Evidence for cytokine mediation of disease expression in adults experimentally infected with influenza A virus

Journal of Infectious Diseases

Volumn 180, Issue 1, 1999, Pages 10-14

  Skoner, David P ^a   Gentile, Deborah A ^a   Patel, Asha ^a   Doyle, William J ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 6; INTERLEUKIN 8; PLACEBO; RIMANTADINE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; INFLUENZA VIRUS A; MAJOR CLINICAL STUDY; MALE; NOSE MUCUS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SYMPTOMATOLOGY; VIRUS PATHOGENESIS; VIRUS REPLICATION; VIRUS SHEDDING;

ADOLESCENT; ADULT; ANTIVIRAL AGENTS; FEMALE; HUMANS; INFLUENZA A VIRUS; INFLUENZA, HUMAN; INTERLEUKIN-6; INTERLEUKIN-8; MALE; MIDDLE AGED; MUCUS; NASAL LAVAGE FLUID; RIMANTADINE; STATISTICS, NONPARAMETRIC;

EID: 0032977441     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/314823     Document Type: Article

References (30)

1. Gwaltney JM. Upper respiratory infections, the common cold. In: Mandell GL, Bennet JE, Dolin R, eds. Principles and practice of infectious diseases. 4th ed. New York: Churchill Livingstone, 1995;561-6.
2. Gwaltney JM Jr. Rhinovirus infection of the normal human airway. Am J Respir Crit Care Med 1995;152:S36-9.
3. Turner RB. Epidemiology, pathogenesis, and treatment of the common cold. Ann Allergy Asthma Immunol 1997;78:531-9.
4. Naclerio RM, Proud D, Lichtenstein LM, et al. Kinins are generated during experimental rhinovirus colds. J Infect Dis 1988;157:133-42.
5. Igarashi Y, Skoner DP, Doyle WJ, White MV, Fireman P, Kaliner MA. Analysis of nasal secretions during phases of experimental rhinovirus upper respiratory tract infection. J Allergy Clin Immunol 1993;92:722-31.
6. Doyle WJ, Skoner DP, White MV, et al. Pattern of nasal secretions during experimental influenza virus infection. Rhinology 1996;34:2-8.
7. Smith H, Sweet C. Lessons for human influenza from pathogenicity studies with ferrels. Rev Infect Dis 1988;10:56-75.
8. Yuta A, Gaumond E, Ali M, et al. Rhinovirus infection induces mucus Hypersecretion. Am J Physiol 1998;274:1017-23.
9. Arnold R, Humbert B, Werchau H, Gallati H, Konig W. Interleukin-8, interleukin-6, and soluble necrosis factor receptor type I release from a human pulmonary epithelial cell line (AS49) exposed to respiratory syncytial virus. Immunology 1994;82:126-33.
10. Arnold R, Werner F, Humbert B, Werchau II, Kinig W. Effect of respiratory syncytial virus-antibody complexes on cytokine (IL-8, IL-6, TNF-α) release and respiratory burst in human granulocytes. Immunology 1994;82:184-91.
11. Arnold R, Konig B, Galatti H, Werchau H, Konig W. Cytokine (IL-8, IL-6, TNF-α) and TNF receptor-I release from peripheral blood mononuclear cells after respiratory syncytial virus infection. Immunology 1995;85:364-72.
12. Subauste MC, Jacoby D, Richards S, Proud D. Infection of a human respiratory epithelial cell line with rhinovirus. Induction of cytokine release and modulation of susceptibility to infection by cytokine exposure. J Clin Invest 1995;96:549-57.
13. Zhu Z, Tang W, Ray A, et al. Rhinovirus stimulation of interleukin-6 in vivo and in vitro: evidence for nuclear factor κB dependent transcriptional activation. J Clin Invest 1996;97:421-30.
14. Einarsson O, Geba GP, Zhu Z, Landry M, Elias JA. Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness. J Clin Invest 1996;97:915-24.
15. Matsukuru S, Kokubu F, Noda H, Tokunaga H, Adachi M. Expression of IL-6, IL-8, and RANTES on human bronchial epithelial cells, NCI-H292, induced by influenza virus A. J Allergy Clin Immunol 1996;98:1080-7.
16. Bruder JT, Kovesdi I. Adenovirus infection stimulates the Raf/MAPK signaling pathway and induces interleukin-8 expression. J Virol 1997;71:398-404.
17. Ito M, Watanabe M, Kamiya H, Sakurai M. Changes in intracellular cytokine levels in lymphocytes induced by measles virus. Clin Immunol Immunopathol 1997;83:281-6.
18. Karp CL, Wysocka M, Wahl LM, Ahearn JM, Cuomo PJ, Sherry B, Trinchieri G, Griffin DE. Mechanism or suppression of cell-mediated immunity by measles virus. Science 1996;273:228-31.
19. Crystal RG, McEvaney NG, Rosenfeld MA, et al. Administration of an adenovirus containing the human CFTR CDNA to the respiratory tract or individuals with cystic fibrosis. Nat Genet 1994;8:42-51.
20. Proud D, Gwaltney JM Jr, Hendley JO, et al. Increased levels of interleukin-1 are detected in nasal secretions of volunteers during experimental rhinovirus colds. J infect Dis 1994;169:1007-13.
21. Noah TL, Henderson FW, Wortman IA, et al. Nasal cytokine production in viral acute upper respiratory infection of childhood. J Infect Dis 1995;171:584-72.
22. Teran LM, Johnston SL, Schroder JM, Church MK, Holgate ST. Role of nasal interleukin-8 in neutrophil recruitment and activation in children with virus-induced asthma. Am J Respir Crit Care Med 1997;155:1362-6.
23. Gentile D, Doyle W, Whiteside T, Fireman P, Hayden FG, Skoner D. Increased interleukin-6 levels in nasal lavage samples following experimental influenza A virus infection. Clin Diagn Lab Immunol 1998;5:604-8.
24. Hayden FG, Fritz R, Lobo MC, Alvord W, Strober W, Straus SF. Local and systemic cytokine responses during experimental human influenza A virus infection. Relation to symptom formation and host defense. J Clin Invest 1998;101:643-9.
25. Turner RB, Weingand KW, Chyon-Hwa Y, Leedy DW. Association between interleukin-8 concentration in nasal secretions and severity of symptoms of experimental rhinovirus colds. Clin Infect Dis 1998;26:840-6.
26. Emery BE, White MV, Igarashi Y, et al. The effect of IL-4 on human nasal mucosal responses. J Allergy Clin Immunol 1992;90:772-81.
27. Douglass JA, Dhami D, Gurr CE, et al. Influence of interleukin-8 challenge in the nasal mucosa in atopic and nonatopic subjects. Am J Respir Crit Care Med 1994;150:1108-13.
28. Vial T, Descotes J. Clinical toxicity of the interferons. Drug Safety 1994;10:115-50.
29. Doyle WJ, Skoner DP, Alper CM, et al. Effect of rimantadine treatment on clinical manifestations and otological complications in adults experimentally infected with influenza A (HINI) virus. J Infect Dis 1998;177:1260-5.
30. Barnes PJ, Adcock IM. Transcription factors. Clin Exp Allergy 1995;25:46-9.