Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K-mTOR pathway in pancreatic adenocarcinoma

Journal of Molecular Medicine

Volumn 89, Issue 9, 2011, Pages 877-889

  Mirzoeva, Olga K ^a   Hann, Byron ^b   Hom, Yun K ^b   Debnath, Jayanta ^a   Aftab, Dana ^c   Shokat, Kevan ^a   Korn, W Michael ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c EXELIXIS INC   (United States)

Author keywords

Apoptosis; Autophagy; Cancer signal transduction; Chloroquine; EGFR pathway; mTOR; Pancreatic adenocarcinoma; PI3K

Indexed keywords

CHLOROQUINE; ENZYME INHIBITOR; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PIK 90; RAPAMYCIN; UNCLASSIFIED DRUG; XL 147; XL 765;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL; CANCER INHIBITION; CANCER SUSCEPTIBILITY; CELL DEATH; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; PANCREAS CARCINOMA;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; HUMANS; MICE; MICE, NUDE; PANCREATIC NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN KINASE INHIBITORS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 80052455843     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-011-0774-y     Document Type: Article

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