The AMPK stress response pathway mediates anoikis resistance through inhibition of mTOR and suppression of protein synthesis

Cell Death and Differentiation

Volumn 19, Issue 3, 2012, Pages 501-510

  Ng, T L ^a,b   Leprivier, G ^a   Robertson, M D ^a   Chow, C ^a   Martin, M J ^c   Laderoute, K R ^d   Davicioni, E ^e   Triche, T J ^f   Sorensen, P H B ^a,b  

^a BRITISH COLUMBIA CANCER RESEARCH CENTRE   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^d SRI INTERNATIONAL   (United States)

^e GenomeDx Biosciences Inc   (Canada)

^f CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

AMPK; anoikis; cellular stress; mTORC1; protein translation

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN;

ANIMAL CELL; ANOIKIS; ARTICLE; BIOENERGY; BREAST CARCINOMA; CANCER CELL CULTURE; CELL MIGRATION; CELL STRESS; CELL SURVIVAL; CELL TRANSFORMATION; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; FIBROBLAST; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; METASTASIS; METASTASIS POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN SYNTHESIS INHIBITION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSLATION REGULATION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANOIKIS; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; EMBRYO, MAMMALIAN; FIBROBLASTS; MICE; MICE, KNOCKOUT; NIH 3T3 CELLS; PROTEIN BIOSYNTHESIS; PROTEINS; TOR SERINE-THREONINE KINASES;

EID: 84857043185     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2011.119     Document Type: Article

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