Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia

Cancer Research

Volumn 61, Issue 1, 2001, Pages 2-7

  Ferrara, F F ^a   Fazi, F ^a   Bianchini, A ^a   Padula, F ^a   Gelmetti, V ^a   Minucci, S ^a   Mancini, M ^a   Pelicci, P G ^a   Lo Coco, F ^a   Nervi, C ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYRIC ACID; GENE PRODUCT; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; HYBRID PROTEIN; PROTEIN ETO; RETINOIC ACID; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX1; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; BLAST CELL; CANCER REGRESSION; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG TARGETING; GENE EXPRESSION REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; LEUKEMOGENESIS; PRIORITY JOURNAL; PROMYELOCYTE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ACETYLATION; ANTINEOPLASTIC AGENTS; CELL DIFFERENTIATION; CORE BINDING FACTOR ALPHA 2 SUBUNIT; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, LEUKEMIC; HISTONE DEACETYLASES; HISTONES; HUMANS; HYDROXAMIC ACIDS; LEUKEMIA, MYELOCYTIC, ACUTE; LEUKEMIA, MYELOMONOCYTIC, ACUTE; ONCOGENE PROTEINS, FUSION; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRETINOIN; TUMOR CELLS, CULTURED;

EID: 0035132140     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Transcription factors, normal myeloid development, and leukemia
2. Neutrophil maturation and the role of retinoic acid
3. Impaired granulocytic differentiation in vitro in hematopoietic cells lacking retinoic acid receptors αl and γ
4. Overexpression of wild-type retinoic acid receptor α (RARα) recapitulates retinoic acid-sensitive transformation of primary myeloid progenitors by acute promyelocytic leukemia RARα-fusion genes
5. Chromatin remodelling and leukemia: New therapeutic paradigms
6. Coactivator and corepressor complexes in nuclear receptor function
7. Histone acetylases and deacetylases in cell proliferation
8. Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia
9. Role of the histone deacetylase complex in acute promyelocytic leukaemia
10. Distinct interactions of PML-RARα and PLZF-RARα with corepressors determine differential responses to RA in APL
11. Therapeutic targeting of transcription in acute promyelocytic leukemia by use of an inhibitor of histone deacetylase
12. Acute myeloid leukemia
13. Differentiation therapy for acute promyelocytic leukemia
14. All-trans retinoic acid in acute promyelocytic leukemias. II. In vitro studies: Structure-function relationship
15. Aberrant recruitment of the nuclear receptor corepressor-histone deacetylase complex by the acute myeloid leukemia fusion partner ETO
16. ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex
17. Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Cooperative Group
18. Molecular remission in PML/RARα-positive acute promyelocytic leukemia by combined all-trans-retinoic acid and idarubicin (AIDA) therapy
19. Combined cytogenetic, FISH and molecular analysis in acute promyelocytic leukemia at diagnosis and in complete remission
20. Characterization of cryptic rearrangements and variant translocations in acute promyelocytic leukemia
21. The acute promyelocytic leukaemia specific PML/RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells
22. Retinoid-induced differentiation of acute promyelocytic leukemia involves PML-RARα-mediated increase of type II transglutaminase
23. Identification of a retinoic acid response element in the retinoic acid receptor β gene
24. The lack of transcriptional activation of the v-erbA oncogene is part due to a mutation present in the binding domain of the protein
25. Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation
26. Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: Investigation of minimal residual disease in acute leukemia
27. A decade of molecular biology of retinoic acid receptors
28. The RXR heterodimers and orphan receptors
29. Altered myeloid development and acute leukemia in transgenic mice expressing PML/RARα under control of cathepsin G regulatory sequences
30. Acute leukemia with promyelocytic features in PML/RARα transgenic mice
31. Transgenic expression of PML/RARα impairs myelopoiesis
32. A PML/RARα transgene initiates murine acute promyelocytic leukemia
33. Effect of polar organic compounds on leukemic cells. Butyrateinduced partial remission of acute myelogenous leukemia in child