Effects of PPAR ligands on leukemia

PPAR Research

Volumn , Issue , 2012, Pages

  Tabe, Yoko ^a   Konopleva, Marina ^b   Andreeff, Michael ^b   Ohsaka, Akimichi ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXY PROSTAGLANDIN J2; 15 HYDROXYICOSATETRAENOIC ACID; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 4 PHENYLBUTYRIC ACID; APOPTOSIS INDUCING FACTOR; BARDOXOLONE; CASPASE 3; CASPASE 8; CCAAT ENHANCER BINDING PROTEIN; CIGLITAZONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT; NUCLEAR RECEPTOR COREPRESSOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; PROTEIN BAX; PROTEIN P300; RETINOIC ACID RECEPTOR ALPHA; RETINOIC ACID RECEPTOR BETA; ROSIGLITAZONE; TRICHOSTATIN A; TROGLITAZONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VALPROIC ACID; VORINOSTAT;

ACUTE GRANULOCYTIC LEUKEMIA; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER CHEMOTHERAPY; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL DEATH; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CHEMICAL STRUCTURE; DNA METHYLATION; ENZYME ACTIVATION; ENZYME INHIBITION; GENE EXPRESSION REGULATION; GENE SILENCING; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; LEUKEMIA CELL; NONHUMAN; PROMYELOCYTIC LEUKEMIA; PROTEIN EXPRESSION; RECEPTOR BINDING; REVIEW; TRANSGENIC MOUSE; UPREGULATION;

EID: 84862278243     PISSN: 16874757     EISSN: 16874765     Source Type: Journal    
DOI: 10.1155/2012/483656     Document Type: Review

References (101)

1. Estey E. H., Treatment of relapsed and refractory acute myelogenous leukemia Leukemia 2000 14 3 476 479 (Pubitemid 30142875)
2. Degos L., Chomienne C., Daniel M. T., Berger R., Dombret H., Fenaux P., Castaigne S., Treatment of first relapse in acute promyelocytic leukaemia with all-trans retinoic acid The Lancet 1990 336 8728 1440 1441
3. Chen Z. X., Xue Y. Q., Zhang R., Tao R. F., Xia X. M., Li C., Wang W., Zu W. Y., Yao X. Z., Ling B. J., A clinical and experimental study on all-trans retinoic acid-treated acute promyelocytic leukemia patients Blood 1991 78 6 1413 1419
4. Meng-er H., Yu-chen Y., Shu-rong C., Jin-ren C., Jia-Xiang L., Lin Z., Long-jun G., Zhen-yi W., Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia Blood 1988 72 2 567 572
5. Warrell R. P., Frankel S. R., Miller W. H., Scheinberg D. A., Itri L. M., Hittelman W. N., Vyas R., Andreeff M., Tafuri A., Jakubowski A., Gabrilove J., Gordon M. S., Dmitrovsky E., Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid) New England Journal of Medicine 1991 324 20 1385 1393
6. Mandelli F., Diverio D., Avvisati G., Luciano A., Barbui T., Bernasconi C., Broccia G., Cerri R., Falda M., Fioritoni G., Leoni F., Liso V., Petti M. C., Rodeghiero F., Saglio G., Vegna M. L., Visani G., Jehn U., Willemze R., Muus P., Pelicci P. G., Biondi A., Lo Coco F., Molecular remission in PML/RAR -positive acute promyelocytic leukemia by combined all-trans retinoic acid and Idarubicin (AIDA) therapy Blood 1997 90 3 1014 1021 (Pubitemid 27314135)
7. Castaigne S., Chomienne C., Daniel M. T., Ballerini P., Berger R., Fenaux P., Degos L., All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results Blood 1990 76 9 1704 1709
8. Tallman M. S., Therapy of acute promyelocytic leukemia: all-trans retinoic acid and beyond Leukemia 1998 12 1 S37 S40
9. Warrell R. P., Retinoid resistance in acute promyelocytic leukemia: new mechanisms, strategies, and implications Blood 1993 82 7 1949 1953
10. Cornic M., Chomienne C., Induction of retinoid resistance by all-trans retinoic acid in acute promyelocytic leukemia after remission Leukemia and Lymphoma 1995 18 3-4 249 257
11. Shao W., Benedetti L., Lamph W. W., Nervi C., Miller W. H., A retinoid-resistant acute promyelocytic leukemia subclone expresses a dominant negative PML-RAR mutation Blood 1997 89 12 4282 4289 (Pubitemid 27260235)
12. Cote S., Zhou D., Bianchini A., Nervi C., Gallagher R. E., Miller W. H., Altered ligand binding and transcriptional regulation by mutations in the PML/RAR ligand-binding domain arising in retinoic acid-resistant patients with acute promyelocytic leukemia Blood 2000 96 9 3200 3208
13. Di Croce L., Raker V. A., Corsaro M., Fazi F., Fanelli M., Faretta M., Fuks F., Lo Coco F., Kouzarides T., Nervi C., Minucci S., Pelicci P. G., Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor Science 2002 295 5557 1079 1082 (Pubitemid 34132239)
14. Pendino F., Sahraoui T., Lanotte M., Ségal-Bendirdijian E., A novel mechanism of retinoic acid resistance in acute promyelocytic leukemia cells through a defective pathway in telomerase regulation Leukemia 2002 16 5 826 832 (Pubitemid 34537554)
15. Mangelsdorf D. J., Thummel C., Beato M., Herrlich P., Schtz G., Umesono K., Blumberg B., Kastner P., Mark M., Chambon P., Evans R. M., The nuclear receptor super-family: the second decade Cell 1995 83 6 835 839
16. Schulman I. G., Shao G., Heyman R. A., Transactivation by retinoid X receptor-peroxisome proliferator-activated receptor (PPAR ) heterodimers: intermolecular synergy requires only the PPRA hormone-dependent activation function Molecular and Cellular Biology 1998 18 6 3483 3494 (Pubitemid 28240520)
17. Rosen E. D., Spiegelman B. M., PPAR : a nuclear regulator of metabolism, differentiation, and cell growth Journal of Biological Chemistry 2001 276 41 37731 37734
18. Pfahl M., Apfel R., Bendik I., Fanjul A., Graupner G., Lee M. O., La-Vista N., Lu X. P., Piedrafita J., Ortiz M. A., Salbert G., Zhang X. K., Nuclear retinoid receptors and their mechanism of action Vitamins and Hormones 1994 49 C 327 382
19. Huang J. T., Welch J. S., Ricote M., Binder C. J., Willson T. M., Kelly C., Witztum J. L., Funk C. D., Conrad D., Glass C. K., Interleukin-4-dependent production of PPAR- ligands in macrophages by 12/15-lipoxygenase Nature 1999 400 6742 378 382 (Pubitemid 29344205)
20. Nagy L., Tontonoz P., Alvarez J. G. A., Chen H., Evans R. M., Oxidized LDL regulates macrophage gene expression through ligand activation of PPAR Cell 1998 93 2 229 240 (Pubitemid 28180856)
21. Berger J., Bailey P., Biswas C., Cullinan C. A., Doebber T. W., Hayes N. S., Saperstein R., Smith R. G., Leibowitz M. D., Thiazolidinediones produce a conformational change in peroxisomal proliferator-activated receptor- : binding and activation correlate with antidiabetic actions in db/db mice Endocrinology 1996 137 10 4189 4195 (Pubitemid 26321865)
22. Lehmann J. M., Moore L. B., Smith-Oliver T. A., Wilkison W. O., Willson T. M., Kliewer S. A., An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor (PPAR ) Journal of Biological Chemistry 1995 270 22 12953 12956
23. Lambe K. G., Tugwood J. D., A human peroxisome-proliferator-activated receptor- is activated by inducers of adipogenesis, including thiazalidinedione drugs European Journal of Biochemistry 1996 239 1 1 7 (Pubitemid 26228133)
24. Lehmann J. M., Lenhard J. M., Oliver B. B., Ringold G. M., Kliewer S. A., Peroxisome proliferator-activated receptors and are activated by indomethacin and other non-steroidal anti-inflammatory drugs Journal of Biological Chemistry 1997 272 6 3406 3410
25. Wang Y., Porter W. W., Suh N., Honda T., Gribble G. W., Leesnitzer L. M., Plunket K. D., Mangelsdorf D. J., Blanchard S. G., Willson T. M., Sporn M. B., A synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO), is a ligand for the peroxisome proliferator-activated receptor Molecular Endocrinology 2000 14 10 1550 1556
26. Tontonoz P., Singer S., Forman B. M., Sarraf P., Fletcher J. A., Fletcher C. D. M., Brun R. P., Mueller E., Altiok S., Oppenheim H., Evans R. M., Spiegelman B. M., Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor and the retinoid X receptor Proceedings of the National Academy of Sciences of the United States of America 1997 94 1 237 241 (Pubitemid 27027193)
27. Demetri G. D., Fletcher C. D. M., Mueller E., Sarraf P., Naujoks R., Campbell N., Spiegelman B. M., Singer S., Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor- ligand troglitazone in patients with liposarcoma Proceedings of the National Academy of Sciences of the United States of America 1999 96 7 3951 3956 (Pubitemid 29169017)
28. Elstner E., Mller C., Koshizuka K., Williamson E. A., Park D., Asou H., Shintaku P., Said J. W., Heber D., Koeffler H. P., Ligands for peroxisome proliferator-activated receptory and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice Proceedings of the National Academy of Sciences of the United States of America 1998 95 15 8806 8811
29. Mueller E., Sarraf P., Tontonoz P., Evans R. M., Martin K. J., Zhang M., Fletcher C., Singer S., Spiegelman B. M., Terminal differentiation of human breast cancer through PPAR Molecular Cell 1998 1 3 465 470 (Pubitemid 128378895)
30. Sarraf P., Mueller E., Jones D., King F. J., DeAngelo D. J., Partridge J. B., Holden S. A., Chen L. B., Singer S., Fletcher C., Spiegelman B. M., Differentiation and reversal of malignant changes in colon cancer through PPAR Nature Medicine 1998 4 9 1046 1052 (Pubitemid 28417337)
31. Sarraf P., Mueller E., Smith W. M., Wright H. M., Jennifer B K., Aaltonen L. A., De Chapelle A. L., Spiegelman B. M., Charis E., Loss-of-function mutations in PPAR associated with human colon cancer Molecular Cell 1999 3 6 799 804 (Pubitemid 29323058)
32. Mueller E., Smith M., Sarraf P., Kroll T., Aiyer A., Kaufman D. S., Oh W., Demetri G., Figg W. D., Zhou X. P., Eng C., Spiegelman B. M., Kantoff P. W., Effects of ligand activation of peroxisome proliferator-activated receptor in human prostate cancer Proceedings of the National Academy of Sciences of the United States of America 2000 97 20 10990 10995
33. Chang T. H., Szabo E., Induction of differentiation and apoptosis by ligands of peroxisome proliferator-activated receptor in non-small cell lung cancer Cancer Research 2000 60 4 1129 1138 (Pubitemid 30129556)
34. Marra F., Efsen E., Romanelli R. G., Caligiuri A., Pastacaldi S., Batignani G., Bonacchi A., Caporale R., Laffi G., Pinzani M., Gentilini P., Ligands of peroxisome proliferator-activated receptor modulate profibrogenic and proinflammatory actions in hepatic stellate cells Gastroenterology 2000 119 2 466 478 (Pubitemid 30621997)
35. Westin S., Kurokawa R., Nolte R. T., Wisely G. B., McInerney E. M., Rose D. W., Milburn M. V., Rosenfeld M. G., Glass C. K., Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators Nature 1998 395 6698 199 202 (Pubitemid 28425662)
36. Puigserver P., Adelmant G., Wu Z., Fan M., Xu J., O'Malley B., Spiegelman B. M., Activation of PPAR coactivator-1 through transcription factor docking Science 1999 286 5443 1368 1371
37. Tontonoz P., Hu E., Spiegelman B. M., Stimulation of adipogenesis in fibroblasts by PPAR 2, a lipid-activated transcription factor Cell 1994 79 7 1147 1156
38. Nolte R. T., Wisely G. B., Westin S., Cobb J. E., Lambert M. H., Kurokawa R., Rosenfeld M. G., Willson T. M., Glass C. K., Milburn M. V., Ligand binding and co-activator assembly of the peroxisome proliferator- activated receptor- Nature 1998 395 6698 137 143 (Pubitemid 28425645)
39. Yang W., Rachez C., Freedman L. P., Discrete roles for peroxisome proliferator-activated receptor and retinoid X receptor in recruiting nuclear receptor coactivators Molecular and Cellular Biology 2000 20 21 8008 8017
40. Kodera Y., Takeyama K. I., Murayama A., Suzawa M., Masuhiro Y., Kato S., Ligand type-specific interactions of peroxisome proliferator-activated receptor with transcriptional coactivators Journal of Biological Chemistry 2000 275 43 33201 33204
41. Chen J., Kinyamu H. K., Archer T. K., Changes in attitude, changes in latitude: nuclear receptors remodeling chromatin to regulate transcription Molecular Endocrinology 2006 20 1 1 13 (Pubitemid 43011666)
42. Rosenfeld M. G., Lunyak V. V., Glass C. K., Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response Genes and Development 2006 20 11 1405 1428 (Pubitemid 43830648)
43. Feige J. N., Gelman L., Michalik L., Desvergne B., Wahli W., From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions Progress in Lipid Research 2006 45 2 120 159 (Pubitemid 43248732)
44. Ikezoe T., Miller C. W., Kawano S., Heaney A., Williamson E. A., Hisatake J., Green E., Hofmann W., Taguchi H., Koeffler H. P., Mutational analysis of the peroxisome proliferator-activated receptor in human malignancies Cancer Research 2001 61 13 5307 5310 (Pubitemid 32681569)
45. Konopleva M., Andreeff M., Role of peroxisome proliferator-activated receptor- in hematologic malignancies Current Opinion in Hematology 2002 9 4 294 302 (Pubitemid 34596873)
46. Tsao T., Kornblau S., Safe S., Watt J. C., Ruvolo V., Chen W., Qiu Y., Coombes K. R., Ju Z., Abdelrahim M., Schober W., Ling X., Kardassis D., Meyer C., Schimmer A., Kantarjian H., Andreeff M., Konopleva M., Role of peroxisome proliferator-activated receptor- and its coactivator DRIP205 in cellular responses to CDDO (RTA-401) in acute myelogenous leukemia Cancer Research 2010 70 12 4949 4960
47. Kubota T., Koshizuka K., Williamson E. A., Asou H., Said J. W., Holden S., Miyoshi I., Koeffler H. P., Ligand for peroxisome proliferator-activated receptor (Troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo Cancer Research 1998 58 15 3344 3352 (Pubitemid 28371075)
48. Tontonoz P., Nagy L., Alvarez J. G. A., Thomazy V. A., Evans R. M., PPAR promotes monocyte/macrophage differentiation and uptake of oxidized LDL Cell 1998 93 2 241 252 (Pubitemid 28180857)
49. Moore K. J., Rosen E. D., Fitzgerald M. L., Randow F., Andersson L. P., Altshuler D., Milstone D. S., Mortensen R. M., Spiegelman B. M., Freeman M. W., The role of PPAR- in macrophage differentiation and cholesterol uptake Nature Medicine 2001 7 1 41 47 (Pubitemid 32095640)
50. Asou H., Verbeek W., Williamson E., Elstner E., Kubota T., Kamada N., Koeffler H. P., Growth inhibition of myeloid leukemia cells by troglitazone, a ligand for peroxisome proliferator activated receptor gamma, and retinoids International Journal of Oncology 1999 15 5 1027 1031
51. Fujimura S., Suzumiya J., Nakamura K., Ono J., Effects of troglitazone on the growth and differentiation of hematopoietic cell lines International Journal of Oncology 1998 13 6 1263 1267 (Pubitemid 28551554)
52. Sugimura A., Kiriyama Y., Nochi H., Tsuchiya H., Tamoto K., Sakurada Y., Ui M., Tokumitsu Y., Troglitazone suppresses cell growth of myeloid leukemia cell lines by induction of p21WAF1/CIP1 cyclin-dependent kinase inhibitor Biochemical and Biophysical Research Communications 1999 261 3 833 837 (Pubitemid 29408143)
53. Yasugi E., Horiuchi A., Uemura I., Okuma E., Nakatsu M., Saeki K., Kamisaka Y., Kagechika H., Yasuda K., Yuo A., Peroxisome proliferator-activated receptor ligands stimulate myeloid differentiation and lipogenensis in human leukemia NB4 cells Development Growth and Differentiation 2006 48 3 177 188
54. Suh N., Wang Y., Honda T., Gribble G. W., Dmitrovsky E., Hickey W. F., Maue R. A., Place A. E., Porter D. M., Spinella M. J., Williams C. R., Wu G., Dannenberg A. J., Flanders K. C., Letterio J. J., Mangelsdorf D. J., Nathan C. F., Nguyen L., Porter W. W., Ren R. F., Roberts A. B., Roche N. S., Subbaramaiah K., Sporn M. B., A novel synthetic oleanane triterpenoid, 2-cyano-3,12- dioxoolean-1,9- dien-28-oic acid, with potent differentiating, antiproliferative, and anti- inflammatory activity Cancer Research 1999 59 2 336 341 (Pubitemid 29048864)
55. Konopleva M., Tsao T., Ruvolo P., Stiouf I., Estrov Z., Leysath C. E., Zhao S., Harris D., Chang S., Jackson C. E., Munsell M., Suh N., Gribble G., Honda T., May W. S., Sporn M. B., Andreeff M., Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia Blood 2002 99 1 326 335
56. Koschmieder S., D'Al F., Radomska H., Schneich C., Ji S. C., Konopleva M., Kobayashi S., Levantini E., Suh N., Di Ruscio A., Voso M. T., Watt J. C., Santhanam R., Sargin B., Kantarjian H., Andreeff M., Sporn M. B., Perrotti D., Berdel W. E., Mller-Tidow C., Serve H., Tenen D. G., CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer-binding protein alpha Blood 2007 110 10 3695 3705 (Pubitemid 350159639)
57. Yamakawa-Karakida N., Sugita K., Inukai T., Goi K., Nakamura M., Uno K., Sato H., Kagami K., Barker N., Nakazawa S., Ligand activation of peroxisome proliferator-activated receptor induces apoptosis of leukemia cells by down-regulating the c-myc gene expression via blockade of the Tcf-4 activity Cell Death and Differentiation 2002 9 5 513 526 (Pubitemid 34521179)
58. Liu J. J., Huang R. W., Lin D. J., Peng J., Wu X. Y., Lin Q., Pan X. L., Song Y. Q., Zhang M. H., Hou M., Chen F., Expression of survivin and bax/bcl-2 in peroxisome proliferator activated receptor- ligands induces apoptosis on human myeloid leukemia cells in vitro Annals of Oncology 2005 16 3 455 459 (Pubitemid 40458324)
59. Liu J. J., Liu P. Q., Lin D. J., Xiao R. Z., Huang M., Li X. D., He Y., Huang R. W., Downregulation of cyclooxygenase-2 expression and activation of caspase-3 are involved in peroxisome proliferator-activated receptor- agonists induced apoptosis in human monocyte leukemia cells in vitro Annals of Hematology 2007 86 3 173 183 (Pubitemid 46195989)
60. Ito Y., Pandey P., Place A., Sporn M. B., Gribble G. W., Honda T., Kharbanda S., Kufe D., The novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien- 28-oic acid induces apoptosis of human myeloid leukemia cells by a caspase-8-dependent mechanism Cell Growth and Differentiation 2000 11 5 261 267 (Pubitemid 30347206)
61. Ito Y., Pandey P., Sporn M. B., Datta R., Kharbanda S., Kufe D., The novel triterpenoid CDDO induces apoptosis and differentiation of human osteosarcoma cells by a caspase-8 dependent mechanism Molecular Pharmacology 2001 59 5 1094 1099 (Pubitemid 32381589)
62. Stadheim T. A., Suh N., Ganju N., Sporn M. B., Eastman A., The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) potently enhances apoptosis induced by tumor necrosis factor in human leukemia cells Journal of Biological Chemistry 2002 277 19 16448 16455 (Pubitemid 34967657)
63. Konopleva M., Tsao T., Estrov Z., Lee R. M., Wang R. Y., Jackson C. E., McQueen T., Monaco G., Munsell M., Belmont J., Kantarjian H., Sporn M. B., Andreeff M., The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces caspase-dependent and -independent apoptosis in acute myelogenous leukemia Cancer Research 2004 64 21 7927 7935 (Pubitemid 39446926)
64. Ikeda T., Kimura F., Nakata Y., Sato K., Ogura K., Motoyoshi K., Sporn M., Kufe D., Triterpenoid CDDO-Im downregulates PML/RAR expression in acute promyelocytic leukemia cells Cell Death and Differentiation 2005 12 5 523 531 (Pubitemid 40662850)
65. Shishodia S., Sethi G., Konopleva M., Andreeff M., Aggarwal B. B., A synthetic triterpenoid, CDDO-Me, inhibits I B kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor B-regulated gene products in human leukemic cells Clinical Cancer Research 2006 12 6 1828 1838
66. Simpson-Haidaris P. J., Pollock S. J., Ramon S., Anticancer role of PPARgamma agonists in hematological malignancies found in the vasculature, marrow, and eyes PPAR Research 2010 2010, article 814609
67. Chintharlapalli S., Papineni S., Konopleva M., Andreef M., Samudio I., Safe S., 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid and related compounds inhibit growth of colon cancer cells through peroxisome proliferator-activated receptor -dependent and -independent pathways Molecular Pharmacology 2005 68 1 119 128 (Pubitemid 41002950)
68. Konopleva M., Elstner E., McQueen T. J., Tsao T., Sudarikov A., Hu W., Schober W. D., Wang R. Y., Chism D., Kornblau S. M., Younes A., Collins S. J., Koeffler H. P., Andreeff M., Peroxisome proliferator-activated receptor and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias Molecular Cancer Therapeutics 2004 3 10 1249 1262 (Pubitemid 39440170)
69. Melichar B., Konopleva M., Hu W., Melicharova K., Andreeff M., Freedman R. S., Growth-inhibitory effect of a novel synthetic triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, on ovarian carcinoma cell lines not dependent on peroxisome proliferator-activated receptor- expression Gynecologic Oncology 2004 93 1 149 154 (Pubitemid 38429564)
70. Ray D. M., Morse K. M., Hilchey S. P., Garcia T. M., Felgar R. E., Maggirwar S. B., Phipps R. P., Bernstein S. H., The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) induces apoptosis of human diffuse large B-cell lymphoma cells through a peroxisome proliferator-activated receptor gamma-independent pathway Experimental Hematology 2006 34 9 1202 1211
71. Ray D. M., Akbiyik F., Phipps R. P., The peroxisome proliferator- activated receptor (PPAR ) ligands 15-deoxy-12,14-prostaglandin J2 and ciglitazone induce human B lymphocyte and B cell lymphoma apoptosis by PPAR -independent mechanisms Journal of Immunology 2006 177 8 5068 5076 (Pubitemid 44527577)
72. Wei S., Yang J., Lee S. L., Kulp S. K., Chen C. S., PPAR -independent antitumor effects of thiazolidinediones Cancer Letters 2009 276 2 119 124
73. Kamashev D., Vitoux D., De Thé H., PML-RARA-RXR oligomers mediate retinoid and rexinoid/cAMP cross-talk in acute promyelocytic leukemia cell differentiation Journal of Experimental Medicine 2004 199 8 1163 1174 (Pubitemid 38619912)
74. Hamadani S. A., Zhang T., Dorrell C., X-retinoic acid receptor a fusion genes in acute promyelocytic leukemia interfere with retinoid and peroxisome-proliferator signaling pathways Blood 2001 98 88a (Pubitemid 33785816)
75. He L. Z., Guidez F., Tribioli C., Peruzzi D., Ruthardt M., Zelent A., Pandolfi P. P., Distinct interactions of PML-RAR and PLZF-RAR with co-repressors determine differential responses to RA in APL Nature Genetics 1998 18 2 126 135 (Pubitemid 28082458)
76. Grignani F., De Matteis S., Nervi C., Tomassoni L., Gelmetti V., Cioce M., Fanelli M., Ruthardt M., Ferrara F. F., Zamir I., Seiser C., Grignani F., Lazar M. A., Minucci S., Pelicci P. G., Fusion proteins of the retinoic acid receptor- recruit histone deacetylase in promyelocytic leukaemia Nature 1998 391 6669 815 818 (Pubitemid 28099683)
77. He L. Z., Tolentino T., Grayson P., Zhong S., Warrell R. P., Rifkind R. A., Marks P. A., Richon V. M., Pandolfi P. P., Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia Journal of Clinical Investigation 2001 108 9 1321 1330 (Pubitemid 33107760)
78. Faria T. N., Mendelsohn C., Chambon P., Gudas L. J., The targeted disruption of both alleles of RAR 2 in F9 cells results in the loss of retinoic acid-associated growth arrest Journal of Biological Chemistry 1999 274 38 26783 26788
79. Duprez E., Wagner K., Koch H., Tenen D. G., C/EBP : a major PML-RARA-responsive gene in retinoic acid-induced differentiation of APL cells EMBO Journal 2003 22 21 5806 5816 (Pubitemid 37408819)
80. Liu M., Iavarone A., Freedman L. P., Transcriptional activation of the human p21(WAF1/CIP1) gene by retinoic acid receptor. Correlation with retinoid induction of U937 cell differentiation Journal of Biological Chemistry 1996 271 49 31723 31728 (Pubitemid 26408639)
81. Mueller B. U., Pabst T., Fos J., Petkovic V., Fey M. F., Asou N., Buergi U., Tenen D. G., ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression Blood 2006 107 8 3330 3338
82. Epping M. T., Wang L., Edel M. J., Carlée L., Hernandez M., Bernards R., The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling Cell 2005 122 6 835 847 (Pubitemid 41345202)
83. Perez A., Kastner P., Sethi S., Lutz Y., Reibel C., Chambon P., PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR EMBO Journal 1993 12 8 3171 3182 (Pubitemid 23232748)
84. Li Y., Dawson M. I., Agadir A., Regulation of RAR expression by RAR- and RXR-selective retinoids in human lung cancer cell lines: effect on growth inhibition and apoptosis induction International Journal of Cancer 1998 75 88 95 (Pubitemid 28113982)
85. Houle B., Rochette-Egly C., Bradley W. E. C., Tumor-suppressive effect of the retinoic acid receptor in human epidermoid lung cancer cells Proceedings of the National Academy of Sciences of the United States of America 1993 90 3 985 989 (Pubitemid 23053935)
86. Liu Y., Lee M. O., Wang H. G., Li Y., Hashimoto Y., Klaus M., Reed J. C., Zhang X. K., Retinoic acid receptor mediates the growth-inhibitory effect of retinoic acid by promoting apoptosis in human breast cancer cells Molecular and Cellular Biology 1996 16 3 1138 1149 (Pubitemid 26061685)
87. Li C., Wan Y. J. Y., Differentiation and antiproliferation effects of retinoic acid receptor in hepatoma cells Cancer Letters 1998 124 2 205 211 (Pubitemid 28073689)
88. Haugen B. R., Larson L. L., Pugazhenthi U., Hays W. R., Klopper J. P., Kramer C. A., Sharma V., Retinoic acid and retinoid X receptors are differentially expressed in thyroid cancer and thyroid carcinoma cell lines and predict response to treatment with retinoids Journal of Clinical Endocrinology and Metabolism 2004 89 1 272 280 (Pubitemid 38183893)
89. Ferrara F. F., Fazi F., Bianchini A., Padula F., Gelmetti V., Minucci S., Mancini M., Pelicci P. G., Lo Coco F., Nervi C., Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia Cancer Research 2001 61 1 2 7 (Pubitemid 32095688)
90. Lehmann S., Paul C., Trm H., The expression of cellular retinoid binding proteins in non-APL leukemic cells and its association with retinoid sensitivity Leukemia and Lymphoma 2002 43 4 851 858 (Pubitemid 34428674)
91. Chambon P., A decade of molecular biology of retinoic acid receptors FASEB Journal 1996 10 9 940 954 (Pubitemid 26285969)
92. Si S. P., Lee X., Tsou H. C., AR 2-mediated growth inhibition in HeLa cells Experimental Cell Research 1996 223 102 111
93. Tabe Y., Konopleva M., Kondo Y., Contractor R., Tsao T., Konoplev S., Shi Y., Ling X., Watt J. C., Tsutsumi-Ishii Y., Ohsaka A., Nagaoka I., Issa J. P. J., Kogan S. C., Andreeff M., PPAR -active triterpenoid CDDO enhances ATRA-induced differentiation in APL Cancer Biology and Therapy 2007 6 12 1967 1977 (Pubitemid 351590411)
94. James S. Y., Lin F., Kolluri S. K., Dawson M. I., Zhang X. K., Regulation of retinoic acid receptor expression by peroxisome proliferator-activated receptor ligands in cancer cells Cancer Research 2003 63 13 3531 3538 (Pubitemid 36793032)
95. Blanco J. C. G., Minucci S., Lu J., Yang X. J., Walker K. K., Chen H., Evans R. M., Nakatani Y., Ozato K., The histone acetylase PCAF is a nuclear receptor coactivator Genes and Development 1998 12 11 1638 1651 (Pubitemid 28299515)
96. Mangelsdorf D. J., Ong E. S., Dyck J. A., Evans R. M., Nuclear receptor that identifies a novel retinoic acid response pathway Nature 1990 345 6272 224 229
97. Heyman R. A., Mangelsdorf D. J., Dyck J. A., Stein R. B., Eichele G., Evans R. M., Thaller C., 9-Cis retinoic acid is a high affinity ligand for the retinoid X receptor Cell 1992 68 2 397 406
98. Cimino G., Lo-Coco F., Fenu S., Travaglini L., Finolezzi E., Mancini M., Nanni M., Careddu A., Fazi F., Padula F., Fiorini R., Spiriti M. A. A., Petti M. C., Venditti A., Amadori S., Mandelli F., Pelicci P. G., Nervi C., Sequential valproic acid/all-trans retinoic acid treatment reprograms differentiation in refractory and high-risk acute myeloid leukemia Cancer Research 2006 66 17 8903 8911 (Pubitemid 44449209)
99. Schlenk R. F., Dhner K., Kneba M., German-Austrian AML Study Group (AMLSG). Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia: results from the AMLSG Trial AML HD98B Haematologica 2009 94 54 60
100. Liu H., Tan B. C. M., Tseng K. H., Chuang C. P., Yeh C. W., Chen K. D., Lee S. C., Yung B. Y. M., Nucleophosmin acts as a novel AP2 -binding transcriptional corepressor during cell differentiation EMBO Reports 2007 8 4 394 400 (Pubitemid 46511041)
101. Balusu R., Fiskus W., Rao R., Targeting levels or oligomerization of nucleophosmin 1 induces differentiation and loss of survival of human AML cells with mutant NPM1 Blood 2011 118 3096 3106