Aldosterone, oxidative stress, and NF-κB activation in hypertension-related cardiovascular and renal diseases

Free Radical Biology and Medicine

Volumn 53, Issue 2, 2012, Pages 314-327

  Queisser, Nina ^a   Schupp, Nicole ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Aldosterone; Hyperaldosteronism; Mineralocorticoid receptor; NF B; Reactive oxygen species

Indexed keywords

8 ISOPROSTANE; ALDOSTERONE; ALDOSTERONE SYNTHASE; CONNECTIVE TISSUE GROWTH FACTOR; CYCLIC AMP; DIACYLGLYCEROL; EPIDERMAL GROWTH FACTOR RECEPTOR; EPITHELIAL SODIUM CHANNEL; ESTROGEN RECEPTOR; GLUCOCORTICOID RECEPTOR; GUANOSINE TRIPHOSPHATASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INOSITOL TRISPHOSPHATE 3 KINASE; INTERCELLULAR ADHESION MOLECULE 1; MESSENGER RNA; NITRIC OXIDE; PHOSPHOLIPASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE P60; PROTEIN P22; PROTEIN P40; PROTEIN P47; PROTEIN P67; RAC1 PROTEIN; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; VASCULAR CELL ADHESION MOLECULE 1;

ALDOSTERONE BLOOD LEVEL; APOPTOSIS; BIOAVAILABILITY; CARDIOVASCULAR DISEASE; CATALYSIS; CELL PROLIFERATION; DNA BINDING; ENZYME ACTIVATION; EPITHELIUM CELL; HEART FAILURE; HUMAN; HYPERALDOSTERONISM; HYPERTENSION; IN VITRO STUDY; KIDNEY CELL; KIDNEY DISEASE; LIPID PEROXIDATION; MORTALITY; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; SODIUM ABSORPTION; SODIUM TRANSPORT; TISSUE SPECIFICITY; WATER ABSORPTION;

ALDOSTERONE; ANIMALS; CARDIOVASCULAR DISEASES; DISEASE MODELS, ANIMAL; HEART FAILURE; HUMANS; HYPERALDOSTERONISM; HYPERTENSION; KIDNEY DISEASES; MINERALOCORTICOID RECEPTOR ANTAGONISTS; NF-KAPPA B; NITRIC OXIDE; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RECEPTORS, MINERALOCORTICOID;

ANIMALIA;

EID: 84862278910     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.05.011     Document Type: Review

References (198)

1. S.A. Simpson, J.F. Tait, A. Wettstein, R. Neher, J. Von Euw, and T. Reichstein [Isolation from the adrenals of a new crystalline hormone with especially high effectiveness on mineral metabolism] Experientia 9 1953 333 335
2. S.M. MacKenzie, C.J. Clark, R. Fraser, C.E. Gomez-Sanchez, J.M. Connell, and E. Davies Expression of 11beta-hydroxylase and aldosterone synthase genes in the rat brain J. Mol. Endocrinol. 24 2000 321 328 (Pubitemid 30415006)
3. J.S. Silvestre, V. Robert, C. Heymes, B. Aupetit-Faisant, C. Mouas, J.M. Moalic, B. Swynghedauw, and C. Delcayre Myocardial production of aldosterone and corticosterone in the rat. Physiological regulation J. Biol. Chem. 273 1998 4883 4891 (Pubitemid 28108638)
4. C. Xue, and H.M. Siragy Local renal aldosterone system and its regulation by salt, diabetes, and angiotensin II type 1 receptor Hypertension 46 2005 584 590 (Pubitemid 41379384)
5. S.M. Mackenzie, J.M. Connell, and E. Davies Non-adrenal synthesis of aldosterone: a reality check Mol. Cell. Endocrinol. 350 2012 163 167
6. J. Funder, and M.I. New Low renin hypertension (LRH): shades of John Laragh Trends Endocrinol. Metab. 19 2008 83 (Pubitemid 351442921)
7. G.P. Rossi, G. Bernini, C. Caliumi, G. Desideri, B. Fabris, C. Ferri, C. Ganzaroli, G. Giacchetti, C. Letizia, M. Maccario, F. Mallamaci, M. Mannelli, M.J. Mattarello, A. Moretti, G. Palumbo, G. Parenti, E. Porteri, A. Semplicini, D. Rizzoni, E. Rossi, M. Boscaro, A.C. Pessina, and F. Mantero A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients J. Am. Coll. Cardiol. 48 2006 2293 2300 (Pubitemid 44873058)
8. R.D. Gordon, M.D. Ziesak, T.J. Tunny, M. Stowasser, and S.A. Klemm Evidence that primary aldosteronism may not be uncommon: 12% incidence among antihypertensive drug trial volunteers Clin. Exp. Pharmacol. Physiol. 20 1993 296 298 (Pubitemid 23140199)
9. D.A. Calhoun, D. Jones, S. Textor, D.C. Goff, T.P. Murphy, R.D. Toto, A. White, W.C. Cushman, W. White, D. Sica, K. Ferdinand, T.D. Giles, B. Falkner, and R.M. Carey Resistant hypertension: diagnosis, evaluation, and treatment: a scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research Circulation 117 2008 e510 e526
10. K.T. Weber Aldosterone in congestive heart failure N. Engl. J. Med. 345 2001 1689 1697 (Pubitemid 33126826)
11. C. Borghi, S. Boschi, E. Ambrosioni, G. Melandri, A. Branzi, and B. Magnani Evidence of a partial escape of renin-angiotensin-aldosterone blockade in patients with acute myocardial infarction treated with ACE inhibitors J. Clin. Pharmacol. 33 1993 40 45 (Pubitemid 23067505)
12. J. Staessen, P. Lijnen, R. Fagard, L.J. Verschueren, and A. Amery Rise in plasma concentration of aldosterone during long-term angiotensin II suppression J. Endocrinol. 91 1981 457 465 (Pubitemid 12203819)
13. B. Pitt "Escape" of aldosterone production in patients with left ventricular dysfunction treated with an angiotensin converting enzyme inhibitor: implications for therapy Cardiovasc. Drugs Ther 9 1995 145 149
14. R. Rocha, P.N. Chander, K. Khanna, A. Zuckerman, and C.T. Stier Jr. Mineralocorticoid blockade reduces vascular injury in stroke-prone hypertensive rats Hypertension 31 1998 451 458
15. R.J. MacFadyen, C.S. Barr, and A.D. Struthers Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patients Cardiovasc. Res 35 1997 30 34 (Pubitemid 27374737)
16. K. Nagata, K. Obata, J. Xu, S. Ichihara, A. Noda, H. Kimata, T. Kato, H. Izawa, T. Murohara, and M. Yokota Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and failure in low-aldosterone hypertensive rats Hypertension 47 2006 656 664 (Pubitemid 43740235)
17. B. Pitt, F. Zannad, W.J. Remme, R. Cody, A. Castaigne, A. Perez, J. Palensky, and J. Wittes The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators N. Engl. J. Med. 341 1999 709 717 (Pubitemid 29407370)
18. B. Pitt, W. Remme, F. Zannad, J. Neaton, F. Martinez, B. Roniker, R. Bittman, S. Hurley, J. Kleiman, and M. Gatlin Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction N. Engl. J. Med. 348 2003 1309 1321 (Pubitemid 36384098)
19. F. Zannad, J.J. McMurray, H. Krum, D.J. van Veldhuisen, K. Swedberg, H. Shi, J. Vincent, S.J. Pocock, and B. Pitt Eplerenone in patients with systolic heart failure and mild symptoms N. Engl. J. Med. 364 2011 11 21
20. W.B. Lea, E.S. Kwak, J.M. Luther, S.M. Fowler, Z. Wang, J. Ma, A.B. Fogo, and N.J. Brown Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt Kidney Int. 75 2009 936 944
21. G. Remuzzi, D. Cattaneo, and N. Perico The aggravating mechanisms of aldosterone on kidney fibrosis J. Am. Soc. Nephrol. 19 2008 1459 1462
22. Y.Y. Fan, M. Kohno, D. Nakano, H. Hitomi, Y. Nagai, Y. Fujisawa, X.M. Lu, H. Fu, J. Du, K. Ohmori, N. Hosomi, S. Kimura, H. Kiyomoto, and A. Nishiyama Inhibitory effects of a dihydropyridine calcium channel blocker on renal injury in aldosterone-infused rats J. Hypertens. 27 2009 1855 1862
23. S. Bianchi, R. Bigazzi, and V.M. Campese Antagonists of aldosterone and proteinuria in patients with CKD: an uncontrolled pilot study Am. J. Kidney Dis. 46 2005 45 51 (Pubitemid 40848432)
24. M. Quinkler, D. Zehnder, K.S. Eardley, J. Lepenies, A.J. Howie, S.V. Hughes, P. Cockwell, M. Hewison, and P.M. Stewart Increased expression of mineralocorticoid effector mechanisms in kidney biopsies of patients with heavy proteinuria Circulation 112 2005 1435 1443 (Pubitemid 41291769)
25. M. Epstein, G.H. Williams, M. Weinberger, A. Lewin, S. Krause, R. Mukherjee, R. Patni, and B. Beckerman Selective aldosterone blockade with eplerenone reduces albuminuria in patients with type 2 diabetes Clin. J. Am. Soc. Nephrol. 1 2006 940 951
26. K.J. Schjoedt, K. Rossing, T.R. Juhl, F. Boomsma, P. Rossing, L. Tarnow, and H.H. Parving Beneficial impact of spironolactone in diabetic nephropathy Kidney Int. 68 2005 2829 2836 (Pubitemid 43251030)
27. L. Tylicki, P. Rutkowski, M. Renke, W. Larczynski, E. Aleksandrowicz, W. Lysiak-Szydlowska, and B. Rutkowski Triple pharmacological blockade of the renin-angiotensin-aldosterone system in nondiabetic CKD: an open-label crossover randomized controlled trial Am. J. Kidney Dis. 52 2008 486 493
28. L. Pascual-Le Tallec, C. Demange, and M. Lombes Human mineralocorticoid receptor A and B protein forms produced by alternative translation sites display different transcriptional activities Eur. J. Endocrinol 150 2004 585 590 (Pubitemid 38584711)
29. K.L. Bruner, A. Derfoul, N.M. Robertson, G. Guerriero, T. Fernandes-Alnemri, E.S. Alnemri, and G. Litwack The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52 Receptors Signal Transduction 7 1997 85 98
30. J.B. Pippal, and P.J. Fuller Structure-function relationships in the mineralocorticoid receptor J. Mol. Endocrinol. 41 2008 405 413
31. A. Murai-Takeda, H. Shibata, I. Kurihara, S. Kobayashi, K. Yokota, N. Suda, Y. Mitsuishi, R. Jo, H. Kitagawa, S. Kato, T. Saruta, and H. Itoh NF-YC functions as a corepressor of agonist-bound mineralocorticoid receptor J. Biol. Chem. 285 2010 8084 8093
32. C. Grossmann, A. Benesic, A.W. Krug, R. Freudinger, S. Mildenberger, B. Gassner, and M. Gekle Human mineralocorticoid receptor expression renders cells responsive for nongenotropic aldosterone actions Mol. Endocrinol. 19 2005 1697 1710 (Pubitemid 41007884)
33. A.H. Beesley, D. Hornby, and S.J. White Regulation of distal nephron K channels (ROMK) mRNA expression by aldosterone in rat kidney J. Physiol. 509 Pt 3 1998 629 634 (Pubitemid 28306129)
34. V.E. Mick, O.A. Itani, R.W. Loftus, R.F. Husted, T.J. Schmidt, and C.P. Thomas The alpha-subunit of the epithelial sodium channel is an aldosterone-induced transcript in mammalian collecting ducts, and this transcriptional response is mediated via distinct cis-elements in the 5′-flanking region of the gene Mol. Endocrinol 15 2001 575 588 (Pubitemid 32324439)
35. U. Schmidt, J. Schmid, H. Schmid, and U.C. Dubach Sodium- and potassium-activated ATPase. A possible target of aldosterone J. Clin. Invest. 55 1975 655 660
36. E. Falkenstein, A.W. Norman, and M. Wehling Mannheim classification of nongenomically initiated (rapid) steroid action(s) J. Clin. Endocrinol. Metab. 85 2000 2072 2075 (Pubitemid 32269322)
37. J. Beron, and F. Verrey Aldosterone induces early activation and late accumulation of Na-K-ATPase at surface of A6 cells Am. J. Physiol 266 1994 C1278 C1290
38. A. May, A. Puoti, H.P. Gaeggeler, J.D. Horisberger, and B.C. Rossier Early effect of aldosterone on the rate of synthesis of the epithelial sodium channel alpha subunit in A6 renal cells J. Am. Soc. Nephrol. 8 1997 1813 1822
39. J. Sancho, R. Re, J. Burton, A.C. Barger, and E. Haber The role of the renin-angiotensin-aldosterone system in cardiovascular homeostasis in normal human subjects Circulation 53 1976 400 405
40. B. Boldyreff, and M. Wehling Aldosterone: refreshing a slow hormone by swift action News Physiol. Sci. 19 2004 97 100
41. R.E. Booth, J.P. Johnson, and J.D. Stockand Aldosterone Adv. Physiol. Educ. 26 2002 8 20
42. P. Geraldes, and G.L. King Activation of protein kinase C isoforms and its impact on diabetic complications Circ. Res. 106 2010 1319 1331
43. P.M. Snyder, D.R. Olson, and B.C. Thomas Serum and glucocorticoid- regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na channel J. Biol. Chem. 277 2002 5 8 (Pubitemid 34952020)
44. K. Klein, and W. Henk [Clinical experimental studies on the influence of aldosterone on hemodynamics and blod coagulation] Z. Kreislaufforschung 52 1963 40 53
45. M. Wehling, C.H. Spes, N. Win, C.P. Janson, B.M. Schmidt, K. Theisen, and M. Christ Rapid cardiovascular action of aldosterone in man J. Clin. Endocrinol. Metab. 83 1998 3517 3522 (Pubitemid 28500882)
46. C. Spach, and D.H. Streeten Retardation of sodium exchange in dog erythrocytes by physiological concentrations of aldosterone, in vitro J. Clin. Invest. 43 1964 217 227
47. M. Wehling, J. Kasmayr, and K. Theisen Rapid effects of mineralocorticoids on sodium-proton exchanger: genomic or nongenomic pathway? Am. J. Physiol. 260 1991 E719 E726
48. R. Alzamora, L. Michea, and E.T. Marusic Role of 11beta-hydroxysteroid dehydrogenase in nongenomic aldosterone effects in human arteries Hypertension 35 2000 1099 1104 (Pubitemid 30327264)
49. A.S. Mihailidou, M. Mardini, and J.W. Funder Rapid, nongenomic effects of aldosterone in the heart mediated by epsilon protein kinase C Endocrinology 145 2004 773 780 (Pubitemid 38183820)
50. M. Christ, A. Gunther, M. Heck, B.M. Schmidt, E. Falkenstein, and M. Wehling Aldosterone, not estradiol, is the physiological agonist for rapid increases in cAMP in vascular smooth muscle cells Circulation 99 1999 1485 1491 (Pubitemid 29140916)
51. M. Christ, C. Meyer, K. Sippel, and M. Wehling Rapid aldosterone signaling in vascular smooth muscle cells: involvement of phospholipase C, diacylglycerol and protein kinase C alpha Biochem. Biophys. Res. Commun. 213 1995 123 129
52. M. Christ, K. Douwes, C. Eisen, G. Bechtner, K. Theisen, and M. Wehling Rapid effects of aldosterone on sodium transport in vascular smooth muscle cells Hypertension 25 1995 117 123
53. 2 in vascular smooth muscle cells Circ. Res. 76 1995 973 979
54. Alzamora, R.; Brown, L.R.; Harvey, B.J. Direct binding and activation of protein kinase C isoforms by aldosterone and 17{beta}-estradiol. Mol. Endocrinol.; 2007.
55. C. Grossmann, and M. Gekle New aspects of rapid aldosterone signaling Mol. Cell. Endocrinol. 308 2009 53 62
56. W. Thomas, and B.J. Harvey Mechanisms underlying rapid aldosterone effects in the kidney Annu. Rev. Physiol. 73 2011 335 357
57. R. Dooley, B.J. Harvey, and W. Thomas Non-genomic actions of aldosterone: From receptors and signals to membrane targets Mol. Cell. Endocrinol. 350 2012 223 234
58. R. Dooley, B.J. Harvey, and W. Thomas The regulation of cell growth and survival by aldosterone Front. Biosci. 16 2011 440 457
59. G.P. Vinson, and J.P. Coghlan Expanding view of aldosterone action, with an emphasis on rapid action Clin. Exp. Pharmacol. Physiol. 37 2010 410 416
60. J.W. Funder Aldosterone and mineralocorticoid receptors in the cardiovascular system Prog. Cardiovasc. Dis. 52 2010 393 400
61. C.A. Farquharson, and A.D. Struthers Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin I/angiotensin II conversion in patients with chronic heart failure Circulation 101 2000 594 597 (Pubitemid 30094728)
62. E. Kotlyar, J.A. Vita, M.R. Winter, E.H. Awtry, D.A. Siwik, J.F. Keaney Jr, D.B. Sawyer, L.A. Cupples, W.S. Colucci, and F. Sam The relationship between aldosterone, oxidative stress, and inflammation in chronic, stable human heart failure J. Cardiac Fail 12 2006 122 127 (Pubitemid 43340154)
63. M. Yamaji, T. Tsutamoto, C. Kawahara, K. Nishiyama, T. Yamamoto, M. Fujii, and M. Horie Serum cortisol as a useful predictor of cardiac events in patients with chronic heart failure: the impact of oxidative stress Circ. Heart Fail 2 2009 608 615
64. S. Keidar, A. Gamliel-Lazarovich, M. Kaplan, E. Pavlotzky, S. Hamoud, T. Hayek, R. Karry, and Z. Abassi Mineralocorticoid receptor blocker increases angiotensin-converting enzyme 2 activity in congestive heart failure patients Circ. Res. 97 2005 946 953 (Pubitemid 41552681)
65. C.L. Laffer, R.J. Bolterman, J.C. Romero, and F. Elijovich Effect of salt on isoprostanes in salt-sensitive essential hypertension Hypertension 47 2006 434 440 (Pubitemid 43740287)
66. C.B. Stehr, R. Mellado, M.P. Ocaranza, C.A. Carvajal, L. Mosso, E. Becerra, M. Solis, L. Garcia, S. Lavandero, J. Jalil, and C.E. Fardella Increased levels of oxidative stress, subclinical inflammation, and myocardial fibrosis markers in primary aldosteronism patients J. Hypertens. 28 2010 2120 2126
67. Calo, L.A.; Pagnin, E.; Davis, P.A.; Armanini, D.; Mormino, P.; Rossi, G.P.; Pessina, A.C. Oxidative stress related proteins in a Conns adenoma tissue. Relevance for aldosterones prooxidative and proinflammatory activity. J. Endocrinol. Invest.; 2009.
68. M.J. Somers, K. Mavromatis, Z.S. Galis, and D.G. Harrison Vascular superoxide production and vasomotor function in hypertension induced by deoxycorticosterone acetate-salt Circulation 101 2000 1722 1728 (Pubitemid 30196634)
69. A. Virdis, M.F. Neves, F. Amiri, E. Viel, R.M. Touyz, and E.L. Schiffrin Spironolactone improves angiotensin-induced vascular changes and oxidative stress Hypertension 40 2002 504 510
70. M. Comporti, C. Signorini, B. Arezzini, D. Vecchio, B. Monaco, and C. Gardi F2-Isoprostanes are not just markers of oxidative stress Free Radic. Biol. Med. 44 2008 247 256
71. D. Giustarini, I. Dalle-Donne, D. Tsikas, and R. Rossi Oxidative stress and human diseases: origin, link, measurement, mechanisms, and biomarkers Crit. Rev. Clin. Lab. Sci. 46 2009 241 281
72. J.F. Ndisang, and A. Jadhav The heme oxygenase system attenuates pancreatic lesions and improves insulin sensitivity and glucose metabolism in deoxycorticosterone acetate hypertension Am. J. Physiol 298 2010 R211 R223
73. L. Jin, R.A. Beswick, T. Yamamoto, T. Palmer, T.A. Taylor, J.S. Pollock, D.M. Pollock, M.W. Brands, and R.C. Webb Increased reactive oxygen species contributes to kidney injury in mineralocorticoid hypertensive rats J. Physiol. Pharmacol. 57 2006 343 357 (Pubitemid 44543871)
74. M.S. Gandhi, P.A. Deshmukh, G. Kamalov, T. Zhao, W. Zhao, J.T. Whaley, J.R. Tichy, S.K. Bhattacharya, R.A. Ahokas, Y. Sun, I.C. Gerling, and K.T. Weber Causes and consequences of zinc dyshomeostasis in rats with chronic aldosteronism J. Cardiovasc. Pharmacol. 52 2008 245 252
75. G. Kamalov, R.A. Ahokas, W. Zhao, T. Zhao, A.U. Shahbaz, P.L. Johnson, S.K. Bhattacharya, Y. Sun, I.C. Gerling, and K.T. Weber Uncoupling the coupled calcium and zinc dyshomeostasis in cardiac myocytes and mitochondria seen in aldosteronism J. Cardiovasc. Pharmacol. 55 2010 248 254
76. A.U. Shahbaz, G. Kamalov, W. Zhao, T. Zhao, P.L. Johnson, Y. Sun, S.K. Bhattacharya, R.A. Ahokas, I.C. Gerling, and K.T. Weber Mitochondria-targeted cardioprotection in aldosteronism J. Cardiovasc. Pharmacol. 57 2011 37 43
77. D. Tsikas Analytical methods for 3-nitrotyrosine quantification in biological samples: the unique role of tandem mass spectrometry Amino Acids 42 2012 45 63
78. Y. Sun, J. Zhang, L. Lu, S.S. Chen, M.T. Quinn, and K.T. Weber Aldosterone-induced inflammation in the rat heart: role of oxidative stress Am. J. Pathol. 161 2002 1773 1781 (Pubitemid 35265535)
79. R.A. Ahokas, K.J. Warrington, I.C. Gerling, Y. Sun, L.A. Wodi, P.A. Herring, L. Lu, S.K. Bhattacharya, A.E. Postlethwaite, and K.T. Weber Aldosteronism and peripheral blood mononuclear cell activation: a neuroendocrine-immune interface Circ. Res. 93 2003 e124 135
80. G. Kamalov, P.A. Deshmukh, N.Y. Baburyan, M.S. Gandhi, P.L. Johnson, R.A. Ahokas, S.K. Bhattacharya, Y. Sun, I.C. Gerling, and K.T. Weber Coupled calcium and zinc dyshomeostasis and oxidative stress in cardiac myocytes and mitochondria of rats with chronic aldosteronism J. Cardiovasc. Pharmacol. 53 2009 414 423
81. J. Habibi, V.G. DeMarco, L. Ma, L. Pulakat, W.E. Rainey, A.T. Whaley-Connell, and J.R. Sowers Mineralocorticoid receptor blockade improves diastolic function independent of blood pressure reduction in a transgenic model of RAAS overexpression Am. J. Physiol. Heart Circ. Physiol 300 2011 H1484 H1491
82. S. Stas, A. Whaley-Connell, J. Habibi, L. Appesh, M.R. Hayden, P.R. Karuparthi, M. Qazi, E.M. Morris, S.A. Cooper, C.D. Link, C. Stump, M. Hay, C. Ferrario, and J.R. Sowers Mineralocorticoid receptor blockade attenuates chronic overexpression of the renin-angiotensin-aldosterone system stimulation of reduced nicotinamide adenine dinucleotide phosphate oxidase and cardiac remodeling Endocrinology 148 2007 3773 3780 (Pubitemid 47105865)
83. S. Dikalov, K.K. Griendling, and D.G. Harrison Measurement of reactive oxygen species in cardiovascular studies Hypertension 49 2007 717 727 (Pubitemid 351688335)
84. J. Zielonka, and B. Kalyanaraman Hydroethidine- and MitoSOX-derived red fluorescence is not a reliable indicator of intracellular superoxide formation: another inconvenient truth Free Radic. Biol. Med 48 2010 983 1001
85. B. Fink, K. Laude, L. McCann, A. Doughan, D.G. Harrison, and S. Dikalov Detection of intracellular superoxide formation in endothelial cells and intact tissues using dihydroethidium and an HPLC-based assay Am. J. Physiol. Cell Physiol 287 2004 C895 C902
86. D.C. Fernandes, J. Wosniak Jr, L.A. Pescatore, M.A. Bertoline, M. Liberman, F.R. Laurindo, and C.X. Santos Analysis of DHE-derived oxidation products by HPLC in the assessment of superoxide production and NADPH oxidase activity in vascular systems Am. J. Physiol. Cell Physiol 292 2007 C413 C422
87. F.R. Laurindo, D.C. Fernandes, and C.X. Santos Assessment of superoxide production and NADPH oxidase activity by HPLC analysis of dihydroethidium oxidation products Methods Enzymol. 441 2008 237 260
88. E.C. Viel, K. Benkirane, D. Javeshghani, R.M. Touyz, and E.L. Schiffrin Xanthine oxidase and mitochondria contribute to vascular superoxide anion generation in DOCA-salt hypertensive rats Am. J. Physiol. Heart Circ. Physiol 295 2008 H281 H288
89. N. Schupp, P. Kolkhof, N. Queisser, S. Gartner, U. Schmid, A. Kretschmer, E. Hartmann, R.G. Oli, and S. Schafer Stopper, H. Mineralocorticoid receptor-mediated DNA damage in kidneys of DOCA-salt hypertensive rats FASEB J 25 2011 968 978
90. Z.H. Zhang, Y. Yu, Y.M. Kang, S.G. Wei, and R.B. Felder Aldosterone acts centrally to increase brain renin-angiotensin system activity and oxidative stress in normal rats Am. J. Physiol. Heart Circ. Physiol 294 2008 H1067 H1074
91. Y.M. Park, B.H. Lim, R.M. Touyz, and J.B. Park Expression of NAD(P)H oxidase subunits and their contribution to cardiovascular damage in aldosterone/salt-induced hypertensive rat J. Korean Med. Sci. 23 2008 1039 1045
92. Y. Li, K.H. Stansbury, H. Zhu, and M.A. Trush Biochemical characterization of lucigenin (bis-N-methylacridinium) as a chemiluminescent probe for detecting intramitochondrial superoxide anion radical production Biochem. Biophys. Res. Commun. 262 1999 80 87 (Pubitemid 29412627)
93. J. Vasquez-Vivar, N. Hogg, K.A. Pritchard Jr, P. Martasek, and B. Kalyanaraman Superoxide anion formation from lucigenin: an electron spin resonance spin-trapping study FEBS Lett 403 1997 127 130 (Pubitemid 27081479)
94. R.A. Beswick, H. Zhang, D. Marable, J.D. Catravas, W.D. Hill, and R.C. Webb Long-term antioxidant administration attenuates mineralocorticoid hypertension and renal inflammatory response Hypertension 37 2001 781 786 (Pubitemid 32199066)
95. R.A. Beswick, A.M. Dorrance, R. Leite, and R.C. Webb NADH/NADPH oxidase and enhanced superoxide production in the mineralocorticoid hypertensive rat Hypertension 38 2001 1107 1111 (Pubitemid 34252814)
96. Y.M. Park, M.Y. Park, Y.L. Suh, and J.B. Park NAD(P)H oxidase inhibitor prevents blood pressure elevation and cardiovascular hypertrophy in aldosterone-infused rats Biochem. Biophys. Res. Commun. 313 2004 812 817 (Pubitemid 38021903)
97. S. Nakano, N. Kobayashi, K. Yoshida, T. Ohno, and H. Matsuoka Cardioprotective mechanisms of spironolactone associated with the angiotensin-converting enzyme/epidermal growth factor receptor/extracellular signal-regulated kinases, NAD(P)H oxidase/lectin-like oxidized low-density lipoprotein receptor-1, and Rho-kinase pathways in aldosterone/salt-induced hypertensive rats Hypertens. Res 28 2005 925 936 (Pubitemid 43173963)
98. M. Rahman, A. Nishiyama, P. Guo, Y. Nagai, G.X. Zhang, Y. Fujisawa, Y.Y. Fan, S. Kimura, N. Hosomi, K. Omori, Y. Abe, and M. Kohno Effects of adrenomedullin on cardiac oxidative stress and collagen accumulation in aldosterone-dependent malignant hypertensive rats J. Pharmacol. Exp. Ther. 318 2006 1323 1329 (Pubitemid 44268342)
99. S. Shibata, M. Nagase, S. Yoshida, H. Kawachi, and T. Fujita Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1 Hypertension 49 2007 355 364 (Pubitemid 46143013)
100. H. Kawarazaki, K. Ando, M. Fujita, H. Matsui, A. Nagae, K. Muraoka, C. Kawarasaki, and T. Fujita Mineralocorticoid receptor activation: a major contributor to salt-induced renal injury and hypertension in young rats Am. J. Physiol. 300 2011 F1402 F1409
101. G. Lastra, A. Whaley-Connell, C. Manrique, J. Habibi, A.A. Gutweiler, L. Appesh, M.R. Hayden, Y. Wei, C. Ferrario, and J.R. Sowers Low-dose spironolactone reduces reactive oxygen species generation and improves insulin-stimulated glucose transport in skeletal muscle in the TG(mRen2)27 rat Am. J. Physiol. 295 2008 E110 E116
102. X. Zhu, R.D. Manning Jr, D. Lu, C.E. Gomez-Sanchez, and Y. Fu Juncos, L. A.; Liu, R. Aldosterone stimulates superoxide production in macula densa cells Am. J. Physiol. 301 2011 F529 F535
103. F. Iwashima, T. Yoshimoto, I. Minami, M. Sakurada, Y. Hirono, and Y. Hirata Aldosterone induces superoxide generation via Rac1 activation in endothelial cells Endocrinology 149 2008 1009 1014 (Pubitemid 351397957)
104. R.M. Touyz, A.M. Briones, M. Sedeek, D. Burger, and A.C. Montezano NOX isoforms and reactive oxygen species in vascular health Mol. Interv. 11 2011 27 35
105. M. Taira, H. Toba, M. Murakami, I. Iga, R. Serizawa, S. Murata, M. Kobara, and T. Nakata Spironolactone exhibits direct renoprotective effects and inhibits renal renin-angiotensin-aldosterone system in diabetic rats Eur. J. Pharmacol. 589 2008 264 271
106. M.L. Onozato, A. Tojo, N. Kobayashi, A. Goto, H. Matsuoka, and T. Fujita Dual blockade of aldosterone and angiotensin II additively suppresses TGF-beta and NADPH oxidase in the hypertensive kidney Nephrol. Dial. Transplant. 22 2007 1314 1322 (Pubitemid 47072218)
107. A. Nishiyama, L. Yao, Y. Nagai, K. Miyata, M. Yoshizumi, S. Kagami, S. Kondo, H. Kiyomoto, T. Shokoji, S. Kimura, M. Kohno, and Y. Abe Possible contributions of reactive oxygen species and mitogen-activated protein kinase to renal injury in aldosterone/salt-induced hypertensive rats Hypertension 43 2004 841 848 (Pubitemid 38405598)
108. M.J. Young, J. Morgan, K. Brolin, P.J. Fuller, and J.W. Funder Activation of mineralocorticoid receptors by exogenous glucocorticoids and the development of cardiovascular inflammatory responses in adrenalectomized rats Endocrinology 151 2010 2622 2628
109. M.A. Bayorh, A. Rollins-Hairston, J. Adiyiah, D. Lyn, and D. Eatman Eplerenone suppresses aldosterone/salt-induced expression of NOX-4 J. Renin Angiotensin Aldosterone Syst 12 2011 195 201
110. M.I. Oliverio, C.F. Best, O. Smithies, and T.M. Coffman Regulation of sodium balance and blood pressure by the AT(1A) receptor for angiotensin II Hypertension 35 2000 550 554 (Pubitemid 30108147)
111. J. Katada, T. Meguro, H. Saito, A. Ohashi, T. Anzai, S. Ogawa, and T. Yoshikawa Persistent cardiac aldosterone synthesis in angiotensin II type 1A receptor-knockout mice after myocardial infarction Circulation 111 2005 2157 2164 (Pubitemid 40632429)
112. X. Chen, W. Li, H. Yoshida, S. Tsuchida, H. Nishimura, F. Takemoto, S. Okubo, A. Fogo, T. Matsusaka, and I. Ichikawa Targeting deletion of angiotensin type 1B receptor gene in the mouse Am. J. Physiol. 272 1997 F299 F304
113. N. Makhanova, J. Hagaman, H.S. Kim, and O. Smithies Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase Hypertension 51 2008 134 140 (Pubitemid 350307115)
114. S. Johar, A.C. Cave, A. Narayanapanicker, D.J. Grieve, and A.M. Shah Aldosterone mediates angiotensin II-induced interstitial cardiac fibrosis via a Nox2-containing NADPH oxidase FASEB J 20 2006 1546 1548
115. M. Bleich, R. Warth, M. Schmidt-Hieber, A. Schulz-Baldes, P. Hasselblatt, D. Fisch, S. Berger, K. Kunzelmann, W. Kriz, G. Schutz, and R. Greger Rescue of the mineralocorticoid receptor knock-out mouse Pflugers Arch. 438 1999 245 254 (Pubitemid 29361742)
116. S. Keidar, M. Kaplan, E. Pavlotzky, R. Coleman, T. Hayek, S. Hamoud, and M. Aviram Aldosterone administration to mice stimulates macrophage NADPH oxidase and increases atherosclerosis development: a possible role for angiotensin-converting enzyme and the receptors for angiotensin II and aldosterone Circulation 109 2004 2213 2220 (Pubitemid 38625399)
117. G.M. Kuster, E. Kotlyar, M.K. Rude, D.A. Siwik, R. Liao, W.S. Colucci, and F. Sam Mineralocorticoid receptor inhibition ameliorates the transition to myocardial failure and decreases oxidative stress and inflammation in mice with chronic pressure overload Circulation 111 2005 420 427 (Pubitemid 40204425)
118. R.P. Brandes Avoiding vicious circles: mineralocorticoid receptor antagonism prevents vascular oxidative stress early after myocardial infarction Hypertension 50 2007 842 843 (Pubitemid 350287522)
119. H. Hayashi, M. Kobara, M. Abe, N. Tanaka, E. Gouda, H. Toba, H. Yamada, T. Tatsumi, T. Nakata, and H. Matsubara Aldosterone nongenomically produces NADPH oxidase-dependent reactive oxygen species and induces myocyte apoptosis Hypertens. Res. 31 2008 363 375 (Pubitemid 351461117)
120. S. Huang, A. Zhang, G. Ding, and R. Chen Aldosterone-induced mesangial cell proliferation is mediated by EGF receptor transactivation Am. J. Physiol. 296 2009 F1323 F1333
121. D. Nagata, M. Takahashi, K. Sawai, T. Tagami, T. Usui, A. Shimatsu, Y. Hirata, and M. Naruse Molecular mechanism of the inhibitory effect of aldosterone on endothelial NO synthase activity Hypertension 48 2006 165 171 (Pubitemid 44297539)
122. N. Schupp, N. Queisser, M. Wolf, P. Kolkhof, L. Barfacker, S. Schafer, and A. Heidland Stopper, H. Aldosterone causes DNA strand breaks and chromosomal damage in renal cells, which are prevented by mineralocorticoid receptor antagonists Horm. Metab. Res. 42 2010 458 465
123. K. Miyata, M. Rahman, T. Shokoji, Y. Nagai, G.X. Zhang, G.P. Sun, S. Kimura, T. Yukimura, H. Kiyomoto, M. Kohno, Y. Abe, and A. Nishiyama Aldosterone stimulates reactive oxygen species production through activation of NADPH oxidase in rat mesangial cells J. Am. Soc. Nephrol. 16 2005 2906 2912 (Pubitemid 44743488)
124. A. Zhang, Z. Jia, X. Guo, and T. Yang Aldosterone induces epithelial-mesenchymal transition via ROS of mitochondrial origin Am. J. Physiol. 293 2007 F723 F731
125. N. Queisser, and P.I. Oteiza Stopper, H.; Oli, R. G.; Schupp, N. Aldosterone induces oxidative stress, oxidative DNA damage and NF-kappaB-activation in kidney tubule cells Mol. Carcinog. 50 2011 123 135
126. G.E. Callera, A.C. Montezano, A. Yogi, R.C. Tostes, Y. He, E.L. Schiffrin, and R.M. Touyz c-Src-dependent nongenomic signaling responses to aldosterone are increased in vascular myocytes from spontaneously hypertensive rats Hypertension 46 2005 1032 1038
127. Min, L.J.; Mogi, M.; Iwanami, J.; Li, J.M.; Sakata, A.; Fujita, T.; Tsukuda, K.; Iwai, M.; Horiuchi, M. Cross-talk between aldosterone and angiotensin II in vascular smooth muscle cell senescence. Cardiovasc. Res.; 2007.
128. N. Queisser, and N. Schupp Stopper, H.; Schinzel, R.; Oteiza, P. I. Aldosterone increases kidney tubule cell oxidants through calcium-mediated activation of NADPH oxidase and nitric oxide synthase Free Radic. Biol. Med. 51 2011 1996 2006
129. H. Wei, X. Mi, L. Ji, L. Yang, Q. Xia, Y. Wei, I. Miyamori, and C. Fan Protein kinase C-delta is involved in induction of NOX1 gene expression by aldosterone in rat vascular smooth muscle cells Biochemistry (Mosc.) 75 2010 304 309
130. C. Fan, Y. Kawai, S. Inaba, K. Arakawa, M. Katsuyama, K. Kajinami, T. Yasuda, C. Yabe-Nishimura, T. Konoshita, and I. Miyamori Synergy of aldosterone and high salt induces vascular smooth muscle hypertrophy through up-regulation of NOX1 J. Steroid Biochem. Mol. Biol. 111 2008 29 36
131. Y. Hashikabe, K. Suzuki, T. Jojima, K. Uchida, and Y. Hattori Aldosterone impairs vascular endothelial cell function J. Cardiovasc. Pharmacol. 47 2006 609 613 (Pubitemid 44309681)
132. L.A. Calo, F. Zaghetto, E. Pagnin, P.A. Davis, P. De Mozzi, P. Sartorato, G. Martire, C. Fiore, and D. Armanini Effect of aldosterone and glycyrrhetinic acid on the protein expression of PAI-1 and p22(phox) in human mononuclear leukocytes J. Clin. Endocrinol. Metab. 89 2004 1973 1976 (Pubitemid 38507960)
133. B.A. Maron, Y.Y. Zhang, D.E. Handy, A. Beuve, S.S. Tang, J. Loscalzo, and J.A. Leopold Aldosterone increases oxidant stress to impair guanylyl cyclase activity by cysteinyl thiol oxidation in vascular smooth muscle cells J. Biol. Chem. 284 2009 7665 7672
134. Y. Hirono, T. Yoshimoto, N. Suzuki, T. Sugiyama, M. Sakurada, S. Takai, N. Kobayashi, M. Shichiri, and Y. Hirata Angiotensin II receptor type 1-mediated vascular oxidative stress and proinflammatory gene expression in aldosterone-induced hypertension: the possible role of local renin-angiotensin system Endocrinology 148 2007 1688 1696 (Pubitemid 46457130)
135. S. Arima, K. Kohagura, H.L. Xu, A. Sugawara, T. Abe, F. Satoh, K. Takeuchi, and S. Ito Nongenomic vascular action of aldosterone in the glomerular microcirculation J. Am. Soc. Nephrol. 14 2003 2255 2263 (Pubitemid 37052371)
136. K. Fukami, S. Inanobe, K. Kanemaru, and Y. Nakamura Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance Prog. Lipid Res. 49 2010 429 437
137. M. Wehling, A. Ulsenheimer, M. Schneider, C. Neylon, and M. Christ Rapid effects of aldosterone on free intracellular calcium in vascular smooth muscle and endothelial cells: subcellular localization of calcium elevations by single
138. Cerella, C.; Diederich, M.; Ghibelli, L. The dual role of calcium as messenger and stressor in cell damage, death, and survival. Int. J. Cell Biol. doi:10.1155/2010/546163:546163; 2010.
139. 2 in M-1 cortical collecting duct cells Kidney Int 57 2000 1395 1403 (Pubitemid 30207897)
140. D.C. Leite-Dellova, M. Oliveira-Souza, G. Malnic, and M. Mello-Aires Genomic and nongenomic dose-dependent biphasic effect of aldosterone on Na/H exchanger in proximal S3 segment: role of cytosolic calcium Am. J. Physiol 295 2008 F1342 F1352
141. M. Schneider, A. Ulsenheimer, M. Christ, and M. Wehling Nongenomic effects of aldosterone on intracellular calcium in porcine endothelial cells Am. J. Physiol. 272 1997 E616 E620
142. P. Geraldes, and G.L. King Activation of protein kinase C isoforms and its impact on diabetic complications Circ. Res. 106 2010 1319 1331
143. M.E. Reyland Protein kinase C isoforms: Multi-functional regulators of cell life and death Front. Biosci. 14 2009 2386 2399
144. E.P. Reeves, L.V. Dekker, L.V. Forbes, F.B. Wientjes, A. Grogan, D.J. Pappin, and A.W. Segal Direct interaction between p47phox and protein kinase C: evidence for targeting of protein kinase C by p47phox in neutrophils Biochem. J. 344 Pt 3 1999 859 866 (Pubitemid 30032535)
145. Z. Ungvari, A. Csiszar, A. Huang, P.M. Kaminski, M.S. Wolin, and A. Koller High pressure induces superoxide production in isolated arteries via protein kinase C-dependent activation of NAD(P)H oxidase Circulation 108 2003 1253 1258 (Pubitemid 37099996)
146. J. El-Benna, P.M. Dang, M.A. Gougerot-Pocidalo, J.C. Marie, and F. Braut-Boucher p47phox, the phagocyte NADPH oxidase/NOX2 organizer: structure, phosphorylation and implication in diseases Exp. Mol. Med. 41 2009 217 225
147. A. Gromotowicz, J. Szemraj, A. Stankiewicz, A. Zakrzeska, M. Mantur, E. Jaroszewicz, F. Rogowski, and E. Chabielska Study of the mechanisms of aldosterone prothrombotic effect in rats J. Renin Angiotensin Aldosterone Syst 12 2011 430 439
148. A. Mutoh, M. Isshiki, and T. Fujita Aldosterone enhances ligand-stimulated nitric oxide production in endothelial cells Hypertens. Res. 31 2008 1811 1820
149. D.L. Wheeler, M. Iida, and E.F. Dunn The role of Src in solid tumors Oncologist 14 2009 667 678
150. Y. Oda, B. Renaux, J. Bjorge, M. Saifeddine, D.J. Fujita, and M.D. Hollenberg cSrc is a major cytosolic tyrosine kinase in vascular tissue Can. J. Physiol. Pharmacol. 77 1999 606 617
151. G.E. Callera, A. Yogi, A.M. Briones, A.C. Montezano, Y. He, R.C. Tostes, E.L. Schiffrin, and R.M. Touyz Vascular proinflammatory responses by aldosterone are mediated via c-Src trafficking to cholesterol-rich microdomains: role of PDGFR Cardiovasc. Res. 91 2011 720 731
152. G.E. Callera, R.M. Touyz, R.C. Tostes, A. Yogi, Y. He, S. Malkinson, and E.L. Schiffrin Aldosterone activates vascular p38MAP kinase and NADPH oxidase via c-Src Hypertension 45 2005 773 779 (Pubitemid 40418380)
153. R.M. Touyz, G. Yao, and E.L. Schiffrin c-Src induces phosphorylation and translocation of p47phox: role in superoxide generation by angiotensin II in human vascular smooth muscle cells Arterioscler. Thromb. Vasc. Biol. 23 2003 981 987 (Pubitemid 36717143)
154. D. Gianni, B. Bohl, S.A. Courtneidge, and G.M. Bokoch The involvement of the tyrosine kinase c-Src in the regulation of reactive oxygen species generation mediated by NADPH oxidase-1 Mol. Biol. Cell 19 2008 2984 2994
155. C. DerMardirossian, G. Rocklin, J.Y. Seo, and G.M. Bokoch Phosphorylation of RhoGDI by Src regulates Rho GTPase binding and cytosol-membrane cycling Mol. Biol. Cell 17 2006 4760 4768 (Pubitemid 44665745)
156. G. Shi, Y. Fu, W. Jiang, A. Yin, M. Feng, Y. Wu, Y. Kawai, I. Miyamori, and C. Fan Activation of Src-ATF1 pathway is involved in upregulation of Nox1, a catalytic subunit of NADPH oxidase, by aldosterone Endocr. J. 58 2011 491 499
157. P. Chiarugi Src redox regulation: there is more than meets the eye Mol. Cells 26 2008 329 337
158. G. Gloire, S. Legrand-Poels, and J. Piette NF-kappaB activation by reactive oxygen species: fifteen years later Biochem. Pharmacol. 72 2006 1493 1505 (Pubitemid 44666727)
159. Y. Habraken, and J. Piette NF-kappaB activation by double-strand breaks Biochem. Pharmacol. 72 2006 1132 1141
160. H.L. Pahl Activators and target genes of Rel/NF-kappaB transcription factors Oncogene 18 1999 6853 6866
161. Z.H. Wu, and S. Miyamoto Many faces of NF-kappaB signaling induced by genotoxic stress J. Mol. Med. 85 2007 1187 1202 (Pubitemid 47622222)
162. B. Haefner, and B. NF-kappa arresting a major culprit in cancer. Drug Discov Today 7 2002 653 663 (Pubitemid 34761898)
163. S. Papa, C. Bubici, F. Zazzeroni, C.G. Pham, C. Kuntzen, J.R. Knabb, K. Dean, and G. Franzoso The NF-kappaB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease Cell Death Differ. 13 2006 712 729
164. B.B. Aggarwal, R.V. Vijayalekshmi, and B. Sung Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe Clin. Cancer Res. 15 2009 425 430
165. D. Sanz-Rosa, and E. Cediel de las Heras, N.; Miana, M.; Balfagon, G.; Lahera, V.; Cachofeiro, V. Participation of aldosterone in the vascular inflammatory response of spontaneously hypertensive rats: role of the NFkappaB/IkappaB system J. Hypertens. 23 2005 1167 1172 (Pubitemid 40862720)
166. V. Cachofeiro, M. Miana, N. de Las Heras, B. Martin-Fernandez, S. Ballesteros, J. Fernandez-Tresguerres, and V. Lahera Aldosterone and the vascular system J. Steroid Biochem. Mol. Biol. 109 2008 331 335
167. S. de Seigneux, V. Leroy, H. Ghzili, M. Rousselot, S. Nielsen, B.C. Rossier, P.Y. Martin, and E. Feraille NF-kappaB inhibits sodium transport via down-regulation of SGK1 in renal collecting duct principal cells J. Biol. Chem 283 2008 25671 25681
168. V. Leroy, S. De Seigneux, V. Agassiz, U. Hasler, M.E. Rafestin-Oblin, M. Vinciguerra, P.Y. Martin, and E. Feraille Aldosterone activates NF-kappaB in the collecting duct J. Am. Soc. Nephrol. 20 2009 131 144
169. Y. Terada, H. Kuwana, T. Kobayashi, T. Okado, N. Suzuki, T. Yoshimoto, Y. Hirata, and S. Sasaki Aldosterone-stimulated SGK1 activity mediates profibrotic signaling in the mesangium J. Am. Soc. Nephrol. 19 2008 298 309 (Pubitemid 351240652)
170. X. Li, Y. Meng, B. Jiang, X.S. Yang, W.W. Wang, D. Guo, Z.S. Lai, and Z.S. Zhang [Effects of angiotensin II and aldosterone on NF-kappaB binding activity in hepatic stellate cells] Zhonghua Yi Xue Za Zhi 85 2005 374 380 (Pubitemid 40347628)
171. X. Li, Y. Meng, P. Wu, Z. Zhang, and X. Yang Angiotensin II and aldosterone stimulating NF-kappaB and AP-1 activation in hepatic fibrosis of rat Regul. Pept. 138 2007 15 25 (Pubitemid 44918126)
172. S.U. Sonder, A. Woetmann, N. Odum, and K. Bendtzen Spironolactone induces apoptosis and inhibits NF-kappaB independent of the mineralocorticoid receptor Apoptosis 11 2006 2159 2165 (Pubitemid 44885392)
173. S.U. Sonder, M. Mikkelsen, K. Rieneck, C.J. Hedegaard, and K. Bendtzen Effects of spironolactone on human blood mononuclear cells: mineralocorticoid receptor independent effects on gene expression and late apoptosis induction Br. J. Pharmacol. 148 2006 46 53 (Pubitemid 43675599)
174. N. Kobayashi, K. Hara, A. Tojo, M.L. Onozato, T. Honda, K. Yoshida, S. Mita, S. Nakano, Y. Tsubokou, and H. Matsuoka Eplerenone shows renoprotective effect by reducing LOX-1-mediated adhesion molecule, PKCepsilon-MAPK-p90RSK, and Rho-kinase pathway Hypertension 45 2005 538 544 (Pubitemid 40411256)
175. S. Fukuda, C. Horimai, K. Harada, T. Wakamatsu, H. Fukasawa, S. Muto, A. Itai, and M. Hayashi Aldosterone-induced kidney injury is mediated by NFkappaB activation Clin. Exp. Nephrol. 15 2011 41 49
176. A. Yogi, G.E. Callera, S.E. OConnor, Y. He, J.W. Correa, R.C. Tostes, A. Mazur, and R.M. Touyz Dysregulation of renal transient receptor potential melastatin 6/7 but not paracellin-1 in aldosterone-induced hypertension and kidney damage in a model of hereditary hypomagnesemia J. Hypertens. 29 2011 1400 1410
177. R. Rocha, A.E. Rudolph, G.E. Frierdich, D.A. Nachowiak, B.K. Kekec, E.A. Blomme, E.G. McMahon, and J.A. Delyani Aldosterone induces a vascular inflammatory phenotype in the rat heart Am. J. Physiol. Heart Circ. Physiol 283 2002 H1802 H1810
178. V. Vallon, A.W. Wyatt, K. Klingel, D.Y. Huang, A. Hussain, S. Berchtold, B. Friedrich, F. Grahammer, R.S. Belaiba, A. Gorlach, P. Wulff, J. Daut, N.D. Dalton, J. Ross Jr, U. Flogel, J. Schrader, H. Osswald, R. Kandolf, D. Kuhl, and F. Lang SGK1-dependent cardiac CTGF formation and fibrosis following DOCA treatment J. Mol. Med. (Berl.) 84 2006 396 404 (Pubitemid 43673614)
179. L.J. Min, M. Mogi, J. Iwanami, J.M. Li, A. Sakata, T. Fujita, K. Tsukuda, M. Iwai, and M. Horiuchi Cross-talk between aldosterone and angiotensin II in vascular smooth muscle cell senescence Cardiovasc. Res. 76 2007 506 516 (Pubitemid 350007454)
180. M.F. Neves, F. Amiri, A. Virdis, Q.N. Diep, and E.L. Schiffrin Role of aldosterone in angiotensin II-induced cardiac and aortic inflammation, fibrosis, and hypertrophy Can. J. Physiol. Pharmacol. 83 2005 999 1006 (Pubitemid 43385544)
181. U. Hasler, S. Nielsen, E. Feraille, and P.Y. Martin Posttranscriptional control of aquaporin-2 abundance by vasopressin in renal collecting duct principal cells Am. J. Physiol. Renal Physiol 290 2006 F177 F187
182. J. Irita, T. Okura, M. Kurata, and K. Miyoshi Fukuoka, T.; Higaki, J. Osteopontin in rat renal fibroblasts: functional properties and transcriptional regulation by aldosterone Hypertension 51 2008 507 513 (Pubitemid 351156440)
183. A. Fiebeler, and F.C. Luft The mineralocorticoid receptor and oxidative stress Heart Fail. Rev. 10 2005 47 52 (Pubitemid 40895315)
184. A.M. Garrido, and K.K. Griendling NADPH oxidases and angiotensin II receptor signaling Mol. Cell. Endocrinol. 302 2009 148 158
185. N. Queisser, G. Fazeli, and N. Schupp Superoxide anion and hydrogen peroxide-induced signaling and damage in angiotensin II and aldosterone action Biol. Chem 391 2010 1265 1279
186. M.E. Ullian, and J.J. Fine Mechanisms of enhanced angiotensin II-stimulated signal transduction in vascular smooth muscle by aldosterone J. Cell. Physiol. 161 1994 201 208 (Pubitemid 24353547)
187. C.A. Lemarie, S.M. Simeone, A. Nikonova, T. Ebrahimian, M.E. Deschenes, T.M. Coffman, P. Paradis, and E.L. Schiffrin Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors Circ. Res. 105 2009 852 859
188. C.A. Lemarie, P. Paradis, and E.L. Schiffrin New insights on signaling cascades induced by cross-talk between angiotensin II and aldosterone J. Mol. Med. (Berl.) 86 2008 673 678
189. S. Filosto, E.M. Khan, E. Tognon, C. Becker, M. Ashfaq, T. Ravid, and T. Goldkorn EGF receptor exposed to oxidative stress acquires abnormal phosphorylation and aberrant activated conformation that impairs canonical dimerization PLoS ONE 6 2011 e23240
190. T. Goldkorn, T. Ravid, and E.M. Khan Life and death decisions: ceramide generation and EGF receptor trafficking are modulated by oxidative stress Antioxid. Redox Signal. 7 2005 119 128 (Pubitemid 40187930)
191. J.W. Funder, P.T. Pearce, R. Smith, and A.I. Smith Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated Science 242 1988 583 585 (Pubitemid 18263202)
192. M.A. Bailey, E. Craigie, D.E. Livingstone, Y.V. Kotelevtsev, E.A. Al-Dujaili, C.J. Kenyon, and J.J. Mullins Hsd11b2 haploinsufficiency in mice causes salt sensitivity of blood pressure Hypertension 57 2011 515 520
193. A.S. Mihailidou, Loan Le, T.Y. Mardini, and M. Funder J. W. Glucocorticoids activate cardiac mineralocorticoid receptors during experimental myocardial infarction Hypertension 54 2009 1306 1312
194. M.J. Young, and A.J. Rickard Mechanisms of mineralocorticoid salt-induced hypertension and cardiac fibrosis Mol. Cell. Endocrinol. 350 2012 248 255
195. M.R. Ward, P. Kanellakis, D. Ramsey, J. Funder, and A. Bobik Eplerenone suppresses constrictive remodeling and collagen accumulation after angioplasty in porcine coronary arteries Circulation 104 2001 467 472 (Pubitemid 32678279)
196. G. Güder, J. Bauersachs, S. Frantz, D. Weismann, B. Allolio, G. Ertl, C.E. Angermann, and S. Stork Complementary and incremental mortality risk prediction by cortisol and aldosterone in chronic heart failure Circulation 115 2007 1754 1761 (Pubitemid 46648612)
197. 2 in peripheral blood mononuclear cells Circulation 111 2005 51 57 (Pubitemid 40070843)
198. L. Yu, H.F. Bao, J.L. Self, D.C. Eaton, and M.N. Helms Aldosterone-induced increases in superoxide production counters nitric oxide inhibition of epithelial Na channel activity in A6 distal nephron cells Am. J. Physiol. 293 2007 F1666 F1677