Heterologous SH3-p85 inhibits influenza A virus replication

Virology Journal

Volumn 7, Issue , 2010, Pages

  Zhang, Dan Gui ^a   Li, Wei Zhong ^a   Wang, Ge Fei ^a   Su, Yun ^a   Zeng, Jun ^a   Zhang, Chi ^a   Zeng, Xiang Xing ^a   Chen, Xiao Xuan ^a   Xu, Yan Xuan ^a   Li, Kang Sheng ^a  

^a SHANTOU UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

NONSTRUCTURAL PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P85; PROTEIN P85BETA; PROTEIN SH3; UNCLASSIFIED DRUG; INS1 PROTEIN, INFLUENZA VIRUS; PROTEIN SUBUNIT; VIRUS PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; GENE OVEREXPRESSION; INFLUENZA VIRUS A; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H3N2; INFLUENZA VIRUS A H9N2; NONHUMAN; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; VIRUS INFECTION; VIRUS INTERFERENCE; VIRUS REPLICATION; VIRUS STRAIN; ANIMAL; CELL LINE; CHEMISTRY; DOG; DOWN REGULATION; ENZYMOLOGY; GENETICS; HUMAN; INFLUENZA; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SRC HOMOLOGY DOMAIN; VIROLOGY;

INFLUENZA A VIRUS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL LINE; DOGS; DOWN-REGULATION; HUMANS; INFLUENZA A VIRUS; INFLUENZA, HUMAN; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN SUBUNITS; PROTO-ONCOGENE PROTEINS C-AKT; SRC HOMOLOGY DOMAINS; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 77954801164     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/1743-422X-7-170     Document Type: Article

References (26)

1. Multiple reassortment events in the evolutionary history of H1N1 influenza A virus since 1918. MI Nelson C Viboud L Simonsen RT Bennett SB Griesemer K St George J Taylor DJ Spiro NA Sengamalay E Ghedin JK Taubenberger EC Holmes, PLoS Pathog 2008 4 1000012 10.1371/journal.ppat.1000012 18463694
2. Human infection with influenza H9N2. M Peiris KY Yuen CW Leung KH Chan PL Ip RW Lai WK Orr KF Shortridge, Lancet 1999 354 916 917 10.1016/S0140-6736(99) 03311-5 10489954
3. Inhibition of interferon-mediated antiviral responses by influenza A viruses and other negative-strand RNA viruses. A Garcia-Sastre, Virology 2001 279 375 384 10.1006/viro.2000.0756 11162793
4. Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems. A Garcia-Sastre A Egorov D Matassov S Brandt DE Levy JE Durbin P Palese T Muster, Virology 1998 252 324 330 10.1006/viro.1998.9508 9878611
5. Intracellular warfare between human influenza viruses and human cells: the roles of the viral NS1 protein. RM Krug W Yuan DL Noah AG Latham, Virology 2003 309 181 189 10.1016/S0042-6822(03)00119-3 12758165
6. Variation in the ability of human influenza A viruses to induce and inhibit the IFN-beta pathway. A Hayman S Comely A Lackenby S Murphy J McCauley S Goodbourn W Barclay, Virology 2006 347 52 64 10.1016/j.virol.2005.11.024 16378631
7. Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling. BG Hale D Jackson YH Chen RA Lamb RE Randall, Proc Natl Acad Sci USA 2006 103 14194 14199 10.1073/pnas.0606109103 16963558
8. Advances in protein kinase B signalling: AKTion on multiple fronts. DP Brazil ZZ Yang BA Hemmings, Trends Biochem Sci 2004 29 233 242 10.1016/j.tibs.2004.03.006 15130559
9. The phosphoinositide 3-kinase pathway. LC Cantley, Science 2002 296 1655 1657 10.1126/science.296.5573.1655 12040186
10. The pivotal role of phosphatidylinositol 3-kinase-Akt signal transduction in virus survival. S Cooray, J Gen Virol 2004 85 1065 1076 10.1099/vir.0.19771- 0 15105524
11. Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit. Yu J Y Zhang J McIlroy T Rordorf-Nikolic GA Orr JM Backer, Mol Cell Biol 1998 18 1379 1387 9488453
12. Phosphoinositide 3-kinase signalling pathways. DA Cantrell, J Cell Sci 2001 114 1439 1445 11282020
13. Signalling by PI3K isoforms: insights from gene-targeted mice. B Vanhaesebroeck K Ali A Bilancio B Geering LC Foukas, Trends Biochem Sci 2005 30 194 204 10.1016/j.tibs.2005.02.008 15817396
14. Influenza A virus NS1 protein activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway by direct interaction with the p85 subunit of PI3K. YK Shin Q Liu SK Tikoo LA Babiuk Y Zhou, J Gen Virol 2007 88 13 18 10.1099/vir.0.82419-0 17170431
15. SH3 binding motif 1 in influenza A virus NS1 protein is essential for PI3K/Akt signaling pathway activation. YK Shin Y Li Q Liu DH Anderson LA Babiuk Y Zhou, J Virol 2007 81 12730 12739 10.1128/JVI.01427-07 17881440
16. Mechanism of influenza A virus NS1 protein interaction with the p85beta, but not the p85alpha, subunit of phosphatidylinositol 3-kinase (PI3K) and up-regulation of PI3K activity. Li Y DH Anderson Q Liu Y Zhou, J Biol Chem 2008 283 23397 23409 10.1074/jbc.M802737200 18534979
17. Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein. BG Hale PS Kerry D Jackson BL Precious A Gray MJ Killip RE Randall RJ Russell, PNAS 2010 107 1954 1959 10.1073/pnas.0910715107 20133840
18. Bivalent role of the phosphatidylinositol-3-kinase (PI3K) during influenza virus infection and host cell defence. C Ehrhardt H Marjuki T Wolff B Nurnberg O Planz S Pleschka S Ludwig, Cell Microbiol 2006 8 1336 1348 10.1111/j.1462-5822.2006.00713.x 16882036
19. Effect of the phosphatidylinositol 3-kinase/Akt pathway on influenza A virus propagation. YK Shin Q Liu SK Tikoo LA Babiuk Y Zhou, J Gen Virol 2007 88 942 950 10.1099/vir.0.82483-0 17325368
20. Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses. C Ehrhardt T Wolff S Pleschka O Planz W Beermann JG Bode M Schmolke S Ludwig, J Virol 2007 81 3058 3067 10.1128/JVI.02082-06 17229704
21. Control of apoptosis in influenza virus-infected cells by up-regulation of Akt and p53 signaling. OP Zhirnov HD Klenk, Apoptosis 2007 12 1419 1432 10.1007/s10495-007-0071-y 17468837
22. A new player in a deadly game: influenza viruses and the PI3K/Akt signalling pathway. C Ehrhardt S Ludwig, Cell Microbiol 2009 11 863 871 10.1111/j.1462-5822.2009.01309.x 19290913
23. PI3K/Akt and apoptosis: size matters. TF Franke CP Hornik L Segev GA Shostak C Sugimoto, Oncogene 2003 22 8983 8998 10.1038/sj.onc.1207115 14663477
24. The multifunctional NS1 protein of influenza A viruses. BG Hale RE Randall J Ortin D Jackson, J Gen Virol 2008 89 2359 2376 10.1099/vir.0.2008/ 004606-0 18796704
25. The CPSF30 binding site on the NS1A protein of influenza A virus is a potential antiviral target. KY Twu DL Noah P Rao RL Kuo RM Krug, J Virol 2006 80 3957 3965 10.1128/JVI.80.8.3957-3965.2006 16571812
26. Differential suppressive effect of promyelocytic leukemia protein on the replication of different subtypes/strains of influenza A virus. W Li G Wang H Zhang D Zhang J Zeng X Chen Y Xu K Li, Biochem Biophys Res Commun 2009 389 84 89 10.1016/j.bbrc.2009.08.091 19703418