Inhibitory effects of a dihydropyridine calcium channel blocker on renal injury in aldosterone-infused rats

Journal of Hypertension

Volumn 27, Issue 9, 2009, Pages 1855-1862

  Fan, Yu Yan ^a,b   Kohno, Masakazu ^a   Nakano, Daisuke ^b   Hitomi, Hirofumi ^b   Nagai, Yukiko ^a   Fujisawa, Yoshihide ^a   Lu, Xiao Mei ^b   Fu, Hua ^a   Du, Jun ^b   Ohmori, Koji ^a   Hosomi, Naohisa ^a   Kimura, Shoji ^b   Kiyomoto, Hideyasu ^a   Nishiyama, Akira ^b  

^a KAGAWA UNIVERSITY   (Japan)

^b KAGAWA UNIVERSITY   (Japan)

Author keywords

Aldosterone; Azelnidipine; Mineralocorticoid receptor; NAD(P)H oxidase; Oxidative stress; Renal injury

Indexed keywords

ALDOSTERONE; AZELNIDIPINE; CALCIUM CHANNEL BLOCKING AGENT; COLLAGEN; CONNECTIVE TISSUE GROWTH FACTOR; DIHYDROPYRIDINE; HYDRALAZINE; MEMBRANE PROTEIN; MESSENGER RNA; PROTEIN P22PHOX; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SUPEROXIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; CREATININE CLEARANCE; ENZYME ACTIVITY; FIBROSING ALVEOLITIS; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOPRECIPITATION; IN VITRO STUDY; INHIBITION KINETICS; KIDNEY CORTEX; KIDNEY FUNCTION; KIDNEY INJURY; MALE; MORPHOLOGY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYSTOLIC BLOOD PRESSURE; UNINEPHRECTOMY; URINARY EXCRETION; WESTERN BLOTTING;

EID: 73249151331     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/HJH.0b013e32832dda6f     Document Type: Article

References (30)

1. Fan YY, Baba R, Nagai Y, Hosomi N, Kimura S, Sun GP, et al. Augmentation of intrarenal angiotensin II levels in uninephrectomized aldosterone/safttreated hypertensive rats; renoprotective effects of an ultrahigh dose of olmesatan. Hypertens Res 2006; 29:169-178.
2. Williams GH, Burgess E, Kolloch RE, Ruilope LM, Niegowska J, Kipnes MS, et al. Efficacy of eplerenone versus enalapril as monotherapy in systemic hypertension. Am J Cardiol 2004; 93:990-996. (Pubitemid 38479452)
3. Sechi LA, Novello M, Lapenna R, Baroselli S, Nadalini E, Colussi GL, Catena C. Long-term renal outcomes in patients with primary aldosteronism. JAMA 2006; 295:2638-2645. (Pubitemid 43882339)
4. Miyata K, Rahman M, Shokoji T, Nagai Y, Zhang GX, Sun GP, et al. Aldosterone stimulates reactive oxygen species production through activation of NADPH oxidase in at mesangial cells. J Am Soc Nephrol 2005; 16:2906-2912. (Pubitemid 44743488)
5. Nishiyama A, Yao L, Nagai Y, Miyata K, Yoshizumi M, Kagami S, et al. Possible contributions of reactive oxygen species and mitogen-activated protein kinase to renal injury in aldosterone/salt-induced hypertensive rats. Hypertension 2004; 43:841-848.
6. Shibata S, Nagase M, Yoshida S, Kawachi H, Fujita T. Podocyte as the target for aldosterone: role of oxidative stress and sgk1. Hypertension 2007; 49:355-364.
7. Dietz JD, Du S, Bolten CW, Payne MA, Xia C, Blinn JR, et al. A number of marketed dihydropyridine calcium channel blockers have mineralocorticoid receptor antagonist activity. Hypertension 2008; 51:742-748. (Pubitemid 351301529)
8. Berkels R, Egink G, Marsen TA, Bartels H, Roesen R, Klais W. Nifedipine increases endothelial nitric oxide bioavailability by antioxidative mechanisms. Hypertension 2001; 37:240-245. (Pubitemid 32199081)
9. Manabe S, Okura T, Fukuoka T, Higaki J. Antioxidative effects of azelnidipine on mesangial cell proliferation induced by highly concentrated insulin. Eur J Pharmacol 2007; 567:252-257. (Pubitemid 46976885)
10. Matsui T, Yamagishi S, Nakamura K, Kikuchi S, Inoue H. Azelnidipine, a dihydropyridine-based calcium antagonist, inhibits angiotensin II-induced oxidative stress generation and downregulation of pigment epitheliumderived factor mRNA levels in microvascular endothelial cells. Drugs Exp Clin Res 2005; 31:215-219. (Pubitemid 43052035)
11. Shridi F, Robak J. The influence of calcium channel blocker on superoxide anions. Pharmcaol Res Commun 1998; 20:13-21.
12. Umemoto S, Tanaka M, Kawahara S, Kubo M, Umeji K, Hashimoto R, Matsuzaki M. Calcium antagonist reduces oxidative stress by upregulating Cu/Zn superoxide dismutase in stroke-prone spontaneously hypertensive rats. Hypertens Res 2004; 27:877-885. (Pubitemid 40309454)
13. Suzuki J, Iwai M, Li Z, Li JM, Min U, Ide A, et al. Effect of combination of calcium antagonist, azelnidipine, and AT1 receptor blocker, olmesartan, on atherosclerosis in apolipoprotein E-deficient mice. J Hypertens 2005; 23:1383-1389. (Pubitemid 40933959)
14. Iwai M, Chen R, Ide A, Iwanami J, Tomochika H, Tomono Y, et al. The calcium-channel blocker, azelnidipine, enhances the inhibitory action of AT1 receptor blockade on ischemic brain damage. J Hypertens 2006; 24:2023-2031. (Pubitemid 44371270)
15. Yamamoto E, Lai ZF, Yamashita T, Tanaka T, Kataoka K, Tokutomi Y, et al. Enhancement of cardiac oxidative stress by tachycardia and its critical role in cardiac hypertrophy and fibrosis. J Hypertens 2006; 24:2057-2069. (Pubitemid 44371273)
16. Ishizaka N, Saito K, Mitani H, Yamazaki I, Sata M, Usui S, et al. Iron overload augments angiotensin II-induced cardiac fibrosis and promotes neointima formation. Circulation 2002; 106:1840-1846.
17. Nishiyama A, Yoshizumi M, Rahman M, Kobori H, Seth DM, Miyatake A, et al. Effects of AT1 receptor blockade on renal injury and mitogen-activated protein activity in Dahl salt-sensitive rats. Kidney Int 2004; 65:972-981. (Pubitemid 38251073)
18. Fujii T, Takaoka M, Tsuruoka N, Kiso Y, Tanaka T, Matsumura Y. Dietary supplementation of L-camosine prevents ischemia/reperfusion-induced renal injury in rats. Biol Pharm Bull 2005; 28:361-363. (Pubitemid 40880025)
19. 1 phase cyclins and cyclindependent kinases during cardiomyocyte hypertrophic growth in rats. Am J Physiol 1998; 275:814-822.
20. Li JM, Shah A. Intracellular localization and preassembly of the NADPH oxidase complex in cultured endothelial cells. J Biol Chem 2002; 277:19952-19960. (Pubitemid 34967517)
21. Kimura S, Zhang GX, Nishiyama A, Shokoji T, Yao L, Fan YY, et al. Role of NAD(P)H oxidase- and Mitochondria-derived reactive oxygen species in cardioprotection of ischemic reperfusion injury by angiotensin II. Hypertension 2005; 45:860-866. (Pubitemid 40628929)
22. Nagai Y, Yao L, Kobori H, Miyata K, Ozawa Y, Miyatake A, et al. Temporary angiotensin II blockade at the prediabetic stage attenuates the development of renal injury in type 2 diabetic rats. J Am Soc Nephrol 2005; 16:703-711. (Pubitemid 41725107)
23. Nishiyama A, Yao L, Fan Y, Kyaw M, Kataoka N, Hashimoto K, et al. Involvement of aldosterone and mineralocorticoid receptors in rat mesangial cell proliferation and deformability. Hypertension 2005; 45:710-716. (Pubitemid 40418370)
24. Choi WS, Kruse SE, Palmiter RD, Xia Z. Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat. Proc Natl Acad Sci U S A 2008; 105:15136-15141.
25. Zhao H, Joseph J, Fales HM, Sokoloski EA, Levine RL, Vasquez-Vivar J, et al. Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence. Proc Natl Acad Sci USA 2005; 102:5727-5732. (Pubitemid 40559627)
26. Cominacini L, Pasini AF, Garbin U, Pastorino AM, Davoli A, Nava C, et al. Antioxidant activity of different dihydropyridines. Biochem Biophys Res Commun 2003; 679-684.
27. Pinto V, Pinho MJ, Hopfer U, Jose PA, Soares-da-Silva P. Oxidative stress and the genomic regulation of aldosterone-stimulated NHE1 activity in SHR renal proximal tubular cells. Mol Cell Biochem 2008; 310:191-201.
28. Saito K, Ishizaka N, Aizawa T, Sata M, Noiri E, Iso-O N, et al. Role of aberrant iron homeostasis in the upregulation of transforming growth factor-β1 in the kidney of angiotensin II-induced hypertensive rats. Hypertens Res 2004; 27:599-607. (Pubitemid 39335077)
29. Gröholm T, Finckenberg P, Palojoki E, Saraste A, Bäcklund T, Eriksson A, et al. Cardioprotective effects of vasopeptidase inhibition vs. angiotensin type 1 -receptor blockade in spontaneously hypertensive rats on a high salt diet. Hypertens Res 2004; 27:609-618. (Pubitemid 39335078)
30. Griffin KA, Abu-Amarah I, Picken M, Bidani AK. Renoprotection by ACE inhibitor or aldosterone blockade is blood pressure-dependent. Hypertension 2003; 41:201-206. (Pubitemid 36204889)