottspeich F, Baumeister W: Existence of a molecular ruler in proteasomes suggested by analysis of degradation products. FEBS Lett 1994, 349:205-209.
20. Ditzel L, Huber R, Mann K, Heinemeyer W, Wolf DH, Groll M: Conformational constraints for protein self-cleavage in the proteasome. J Mol Biol 1998, 279:1187-1191.
21. Akopian TN, Kisselev AF, Goldberg AL: Processive degradation of proteins and other catalytic properties of the proteasome from thermoplasma-acidophilum. J Biol Chem 1997, 272:1791-1798.
22. Neefjes JJ, Momburg F, Hämmerling GJ: Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter. Science 1993, 261:769-771.
23. Androlewicz MJ, Anderson KS, Cresswell P: Evidence that transporters associated with antigen processing translocate a major histocompatibility complex class I-binding peptide into the endoplasmic reticulum in an ATP-dependent manner. Proc Natl Acad Sci USA 1993, 90:9130-9134.
24. Schumacher TN, Kantesaria DV, Heemels MT, Ashton-Rickardt PG, Shepherd JC, Früh K, Yang Y, Peterson PA, Tonegawa S, Ploegh HL: Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator. J Exp Med 1994, 179:533-540.
25. Heemels MT, Ploegh HL: Substrate-specificity of allelic variants of the TAP peptide transporter. Immunity 1994, 1:775-784.
26. Neefjes J, Gottfried E, Roelse J, Grommé M, Obst R, Hämmerling GJ, Momburg F: Analysis of the fine specificity of rat, mouse and human TAP peptide transporters. Eur J Immunol 1995, 25:1113-1136.
27. Momburg F, Roelse J, Howard JC, Butcher GW, Hämmerling GJ, Neefjes JJ: Selectivity of MHC-encoded peptide transporters from human, mouse and rat Nature 1994, 367:648-651.
28. van Endert PM, Tampé R, Meyer TH, Tisch R, Bach JF, McDevitt HO: A sequential model for peptide binding and transport by the transporters associated with antigen processing. Immunity 1994, 1:491-500.
29. Uebel S, Meyer TH, Kraas W, Kienle S, Jung G, Wiesmüller KH, Tampé R: Requirements for peptide binding to the human transporter associated with antigen-processing revealed by peptide scans and complex peptide libraries. J Biol Chem 1995, 270:18512-18516.
30. van Endert PM, Riganelli D, Greco G, Fleischhauer K, Sidney J, Sette A, Bach JF: The peptide-binding motif for the human transporter associated with antigen-processing. J Exp Med 1995, 182:1883-1895.
31. Uebel S, Kraas W, Kienle S, Wiesmüller K-H, Jung G, Tampé R: Recognition principle of the TAP-transporter disclosed by combinatorial peptide libraries. Proc Natl Acad Sci USA 1997, 94:8976-8981. This study provides the binding motif for human TAP at high resolution using complex peptide libraries. The use of libraries containing D-amino acids allows the extension of the motif to different-length peptides and highlights the relevance of the peptide backbone for binding to TAP, leading to a model for the interaction of TAP and peptide at the molecular level.
32. Koopmann JO, Post M, Neefjes JJ, Hämmerling GJ, Momburg F: Translocation of long peptides by transporters associated with antigen-processing (TAP). Eur J Immunol 1996, 26:1720-1728.
33. Androlewicz MJ, Cresswell P: How selective is the transporter associated with antigen-processing? Immunity 1996, 5:1-5.
34. Obst R, Armandola EA, Nijenhuis M, Momburg F, Hämmerling GJ: TAP polymorphism does not influence transport of peptide variants in mice and humans. Eur J Immunol 1995, 25:2170-2176.
35. Daniel S, Brusic V, Caillatzucman S, Petrovsky N, Harrison L, Riganelli D, Sinigaglia F, Gallazzi F, Hammer J, van Endert PM: Relationship between peptide selectivities of human transporters associated with antigen-processing and HLA class-I molecules. J Immunol 1998, 161:617-624. The authors present a matrix for predicting human TAP peptide-binding affinities using a polyalanine-based peptide. The interesting aspect of the study is the comparison of TAP affinities for known class-I binders with randomly selected sequences. The observed bias for the class-I binders represents the first proof for the relevance of epitope selection by human TAP in vivo. Unfortunately, the binding affinities for TAP that are used are predicted rather than being experimental values.
36. Joly E, Lerolle AF, Gonzalez AL, Mehling B, Stevens J, Coadwell WJ, Hunig T, Howard JC, Butcher GW: Coevolution of rat TAP transporters and MHC class-I RT1 -a molecules. Curr Biol 1998, 8:169-172.
37. Schumacher TNM, Kantesaria DV, Serreze DV, Roopenian DC, Ploegh HL: Transporters from H-2(b), H-2(d), H-2(s), H-2(k), and H-2(g7) (NOD/lt) haplotype translocate similar sets of peptides. Proc Natl Acad Sci USA 1994, 91:13004-13008.
38. Daniel S, Caillatzucman S, Hammer J, Bach JF, van Endert PM: Absence of functional relevance of human transporter associated with antigen-processing polymorphism for peptide selection. J Immunol 1997, 159:2350-2357. This is a systematic search for a functional polymorphism in human TAR Although a sensitive binding assay is used, no differences were observed for the alleles tested.