New aspects of rapid aldosterone signaling

Molecular and Cellular Endocrinology

Volumn 308, Issue 1-2, 2009, Pages 53-62

  Grossmann, C ^a   Gekle, M ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Aldosterone; Mineralocorticoid receptor; Nongenomic; Renocardiovascular remodeling

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALDOSTERONE; ANGIOTENSIN II; EPIDERMAL GROWTH FACTOR RECEPTOR; EPLERENONE; MINERALOCORTICOID ANTAGONIST; MINERALOCORTICOID RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SPIRONOLACTONE;

ALDOSTERONE RELEASE; BLOOD VESSEL TONE; CALCIUM CELL LEVEL; CARDIOVASCULAR DISEASE; CELL PH; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; CORONARY ARTERY BLOOD FLOW; ELECTROLYTE BALANCE; ENDOTHELIAL DYSFUNCTION; GENOMICS; GLOMERULUS FILTRATION RATE; HEART FAILURE; HEART HYPERTROPHY; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE FIBROSIS; HEART VENTRICLE REMODELING; HUMAN; HYPERTENSION; INFLAMMATION; ION TRANSPORT; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; VASCULAR RESISTANCE; VASCULAR SMOOTH MUSCLE;

ALDOSTERONE; ANIMALS; BRAIN; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMANS; RECEPTORS, MINERALOCORTICOID; SIGNAL TRANSDUCTION;

EID: 67349208215     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2009.02.005     Document Type: Review

References (152)

1. Ahmed T., Frey J.U., and Korz V. Long-term effects of brief acute stress on cellular signaling and hippocampal LTP. J. Neurosci. 26 (2006) 3951-3958
2. Alzamora R., Michea L., and Marusic E.T. Role of 11beta-hydroxysteroid dehydrogenase in nongenomic aldosterone effects in human arteries. Hypertension 35 (2000) 1099-1104
3. Alzamora R., Brown L.R., and Harvey B.J. Direct binding and activation of protein kinase C isoforms by aldosterone and 17β-estradiol. Mol. Endocrinol. 21 (2007) 2637-2650
4. Alzamora R., Marusic E.T., Gonzalez M., and Michea L. Nongenomic effect of aldosterone on Na+, K+-adenosine triphosphatase in arterial vessels. Endocrinology 144 (2003) 1266-1272
5. Arima S., Kohagura K., Xu H.L., Sugawara A., Abe T., Satoh F., Takeuchi K., and Ito S. Nongenomic vascular action of aldosterone in the glomerular microcirculation. J. Am. Soc. Nephrol. 14 (2003) 2255-2263
6. Arima S., Kohagura K., Xu H.L., Sugawara A., Uruno A., Satoh F., Takeuchi K., and Ito S. Endothelium-derived nitric oxide modulates vascular action of aldosterone in renal arteriole. Hypertension 43 (2004) 352-357
7. Avital A., Segal M., and Richter-Levin G. Contrasting roles of corticosteroid receptors in hippocampal plasticity. J. Neurosci. 26 (2006) 9130-9134
8. Barbato J.C., Mulrow P.J., Shapiro J.I., and Franco-Saenz R. Rapid effects of aldosterone and spironolactone in the isolated working rat heart. Hypertension 40 (2002) 130-135
9. Beckman J.S., Beckman T.W., Chen J., Marshall P., and Freeman B.A. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. U.S.A. 87 (1990) 1620-1624
10. Beckman J.S., and Koppenol W.H. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. AJP: Cell Physiol. 271 (1996) C1424-C1437
11. + channels (ROMK) mRNA expression by aldosterone in rat kidney. J. Physiol. (Lond.) 509 (1998) 629-634
12. Beggah A.T., Escoubet B., Puttini S., Cailmail S., Delage V., Ouvrard-Pascaud A., Bocchi B., Peuchmaur M., Delcayre C., Farman N., et al. Reversible cardiac fibrosis and heart failure induced by conditional expression of an antisense mRNA of the mineralocorticoid receptor in cardiomyocytes. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 7160-7165
13. Berger S., Wolfer D.P., Selbach O., Alter H., Erdmann G., Reichardt H.M., Chepkova A.N., Welzl H., Haas H.L., Lipp H.P., et al. Loss of the limbic mineralocorticoid receptor impairs behavioral plasticity. Proc. Natl. Acad. Sci. U.S.A. 103 (2006) 195-200
14. Blasi E.R., Rocha R., Rudolph A.E., Blomme E.A., Polly M.L., and McMahon E.G. Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats. Kidney Int. 63 (2003) 1791-1800
15. Blazer-Yost B.L., Helman S.I., Lee K.D., and Vlahos C.J. Phosphoinositide 3-kinase is required for aldosterone-regulated sodium reabsorption. AJP: Cell Physiol. 277 (1999) C531-C536
16. Bokemeyer D., Schmitz U., and Kramer H.J. Angiotensin II-induced growth of vascular smooth muscle cells requires an Src-dependent activation of the epidermal growth factor receptor. Kidney Int. 58 (2000) 549-558
17. Bowley K.A., Linley J.E., Robins G.G., Kopanati S., Hunter M., and Sandle G.I. Role of protein kinase C in aldosterone-induced non-genomic inhibition of basolateral potassium channels in human colonic crypts. J. Steroid Biochem. Mol. Biol. 104 (2007) 45-52
18. Braun S., Lösel R.M., Wehling M., and Boldyreff B. Aldosterone rapidly activates Src kinase in M-1 cells involving the mineralocorticoid receptor and HSP84. FEBS Lett. 570 (2004) 69-72
19. Brilla C.G., and Weber K.T. Mineralocorticoid excess, dietary sodium, and myocardial fibrosis. J. Lab. Clin. Med. 120 (1992) 893-901
20. Callera G.E., Montezano A.C.I., Yogi A., Tostes R.C., He Y., Schiffrin E.L., and Touyz R.M. c-Src-dependent nongenomic signaling responses to aldosterone are increased in vascular myocytes from spontaneously hypertensive rats. Hypertension 46 (2005) 1032-1038
21. Callera G.E., Touyz R.M., Tostes R.C., Yogi A., He Y., Malkinson S., and Schiffrin E.L. Aldosterone activates vascular p38MAP kinase and NADPH oxidase via c-Src. Hypertension 45 (2005) 773-779
22. Chai W., Garrelds I.M., Vries R.D., Batenburg W.W., van Kats J.P., and Danser A.H.J. Nongenomic effects of aldosterone in the human heart. Interaction with angiotensin II. Hypertension 46 (2005) 701-706
23. Chen S.-Y., Bhargava A., Mastroberardino L., Meijer O.C., Wang J., Buse P., Firestone G.L., Verrey F., and Pearce D. Epithelial sodium channel regulated by aldosterone-induced protein sgk. Proc. Natl. Acad. Sci. U.S.A. 96 (1999) 2514-2519
24. Christ M., Douwes K., Eisen C., Bechtner G., Theisen K., and Wehling M. Rapid effects of aldosterone on sodium transport in vascular smooth muscle cells. Hypertension 25 (1995) 117-123
25. Christ M., Eisen C., Aktas J., Theisen K., and Wehling M. The inositol-1,4,5-trisphosphate system is involved in rapid effects of aldosterone in human mononuclear leukocytes. J. Clin. Endocr. Metab. 77 (1993) 1452-1457
26. Christ M., Günther A., Heck M., Schmidt B.M.W., Falkenstein E., and Wehling M. Aldosterone, not estradiol, is the physiological agonist for rapid increases in cAMP in vascular smooth muscle cells. Circulation 99 (1999) 1485-1491
27. Christ M., Meyer C., Sippel K., and Wehling M. Rapid aldosterone signaling in vascular smooth muscle cells: involvement of phospholipase C, diacylglycerol and protein kinase C α. Biochem. Biophys. Res. Commun. 213 (1995) 123-129
28. Connell J.M.C., Fraser R., MacKenzie S., and Davies E. Is altered adrenal steroid biosynthesis a key intermediate phenotype in hypertension?. Hypertension 41 (2003) 993-999
29. Dallman M.F. Fast glucocorticoid actions on brain: back to the future. Front. Neuroendocrinol. 26 (2005) 103-108
30. de Kloet E.R., Karst H., and Joδls M. Corticosteroid hormones in the central stress response: quick-and-slow. Front. Neuroendocrinol. 29 (2008) 268-272
31. Di Zhang A., Cat A.N.D., Soukaseum C., Escoubet B., Cherfa A., Messaoudi S., Delcayre C., Samuel J.L., and Jaisser F. Cross-talk between mineralocorticoid and angiotensin II signaling for cardiac remodeling. Hypertension 52 (2008) 1060-1067
32. Di S., Malcher-Lopes R., Halmos K.C., and Tasker J.G. Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: a fast feedback mechanism. J. Neurosci. 23 (2003) 4850-4857
33. Doolan C.M., and Harvey B.J. Modulation of cytosolic protein kinase C and calcium ion activity by steroid hormones in rat distal colon. J. Biol. Chem. 271 (1996) 8763-8767
34. Doolan C.M., and Harvey B.J. Rapid effects of steroid hormones on free intracellular calcium in T84 colonic epithelial cells. Am. J. Physiol. 271 (1996) C1935-C1941
35. Doolan C.M., O'Sullivan G.C., and Harvey B.J. Rapid effects of corticosteroids on cytosolic protein kinase C and intracellular calcium concentration in human distal colon. Mol. Cell. Endocrinol. 138 (1998) 71-79
36. Dorrance A.M., Osborn H.L., Grekin R., and Webb R.C. Spironolactone reduces cerebral infarct size and EGF-receptor mRNA in stroke-prone rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281 (2001) R944-R950
37. Dorrance A.M., Rupp N.C., and Nogueira E.F. Mineralocorticoid receptor activation causes cerebral vessel remodeling and exacerbates the damage caused by cerebral ischemia. Hypertension 47 (2006) 590-595
38. + exchange in vascular smooth muscle cells by nongenomic and genomic mechanisms. Kidney Int. 56 (1999) 1400-1412
39. Estrada M., Liberona J.L., Miranda M., and Jaimovich E. Aldosterone- and testosterone-mediated intracellular calcium response in skeletal muscle cell cultures. Am. J. Physiol. Endocrinol. Metab. 279 (2000) E132-E139
40. Fardella C.E., Mosso L., Gomez-Sanchez C., Cortes P., Soto J., Gomez L., Pinto M., Huete A., Oestreicher E., Foradori A., et al. Primary hyperaldosteronism in essential hypertensives: prevalence, biochemical profile, and molecular biology. J. Clin. Endocrinol. Metab. 85 (2000) 1863-1867
41. Fiebeler A., Schmidt F., Muller D.N., Park J.K., Dechend R., Bieringer M., Shagdarsuren E., Breu V., Haller H., and Luft F.C. Mineralocorticoid receptor affects AP-1 and nuclear factor-kappab activation in angiotensin II-induced cardiac injury. Hypertension 37 (2001) 787-793
42. Fiebeler A., Nussberger J., Shagdarsuren E., Rong S., Hilfenhaus G., Al Saadi N., Dechend R., Wellner M., Meiners S., Maser-Gluth C., et al. Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage. Circulation 111 (2005) 3087-3094
43. Flamant M., Tharaux P.L., Placier S., Henrion D., Coffman T., Chatziantoniou C., and Dussaule J.C. Epidermal growth factor receptor transactivation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice. FASEB J. 17 (2003) 327-329
44. Florian J.A., Dorrance A., Webb R.C., and Watts S.W. Mineralocorticoids upregulate arterial contraction to epidermal growth factor. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2001) R878-R886 (JID-100901230 281)
45. Francois H., Placier S., Flamant M., Tharaux P.L., Chansel D., Dussaule J.C., and Chatziantoniou C. Prevention of renal vascular and glomerular fibrosis by epidermal growth factor receptor inhibition. FASEB J. 18 (2004) 926-928
46. Fujisawa G., Okada K., Muto S., Fujita N., Itabashi N., Kusano E., and Ishibashi S. Na/H exchange isoform 1 is involved in mineralocorticoid/salt-induced cardiac injury. Hypertension 41 (2003) 493-498
47. Fujita M., Minamino T., Asanuma H., Sanada S., Hirata A., Wakeno M., Myoishi M., Okuda H., Ogai A., Okada K.I., et al. Aldosterone nongenomically worsens ischemia via protein kinase C-dependent pathways in hypoperfused canine hearts. Hypertension 46 (2005) 113-117
48. Ganong W.F., and Mulrow P.J. Rate of change in sodium and potassium excretion after injection of aldosterone into the aorta and renal artery of the dog. Am. J. Physiol. 195 (1958) 337-342
49. +-exchange in MDCK-cells by aldosterone involves MAP-kinases ERK1/2. Pflügers Arch. 441 (2001) 781-786
50. Gekle M., Freudinger R., Mildenberger S., and Silbernagl S. Aldosterone interaction with epidermal growth factor receptor signaling in MDCK cells. Am. J. Physiol. Renal Physiol. 282 (2002) F669-F679
51. 2+ and stimulation of a plasma membrane proton conductance. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 10500-10504
52. Gekle M., Silbernagl S., and Oberleithner H. The mineralocorticoid aldosterone activates a proton conductance in cultured kidney cells. Am. J. Physiol. 273 (1997) C1673-C1678
53. Gekle M., Mildenberger S., Freudinger R., and Grossmann C. Altered collagen homeostasis in human aortic smooth muscle cells (HAoSMCs) induced by aldosterone. Pfluegers Arch. Eur. J. Physiol. 454 (2007) 403-413
54. Golestaneh N., Klein C., Valamanesh F., Suarez G., Agarwal M.K., and Mirshahi M. Mineralocorticoid receptor-mediated signaling regulates the ion gated sodium channel in vascular endothelial cells and requires an intact cytoskeleton. Biochem. Biophys. Res. Commun. 280 (2001) 1300-1306
55. - absorption via a nongenomic pathway in medullary thick ascending limb. Am. J. Physiol. 283 (2002) F699-F706
56. + exchanger. AJP: Cell Physiol. 290 (2006) C757-C763
57. Gros R., Ding Q., Armstrong S., O'Neil C., Pickering J.G., and Feldman R.D. Rapid effects of aldosterone on clonal human vascular smooth muscle cells. AJP: Cell Physiol. 292 (2007) C788-C794
58. Grossmann C., Benesic A., Krug A.W., Freudinger R., Mildenberger S., Gassner B., and Gekle M. Human mineralocorticoid receptor expression renders cells responsive for nongenotropic aldosterone actions. Mol. Endocrinol. 19 (2005) 1697-1710
59. Grossmann C., Freudinger R., Mildenberger S., Husse B., and Gekle M. EF domains are sufficient for nongenomic mineralocorticoid receptor actions. J. Biol. Chem. 283 (2008) 7109-7116
60. Grossmann C., Krug A.W., Freudinger R., Mildenberger S., Voelker K., and Gekle M. Aldosterone-induced EGFR expression: interaction between the human mineralocorticoid receptor and the human EGFR promoter. Am. J. Physiol. Endocrinol. Metab. 292 (2007) E1790-E1800
61. Gunaruwan P., Schmitt M., Sharman J., Lee L., Struthers A., and Frenneaux M. Effects of aldosterone on forearm vasculature in treated chronic heart failure. Am. J. Cardiol. 95 (2005) 412-414
62. Guo X., Razandi M., Pedram A., Kassab G., and Levin E.R. Estrogen induces vascular wall dilation: mediation through kinase signaling to nitric oxide and estrogen receptors alpha and beta. J. Biol. Chem. 280 (2005) 19704-19710
63. 2+ in M-1 cortical collecting duct cells. Kidney Int. 57 (2000) 1395-1403
64. Harvey B.J., Doolan C.M., Condliffe S.B., Renard C., Alzamora R., and Urbach V. Non-genomic convergent and divergent signalling of rapid responses to aldosterone and estradiol in mammalian colon. Steroids 67 (2002) 483-491
65. Haseroth K., Gerdes D., Berger S., Feuring M., Günther A., Herbst C., Christ M., and Wehling M. Rapid nongenomic effects of aldosterone in mineralocorticoid-receptor-knockout mice. Biochem. Biophys. Res. Commun. 266 (1999) 257-261
66. Hayashi H., Kobara M., Abe M.K., Tanaka N., Gouda E., Toba H., Yamada H., Tatsumi T., Nakata T., and Matsubara H. Aldosterone nongenomically produces NADPH oxidase-dependent reactive oxygen species and induces myocyte apoptosis. Hypertens. Res. 31 (2008) 363-375
67. Ishizawa K., Izawa Y., Ito H., Miki C., Miyata K., Fujita Y., Kanematsu Y., Tsuchiya K., Tamaki T., Nishiyama A., et al. Aldosterone stimulates vascular smooth muscle cell proliferation via big mitogen-activated protein kinase 1 activation. Hypertension 46 (2005) 1046-1052
68. Iwashima F., Yoshimoto T., Minami I., Sakurada M., Hirono Y., and Hirata Y. Aldosterone induces superoxide generation via Rac1 activation in endothelial cells. Endocrinology 149 (2008) 1009-1014
69. Jaffe I.Z., and Mendelsohn M.E. Angiotensin II and aldosterone regulate gene transcription via functional mineralocortocoid receptors in human coronary artery smooth muscle cells. Circ. Res. 96 (2005) 643-650
70. Kagiyama S., Qian K., Kagiyama T., and Phillips M.I. Antisense to epidermal growth factor receptor prevents the development of left ventricular hypertrophy. Hypertension 41 (2003) 824-829
71. Kagiyama S., Eguchi S., Frank G.D., Inagami T., Zhang Y.C., and Phillips M.I. Angiotensin II-induced cardiac hypertrophy and hypertension are attenuated by epidermal growth factor receptor antisense. Circulation 106 (2002) 909-912
72. Karst H., Berger S., Turiault M., Tronche F., and Schütz G. Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 19204-19207
73. Khaksari M., Rashidy-Pour A., and Vafaei A.A. Central mineralocorticoid receptors are indispensable for corticosterone-induced impairment of memory retrieval in rats. Neuroscience 149 (2007) 729-738
74. Klein K., and Henk W. Klinisch-experimentelle Untersuchung über den Einfluss von Aldosteron auf Hämodynamik und Gerinnung. Z. Kreisl. Forsch. 52 (1964) 40-53
75. Kobayashi N., Yoshida K., Nakano S., Ohno T., Honda T., Tsubokou Y., and Matsuoka H. Cardioprotective mechanisms of eplerenone on cardiac performance and remodeling in failing rat hearts. Hypertension 47 (2006) 671-679
76. Kolla V., and Litwack G. Transcriptional regulation of the human Na/K ATPase via the human mineralocorticoid receptor. Mol. Cell. Biochem. 204 (2000) 35-40
77. Kometiani P., Li J., Gnudi L., Kahn B.B., Askari A., and Xie Z. Multiple signal transduction pathways link Na+/K+-ATPase to growth-related genes in cardiac myocytes. The roles of Ras and mitogen-activated protein kinases. J. Biol. Chem. 273 (1998) 15249-15256
78. Korz V., and Frey J.U. Stress-related modulation of hippocampal long-term potentiation in rats: involvement of adrenal steroid receptors. J. Neurosci. 23 (2003) 7281-7287
79. Krug A.W., Schuster C., Gassner B., Freudinger R., Mildenberger S., Troppmair J., and Gekle M. Human EGF receptor 1 (HER1) expression renders CHO cells sensitive to alternative aldosterone signaling. J. Biol. Chem. 277 (2002) 45892-45897
80. Kuzkaya N., Weissmann N., Harrison D.G., and Dikalov S. Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase. J. Biol. Chem. 278 (2003) 22546-22554
81. Le Moellic C., Ouvrard-Pascaud A., Capurro C., Cluzeaud F., Fay M., Jaisser F., Farman N., and Blot-Chabaud M. Early nongenomic events in aldosterone action in renal collecting duct cells: PKCalpha activation, mineralocorticoid receptor phosphorylation, and cross-talk with the genomic response. J. Am. Soc. Nephrol. 15 (2004) 1145-1160
82. Leopold J.A., Dam A., Maron B.A., Scribner A.W., Liao R., Handy D.E., Stanton R.C., Pitt B., and Loscalzo J. Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity. Nat. Med. 13 (2007) 189-197
83. Liu S.L., Schmuck S., Chorazcyzewski J.Z., Gros R., and Feldman R.D. Aldosterone regulates vascular reactivity: short-term effects mediated by phosphatidylinositol 3-kinase-dependent nitric oxide synthase activation. Circulation 108 (2003) 2400-2406
84. Maguire D., MacNamara B., Cuffe J.E., Winter D., Doolan C.M., Urbach V., O'Sullivan G.C., and Harvey B.J. Rapid responses to aldosterone in human distal colon. Steroids 64 (1999) 51-63
85. Malcher-Lopes R., Di S., Marcheselli V.S., Weng F.J., Stuart C.T., Bazan N.G., and Tasker J.G. Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid release. J. Neurosci. 26 (2006) 6643-6650
86. + exchange in M-1 cortical collecting duct cells via a PKC-MAPK pathway. Nephron Physiol. 99 (2005) 1-9
87. Mazak I., Fiebeler A., Muller D.N., Park J.K., Shagdarsuren E., Lindschau C., Dechend R., Viedt C., Pilz B., Haller H., et al. Aldosterone potentiates angiotensin II-induced signaling in vascular smooth muscle cells. Circulation 109 (2004) 2792-2800
88. McEneaney V., Harvey B.J., and Thomas W. Aldosterone rapidly activates protein kinase D via a mineralocorticoid receptor/EGFR trans-activation pathway in the M1 kidney CCD cell line. J. Steroid Biochem. Mol. Biol. 107 (2007) 180-190
89. McEneaney V., Harvey B.J., and Thomas W. Aldosterone regulates rapid trafficking of epithelial sodium channel subunits in renal cortical collecting duct cells via protein kinase D activation. Mol. Endocrinol. 22 (2008) 881-892
90. 2+ levels, and vasoconstriction in mesenteric resistance vessels. Endocrinology 146 (2005) 973-980
91. +pump activation during short-term exposure of cardiac myocytes to aldosterone. Am. J. Physiol. 274 (1998) C175-C181
92. + pump. Circ. Res. 86 (2000) 37-42
93. Mihailidou A.S., and Funder J.W. Nongenomic effects of mineralocorticoid receptor activation in the cardiovascular system. Steroids 70 (2005) 347-351
94. Mihailidou A.S., Mardini M., and Funder J.W. Rapid, nongenomic effects of aldosterone in the heart mediated by epsilon protein kinase C. Endocrinology 145 (2004) 773-780
95. Mihailidou A.S. Nongenomic actions of aldosterone: physiological or pathophysiological role?. Steroids 71 (2006) 277-280
96. Mihailidou A.S., Mardini M., and Funder J.W. Rapid, nongenomic effects of aldosterone in the heart mediated by {epsilon} protein kinase C. Endocrinology 145 (2004) 773-780
97. Mihailidou A.S., Mardini M., Funder J.W., and Raison M. Mineralocorticoid and angiotensin receptor antagonism during hyperaldosteronemia. Hypertension 40 (2002) 124-129
98. Min L.J., Mogi M., Li J.M., Iwanami J., Iwai M., and Horiuchi M. Aldosterone and angiotensin II synergistically induce mitogenic response in vascular smooth muscle cells. Circ. Res. 97 (2005) 434-442
99. + exchange in vascular smooth muscle cells. J. Hypertens. 12 (2005) 2237-2250
100. Miyata K., Rahman M., Shokoji T., Nagai Y., Zhang G.X., Sun G.P., Kimura S., Yukimura T., Kiyomoto H., Kohno M., et al. Aldosterone stimulates reactive oxygen species production through activation of NADPH oxidase in rat mesangial cells. J. Am. Soc. Nephrol. 16 (2005) 2906-2912
101. Montezano A.C., Callera G.E., Yogi A., He Y., Tostes R.C., He G., Schiffrin E.L., and Touyz R.M. Aldosterone and angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways. Arterioscler. Thromb. Vasc. Biol. 28 (2008) 1511-1518
102. Moura A.M., and Worcel M. Direct action of aldosterone on transmembrane 22Na efflux from arterial smooth muscle. Rapid and delayed effects. Hypertension 6 (1984) 425-430
103. Mutoh A., Isshiki M., and Fujita T. Aldosterone enhances ligand-stimulated nitric oxide production in endothelial cells. Hypertens. Res. 31 (2008) 1811-1820
104. Nagata D., Takahashi M., Sawai K., Tagami T., Usui T., Shimatsu A., Hirata Y., and Naruse M. Molecular mechanism of the inhibitory effect of aldosterone on endothelial NO synthase activity. Hypertension 48 (2006) 165-171
105. Nakano S., Kobayashi N., Yoshida K., Ohno T., and Matsuoka H. Cardioprotective mechanisms of spironolactone associated with the angiotensin-converting enzyme/epidermal growth factor receptor/extracellular signal-regulated kinases, NAD(P)H oxidase/lectin-like oxidized low-density lipoprotein receptor-1, and Rho-Kinase pathways in aldosterone/salt-induced hypertensive rats. Hypertens. Res. 28 (2005) 925-936
106. Nietlispach F., Julius B., Schindler R., Bernheim A., Binkert C., Kiowski W., and Brunner-La Rocca H.P. Influence of acute and chronic mineralocorticoid excess on endothelial function in healthy men. Hypertension 50 (2007) 82-88
107. +exchange and raises cytoplasmic pH in target cells of the amphibian kidney. Proc. Natl. Acad. Sci. U.S.A. 84 (1987) 1464-1468
108. Oitzl M., Flyvbjerg A., and de Kloet E.R. The effect of corticosterone on reactivity to spatial novelty is mediated by central mineralocorticosteroid receptors. Eur. J. Neurosci. 6 (1994) 1072-1079
109. Olijslagers J., de Kloet E.R., Elgersma Y., van Woerden G., Joels M., and Karst H. Rapid changes in hippocampal CA1 pyramidal cell function via pre- as well as postsynaptic membrane mineralocorticoid receptors. Eur. J. Neurosci. 27 (2008) 2542-2550
110. Orshal J.M., and Khalil R.A. Gender, sex hormones, and vascular tone. AJP: Regul. Integr. Comp. Physiol. 286 (2004) R233-R249
111. Ouvrard-Pascaud A., Sainte-Marie Y., Benitah J.P., Perrier R., Soukaseum C., Cat A.N.D., Royer A., Le Quang K., Charpentier F., Demolombe S., et al. Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias. Circulation 111 (2005) 3025-3033
112. Pitt B., Remme W., Zannad F., Neaton J., Martinez F., Roniker B., Bittman R., Hurley S., Kleiman J., and Gatlin M. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N. Engl. J. Med. 348 (2003) 1309-1321
113. Pitt B., Zannad F., Remme W.J., Cody R., Castaigne A., Perez A., Palensky J., and Wittes J. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N. Engl. J. Med. 341 (1999) 709-717
114. Pitt B., Reichek N., Willenbrock R., Zannad F., Phillips R.A., Roniker B., Kleiman J., Krause S., Burns D., and Williams G.H. Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study. Circulation 108 (2003) 1831-1838
115. Pu Z., Krugers H., and Joels M. Corticosterone time-dependently modulates beta-adrenergic effects on long-term potentiation in the hippocampal dentate gyrus. Learn Memory 14 (2007) 359-367
116. Qin W., Rudolph A.E., Bond B.R., Rocha R., Blomme E.A.G., Goellner J.J., Funder J.W., and McMahon E.G. Transgenic model of aldosterone-driven cardiac hypertrophy and heart failure. Circ. Res. 93 (2003) 69-76
117. Rocha R., Rudolph A.E., Frierdich G.E., Nachowiak D.A., Kekec B.K., Blomme E.A., McMahon E.G., and Delyani J.A. Aldosterone induces a vascular inflammatory phenotype in the rat heart. Am. J. Physiol. Heart Circ. Physiol. 283 (2002) H1802-H1810
118. Romagni P., Rossi F., Guerrini L., Quirini C., and Santiemma V. Aldosterone induces contraction of the resistance arteries in man. Atherosclerosis 166 (2003) 345-349
119. Rossi G.P., Bernini G., Caliumi C., Desideri G., Fabris B., Ferri C., Ganzaroli C., Giacchetti G., Letizia C., Maccario M., et al. A Prospective Study of the Prevalence of Primary Aldosteronism in 1,125 Hypertensive Patients. J. Am. Coll. Cardiol. 48 (2006) 2293-2300
120. Rossol-Haseroth K., Zhou Q., Braun S., Boldyreff B., Falkenstein E., Wehling M., and Losel R.M. Mineralocorticoid receptor antagonists do not block rapid ERK activation by aldosterone. Biochem. Biophys. Res Commun. 318 (2004) 281-288
121. Rude M.K., Duhaney T.A., Kuster G.M., Judge S., Heo J., Colucci W.S., Siwik D.A., and Sam F. Aldosterone stimulates matrix metalloproteinases and reactive oxygen species in adult rat ventricular cardiomyocytes. Hypertension 46 (2005) 555-561
122. Schmidt B.M., Sammer U., Fleischmann I., Schlaich M., Delles C., and Schmieder R.E. Rapid nongenomic effects of aldosterone on the renal vasculature in humans. Hypertension 47 (2006) 650-655
123. Schmidt B.M.W., Georgens A.C., Martin N., Tillmann H.-C., Feuring M., Christ M., and Wehling M. Interaction of rapid nongenomic cardiovascular aldosterone effects with the adrenergic system. J. Clin. Endocrinol. Metab. 86 (2001) 761-767
124. Schmidt B.M.W., Montealegre A., Janson C.P., Martin N., Stein-Kemmesies C., Scherhag A., Feuring M., Christ M., and Wehling M. Short term cardiovascular effects of aldosterone in healthy male volunteers. J. Clin. Endocrinol. Metab. 84 (1999) 3528-3533
125. Schmidt B.M.W., Oehmer S., Delles C., Bratke R., Schneider M.P., Klingbeil A., Fleischmann E.H., and Schmieder R.E. Rapid nongenomic effects of aldosterone on human forearm vasculature. Hypertension 42 (2003) 156-160
126. Schneider M., Ulsenheimer A., Christ M., and Wehling M. Nongenomic effects of aldosterone on intracellular calcium in porcine endothelial cells. Am. J. Physiol. Endocrinol. Metab. 272 (1997) E616-E620
127. Schneider S.W., Yano Y., Sumpio B.E., Jena B.P., Geibel J.P., Gekle M., and Oberleithner H. Rapid aldosterone-induced cell volume increase of endothelial cells measured by the atomic force microscope. Cell Biol. Int. 21 (1997) 759-768
128. Sheader E.A., Wargent E.T., Ashton N., and Balment R.J. Rapid stimulation of cyclic AMP production by aldosterone in rat inner medullary collecting ducts. J. Endocrinol. 175 (2002) 343-347
129. Simpson S., Tait J., Wettstein A., Neher R., von Euw J., Schindler O., and Reichenstein T. Constitution of aldosterone, a new mineralocorticoid. Experientia 10 (1954) 132-133
130. Skott O., Uhrenholt T.R., Schjerning J., Hansen P.B.L., Rasmussen L.E., and Jensen B.L. Rapid actions of aldosterone in vascular health and disease--friend or foe?. Pharmacol. Ther. 111 (2006) 495-507
131. Spach C., and Streeten D.H. Retardation of sodium exchange in dog erythrocytes by physiological concentrations of aldosterone, in vitro. J.Clin. Invest. 43 (1964) 217-227
132. Stockand J.D., and Meszaros J.G. Aldosterone stimulates proliferation of cardiac fibroblasts by activating Ki-RasA and MAPK1/2 signaling. Am. J. Physiol. Heart Circ. Physiol. 284 (2003) H176-H184
133. Terada Y., Kobayashi T., Kuwana H., Tanaka H., Inoshita S., Kuwahara M., and Sasaki S. Aldosterone stimulates proliferation of mesangial cells by activating mitogen-activated protein kinase 1/2, cyclin D1, and cyclin A. J. Am. Soc. Nephrol. 16 (2005) 2296-2305
134. Terzi F., Burtin M., Hekmati M., Federici P., Grimber G., Briand P., and Friedlander G. Targeted expression of a dominant-negative EGF-R in the kidney reduces tubulo-interstitial lesions after renal injury. J. Clin. Invest. 106 (2000) 225-234
135. Uhrenholt T.R., Schjerning J., Hansen P.B., Norregaard R., Jensen B.L., Sorensen G.L., and Skott O. Rapid inhibition of vasoconstriction in renal afferent arterioles by aldosterone. Circ. Res. 93 (2003) 1258-1266
136. Ullian M.E., Walsh L.G., and Morinelli T.A. Potentiation of angiotensin II action by corticosteroids in vascular tissue. Cardiovas. Res. 32 (1996) 266-273
137. Virdis A., Neves M.F., Amiri F., Viel E., Touyz R.M., and Schiffrin E.L. Spironolactone improves angiotensin-induced vascular changes and oxidative stress. Hypertension 40 (2002) 504-510
138. Watts III B.A., George T., and Good D.W. Aldosterone inhibits apical NHE3 and HCO3- absorption via a nongenomic ERK-dependent pathway in medullary thick ascending limb. AJP: Renal Physiol. 291 (2006) F1005-F1013
139. Wehling M., Bauer M.M., Ulsenheimer A., Schneider M., Neylon C.B., and Christ M. Nongenomic effects of aldosterone on intracellular pH in vascular smooth muscle cells. Biochem. Biophys. Res. Commun. 223 (1996) 181-186
140. Wehling M., Käsmayr J., and Theisen K. Fast effects of aldosterone on electrolytes in human lymphocytes are mediated by the sodium-proton-exchanger of the cell membrane. Biochem. Biophys. Res. Commun. 164 (1989) 961-967
141. Wehling M., Käsmayr J., and Theisen K. Aldosterone influences free intracellular calcium in human mononuclear leukocytes in vitro. Cell Calcium 11 (1990) 565-571
142. Wehling M., Kuhls S., and Armanini D. Volume regulation of human lymphocytes by aldosterone in isotonic media. Am. J. Physiol. 257 (1989) E170-E174
143. 2+ in vascular smooth muscle cells. Circ. Res. 76 (1995) 973-979
144. Wehling M., Spes C.H., Win N., Janson C.P., Schmidt B.M.W., Theisen K., and Christ M. Rapid cardiovascular action of aldosterone in man. J. Clin. Endocrinol. Metab. 83 (1998) 3517-3522
145. Wehling M., Ulsenheimer A., Schneider M., Neylon C., and Christ M. Rapid effects of aldosterone on free intracellular calcium in vascular smooth muscle and endothelial cells: subcellular localization of calcium elevations by single cell imaging. Biochem. Biophys. Res. Commun. 204 (1994) 475-481
146. +-ATPases in intercalated renal tubule cells by aldosterone. Proc. Natl. Acad. Sci. 101 (2004) 2636-2641
147. Xiao F., Puddefoot J., and Vinson G.P. Aldosterone mediates angiotensin II-stimulated rat vascular smooth muscle cell proliferation. J. Endocrinol. 165 (2000) 533-536
148. Xiao F., Puddefoot J.R., Barker S., and Vinson G.P. Mechanism for aldosterone potentiation of angiotensin II-stimulated rat arterial smooth muscle cell proliferation. Hypertension 44 (2004) 340-345
149. Young M., and Funder J. Mineralocorticoid action and sodium-hydrogen exchange: studies in experimental cardiac fibrosis. Endocrinology 144 (2003) 3848-3851
150. Zhai P., Galeotti J., Liu J., Holle E., Yu X., Wagner T., and Sadoshima J. An angiotensin II type 1 receptor mutant lacking epidermal growth factor receptor transactivation does not induce angiotensin II-mediated cardiac hypertrophy. Circ. Res. 99 (2006) 528-536
151. Zhang A., Jia Z., Guo X., and Yang T. Aldosterone induces epithelial-mesenchymal transition via ROS of mitochondrial origin. AJP: Renal Physiol. 293 (2007) F723-F731
152. Zhu Y., Rice C.D., Pang Y., Pace M., and Thomas P. Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 2231-2236