Enhanced beta cell proliferation in mice overexpressing a constitutively active form of Akt and one allele of p21 Cip

Diabetologia

Volumn 55, Issue 5, 2012, Pages 1380-1389

  Blandino Rosano, M ^a   Alejandro, E U ^a   Sathyamurthy, A ^b   Scheys, J O ^a   Gregg, B ^a   Chen, A Y ^a   Rachdi, L ^b,c   Weiss, A ^b   Barker, D J ^b   Gould, A P ^b   Elghazi, L ^a   Bernal Mizrachi, E ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c INSERM   (France)

Author keywords

Akt; Apoptosis; Beta cell signalling; Beta cells; Cell cycle; Glucose homeostasis; Insulin; Islets; P21 Cip; Proliferation

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; GLUCOSE; PROTEIN KINASE B;

ADAPTATION; ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; CELL PROTECTION; CELL SURVIVAL; CELLULAR DISTRIBUTION; CELLULAR PARAMETERS; CONTROLLED STUDY; DIET RESTRICTION; ENZYME REGULATION; GENE EXPRESSION; GLUCOSE TOLERANCE TEST; HYPERINSULINEMIA; HYPOGLYCEMIA; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET BETA CELL MASS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FASTING; GLUCOSE TOLERANCE TEST; HYPERINSULINISM; HYPOGLYCEMIA; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PROTEIN STABILITY; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84862561252     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2465-9     Document Type: Article

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