Direct evidence that the N-terminal extensions of the TAP complex act as autonomous interaction scaffolds for the assembly of the MHC i peptide-loading complex

Cellular and Molecular Life Sciences

Volumn 69, Issue 19, 2012, Pages 3317-3327

  Hulpke, Sabine ^a   Tomioka, Maiko ^b   Kremmer, Elisabeth ^c   Ueda, Kazumitsu ^b   Abele, Rupert ^a   Tampé, Robert ^a  

^a GOETHE UNIVERSITY   (Germany)

^b KYOTO UNIVERSITY   (Japan)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

ABC transporter; Antigen processing; Macromolecular membrane complex; Membrane protein interaction; Tapasin

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; TAPASIN; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING 1;

AMINO TERMINAL SEQUENCE; ANTIGEN PRESENTATION; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; HUMAN; HUMAN CELL; PROTEIN ASSEMBLY; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SUBUNIT; PROTEIN TARGETING; SIGNAL TRANSDUCTION; STOICHIOMETRY;

ANTIGEN PRESENTATION; ATP-BINDING CASSETTE TRANSPORTERS; BASE SEQUENCE; BINDING SITES; CELL MEMBRANE; ENDOPLASMIC RETICULUM; HELA CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; MEMBRANE TRANSPORT PROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT;

EID: 84866114976     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-012-1005-6     Document Type: Article

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