Spontaneous firing and evoked responses of spinal nociceptive neurons are attenuated by blockade of P2X3 and P2X2/3 receptors in inflamed rats

Journal of Neuroscience Research

Volumn 90, Issue 8, 2012, Pages 1597-1606

  Xu, Jun ^a   Chu, Katharine L ^a   Brederson, Jill Desiree ^a   Jarvis, Michael F ^a   Mcgaraughty, Steve ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Electrophysiology; Hyperalgesia; Inflammation; Purinergic receptors; Spinal cord

Indexed keywords

5 [[(3 PHENOXYBENZYL)(1,2,3,4 TETRAHYDRO 1 NAPHTHYL)AMINO]CARBONYL]TRIMELLITIC ACID; PURINERGIC P2X2 RECEPTOR; PURINERGIC P2X3 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC INFLAMMATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; EVOKED RESPONSE; INFLAMMATORY PAIN; MALE; NOCICEPTION; NOCICEPTIVE RECEPTOR; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BLOCKING; RECEPTOR INTRINSIC ACTIVITY; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; SPINAL CORD NERVE CELL; STIMULUS RESPONSE;

ANIMALS; ELECTROPHYSIOLOGY; EVOKED POTENTIALS; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; NOCICEPTORS; PHENOLS; POLYCYCLIC COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2X2; RECEPTORS, PURINERGIC P2X3; SPINAL CORD;

EID: 84862809572     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.23042     Document Type: Article

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