메뉴 건너뛰기




Volumn 23, Issue 4, 2012, Pages 402-411

The regulation of cancer cell death and metabolism by extracellular matrix attachment

Author keywords

Anoikis; Cancer metabolism; Cell death; Extracellular matrix; Metastasis; Reactive oxygen species

Indexed keywords

ANGIOPOIETIN; B RAF KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GLUCOSE; GLUTAMATE AMMONIA LIGASE; GLUTAMATE DEHYDROGENASE; GLUTAMINE; GLYCOGEN PHOSPHORYLASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MYC PROTEIN; PYRUVATE DEHYDROGENASE; PYRUVIC ACID; REACTIVE OXYGEN METABOLITE; RECEPTOR INTERACTING PROTEIN 140; TRANSCRIPTION FACTOR NRF2; TRICARBOXYLIC ACID;

EID: 84861982020     PISSN: 10849521     EISSN: 10963634     Source Type: Journal    
DOI: 10.1016/j.semcdb.2012.04.007     Document Type: Review
Times cited : (94)

References (94)
  • 1
    • 34247269026 scopus 로고    scopus 로고
    • Genetic determinants of cancer metastasis
    • Nguyen D.X., Massague J. Genetic determinants of cancer metastasis. Nature Reviews Genetics 2007, 8:341-352.
    • (2007) Nature Reviews Genetics , vol.8 , pp. 341-352
    • Nguyen, D.X.1    Massague, J.2
  • 2
    • 85027930332 scopus 로고    scopus 로고
    • Rethinking the metastatic cascade as a therapeutic target
    • Mina L.A., Sledge G.W. Rethinking the metastatic cascade as a therapeutic target. Nature Reviews Clinical Oncology 2011, 8:325-332.
    • (2011) Nature Reviews Clinical Oncology , vol.8 , pp. 325-332
    • Mina, L.A.1    Sledge, G.W.2
  • 3
    • 63049117518 scopus 로고    scopus 로고
    • Learning therapeutic lessons from metastasis suppressor proteins
    • Smith S.C., Theodorescu D. Learning therapeutic lessons from metastasis suppressor proteins. Nature Reviews Cancer 2009, 9:253-264.
    • (2009) Nature Reviews Cancer , vol.9 , pp. 253-264
    • Smith, S.C.1    Theodorescu, D.2
  • 4
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis
    • Yang J., Weinberg R.A. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Developmental Cell 2008, 14:818-829.
    • (2008) Developmental Cell , vol.14 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 5
    • 77950931419 scopus 로고    scopus 로고
    • Matrix metalloproteinases: regulators of the tumor microenvironment
    • Kessenbrock K., Plaks V., Werb Z. Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 2010, 141:52-67.
    • (2010) Cell , vol.141 , pp. 52-67
    • Kessenbrock, K.1    Plaks, V.2    Werb, Z.3
  • 6
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • Joyce J.A., Pollard J.W. Microenvironmental regulation of metastasis. Nature Reviews Cancer 2009, 9:239-252.
    • (2009) Nature Reviews Cancer , vol.9 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 9
    • 0028057613 scopus 로고
    • Disruption of epithelial cell-matrix interactions induces apoptosis
    • Frisch S.M., Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. Journal of Cell Biology 1994, 124:619-626.
    • (1994) Journal of Cell Biology , vol.124 , pp. 619-626
    • Frisch, S.M.1    Francis, H.2
  • 12
    • 36248962144 scopus 로고    scopus 로고
    • A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion
    • Overholtzer M., Mailleux A.A., Mouneimne G., Normand G., Schnitt S.J., King R.W., et al. A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion. Cell 2007, 131:966-979.
    • (2007) Cell , vol.131 , pp. 966-979
    • Overholtzer, M.1    Mailleux, A.A.2    Mouneimne, G.3    Normand, G.4    Schnitt, S.J.5    King, R.W.6
  • 13
    • 41449109334 scopus 로고    scopus 로고
    • Induction of autophagy during extracellular matrix detachment promotes cell survival
    • Fung C., Lock R., Gao S., Salas E., Debnath J. Induction of autophagy during extracellular matrix detachment promotes cell survival. Molecular Biology of the Cell 2008, 19:797-806.
    • (2008) Molecular Biology of the Cell , vol.19 , pp. 797-806
    • Fung, C.1    Lock, R.2    Gao, S.3    Salas, E.4    Debnath, J.5
  • 14
    • 78649704325 scopus 로고    scopus 로고
    • Autophagy and metabolism
    • Rabinowitz J.D., White E. Autophagy and metabolism. Science 2010, 330:1344-1348.
    • (2010) Science , vol.330 , pp. 1344-1348
    • Rabinowitz, J.D.1    White, E.2
  • 16
    • 69949101473 scopus 로고    scopus 로고
    • Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment
    • Schafer Z.T., Grassian A.R., Song L., Jiang Z., Gerhart-Hines Z., Irie H.Y., et al. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature 2009, 461:109-113.
    • (2009) Nature , vol.461 , pp. 109-113
    • Schafer, Z.T.1    Grassian, A.R.2    Song, L.3    Jiang, Z.4    Gerhart-Hines, Z.5    Irie, H.Y.6
  • 17
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: a cancer hallmark even warburg did not anticipate
    • Ward P.S., Thompson C.B. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell 2012, 21:297-308.
    • (2012) Cancer Cell , vol.21 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 18
    • 79960060305 scopus 로고    scopus 로고
    • Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
    • DeNicola G.M., Karreth F.A., Humpton T.J., Gopinathan A., Wei C., Frese K., et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 2011, 475:106-109.
    • (2011) Nature , vol.475 , pp. 106-109
    • DeNicola, G.M.1    Karreth, F.A.2    Humpton, T.J.3    Gopinathan, A.4    Wei, C.5    Frese, K.6
  • 21
    • 0032953192 scopus 로고    scopus 로고
    • Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
    • Itoh K., Wakabayashi N., Katoh Y., Ishii T., Igarashi K., Engel J.D., et al. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes and Development 1999, 13:76-86.
    • (1999) Genes and Development , vol.13 , pp. 76-86
    • Itoh, K.1    Wakabayashi, N.2    Katoh, Y.3    Ishii, T.4    Igarashi, K.5    Engel, J.D.6
  • 23
    • 0031577292 scopus 로고    scopus 로고
    • An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
    • Itoh K., Chiba T., Takahashi S., Ishii T., Igarashi K., Katoh Y., et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochemical and Biophysical Research Communications 1997, 236:313-322.
    • (1997) Biochemical and Biophysical Research Communications , vol.236 , pp. 313-322
    • Itoh, K.1    Chiba, T.2    Takahashi, S.3    Ishii, T.4    Igarashi, K.5    Katoh, Y.6
  • 26
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science 1956, 123:309-314.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 27
    • 0001221508 scopus 로고
    • On respiratory impairment in cancer cells
    • Warburg O. On respiratory impairment in cancer cells. Science 1956, 124:269-270.
    • (1956) Science , vol.124 , pp. 269-270
    • Warburg, O.1
  • 28
    • 40749163248 scopus 로고    scopus 로고
    • The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
    • Christofk H.R., Vander Heiden M.G., Harris M.H., Ramanathan A., Gerszten R.E., Wei R., et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 2008, 452:230-233.
    • (2008) Nature , vol.452 , pp. 230-233
    • Christofk, H.R.1    Vander Heiden, M.G.2    Harris, M.H.3    Ramanathan, A.4    Gerszten, R.E.5    Wei, R.6
  • 30
    • 0032939854 scopus 로고    scopus 로고
    • Expression of pyruvate kinase M2 in preneoplastic hepatic foci of N-nitrosomorpholine-treated rats
    • Steinberg P., Klingelhoffer A., Schafer A., Wust G., Weisse G., Oesch F., et al. Expression of pyruvate kinase M2 in preneoplastic hepatic foci of N-nitrosomorpholine-treated rats. Virchows Archiv 1999, 434:213-220.
    • (1999) Virchows Archiv , vol.434 , pp. 213-220
    • Steinberg, P.1    Klingelhoffer, A.2    Schafer, A.3    Wust, G.4    Weisse, G.5    Oesch, F.6
  • 31
    • 0026642691 scopus 로고
    • Immunohistological demonstration of pyruvate kinase isoenzyme type L in rat with monoclonal antibodies
    • Domingo M., Einig C., Eigenbrodt E., Reinacher M. Immunohistological demonstration of pyruvate kinase isoenzyme type L in rat with monoclonal antibodies. Journal of Histochemistry and Cytochemistry 1992, 40:665-673.
    • (1992) Journal of Histochemistry and Cytochemistry , vol.40 , pp. 665-673
    • Domingo, M.1    Einig, C.2    Eigenbrodt, E.3    Reinacher, M.4
  • 32
    • 0028175496 scopus 로고
    • L- and M2-pyruvate kinase expression in renal cell carcinomas and their metastases
    • Brinck U., Eigenbrodt E., Oehmke M., Mazurek S., Fischer G. L- and M2-pyruvate kinase expression in renal cell carcinomas and their metastases. Virchows Archiv 1994, 424:177-185.
    • (1994) Virchows Archiv , vol.424 , pp. 177-185
    • Brinck, U.1    Eigenbrodt, E.2    Oehmke, M.3    Mazurek, S.4    Fischer, G.5
  • 34
    • 0022930036 scopus 로고
    • The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing
    • Noguchi T., Inoue H., Tanaka T. The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing. Journal of Biological Chemistry 1986, 261:13807-13812.
    • (1986) Journal of Biological Chemistry , vol.261 , pp. 13807-13812
    • Noguchi, T.1    Inoue, H.2    Tanaka, T.3
  • 36
    • 0018693275 scopus 로고
    • Immunohistochemical localization of pyruvate kinase isoenzymes in chicken tissues
    • Reinacher M., Eigenbrodt E., Schering B., Schoner W. Immunohistochemical localization of pyruvate kinase isoenzymes in chicken tissues. Histochemistry 1979, 64:145-161.
    • (1979) Histochemistry , vol.64 , pp. 145-161
    • Reinacher, M.1    Eigenbrodt, E.2    Schering, B.3    Schoner, W.4
  • 38
    • 0019487346 scopus 로고
    • Immunohistological demonstration of the same type of pyruvate kinase isoenzyme (M2-Pk) in tumors of chicken and rat
    • Reinacher M., Eigenbrodt E. Immunohistological demonstration of the same type of pyruvate kinase isoenzyme (M2-Pk) in tumors of chicken and rat. Virchows Archiv B, Cell Pathology Including Molecular Pathology 1981, 37:79-88.
    • (1981) Virchows Archiv B, Cell Pathology Including Molecular Pathology , vol.37 , pp. 79-88
    • Reinacher, M.1    Eigenbrodt, E.2
  • 39
    • 0026352957 scopus 로고
    • The role of red cell aging in the diagnosis of glycolytic enzyme defects
    • Staal G.E., Rijksen G. The role of red cell aging in the diagnosis of glycolytic enzyme defects. Advances in Experimental Medicine and Biology 1991, 307:239-249.
    • (1991) Advances in Experimental Medicine and Biology , vol.307 , pp. 239-249
    • Staal, G.E.1    Rijksen, G.2
  • 42
    • 84863229429 scopus 로고    scopus 로고
    • Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells
    • Tamada M., Nagano O., Tateyama S., Ohmura M., Yae T., Ishimoto T., et al. Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells. Cancer Research 2012, 72:1438-1448.
    • (2012) Cancer Research , vol.72 , pp. 1438-1448
    • Tamada, M.1    Nagano, O.2    Tateyama, S.3    Ohmura, M.4    Yae, T.5    Ishimoto, T.6
  • 43
    • 80052751477 scopus 로고    scopus 로고
    • Pyruvate kinase triggers a metabolic feedback loop that controls redox metabolism in respiring cells
    • Gruning N.M., Rinnerthaler M., Bluemlein K., Mulleder M., Wamelink M.M., Lehrach H., et al. Pyruvate kinase triggers a metabolic feedback loop that controls redox metabolism in respiring cells. Cell Metabolism 2011, 14:415-427.
    • (2011) Cell Metabolism , vol.14 , pp. 415-427
    • Gruning, N.M.1    Rinnerthaler, M.2    Bluemlein, K.3    Mulleder, M.4    Wamelink, M.M.5    Lehrach, H.6
  • 44
    • 82755166890 scopus 로고    scopus 로고
    • Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses
    • Anastasiou D., Poulogiannis G., Asara J.M., Boxer M.B., Jiang J.K., Shen M., et al. Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science 2011, 334:1278-1283.
    • (2011) Science , vol.334 , pp. 1278-1283
    • Anastasiou, D.1    Poulogiannis, G.2    Asara, J.M.3    Boxer, M.B.4    Jiang, J.K.5    Shen, M.6
  • 49
    • 70350575440 scopus 로고    scopus 로고
    • Modulation of intracellular ROS levels by TIGAR controls autophagy
    • Bensaad K., Cheung E.C., Vousden K.H. Modulation of intracellular ROS levels by TIGAR controls autophagy. EMBO Journal 2009, 28:3015-3026.
    • (2009) EMBO Journal , vol.28 , pp. 3015-3026
    • Bensaad, K.1    Cheung, E.C.2    Vousden, K.H.3
  • 50
    • 48449101433 scopus 로고    scopus 로고
    • P53 target genes sestrin 1 and sestrin 2 connect genotoxic stress and mTOR signaling
    • Budanov A.V., Karin M. p53 target genes sestrin 1 and sestrin 2 connect genotoxic stress and mTOR signaling. Cell 2008, 134:451-460.
    • (2008) Cell , vol.134 , pp. 451-460
    • Budanov, A.V.1    Karin, M.2
  • 51
    • 20844449238 scopus 로고    scopus 로고
    • AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
    • Jones R.G., Plas D.R., Kubek S., Buzzai M., Mu J., Xu Y., et al. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Molecular Cell 2005, 18:283-293.
    • (2005) Molecular Cell , vol.18 , pp. 283-293
    • Jones, R.G.1    Plas, D.R.2    Kubek, S.3    Buzzai, M.4    Mu, J.5    Xu, Y.6
  • 52
    • 77956294919 scopus 로고    scopus 로고
    • Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation
    • Bungard D., Fuerth B.J., Zeng P.Y., Faubert B., Maas N.L., Viollet B., et al. Signaling kinase AMPK activates stress-promoted transcription via histone H2B phosphorylation. Science 2010, 329:1201-1205.
    • (2010) Science , vol.329 , pp. 1201-1205
    • Bungard, D.1    Fuerth, B.J.2    Zeng, P.Y.3    Faubert, B.4    Maas, N.L.5    Viollet, B.6
  • 53
    • 84857043185 scopus 로고    scopus 로고
    • The AMPK stress response pathway mediates anoikis resistance through inhibition of mTOR and suppression of protein synthesis
    • Ng T.L., Leprivier G., Robertson M.D., Chow C., Martin M.J., Laderoute K.R., et al. The AMPK stress response pathway mediates anoikis resistance through inhibition of mTOR and suppression of protein synthesis. Cell Death and Differentiation 2011, 19:501-510.
    • (2011) Cell Death and Differentiation , vol.19 , pp. 501-510
    • Ng, T.L.1    Leprivier, G.2    Robertson, M.D.3    Chow, C.4    Martin, M.J.5    Laderoute, K.R.6
  • 54
    • 33748037026 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1alpha expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer
    • Generali D., Berruti A., Brizzi M.P., Campo L., Bonardi S., Wigfield S., et al. Hypoxia-inducible factor-1alpha expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer. Clinical Cancer Research 2006, 12:4562-4568.
    • (2006) Clinical Cancer Research , vol.12 , pp. 4562-4568
    • Generali, D.1    Berruti, A.2    Brizzi, M.P.3    Campo, L.4    Bonardi, S.5    Wigfield, S.6
  • 56
    • 57749105319 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha mediates anoikis resistance via suppression of alpha5 integrin
    • Rohwer N., Welzel M., Daskalow K., Pfander D., Wiedenmann B., Detjen K., et al. Hypoxia-inducible factor 1alpha mediates anoikis resistance via suppression of alpha5 integrin. Cancer Research 2008, 68:10113-10120.
    • (2008) Cancer Research , vol.68 , pp. 10113-10120
    • Rohwer, N.1    Welzel, M.2    Daskalow, K.3    Pfander, D.4    Wiedenmann, B.5    Detjen, K.6
  • 57
    • 79954819890 scopus 로고    scopus 로고
    • S100A4 protects gastric cancer cells from anoikis through regulation of alphav and alpha5 integrin
    • Shen W., Chen D., Fu H., Liu S., Sun K., Sun X. S100A4 protects gastric cancer cells from anoikis through regulation of alphav and alpha5 integrin. Cancer Science 2011, 102:1014-1018.
    • (2011) Cancer Science , vol.102 , pp. 1014-1018
    • Shen, W.1    Chen, D.2    Fu, H.3    Liu, S.4    Sun, K.5    Sun, X.6
  • 61
    • 79960456668 scopus 로고    scopus 로고
    • Surviving without oxygen: hypoxia regulation of mammary morphogenesis and anoikis
    • Whelan K.A., Reginato M.J. Surviving without oxygen: hypoxia regulation of mammary morphogenesis and anoikis. Cell Cycle 2011, 10:2287-2294.
    • (2011) Cell Cycle , vol.10 , pp. 2287-2294
    • Whelan, K.A.1    Reginato, M.J.2
  • 62
    • 50849088969 scopus 로고    scopus 로고
    • Extracellular matrix regulation of autophagy
    • Lock R., Debnath J. Extracellular matrix regulation of autophagy. Current Opinion in Cell Biology 2008, 20:583-588.
    • (2008) Current Opinion in Cell Biology , vol.20 , pp. 583-588
    • Lock, R.1    Debnath, J.2
  • 63
    • 64649085325 scopus 로고    scopus 로고
    • Autophagy and cancer: dynamism of the metabolism of tumor cells and tissues
    • Tsuchihara K., Fujii S., Esumi H. Autophagy and cancer: dynamism of the metabolism of tumor cells and tissues. Cancer Letters 2009, 278:130-138.
    • (2009) Cancer Letters , vol.278 , pp. 130-138
    • Tsuchihara, K.1    Fujii, S.2    Esumi, H.3
  • 64
    • 0037020196 scopus 로고    scopus 로고
    • The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini
    • Debnath J., Mills K.R., Collins N.L., Reginato M.J., Muthuswamy S.K., Brugge J.S. The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell 2002, 111:29-40.
    • (2002) Cell , vol.111 , pp. 29-40
    • Debnath, J.1    Mills, K.R.2    Collins, N.L.3    Reginato, M.J.4    Muthuswamy, S.K.5    Brugge, J.S.6
  • 65
    • 80052455843 scopus 로고    scopus 로고
    • Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI(3)K-mTOR pathway in pancreatic adenocarcinoma
    • Mirzoeva O.K., Hann B., Hom Y.K., Debnath J., Aftab D., Shokat K., et al. Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI(3)K-mTOR pathway in pancreatic adenocarcinoma. Journal of Molecular Medicine (Berlin) 2011, 89:877-889.
    • (2011) Journal of Molecular Medicine (Berlin) , vol.89 , pp. 877-889
    • Mirzoeva, O.K.1    Hann, B.2    Hom, Y.K.3    Debnath, J.4    Aftab, D.5    Shokat, K.6
  • 66
    • 79551598347 scopus 로고    scopus 로고
    • AMPK and mTOR regulate autophagy through direct phosphorylation of ULK1
    • Kim J., Kundu M., Viollet B., Guan K.L. AMPK and mTOR regulate autophagy through direct phosphorylation of ULK1. Nature Cell Biology 2011, 13:132-141.
    • (2011) Nature Cell Biology , vol.13 , pp. 132-141
    • Kim, J.1    Kundu, M.2    Viollet, B.3    Guan, K.L.4
  • 68
    • 33751285479 scopus 로고    scopus 로고
    • The PERK/eIF2alpha/ATF4 module of the UPR in hypoxia resistance and tumor growth
    • Fels D.R., Koumenis C. The PERK/eIF2alpha/ATF4 module of the UPR in hypoxia resistance and tumor growth. Cancer Biology and Therapy 2006, 5:723-728.
    • (2006) Cancer Biology and Therapy , vol.5 , pp. 723-728
    • Fels, D.R.1    Koumenis, C.2
  • 70
    • 80455122654 scopus 로고    scopus 로고
    • Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes
    • Florey O., Kim S.E., Sandoval C.P., Haynes C.M., Overholtzer M. Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes. Nature Cell Biology 2011, 13:1335-1343.
    • (2011) Nature Cell Biology , vol.13 , pp. 1335-1343
    • Florey, O.1    Kim, S.E.2    Sandoval, C.P.3    Haynes, C.M.4    Overholtzer, M.5
  • 71
    • 33644840693 scopus 로고    scopus 로고
    • Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
    • Degterev A., Huang Z., Boyce M., Li Y., Jagtap P., Mizushima N., et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nature Chemical Biology 2005, 1:112-119.
    • (2005) Nature Chemical Biology , vol.1 , pp. 112-119
    • Degterev, A.1    Huang, Z.2    Boyce, M.3    Li, Y.4    Jagtap, P.5    Mizushima, N.6
  • 72
    • 57649181391 scopus 로고    scopus 로고
    • Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway
    • Hitomi J., Christofferson D.E., Ng A., Yao J., Degterev A., Xavier R.J., et al. Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell 2008, 135:1311-1323.
    • (2008) Cell , vol.135 , pp. 1311-1323
    • Hitomi, J.1    Christofferson, D.E.2    Ng, A.3    Yao, J.4    Degterev, A.5    Xavier, R.J.6
  • 74
    • 0041853690 scopus 로고    scopus 로고
    • Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    • Micheau O., Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 2003, 114:181-190.
    • (2003) Cell , vol.114 , pp. 181-190
    • Micheau, O.1    Tschopp, J.2
  • 75
    • 33646034316 scopus 로고    scopus 로고
    • Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
    • Ea C.K., Deng L., Xia Z.P., Pineda G., Chen Z.J. Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Molecular Cell 2006, 22:245-257.
    • (2006) Molecular Cell , vol.22 , pp. 245-257
    • Ea, C.K.1    Deng, L.2    Xia, Z.P.3    Pineda, G.4    Chen, Z.J.5
  • 76
    • 43049152912 scopus 로고    scopus 로고
    • TNF-alpha induces two distinct caspase-8 activation pathways
    • Wang L., Du F., Wang X. TNF-alpha induces two distinct caspase-8 activation pathways. Cell 2008, 133:693-703.
    • (2008) Cell , vol.133 , pp. 693-703
    • Wang, L.1    Du, F.2    Wang, X.3
  • 77
    • 67650812332 scopus 로고    scopus 로고
    • RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis
    • Zhang D.W., Shao J., Lin J., Zhang N., Lu B.J., Lin S.C., et al. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 2009, 325:332-336.
    • (2009) Science , vol.325 , pp. 332-336
    • Zhang, D.W.1    Shao, J.2    Lin, J.3    Zhang, N.4    Lu, B.J.5    Lin, S.C.6
  • 78
    • 66749183275 scopus 로고    scopus 로고
    • Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha
    • He S., Wang L., Miao L., Wang T., Du F., Zhao L., et al. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell 2009, 137:1100-1111.
    • (2009) Cell , vol.137 , pp. 1100-1111
    • He, S.1    Wang, L.2    Miao, L.3    Wang, T.4    Du, F.5    Zhao, L.6
  • 79
    • 66449133280 scopus 로고    scopus 로고
    • Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation
    • Cho Y.S., Challa S., Moquin D., Genga R., Ray T.D., Guildford M., et al. Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 2009, 137:1112-1123.
    • (2009) Cell , vol.137 , pp. 1112-1123
    • Cho, Y.S.1    Challa, S.2    Moquin, D.3    Genga, R.4    Ray, T.D.5    Guildford, M.6
  • 80
    • 84862907788 scopus 로고    scopus 로고
    • Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase
    • Sun L., Wang H., Wang Z., He S., Chen S., Liao D., et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell 2012, 148:213-227.
    • (2012) Cell , vol.148 , pp. 213-227
    • Sun, L.1    Wang, H.2    Wang, Z.3    He, S.4    Chen, S.5    Liao, D.6
  • 81
    • 84862909353 scopus 로고    scopus 로고
    • The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways
    • Wang Z., Jiang H., Chen S., Du F., Wang X. The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways. Cell 2012, 148:228-243.
    • (2012) Cell , vol.148 , pp. 228-243
    • Wang, Z.1    Jiang, H.2    Chen, S.3    Du, F.4    Wang, X.5
  • 82
    • 42649130014 scopus 로고    scopus 로고
    • PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria
    • Lo S.C., Hannink M. PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria. Experimental Cell Research 2008, 314:1789-1803.
    • (2008) Experimental Cell Research , vol.314 , pp. 1789-1803
    • Lo, S.C.1    Hannink, M.2
  • 83
    • 77951568703 scopus 로고    scopus 로고
    • Phosphoinositide signalling in cancer: beyond PI(3)K and PTEN
    • Bunney T.D., Katan M. Phosphoinositide signalling in cancer: beyond PI(3)K and PTEN. Nature Reviews Cancer 2010, 10:342-352.
    • (2010) Nature Reviews Cancer , vol.10 , pp. 342-352
    • Bunney, T.D.1    Katan, M.2
  • 84
    • 67749122122 scopus 로고    scopus 로고
    • Targeting PI(3)K signalling in cancer: opportunities, challenges and limitations
    • Engelman J.A. Targeting PI(3)K signalling in cancer: opportunities, challenges and limitations. Nature Reviews Cancer 2009, 9:550-562.
    • (2009) Nature Reviews Cancer , vol.9 , pp. 550-562
    • Engelman, J.A.1
  • 85
    • 67649814136 scopus 로고    scopus 로고
    • PI(3)K/PTEN signaling in angiogenesis and tumorigenesis
    • Jiang B.H., Liu L.Z. PI(3)K/PTEN signaling in angiogenesis and tumorigenesis. Advances in Cancer Research 2009, 102:19-65.
    • (2009) Advances in Cancer Research , vol.102 , pp. 19-65
    • Jiang, B.H.1    Liu, L.Z.2
  • 86
    • 84858796367 scopus 로고    scopus 로고
    • A two-way street: reciprocal regulation of metabolism and signalling
    • Wellen K.E., Thompson C.B. A two-way street: reciprocal regulation of metabolism and signalling. Nature Reviews Molecular Cell Biology 2012, 13:270-276.
    • (2012) Nature Reviews Molecular Cell Biology , vol.13 , pp. 270-276
    • Wellen, K.E.1    Thompson, C.B.2
  • 87
    • 42949176742 scopus 로고    scopus 로고
    • Survival of cancer cells is maintained by EGFR independent of its kinase activity
    • Weihua Z., Tsan R., Huang W.C., Wu Q., Chiu C.H., Fidler I.J., et al. Survival of cancer cells is maintained by EGFR independent of its kinase activity. Cancer Cell 2008, 13:385-393.
    • (2008) Cancer Cell , vol.13 , pp. 385-393
    • Weihua, Z.1    Tsan, R.2    Huang, W.C.3    Wu, Q.4    Chiu, C.H.5    Fidler, I.J.6
  • 88
    • 23844533212 scopus 로고    scopus 로고
    • The neurotrophic receptor TrkB in anoikis resistance and metastasis: a perspective
    • Geiger T.R., Peeper D.S. The neurotrophic receptor TrkB in anoikis resistance and metastasis: a perspective. Cancer Research 2005, 65:7033-7036.
    • (2005) Cancer Research , vol.65 , pp. 7033-7036
    • Geiger, T.R.1    Peeper, D.S.2
  • 89
    • 4344627055 scopus 로고    scopus 로고
    • Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB
    • Douma S., Van Laar T., Zevenhoven J., Meuwissen R., Van Garderen E., Peeper D.S. Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB. Nature 2004, 430:1034-1039.
    • (2004) Nature , vol.430 , pp. 1034-1039
    • Douma, S.1    Van Laar, T.2    Zevenhoven, J.3    Meuwissen, R.4    Van Garderen, E.5    Peeper, D.S.6
  • 90
    • 79951900121 scopus 로고    scopus 로고
    • Functional characterization of human cancer-derived TRKB mutations
    • Geiger T.R., Song J.Y., Rosado A., Peeper D.S. Functional characterization of human cancer-derived TRKB mutations. PLoS One 2011, 6:e16871.
    • (2011) PLoS One , vol.6
    • Geiger, T.R.1    Song, J.Y.2    Rosado, A.3    Peeper, D.S.4
  • 91
    • 38949109297 scopus 로고    scopus 로고
    • Suppression of anoikis by the neurotrophic receptor TrkB in human ovarian cancer
    • Yu X., Liu L., Cai B., He Y., Wan X. Suppression of anoikis by the neurotrophic receptor TrkB in human ovarian cancer. Cancer Science 2008, 99:543-552.
    • (2008) Cancer Science , vol.99 , pp. 543-552
    • Yu, X.1    Liu, L.2    Cai, B.3    He, Y.4    Wan, X.5
  • 92
    • 66149157927 scopus 로고    scopus 로고
    • TrkA overexpression enhances growth and metastasis of breast cancer cells
    • Lagadec C., Meignan S., Adriaenssens E., Foveau B., Vanhecke E., Romon R., et al. TrkA overexpression enhances growth and metastasis of breast cancer cells. Oncogene 2009, 28:1960-1970.
    • (2009) Oncogene , vol.28 , pp. 1960-1970
    • Lagadec, C.1    Meignan, S.2    Adriaenssens, E.3    Foveau, B.4    Vanhecke, E.5    Romon, R.6
  • 93
    • 78149274357 scopus 로고    scopus 로고
    • TrkC plays an essential role in breast tumor growth and metastasis
    • Jin W., Kim G.M., Kim M.S., Lim M.H., Yun C., Jeong J., et al. TrkC plays an essential role in breast tumor growth and metastasis. Carcinogenesis 2010, 31:1939-1947.
    • (2010) Carcinogenesis , vol.31 , pp. 1939-1947
    • Jin, W.1    Kim, G.M.2    Kim, M.S.3    Lim, M.H.4    Yun, C.5    Jeong, J.6
  • 94
    • 60949083613 scopus 로고    scopus 로고
    • The molecular determinants of de novo nucleotide biosynthesis in cancer cells
    • Tong X., Zhao F., Thompson C.B. The molecular determinants of de novo nucleotide biosynthesis in cancer cells. Current Opinion in Genetics and Development 2009, 19(1):32-37.
    • (2009) Current Opinion in Genetics and Development , vol.19 , Issue.1 , pp. 32-37
    • Tong, X.1    Zhao, F.2    Thompson, C.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.