Vascular proinflammatory responses by aldosterone are mediated via c-Src trafficking to cholesterol-rich microdomains: Role of PDGFR

Cardiovascular Research

Volumn 91, Issue 4, 2011, Pages 720-731

  Callera, Glaucia E ^a   Yogi, Alvaro ^a   Briones, Ana M ^a   Montezano, Augusto C I ^a   He, Ying ^a   Tostes, Rita C A ^b   Schiffrin, Ernesto L ^c   Touyz, Rhian M ^a  

^a OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Aldosterone; c Src; Lipid rafts caveolae; PDGFR; Vascular smooth muscle cells

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; 6,7 DIMETHOXY 2 PHENYLQUINOXALINE; ALDOSTERONE; CAVEOLIN 1; CELL ADHESION MOLECULE; CHOLESTEROL; CORTACTIN; FLOTILLIN 2; FOCAL ADHESION KINASE 2; METHYL BETA CYCLODEXTRIN; MINERALOCORTICOID RECEPTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR;

ANIMAL CELL; ARTICLE; CELL ADHESION; IMMUNOPRECIPITATION; INFLAMMATION; LIPID RAFT; MONOCYTE; NONHUMAN; ONCOGENE SRC; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ALDOSTERONE; ANIMALS; CAVEOLAE; CHOLESTEROL; INFLAMMATION; MEMBRANE MICRODOMAINS; MICE; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTEIN-TYROSINE KINASES; RATS; RATS, INBRED WKY; RECEPTORS, MINERALOCORTICOID; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR;

EID: 80051964047     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvr131     Document Type: Article

References (49)

1. Briet M, Schiffrin EL. Aldosterone: effects on the kidney and cardiovascular system. Nat Rev Nephrol 2010;6:261-273.
2. Funder J. Mineralocorticoids and cardiac fibrosis: the decade in review. Clin Exp Pharmacol Physiol 2001;28:1002-1006. (Pubitemid 34053511)
3. Fiebeler A, Haller H. Participation of the mineralocorticoid receptor in cardiac and vascular remodeling. Nephron Physiol 2003;94:47-50.
4. Virdis A, Neves MF, Amiri F, Viel E, Touyz RM, Schiffrin EL. Spironolactone improves angiotensin-induced vascular changes and oxidative stress. Hypertension 2002;40: 504-510.
5. Schiffrin EL. Effects of aldosterone on the vasculature. Hypertension 2006;47:312-318. (Pubitemid 43740260)
6. Gekle M, Golenhofen N, Oberleithner H, Silbernagl S. Rapid activation of Na+/H+ exchange by aldosterone in renal epithelial cells requires Ca2+ and stimulation of a plasma membrane proton conductance. Proc Natl Acad Sci USA 1996;93: 10500-10504.
7. Wehling M, Ulsenheimer A, Schneider M, Neylon C, Christ M. Rapid effects of aldosterone on free intracellular calcium in vascular smooth muscle and endothelial cells: subcellular localization of calcium elevations by single cell imaging. Biochem Biophys Res Commun 1994;204:475-481.
8. Christ M, Gunther A, Heck M, Schmidt BM, Falkenstein E, Wehling M. Aldosterone, not estradiol, is the physiological agonist for rapid increases in cAMP in vascular smooth muscle cells. Circulation 1999;99:1485-1491. (Pubitemid 29140916)
9. Christ M, Meyer C, Sippel K, Wehling M. Rapid aldosterone signaling in vascular smooth muscle cells: involvement of phospholipase C, diacylglycerol and protein kinase C alpha. Biochem Biophys Res Commun 1995;213:123-129.
10. Liu SL, Schmuck S, Chorazcyzewski JZ, Gros R, Feldman RD. Aldosterone regulates vascular reactivity: short-term effects mediated by phosphatidylinositol 3-kinase-dependent nitric oxide synthase activation. Circulation 2003;108:2400-2406. (Pubitemid 37413549)
11. Krug AW, Grossmann C, Schuster C, Freudinger R, Mildenberger S, Govindan MV et al. Aldosterone stimulates epidermal growth factor receptor expression. J Biol Chem 2003;278:43060-43066. (Pubitemid 37345921)
12. Holzman J, Liu L, Duke BJ, Kemendy A, Eaton DC. Transactivation of the IGF-1R by aldosterone. Am J Physiol Renal Physiol 2007;292:F1219-F1228. (Pubitemid 46572441)
13. Ishizawa K, Izawa Y, Ito H, Miki C, Miyata K, Fujita Y et al. Aldosterone stimulates vascular smooth muscle cell proliferation via big mitogen-activated protein kinase 1 activation. Hypertension 2005;46:1046-1052.
14. Nagai Y, Miyata K, Sun GP, Rahman M, Kimura S, Miyatake A et al. Aldosterone stimulates collagen gene expression and synthesis via activation of ERK1/2 in rat renal fibroblasts. Hypertension 2005;46:1039-1045.
15. Manegold JC, Falkenstein E, Wehling M, Christ M. Rapid aldosterone effects on tyrosine phosphorylation in vascular smooth muscle cells. Cell Mol Biol 1999;45:805-813.
16. Callera GE, Touyz RM, Tostes RC, Yogi A, He Y, Malkinson S et al. Aldosterone activates vascular p38MAP kinase and NADPH oxidase via c-Src. Hypertension 2005;45: 773-779. (Pubitemid 40418380)
17. Martin GS. The hunting of the Src. Nat Rev Mol Cell Biol 2001;2:467-475.
18. Oda Y, Renaux B, Bjorge J, Saifeddine M, Fujita DJ, Hollenberg MD. c-Src is a major cytosolic tyrosine kinase in vascular tissue. Can J Physiol Pharmacol 1999;77:606-617.
19. Touyz RM, He G, Wu XH, Park JB, Mabrouk ME, Schiffrin EL. Src is an important mediator of extracellular signal-regulated kinase 1/2-dependent growth signaling by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients. Hypertension 2001;38:56-64. (Pubitemid 34224771)
20. Ishida M, Ishida T, Thomas SM, Berk BC. Activation of extracellular signalregulated kinases (ERK1/2) by angiotensin II is dependent on c-Src in vascular smooth muscle cells. Circ Res 1998;82:7-12. (Pubitemid 28074013)
21. Thomas SM, Brugge JS. Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 1997;13:513-609. (Pubitemid 28034534)
22. Li S, Couet J, Lisanti MP. Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases. J Biol Chem 1996;271: 29182-29190. (Pubitemid 26382628)
23. Shenoy-Scaria AM, Dietzen DJ, Kwong J, Link DC, Lublin DM. Cysteine3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae. J Cell Biol 1994;126:353-363.
24. Zacharias DA, Violin JD, Newton AC, Tsien RY. Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science 2002;296:913-916. (Pubitemid 34464897)
25. Gratton JP, Bernatchez P, Sessa WC. Caveolae and caveolins in the cardiovascular system. Circ Res 2004;94:1408-1417. (Pubitemid 38780313)
26. Simons K, Toomre D. Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 2000;1:31-39.
27. Liu P, Ying Y, Ko YG, Anderson RG. Localization of platelet-derived growth factorstimulated phosphorylation cascade to caveolae. J Biol Chem 1996;271:10299-10303. (Pubitemid 26132521)
28. Liu P, Ying Y, Anderson RG. Platelet-derived growth factor activates mitogen activated protein kinase in isolated caveolae. Proc Natl Acad Sci USA 1997;94: 13666-13670. (Pubitemid 28009640)
29. Sowa G, Pypaert M, Sessa WC. Distinction between signaling mechanisms in lipid rafts vs. caveolae. Proc Natl Acad Sci USA 2001;98:14072-14077. (Pubitemid 33116026)
30. Fielding CJ, Fielding PE. Relationship between cholesterol trafficking and signaling in rafts and caveolae. Biochim Biophys Acta 2003;1610:219-228. (Pubitemid 36324466)
31. Weernink PA, Rijksen G. Activation and translocation of c-Src to the cytoskeleton by both platelet-derived growth factor and epidermal growth factor. J Biol Chem 1995; 270:2264-2267.
32. Roskoski R. Src kinase regulation by phosphorylation and dephosphorylation. Biochem Biophys Res Commun 2005;331:1-14.
33. Heldin CH, Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev 1999;79:1283-1316. (Pubitemid 29473317)
34. Holthius JCM, Levine TP. Lipid traffic: floppy drives and a superhighway. Nature Rev 2005;6:209-220. (Pubitemid 40314922)
35. Ishizaka N, Griendling KK, Lassegue B, Alexander RW. Angiotensin II type 1 receptor: relationship with caveolae and caveolin after initial agonist stimulation. Hypertension 1998;32:459-466. (Pubitemid 28429134)
36. Zuo L, Ushio-Fukai M, Ikeda S, Hilenski L, Patrushev N, Alexander RW. Caveolin-1 is essential for activation of Rac1 and NAD(P)H oxidase after angiotensin II type 1 receptor stimulation in vascular smooth muscle cells: role in redox signaling and vascular hypertrophy. Arterioscler Thromb Vasc Biol 2005;25:1824-1830. (Pubitemid 41243449)
37. Ushio-Fukai M, Hilenski L, Santanam N, Becker PL, Ma Y, Griendling KK et al. Cholesterol depletion inhibits epidermal growth factor receptor transactivation by angiotensin II in vascular smooth muscle cells. J Biol Chem 2001;276: 48269-48275.
38. Mineo C, Gill GN, Anderson RGW. Regulated migration of epidermal growth factor receptor from caveolae. J Biol Chem 1999;274:30636-30643.
39. Simons K, Ikonen E. Functional rafts in cell membranes. Nature 1997;5:569-572. (Pubitemid 27248754)
40. Marney AM, Brown NJ. Aldosterone and end-organ damage. Clin Sci (Lond) 2007;113: 267-278. (Pubitemid 47372685)
41. Thomas SM, Brugge JS. Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 1997;3:513-609. (Pubitemid 28034534)
42. Chiang GG, Sefton BM. Phosphorylation of a Src kinase at the autophosphorylation site in the absence of Src kinase activity. J Biol Chem 2000;275:6055-6058. (Pubitemid 30129885)
43. Stover DR, Furet P, Lydon NB. Modulation of the SH2 binding specificity and kinase activity of Src by tyrosine phosphorylation within its SH2 domain. J Biol Chem 1996; 271:12481-12487. (Pubitemid 26160919)
44. Ralston R, Bishop JM. The product of the protooncogene c-src is modified during the cellular response to platelet derived growth factor. Proc Natl Acad Sci USA 1985;82: 7845-7849. (Pubitemid 16169453)
45. Gould KL, Hunter T. Platelet-derived growth factor induces multisite phosphorylation of pp60 c-Src and increases its protein-tyrosine kinase activity. Mol Cell Biol 1988;8: 3345-3356.
46. Sandilands E, Cans C, Fincham VJ, Brunton VG, Mellor H, Prendergast GC et al. RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane. Dev Cell 2004;7:855-869. (Pubitemid 39654730)
47. Fincham VJ, Unlu M, Brunton VG, Pitts JD, Wyke JA, Frame MC. Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins. J Cell Biol 1996;135:1551-1564. (Pubitemid 26427651)
48. Ouyang M, Sun J, Chien S, Wang Y. Determination of hierarchical relationship of Src and Rac at subcellular locations with FRET biosensors. Proc Natl Acad Sci USA 2008; 105:14353-14358.
49. Pojoga LH, Romero JR, Yao TM, Loutraris P, Ricchiuti V, Coutinho P et al. Caveolin-1 ablation reduces the adverse cardiovascular effects of N-omega-nitro-L-arginine methyl ester and angiotensin II. Endocrinology 2010;151:1236-1246.