Non-genomic actions of aldosterone: From receptors and signals to membrane targets

Molecular and Cellular Endocrinology

Volumn 350, Issue 2, 2012, Pages 223-234

  Dooley, Ruth ^a   Harvey, Brian J ^a   Thomas, Warren ^a  

^a BEAUMONT HOSPITAL   (Ireland)

Author keywords

Aldosterone; ENaC; Kidney; Mineralocorticoid receptor; Non genomic; Protein kinase D

Indexed keywords

ALDOSTERONE; CALCIUM ION; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; EPIDERMAL GROWTH FACTOR RECEPTOR; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; MICRORNA; MITOGEN ACTIVATED PROTEIN KINASE; POTASSIUM ION; PROTEIN KINASE C; STEROID RECEPTOR COACTIVATOR 3;

APOPTOSIS; CELL CYCLE PROGRESSION; CELL GROWTH; CELL SURVIVAL; DNA REPAIR; HORMONE ACTION; HORMONE BINDING; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; PROTEIN TARGETING; REVIEW;

ALDOSTERONE; ANIMALS; CELL MEMBRANE; CYTOPLASM; HUMANS; MODELS, BIOLOGICAL; PROTEIN KINASES; RECEPTOR CROSS-TALK; RECEPTORS, ALDOSTERONE; SECOND MESSENGER SYSTEMS; SIGNAL TRANSDUCTION;

EID: 84855642277     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2011.07.019     Document Type: Review

References (157)

1. Acconcia F., Ascenzi P., Bocedi A., Spisni E., Tomasi V., Trentalance A., Visca P., Marino M. Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol. Mol. Biol. Cell 2005, 16:231-237.
2. Aguilar-Bryan L., Clement J.P.T., Gonzalez G., Kunjilwar K., Babenko A., Bryan J. Toward understanding the assembly and structure of KATP channels. Physiol. Rev. 1998, 78:227-245.
3. + transport by aldosterone in turtle urinary bladder. J. Clin. Invest. 1976, 58:351-358.
4. Alzamora R., Harvey B.J. Direct binding and activation of protein kinase C isoforms by steroid hormones. Steroids 2008, 73:885-888.
5. Alzamora R., Brown L.R., Harvey B.J. Direct binding and activation of protein kinase C isoforms by aldosterone and 17beta-estradiol. Mol. Endocrinol. 2007, 21:2637-2650.
6. Amazit L., Pasini L., Szafran A.T., Berno V., Wu R.C., Mielke M., Jones E.D., Mancini M.G., Hinojos C.A., O'Malley B.W., Mancini M.A. Regulation of SRC-3 intercompartmental dynamics by estrogen receptor and phosphorylation. Mol. Cell. Biol. 2007, 27:6913-6932.
7. Arima S., Kohagura K., Xu H.L., Sugawara A., Abe T., Satoh F., Takeuchi K., Ito S. Nongenomic vascular action of aldosterone in the glomerular microcirculation. J. Am. Soc. Nephrol. 2003, 14:2255-2263.
8. Arima S., Kohagura K., Xu H.L., Sugawara A., Uruno A., Satoh F., Takeuchi K., Ito S. Endothelium-derived nitric oxide modulates vascular action of aldosterone in renal arteriole. Hypertension 2004, 43:352-357.
9. + exchanger. Ann. NY Acad. Sci. 1985, 456:220-228.
10. + channel subunits. Am. J. Physiol. 1996, 271:C605-C611.
11. + channels (ROMK) mRNA expression by aldosterone in rat kidney. J. Physiol. 1998, 509(Pt 3):629-634.
12. Bhargava A., Fullerton M.J., Myles K., Purdy T.M., Funder J.W., Pearce D., Cole T.J. The serum- and glucocorticoid-induced kinase is a physiological mediator of aldosterone action. Endocrinology 2001, 142:1587-1594.
13. + transport. J. Physiol. 1989, 410:425-441.
14. Biondi R.M., Kieloch A., Currie R.A., Deak M., Alessi D.R. The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB. EMBO J. 2001, 20:4380-4390.
15. Blind R.D., Garabedian M.J. Differential recruitment of glucocorticoid receptor phospho-isoforms to glucocorticoid-induced genes. J. Steroid Biochem. Mol. Biol. 2008, 109:150-157.
16. Bowley K.A., Morton M.J., Hunter M., Sandle G.I. Non-genomic regulation of intermediate conductance potassium channels by aldosterone in human colonic crypt cells. Gut 2003, 52:854-860.
17. Bowley K.A., Linley J.E., Robins G.G., Kopanati S., Hunter M., Sandle G.I. Role of protein kinase C in aldosterone-induced non-genomic inhibition of basolateral potassium channels in human colonic crypts. J. Steroid Biochem. Mol. Biol. 2007, 104:45-52.
18. Callera G.E., Montezano A.C., Yogi A., Tostes R.C., He Y., Schiffrin E.L., Touyz R.M. C-Src-dependent nongenomic signaling responses to aldosterone are increased in vascular myocytes from spontaneously hypertensive rats. Hypertension 2005, 46:1032-1038.
19. Calo L.A., Zaghetto F., Pagnin E., Davis P.A., De Mozzi P., Sartorato P., Martire G., Fiore C., Armanini D. Effect of aldosterone and glycyrrhetinic acid on the protein expression of PAI-1 and p22(phox) in human mononuclear leukocytes. J. Clin. Endocrinol. Metab. 2004, 89:1973-1976.
20. Chen C., Liang W., Jia J., van Goor H., Singhal P.C., Ding G. Aldosterone induces apoptosis in rat podocytes: role of PI3-K/Akt and p38MAPK signaling pathways. Nephron Exp. Nephrol. 2009, 113:e26-e34.
21. Christ M., Gunther A., Heck M., Schmidt B.M., Falkenstein E., Wehling M. Aldosterone, not estradiol, is the physiological agonist for rapid increases in cAMP in vascular smooth muscle cells. Circulation 1999, 99:1485-1491.
22. Debonneville C., Flores S.Y., Kamynina E., Plant P.J., Tauxe C., Thomas M.A., Munster C., Chraibi A., Pratt J.H., Horisberger J.D., Pearce D., Loffing J., Staub O. Phosphorylation of Nedd4-2 by SGK1 regulates epithelial Na(+) channel cell surface expression. EMBO J. 2001, 20:7052-7059.
23. Diah S., Zhang G.X., Nagai Y., Zhang W., Gang L., Kimura S., Hamid M.R., Tamiya T., Nishiyama A., Hitomi H. Aldosterone induces myofibroblastic transdifferentiation and collagen gene expression through the Rho-kinase dependent signaling pathway in rat mesangial cells. Exp. Cell Res. 2008, 314:3654-3662.
24. Doolan C.M., O'Sullivan G.C., Harvey B.J. Rapid effects of corticosteroids on cytosolic protein kinase C and intracellular calcium concentration in human distal colon. Mol. Cell. Endocrinol. 1998, 138:71-79.
25. Doolan C.M., Condliffe S.B., Harvey B.J. Rapid non-genomic activation of cytosolic cyclic AMP-dependent protein kinase activity and [Ca(2+)](i) by 17beta-oestradiol in female rat distal colon. Br. J. Pharmacol. 2000, 129:1375-1386.
26. Drumm K., Kress T.R., Gassner B., Krug A.W., Gekle M. Aldosterone stimulates activity and surface expression of NHE3 in human primary proximal tubule epithelial cells (RPTEC). Cell. Physiol. Biochem. 2006, 17:21-28.
27. + exchange in vascular smooth muscle cells by nongenomic and genomic mechanisms. Kidney Int. 1999, 56:1400-1412.
28. Ehrenfeld J., Garcia-Romeu F. Active hydrogen excretion and sodium absorption through isolated frog skin. Am. J. Physiol. 1977, 233:F46-F54.
29. Elvira-Matelot E., Zhou X.O., Farman N., Beaurain G., Henrion-Caude A., Hadchouel J., Jeunemaitre X. Regulation of WNK1 expression by miR-192 and aldosterone. J. Am. Soc. Nephrol. 2010, 21:1724-1731.
30. Forstermann, U., Li, H., 2010. Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling. Br. J. Pharmacol., in press, doi:10.1111/j.1476-5381.2010.01196.x.
31. + exchange system in vascular smooth muscle cells. Adv. Nephrol. Necker Hosp. 1990, 19:17-29.
32. Fuller P.J., Verity K. Mineralocorticoid receptor gene expression in the gastrointestinal tract: distribution and ontogeny. J. Steroid Biochem. 1990, 36:263-267.
33. 2+ and stimulation of a plasma membrane proton conductance. Proc. Natl. Acad. Sci. USA 1996, 93:10500-10504.
34. +-exchange in MDCK cells by aldosterone involves MAP-kinase ERK1/2. Pflugers Arch. 2001, 441:781-786.
35. Gianni M., Parrella E., Raska I., Gaillard E., Nigro E.A., Gaudon C., Garattini E., Rochette-Egly C. P38MAPK-dependent phosphorylation and degradation of SRC-3/AIB1 and RARalpha-mediated transcription. EMBO J. 2006, 25:739-751.
36. Giovannardi S., Forlani G., Balestrini M., Bossi E., Tonini R., Sturani E., Peres A., Zippel R. Modulation of the inward rectifier potassium channel IRK1 by the Ras signaling pathway. J. Biol. Chem. 2002, 277:12158-12163.
37. Good D.W., George T., Watts B.A. Aldosterone inhibits HCO absorption via a nongenomic pathway in medullary thick ascending limb. Am. J. Physiol. Renal Physiol. 2002, 283:F699-F706.
38. Good D.W., George T., Watts B.A. Nongenomic regulation by aldosterone of the epithelial NHE3 Na(+)/H(+) exchanger. Am. J. Physiol. Cell Physiol. 2006, 290:C757-C763.
39. Goto J., Otsuka F., Yamashita M., Suzuki J., Otani H., Takahashi H., Miyoshi T., Mimura Y., Ogura T., Makino H. Enhancement of aldosterone-induced catecholamine production by bone morphogenetic protein-4 through activating Rho and SAPK/JNK pathway in adrenomedullar cells. Am. J. Physiol. Endocrinol. Metab. 2009, 296:E904-E916.
40. + channel by interaction of Nedd4 with a PY motif deleted in Liddle's syndrome. J. Biol. Chem. 1998, 273:30012-30017.
41. Gros R., Ding Q., Sklar L.A., Prossnitz E.E., Arterburn J.B., Chorazyczewski J., Feldman R.D. GPR30 expression is required for the mineralocorticoid receptor-independent rapid vascular effects of aldosterone. Hypertension 2011, 57:442-451.
42. Grossmann C., Benesic A., Krug A.W., Freudinger R., Mildenberger S., Gassner B., Gekle M. Human mineralocorticoid receptor expression renders cells responsive for nongenotropic aldosterone actions. Mol. Endocrinol. 2005, 19:1697-1710.
43. Grossmann C., Krug A.W., Freudinger R., Mildenberger S., Voelker K., Gekle M. Aldosterone-induced EGFR expression: interaction between the human mineralocorticoid receptor and the human EGFR promoter. Am. J. Physiol. Endocrinol. Metab. 2007, 292:E1790-E1800.
44. Grossmann C., Husse B., Mildenberger S., Schreier B., Schuman K., Gekle M. Colocalization of mineralocorticoid and EGF receptor at the plasma membrane. Biochim. Biophys. Acta 2010, 1803:584-590.
45. Grossmann C., Wuttke M., Ruhs S., Seiferth A., Mildenberger S., Rabe S., Schwerdt G., Gekle M. Mineralocorticoid receptor inhibits CREB signaling by calcineurin activation. FASEB J. 2010, 24:2010-2019.
46. Harvey B.J. Energization of sodium absorption by the H(+)-ATPase pump in mitochondria-rich cells of frog skin. J. Exp. Biol. 1992, 172:289-309.
47. 2+ in M-1 cortical collecting duct cells. Kidney Int. 2000, 57:1395-1403.
48. Hashikabe Y., Suzuki K., Jojima T., Uchida K., Hattori Y. Aldosterone impairs vascular endothelial cell function. J. Cardiovasc. Pharmacol. 2006, 47:609-613.
49. Hausser A., Storz P., Martens S., Link G., Toker A., Pfizenmaier K. Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIbeta at the Golgi complex. Nat. Cell Biol. 2005, 7:880-886.
50. Hayashi K., Ozawa Y., Fujiwara K., Wakino S., Kumagai H., Saruta T. Role of actions of calcium antagonists on efferent arterioles - with special references to glomerular hypertension. Am. J. Nephrol. 2003, 23:229-244.
51. Hayashi H., Kobara M., Abe M., Tanaka N., Gouda E., Toba H., Yamada H., Tatsumi T., Nakata T., Matsubara H. Aldosterone nongenomically produces NADPH oxidase-dependent reactive oxygen species and induces myocyte apoptosis. Hypertens. Res. 2008, 31:363-375.
52. Hebert S.C., Desir G., Giebisch G., Wang W. Molecular diversity and regulation of renal potassium channels. Physiol. Rev. 2005, 85:319-371.
53. Helms M.N., Liu L., Liang Y.Y., Al-Khalili O., Vandewalle A., Saxena S., Eaton D.C., Ma H.P. Phosphatidylinositol 3,4,5-trisphosphate mediates aldosterone stimulation of epithelial sodium channel (ENaC) and interacts with gamma-ENaC. J. Biol. Chem. 2005, 280:40885-40891.
54. Hirono Y., Yoshimoto T., Suzuki N., Sugiyama T., Sakurada M., Takai S., Kobayashi N., Shichiri M., Hirata Y. Angiotensin II receptor type 1-mediated vascular oxidative stress and proinflammatory gene expression in aldosterone-induced hypertension: the possible role of local renin-angiotensin system. Endocrinology 2007, 148:1688-1696.
55. Hoang T., Fenne I.S., Cook C., Borud B., Bakke M., Lien E.A., Mellgren G. CAMP-dependent protein kinase regulates ubiquitin-proteasome-mediated degradation and subcellular localization of the nuclear receptor coactivator GRIP1. J. Biol. Chem. 2004, 279:49120-49130.
56. Huang Y., Kim S.O., Jiang J., Frank S.J. Growth hormone-induced phosphorylation of epidermal growth factor (EGF) receptor in 3T3-F442A cells. Modulation of EGF-induced trafficking and signaling. J. Biol. Chem. 2003, 278:18902-18913.
57. Huang B., Chen S.C., Wang D.L. Shear flow increases S-nitrosylation of proteins in endothelial cells. Cardiovasc. Res. 2009, 83:536-546.
58. Inui M., Martello G., Piccolo S. MicroRNA control of signal transduction. Nat. Rev. Mol. Cell Biol. 2010, 11:252-263.
59. Iwakiri Y., Satoh A., Chatterjee S., Toomre D.K., Chalouni C.M., Fulton D., Groszmann R.J., Shah V.H., Sessa W.C. Nitric oxide synthase generates nitric oxide locally to regulate compartmentalized protein S-nitrosylation and protein trafficking. Proc. Natl. Acad. Sci. USA 2006, 103:19777-19782.
60. Jasti J., Furukawa H., Gonzales E.B., Gouaux E. Structure of acid-sensing ion channel 1 at 1.9A resolution and low pH. Nature 2007, 449:316-323.
61. Kato S., Endoh H., Masuhiro Y., Kitamoto T., Uchiyama S., Sasaki H., Masushige S., Gotoh Y., Nishida E., Kawashima H., Metzger D., Chambon P. Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. Science 1995, 270:1491-1494.
62. Kim H.P., Lee J.Y., Jeong J.K., Bae S.W., Lee H.K., Jo I. Nongenomic stimulation of nitric oxide release by estrogen is mediated by estrogen receptor alpha localized in caveolae. Biochem. Biophys. Res. Commun. 1999, 263:257-262.
63. Kino T., Souvatzoglou E., Charmandari E., Ichijo T., Driggers P., Mayers C., Alatsatianos A., Manoli I., Westphal H., Chrousos G.P., Segars J.H. Rho family guanine nucleotide exchange factor Brx couples extracellular signals to the glucocorticoid signaling system. J. Biol. Chem. 2006, 281:9118-9126.
64. Kobayashi T., Cohen P. Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2. Biochem. J. 1999, 339(Pt 2):319-328.
65. Kohda Y., Ding W., Phan E., Housini I., Wang J., Star R.A., Huang C.L. Localization of the ROMK potassium channel to the apical membrane of distal nephron in rat kidney. Kidney Int. 1998, 54:1214-1223.
66. Kolla V., Litwack G. Transcriptional regulation of the human Na/K ATPase via the human mineralocorticoid receptor. Mol. Cell. Biochem. 2000, 204:35-40.
67. Krug A.W., Papavassiliou F., Hopfer U., Ullrich K.J., Gekle M. Aldosterone stimulates surface expression of NHE3 in renal proximal brush borders. Pflugers Arch. 2003, 446:492-496.
68. Kunzelmann K., Mall M. Electrolyte transport in the mammalian colon: mechanisms and implications for disease. Physiol. Rev. 2002, 82:245-289.
69. Le Moellic C., Ouvrard-Pascaud A., Capurro C., Cluzeaud F., Fay M., Jaisser F., Farman N., Blot-Chabaud M. Early nongenomic events in aldosterone action in renal collecting duct cells: PKCalpha activation, mineralocorticoid receptor phosphorylation, and cross-talk with the genomic response. J. Am. Soc. Nephrol. 2004, 15:1145-1160.
70. +-ATPase in proximal S3 segment. Am. J. Physiol. Renal Physiol. 2011, 300:F682-F691.
71. Liang X., Butterworth M.B., Peters K.W., Frizzell R.A. AS160 modulates aldosterone-stimulated epithelial sodium channel forward trafficking. Mol. Biol. Cell 2010, 21:2024-2033.
72. Lin D., Sterling H., Lerea K.M., Giebisch G., Wang W.H. Protein kinase C (PKC)-induced phosphorylation of ROMK1 is essential for the surface expression of ROMK1 channels. J. Biol. Chem. 2002, 277:44278-44284.
73. Little P.J., Cragoe E.J., Bobik A. Na-H exchange is a major pathway for Na influx in rat vascular smooth muscle. Am. J. Physiol. 1986, 251:C707-C712.
74. Liu S.L., Schmuck S., Chorazcyzewski J.Z., Gros R., Feldman R.D. Aldosterone regulates vascular reactivity: short-term effects mediated by phosphatidylinositol 3-kinase-dependent nitric oxide synthase activation. Circulation 2003, 108:2400-2406.
75. Liu H., Pedram A., Kim J.K. Oestrogen prevents cardiomyocyte apoptosis by suppressing p38alpha-mediated activation of p53 and by down-regulating p53 inhibition on p38beta. Cardiovasc. Res. 2011, 89:119-128.
76. Lovett F.A., Cosgrove R.A., Gonzalez I., Pell J.M. Essential role for p38alpha MAPK but not p38gamma MAPK in Igf2 expression and myoblast differentiation. Endocrinology 2010, 151:4368-4380.
77. Lu M.L., Schneider M.C., Zheng Y., Zhang X., Richie J.P. Caveolin-1 interacts with androgen receptor. A positive modulator of androgen receptor mediated transactivation. J. Biol. Chem. 2001, 276:13442-13451.
78. Lu M., Leng Q., Egan M.E., Caplan M.J., Boulpaep E.L., Giebisch G.H., Hebert S.C. CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney. J. Clin. Invest. 2006, 116:797-807.
79. Lu M., Wang J., Jones K.T., Ives H.E., Feldman M.E., Yao L.J., Shokat K.M., Ashrafi K., Pearce D. MTOR complex-2 activates ENaC by phosphorylating SGK1. J. Am. Soc. Nephrol. 2010, 21:811-818.
80. Maggio N., Segal M., 2010. Cellular basis of a rapid effect of mineralocorticosteroid receptors activation on LTP in ventral hippocampal slices Hippocampus, in press, doi:10.1002/hipo.20893.
81. Maguire D., MacNamara B., Cuffe J.E., Winter D., Doolan C.M., Urbach V., O'Sullivan G.C., Harvey B.J. Rapid responses to aldosterone in human distal colon. Steroids 1999, 64:51-63.
82. Manegold J.C., Falkenstein E., Wehling M., Christ M. Rapid aldosterone effects on tyrosine phosphorylation in vascular smooth muscle cells. Cell. Mol. Biol. (Noisy-le-grand) 1999, 45:805-813.
83. + exchange in M-1 cortical collecting duct cells via a PKC-MAPK pathway. Nephron Physiol. 2005, 99:p1-p9.
84. Massaad C., Houard N., Lombes M., Barouki R. Modulation of human mineralocorticoid receptor function by protein kinase A. Mol. Endocrinol. 1999, 13:57-65.
85. Matthews L., Berry A., Ohanian V., Ohanian J., Garside H., Ray D. Caveolin mediates rapid glucocorticoid effects and couples glucocorticoid action to the antiproliferative program. Mol. Endocrinol. 2008, 22:1320-1330.
86. McEneaney V., Harvey B.J., Thomas W. Aldosterone rapidly activates protein kinase D via a mineralocorticoid receptor/EGFR trans-activation pathway in the M1 kidney CCD cell line. J. Steroid Biochem. Mol. Biol. 2007, 107:180-190.
87. McEneaney V., Harvey B.J., Thomas W. Aldosterone regulates rapid trafficking of epithelial sodium channel subunits in renal cortical collecting duct cells via protein kinase D activation. Mol. Endocrinol. 2008, 22:881-892.
88. McEneaney V., Dooley R., Harvey B.J., Thomas W. Protein kinase D stabilizes aldosterone-induced ERK1/2 MAP kinase activation in M1 renal cortical collecting duct cells to promote cell proliferation. J. Steroid Biochem. Mol. Biol. 2010, 118:18-28.
89. McEneaney V., Dooley R., Yusef Y.R., Keating N., Quinn U., Harvey B.J., Thomas W. Protein kinase D1 modulates aldosterone-induced ENaC activity in a renal cortical collecting duct cell line. Mol. Cell. Endocrinol. 2010, 325:8-17.
90. Miyata K., Hitomi H., Guo P., Zhang G.X., Kimura S., Kiyomoto H., Hosomi N., Kagami S., Kohno M., Nishiyama A. Possible involvement of Rho-kinase in aldosterone-induced vascular smooth muscle cell remodeling. Hypertens. Res. 2008, 31:1407-1413.
91. Moe O.W. Acute regulation of proximal tubule apical membrane Na/H exchanger NHE-3: role of phosphorylation, protein trafficking, and regulatory factors. J. Am. Soc. Nephrol. 1999, 10:2412-2425.
92. + pump activity. Am. J. Physiol. Gastrointest. Liver Physiol. 2008, 295:G909-G919.
93. Mutoh A., Isshiki M., Fujita T. Aldosterone enhances ligand-stimulated nitric oxide production in endothelial cells. Hypertens. Res. 2008, 31:1811-1820.
94. Nagai Y., Miyata K., Sun G.P., Rahman M., Kimura S., Miyatake A., Kiyomoto H., Kohno M., Abe Y., Yoshizumi M., Nishiyama A. Aldosterone stimulates collagen gene expression and synthesis via activation of ERK1/2 in rat renal fibroblasts. Hypertension 2005, 46:1039-1045.
95. Nagata D., Takahashi M., Sawai K., Tagami T., Usui T., Shimatsu A., Hirata Y., Naruse M. Molecular mechanism of the inhibitory effect of aldosterone on endothelial NO synthase activity. Hypertension 2006, 48:165-171.
96. Naray-Fejes-Toth A., Fejes-Toth G. The SGK, an aldosterone-induced gene in mineralocorticoid target cells, regulates the epithelial sodium channel. Kidney Int. 2000, 57:1290-1294.
97. Nishiyama A., Abe Y. Molecular mechanisms and therapeutic strategies of chronic renal injury: renoprotective effects of aldosterone blockade. J. Pharmacol. Sci. 2006, 100:9-16.
98. Nishiyama A., Yao L., Fan Y., Kyaw M., Kataoka N., Hashimoto K., Nagai Y., Nakamura E., Yoshizumi M., Shokoji T., Kimura S., Kiyomoto H., Tsujioka K., Kohno M., Tamaki T., Kajiya F., Abe Y. Involvement of aldosterone and mineralocorticoid receptors in rat mesangial cell proliferation and deformability. Hypertension 2005, 45:710-716.
99. Nishizaka M.K., Zaman M.A., Green S.A., Renfroe K.Y., Calhoun D.A. Impaired endothelium-dependent flow-mediated vasodilation in hypertensive subjects with hyperaldosteronism. Circulation 2004, 109:2857-2861.
100. Oakley R.H., Cidlowski J.A. Cellular processing of the glucocorticoid receptor gene and protein: new mechanisms for generating tissue-specific actions of glucocorticoids. J. Biol. Chem. 2011, 286:3177-3184.
101. + exchange and raises cytoplasmic pH in target cells of the amphibian kidney. Proc. Natl. Acad. Sci. USA 1987, 84:1464-1468.
102. Okamoto T., Schlegel A., Scherer P.E., Lisanti M.P. Caveolins, a family of scaffolding proteins for organizing " preassembled signaling complexes" at the plasma membrane. J. Biol. Chem. 1998, 273:5419-5422.
103. Okoshi M.P., Yan X., Okoshi K., Nakayama M., Schuldt A.J., O'Connell T.D., Simpson P.C., Lorell B.H. Aldosterone directly stimulates cardiac myocyte hypertrophy. J. Card. Fail. 2004, 10:511-518.
104. + conductances of cortical collecting duct using microelectrode techniques. Am. J. Physiol. 1984, 247:F14-F24.
105. Park J., Leong M.L., Buse P., Maiyar A.C., Firestone G.L., Hemmings B.A. Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. EMBO J. 1999, 18:3024-3033.
106. Pedram A., Razandi M., Sainson R.C., Kim J.K., Hughes C.C., Levin E.R. A conserved mechanism for steroid receptor translocation to the plasma membrane. J. Biol. Chem. 2007, 282:22278-22288.
107. + channel in response to RhoA signaling. J. Biol. Chem. 2006, 281:26520-26527.
108. + channel toward the plasma membrane with total internal reflection fluorescence-fluorescence recovery after photobleaching. J. Biol. Chem. 2007, 282:14576-14585.
109. Razandi M., Oh P., Pedram A., Schnitzer J., Levin E.R. ERs associate with and regulate the production of caveolin: implications for signaling and cellular actions. Mol. Endocrinol. 2002, 16:100-115.
110. Razandi M., Pedram A., Levin E.R. Heat shock protein 27 is required for sex steroid receptor trafficking to and functioning at the plasma membrane. Mol. Cell. Biol. 2010, 30:3249-3261.
111. Revankar C.M., Cimino D.F., Sklar L.A., Arterburn J.B., Prossnitz E.R. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 2005, 307:1625-1630.
112. + homeostasis. Proc. Natl. Acad. Sci. USA 2007, 104:4025-4029.
113. Rizzo M.A., Piston D.W. Regulation of beta cell glucokinase by S-nitrosylation and association with nitric oxide synthase. J. Cell Biol. 2003, 161:243-248.
114. Robert-Nicoud M., Flahaut M., Elalouf J.M., Nicod M., Salinas M., Bens M., Doucet A., Wincker P., Artiguenave F., Horisberger J.D., Vandewalle A., Rossier B.C., Firsov D. Transcriptome of a mouse kidney cortical collecting duct cell line: effects of aldosterone and vasopressin. Proc. Natl. Acad. Sci. USA 2001, 98:2712-2716.
115. Romagni P., Rossi F., Guerrini L., Quirini C., Santiemma V. Aldosterone induces contraction of the resistance arteries in man. Atherosclerosis 2003, 166:345-349.
116. Rubino D., Driggers P., Arbit D., Kemp L., Miller B., Coso O., Pagliai K., Gray K., Gutkind S., Segars J. Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action. Oncogene 1998, 16:2513-2526.
117. Rykx A., De Kimpe L., Mikhalap S., Vantus T., Seufferlein T., Vandenheede J.R., Van Lint J. Protein kinase D: a family affair. FEBS Lett. 2003, 546:81-86.
118. Sansom S.C., O'Neil R.G. Effects of mineralocorticoids on transport properties of cortical collecting duct basolateral membrane. Am. J. Physiol. 1986, 251:F743-F757.
119. Schmidt B.M., Oehmer S., Delles C., Bratke R., Schneider M.P., Klingbeil A., Fleischmann E.H., Schmieder R.E. Rapid nongenomic effects of aldosterone on human forearm vasculature. Hypertension 2003, 42:156-160.
120. Schmidt B.M., Sammer U., Fleischmann I., Schlaich M., Delles C., Schmieder R.E. Rapid nongenomic effects of aldosterone on the renal vasculature in humans. Hypertension 2006, 47:650-655.
121. Shibata S., Nagase M., Yoshida S., Kawarazaki W., Kurihara H., Tanaka H., Miyoshi J., Takai Y., Fujita T. Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease. Nat. Med. 2008, 14:1370-1376.
122. Shimkets R.A., Warnock D.G., Bositis C.M., Nelson-Williams C., Hansson J.H., Schambelan M., Gill J.R., Ulick S., Milora R.V., Findling J.W., et al. Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell 1994, 79:407-414.
123. Sinnett-Smith J., Zhukova E., Hsieh N., Jiang X., Rozengurt E. Protein kinase D potentiates DNA synthesis induced by Gq-coupled receptors by increasing the duration of ERK signaling in swiss 3T3 cells. J. Biol. Chem. 2004, 279:16883-16893.
124. Slater S.J., Kelly M.B., Taddeo F.J., Larkin J.D., Yeager M.D., McLane J.A., Ho C., Stubbs C.D. Direct activation of protein kinase C by 1 alpha, 25-dihydroxyvitamin D3. J. Biol. Chem. 1995, 270:6639-6643.
125. + channel. J. Biol. Chem. 2002, 277:5-8.
126. Snyder P.M., Olson D.R., Kabra R., Zhou R., Steines J.C. CAMP and serum and glucocorticoid-inducible kinase (SGK) regulate the epithelial Na(+) channel through convergent phosphorylation of Nedd4-2. J. Biol. Chem. 2004, 279:45753-45758.
127. Sober S., Laan M., Annilo T. MicroRNAs miR-124 and miR-135a are potential regulators of the mineralocorticoid receptor gene (NR3C2) expression. Biochem. Biophys. Res. Commun. 2010, 391:727-732.
128. Soundararajan R., Melters D., Shih I.C., Wang J., Pearce D. Epithelial sodium channel regulated by differential composition of a signaling complex. Proc. Natl. Acad. Sci. USA 2009, 106:7804-7809.
129. Soundararajan R., Wang J., Melters D., Pearce D. Glucocorticoid-induced leucine zipper 1 stimulates the epithelial sodium channel by regulating serum- and glucocorticoid-induced kinase 1 stability and subcellular localization. J. Biol. Chem. 2010, 285:39905-39913.
130. + exchanger activity in the syncytiotrophoblast of the human placenta: effect of fetal sex. Placenta 2010, 31:289-294.
131. Staruschenko A., Patel P., Tong Q., Medina J.L., Stockand J.D. Ras activates the epithelial Na(+) channel through phosphoinositide 3-OH kinase signaling. J. Biol. Chem. 2004, 279:37771-37778.
132. + channel. Biochim. Biophys. Acta 2005, 1669:108-115.
133. Stockand J.D., Meszaros J.G. Aldosterone stimulates proliferation of cardiac fibroblasts by activating Ki-RasA and MAPK1/2 signaling. Am. J. Physiol. Heart Circ. Physiol. 2003, 284:H176-H184.
134. Stolte H., Wiederholt M., Fuchs G., Hierholzer K. Time course of development of transtubular sodium concentration differences in proximal surface tubules of the rat kidney. Micropuncture experiments in intact and adrenalectomized rats. Pflugers Arch. 1969, 313:252-270.
135. Su L.F., Knoblauch R., Garabedian M.J. Rho GTPases as modulators of the estrogen receptor transcriptional response. J. Biol. Chem. 2001, 276:3231-3237.
136. Sweiry J.H., Binder H.J. Characterization of aldosterone-induced potassium secretion in rat distal colon. J. Clin. Invest. 1989, 83:844-851.
137. + transport by aldosterone: signaling convergence and cross talk between the PI3-K and MAPK1/2 cascades. Am. J. Physiol. Renal Physiol. 2004, 286:F1232-F1238.
138. Tsybouleva N., Zhang L., Chen S., Patel R., Lutucuta S., Nemoto S., DeFreitas G., Entman M., Carabello B.A., Roberts R., Marian A.J. Aldosterone, through novel signaling proteins, is a fundamental molecular bridge between the genetic defect and the cardiac phenotype of hypertrophic cardiomyopathy. Circulation 2004, 109:1284-1291.
139. Uhrenholt T.R., Schjerning J., Hansen P.B., Norregaard R., Jensen B.L., Sorensen G.L., Skott O. Rapid inhibition of vasoconstriction in renal afferent arterioles by aldosterone. Circ. Res. 2003, 93:1258-1266.
140. Urbach V., Van Kerkhove E., Maguire D., Harvey B.J. Rapid activation of KATP channels by aldosterone in principal cells of frog skin. J. Physiol. 1996, 491(Pt 1):111-120.
141. Ushio-Fukai M. Vascular signaling through G protein-coupled receptors: new concepts. Curr. Opin. Nephrol. Hypertens. 2009, 18:153-159.
142. Van Lint J., Rykx A., Maeda Y., Vantus T., Sturany S., Malhotra V., Vandenheede J.R., Seufferlein T. Protein kinase D: an intracellular traffic regulator on the move. Trends Cell Biol. 2002, 12:193-200.
143. Vicent G.P., Ballare C., Nacht A.S., Clausell J., Subtil-Rodriguez A., Quiles I., Jordan A., Beato M. Induction of progesterone target genes requires activation of Erk and Msk kinases and phosphorylation of histone H3. Mol. Cell 2006, 24:367-381.
144. Wang W.H., Giebisch G. Regulation of potassium (K) handling in the renal collecting duct. Pflugers Arch. 2009, 458:157-168.
145. Watts B.A., George T., Good D.W. Aldosterone inhibits apical NHE3 and HCO3- absorption via a nongenomic ERK-dependent pathway in medullary thick ascending limb. Am. J. Physiol. Renal Physiol. 2006, 291:F1005-F1013.
146. Webster J.C., Jewell C.M., Bodwell J.E., Munck A., Sar M., Cidlowski J.A. Mouse glucocorticoid receptor phosphorylation status influences multiple functions of the receptor protein. J. Biol. Chem. 1997, 272:9287-9293.
147. Wehling M., Ulsenheimer A., Schneider M., Neylon C., Christ M. Rapid effects of aldosterone on free intracellular calcium in vascular smooth muscle and endothelial cells: subcellular localization of calcium elevations by single cell imaging. Biochem. Biophys. Res. Commun. 1994, 204:475-481.
148. Will P.C., Lebowitz J.L., Hopfer U. Induction of amiloride-sensitive sodium transport in the rat colon by mineralocorticoids. Am. J. Physiol. 1980, 238:F261-F268.
149. Willette R.N., Eybye M.E., Olzinski A.R., Behm D.J., Aiyar N., Maniscalco K., Bentley R.G., Coatney R.W., Zhao S., Westfall T.D., Doe C.P. Differential effects of p38 mitogen-activated protein kinase and cyclooxygenase 2 inhibitors in a model of cardiovascular disease. J. Pharmacol. Exp. Ther. 2009, 330:964-970.
150. Winter D.C., Schneider M.F., O'Sullivan G.C., Harvey B.J., Geibel J.P. Rapid effects of aldosterone on sodium-hydrogen exchange in isolated colonic crypts. J. Membr. Biol. 1999, 170:17-26.
151. +-ATPases in intercalated renal tubule cells by aldosterone. Proc. Natl. Acad. Sci. USA 2004, 101:2636-2641.
152. Wu C.C., Wu X., Han J., Sun P. P38gamma regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage. Protein Cell 2010, 1:573-583.
153. Yoo D., Kim B.Y., Campo C., Nance L., King A., Maouyo D., Welling P.A. Cell surface expression of the ROMK (Kir 1.1) channel is regulated by the aldosterone-induced kinase, SGK-1, and protein kinase A. J. Biol. Chem. 2003, 278:23066-23075.
154. Yoo D., Flagg T.P., Olsen O., Raghuram V., Foskett J.K., Welling P.A. Assembly and trafficking of a multiprotein ROMK (Kir 1.1) channel complex by PDZ interactions. J. Biol. Chem. 2004, 279:6863-6873.
155. + channel ROMK1. J. Am. Soc. Nephrol. 2002, 13:2823-2830.
156. Zeng W.Z., Li X.J., Hilgemann D.W., Huang C.L. Protein kinase C inhibits ROMK1 channel activity via a phosphatidylinositol 4,5-bisphosphate-dependent mechanism. J. Biol. Chem. 2003, 278:16852-16856.
157. Zheng F.F., Wu R.C., Smith C.L., O'Malley B.W. Rapid estrogen-induced phosphorylation of the SRC-3 coactivator occurs in an extranuclear complex containing estrogen receptor. Mol. Cell. Biol. 2005, 25:8273-8284.