Avian influenza A (H5N1) infection in humans

New England Journal of Medicine

Volumn 353, Issue 13, 2005, Pages 1374-1385

  Beigel, John H ^a   Farrar, Jeremy ^b   Han, Aye Maung ^c   Hayden, Frederick G ^d   Hyer, Randy ^e   De Jong, Menno D ^b   Lochindarat, Sorasak ^f   Tien, Nguyen Thi Kim ^g   Hien, Nguyen Tran ^h   Hien, Tran Tinh ^b   Nicoll, Angus ⁱ   Touch, Sok ^j   Yuen, Kwok Yung ^k  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^c Institute of Medicine   (Myanmar)

^d UNIVERSITY OF VIRGINIA   (United States)

^e WORLD HEALTH ORGANIZATION   (Switzerland)

^f QUEEN SIRIKIT NATIONAL INSTITUTE OF CHILD HEALTH   (Thailand)

^g PASTEUR INSTITUTE   (Viet Nam)

^h NATIONAL INSTITUTE OF HYGIENE AND EPIDEMIOLOGY   (Viet Nam)

ⁱ PUBLIC HEALTH ENGLAND   (United Kingdom)

^j Ministry of Health Cambodia   (Cambodia)

^k UNIVERSITY OF HONG KONG   (Hong Kong)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; CORTICOSTEROID; DEXAMETHASONE; N ACETYLMURAMYLALANYL DEXTRO ISOGLUTAMINYLALANYL DIPALMITOYLPHOSPHATIDYLETHANOLAMINE; OSELTAMIVIR; PERAMIVIR; RECOMBINANT ALPHA INTERFERON; RIBAVIRIN; SIALIDASE INHIBITOR; VIRUS VACCINE; ZANAMIVIR;

AVIAN INFLUENZA; CHRONOTHERAPY; CLINICAL FEATURE; CLINICAL TRIAL; DISEASE COURSE; DRUG MECHANISM; DRUG MEGADOSE; HOSPITAL INFECTION; HOSPITALIZATION; HOUSEHOLD; HUMAN; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOMODULATION; INCIDENCE; INCUBATION TIME; INFLUENZA VIRUS A; LABORATORY TEST; MORTALITY; NONHUMAN; PATHOLOGY; PRIORITY JOURNAL; REVIEW; SYMPTOM; VIRUS CHARACTERIZATION; VIRUS DETECTION; VIRUS ISOLATION; VIRUS PATHOGENESIS; VIRUS REPLICATION; VIRUS TRANSMISSION;

ANIMALS; ANTIVIRAL AGENTS; ASIA, SOUTHEASTERN; DISEASE OUTBREAKS; DISEASE PROGRESSION; HUMANS; INCIDENCE; INFLUENZA A VIRUS; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA IN BIRDS; INFLUENZA VACCINES; INFLUENZA, HUMAN; POULTRY; VIRUS REPLICATION;

EID: 25444432780     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMra052211     Document Type: Review

References (71)

1. World Health Organization. WHO interim guidelines on clinical management of humans infected by influenza A(H5N1). February 20, 2004. (Accessed September 2, 2005, at http://www.who.int/csr/disease/avian_ influenza/guidelines/ Guidelines_Clinical%20Management_H5N1_rev.pdf.)
2. Liu J, Xiao H, Lei F, et al. Highly pathogenic H5N1 influenza virus infection in migratory birds. Science 2005;309:1206.
3. Chen H, Smith JD, Zhang SY, et al. Avian flu: H5N1 virus outbreak in migratory waterfowl. Nature 2005;436:191-2.
4. Salgado CD, Farr BM, Hall KK, Hayden FG. Influenza in the acute hospital setting. Lancet Infect Dis 2002;2:145-55. [Erratum, Lancet Infect Dis 2002;2:383.]
5. Bridges CB, Kuehnert MJ, Hall CB. Transmission of influenza: implications for control in health care settings. Clin Infect Dis 2003;37:1094-101.
6. Mounts AW, Kwong H, Izurieta HS, et al. Case-control study of risk factors for avian influenza A (H5N1) disease, Hong Kong, 1997. J Infect Dis 1999;180:505-8.
7. Bridges CB, Lim W, Hu-Primmer J, et al. Risk of influenza A (H5N1) infection among poultry workers, Hong Kong, 1997-1998. J Infect Dis 2002;185:1005-10.
8. Katz JM, Lim W, Bridges CB, et al. Antibody response in individuals infected with avian influenza A (H5N1) viruses and detection of anti-H5 antibody among household and social contacts. J Infect Dis 1999;180:1763-70.
9. Buxton Bridges C, Katz JM, Seto WH, et al. Risk of influenza A (H5N1) infection among health care workers exposed to patients with influenza A (H5N1), Hong Kong. J Infect Dis 2000;181:344-8.
10. Liem NT, World Health Organization International Avian Influenza Investigation Team, Vietnam, Lim W. Lack of H5N1 avian influenza transmission to hospital employees, Hanoi, 2004. Emerg Infect Dis 2005;11:210-5.
11. Schultsz C, Dong VC, Chau NVV, et al. Avian influenza H5N1 and healthcare workers. Emerg Infect Dis 2005;11:1158-9. (Also available at http://www.cdc.gov/ncidod/EID/vol11no07/05-0070.htm.)
12. Apisarnthanarak A, Kitphati R, Thongphubeth K, et al. Atypical avian influenza (H5N1). Emerg Infect Dis 2004;10:1321-4.
13. Yuen KY, Chan PK, Peiris M, et al. Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus. Lancet 1998;351:467-71.
14. Chan PK. Outbreak of avian influenza A(H5N1) virus infection in Hong Kong in 1997. Clin Infect Dis 2002;34:Suppl 2:S58-S64.
15. Chotpitayasunondh T, Ungchusak K, Hanshaoworakul W, et al. Human disease from influenza A (H5N1), Thailand, 2004. Emerg Infect Dis 2005;11:201-9.
16. Hien TT, Liem NT, Dung NT, et al. Avian influenza A (H5N1) in 10 patients in Vietnam. N Engl J Med 2004;350:1179-88.
17. Keawcharoen J, Oraveerakul K, Kuiken T, et al. Avian influenza H5N1 in tigers and leopards. Emerg Infect Dis 2004;10:2189-91.
18. Thanawongnuwech R, Amonsin A, Tantilertcharoen R, et al. Probable tiger-to-tiger transmission of avian influenza H5N1. Emerg Infect Dis 2005;11:699-701.
19. Kuiken T, Rimmelzwaan G, van Riel D, et al. Avian H5N1 influenza in cats. Science 2004;306:241.
20. Ungchusak K, Auewarakul P, Dowell SF, et al. Probable person-to-person transmission of avian influenza A (H5N1). N Engl J Med 2005;352:333-40.
21. World Health Organization. WHO inter-country-consultation: influenza A/H5N1 in humans in Asia: Manila, Philippines, 6-7 May 2005. (Accessed September 2, 2005, at http://www.who.int/csr/resources/publications/influenza/ WHO_CDS_CSR_GIP_2005_7/en/.)
22. de Jong MD, Cam BV, Qui PT, et al. Fatal Avian influenza A (H5N1) in a child presenting with diarrhea followed by coma. N Engl J Med 2005;352:686-91.
23. Fouchier RAM, Schneeberger PM, Rozendaal FW, et al. Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome. Proc Natl Acad Sci U S A 2004;101:1356-61.
24. Tam JS. Influenza A (H5N1) in Hong Kong: an overview. Vaccine 2002;20:Suppl 2:S77-S81.
25. Nicholson KG. Human influenza. In: Nicholson KG, Webster RG, Hay AJ, eds. Textbook of influenza. Oxford, England: Blackwell Science, 1998:219-64.
26. Kaiser L, Briones MS, Hayden FG. Performance of virus isolation and Directigen Flu A to detect influenza A virus in experimental human infection. J Clin Virol 1999;14:191-7.
27. Peiris JS, Yu WC, Leung CW, et al. Reemergence of fatal human influenza A subtype H5N1 disease. Lancet 2004;363:617-9.
28. Hatta M, Gao P, Halfmann P, Kawaoka Y. Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science 2001;293:1840-2.
29. Shinya K, Hamm S, Hatta M, Ito H, Ito T, Kawaoka Y. PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in mice. Virology 2004;320:258-66.
30. Seo SH, Hoffman E, Webster RG. Lethal H5N1 influenza viruses escape host anti-viral cytokine responses. Nat Med 2002;8:950-4.
31. Cheung CY, Poon LL, Lau AS, et al. Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease? Lancet 2002;360:1831-7.
32. Guan Y, Peiris JSM, Lipatov AS, et al. Emergence of multiple genotypes of H5N1 avian influenza viruses in Hong Kong SAR. Proc Natl Acad Sci U S A 2002;99:8950-5.
33. Li KS, Guan Y, Wang J, et al. Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia. Nature 2004;430:209-13.
34. Avian influenza A (H5N1). Weekly Epidemiol Rec 2004;79(7):65-70. (Also available at http://www.who.int/wer/2004/en/wer7907.pdf.)
35. Sims LD, Ellis TM, Liu KK, et al. Avian influenza in Hong Kong 1997-2002. Avian Dis 2003;47:Suppl:832-8.
36. Horimoto T, Fukuda N, Iwatsuki-Horimoto K, et al. Antigenic differences between H5N1 human influenza viruses isolated in 1997 and 2003. J Vet Med Sci 2004;66:303-5.
37. Sturm-Ramirez KM, Ellis T, Bousfield B, et al. Reemerging H5N1 influenza viruses in Hong Kong in 2002 are highly pathogenic to ducks. J Virol 2004;78:4892-901.
38. Perkins LE, Swayne DE. Pathogenicity of a Hong Kong-origin H5N1 highly pathogenic avian influenza virus for emus, geese, ducks, and pigeons. Avian Dis 2002;46:53-63.
39. Zitzow LA, Rowe T, Morken T, Shieh WJ, Zaki S, Katz JM. Pathogenesis of avian influenza A (H5N1) viruses in ferrets. J Virol 2002;76:4420-9.
40. Govorkova EA, Rehg JE, Krauss S, et al. Lethality to ferrets of H5N1 influenza viruses isolated from humans and poultry in 2004. J Virol 2005;79:2191-8.
41. Uiprasertkul M, Puthavathana P, Sangsiriwut K, et al. Influenza A H5N1 replication sites in humans. Emerg Infect Dis 2005;11:1036-41.
42. To KF, Chan PK, Chan KF, et al. Pathology of fatal human infection associated with avian influenza A H5N1 virus. J Med Virol 2001;63:242-6.
43. Guarner J, Shieh W-J, Dawson J, et al. Immunohistochemical and in situ hybridization studies of influenza A virus infection in human lungs. Am J Clin Pathol 2000;114:227-33.
44. World Health Organization. Recommended laboratory tests to identify influenza A/H5 virus in specimens from patients with an influenza-like illness. 2005. (Accessed September 2, 2005, at http://www.who.int/csr/disease/ avian_influenza/guidelines/avian_ labtests1.pdf.)
45. Centers for Disease Control and Prevention. Update: notice to travelers about avian influenza A (H5N1). July 29, 2005. (Accessed September 2, 2005, at http://www.cdc.gov/travel/other/avian_flu_ah5n1_031605.htm.)
46. Leneva IA, Roberts N, Govorkova EA, Goloubeva OG, Webster RG. The neuraminidase inhibitor GS4104 (oseltamivir phosphate) is efficacious against A/Hong Kong/156/97 (H5N1) and A/Hong Kong/1074/99 (H9N2) influenza viruses. Antiviral Res 2000;48:101-15.
47. Govorkova EA, Leneva IA, Goloubeva OG, Bush K, Webster RG. Comparison of efficacies of RWJ-270201, zanamivir, and oseltamivir against H5N1, H9N2, and other avian influenza viruses. Antimicrob Agents Chemother 2001;45:2723-32.
48. Gubareva LV, McCullers JA, Bethell RC, Webster RG. Characterization of influenza A/HongKong/156/97 (H5N1) virus in a mouse model and protective effect of zanamivir on H5N1 infection in mice. J Infect Dis 1998;178:1592-6.
49. Leneva IA, Goloubeva O, Fenton RJ, Tisdale M, Webster RG. Efficacy of zanamivir against avian influenza A viruses that possess genes encoding H5N1 internal proteins and are pathogenic in mammals. Antimicrob Agents Chemother 2001;45:1216-24.
50. Yen HL, Monto AS, Webster RG, Govorkova EA. Virulence may determine the necessary duration and dosage of oseltamivir treatment for highly pathogenic A/Vietnam/1203/04 influenza virus in mice. J Infect Dis 2005;192:665-72.
51. Treanor JJ, Hayden FG, Vrooman PS, et al. Efficacy and safety of the oral neuraminidase inhibitor oseltamivir in treating acute influenza: a randomized controlled trial. JAMA 2000;283:1016-24.
52. Cooper NJ, Sutton AJ, Abrams KR, Wailoo A, Turner D, Nicholson KG. Effectiveness of neuraminidase inhibitors in treatment and prevention of influenza A and B: systematic review and meta-analyses of randomised controlled trials. BMJ 2003;326:1235.
53. Monto AS, Fleming DM, Henry D, et al. Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenza A and B virus infections. J Infect Dis 1999;180:254-61.
54. Ward P, Small I, Smith J, Suter P, Dutkowski R. Oseltamivir (Tamiflu) and its potential for use in the event of an influenza pandemic. J Antimicrob Chemother 2005;55:Suppl 1:i5-i21.
55. Ives JAL, Carr JA, Mendel DB, et al. The H274Y mutation in the influenza A/H1N1 neuraminidase active site following oseltamivir phosphate treatment leaves virus severely compromised both in vitro and in vivo. Antiviral Res 2002;55:307-17.
56. Herlocher ML, Truscon R, Elias S, et al. Influenza viruses resistant to the antiviral drug oseltamivir: transmission studies in ferrets. J Infect Dis 2004;190:1627-30.
57. Wetherall NT, Trivedi T, Zeller J, et al. Evaluation of neuraminidase enzyme assays using different substrates to measure susceptibility of influenza virus clinical isolates to neuraminidase inhibitors: report of the neuraminidase inhibitor susceptibility network. J Clin Microbiol 2003;41:742-50.
58. Gubareva LV, Webster RG, Hayden FG. Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variants. Antimicrob Agents Chemother 2001;45:3403-8.
59. Madren LK, Shipman C Jr, Hayden FG. In vitro inhibitory effects of combinations of anti-influenza agents. Antivir Chem Chemother 1995;6:109-13.
60. Knight V, Gilbert BE. Ribavirin aerosol treatment of influenza. Infect Dis Clin North Am 1987;1:441-57.
61. Baron S, Isaacs A. Absence of interferon in lungs from fatal cases of influenza. Br Med J 1962;5270:18-20.
62. Treanor JJ, Wilkinson BE, Masseoud F, et al. Safety and immunogenicity of a recombinant hemagglutinin vaccine for H5 influenza in humans. Vaccine 2001;19:1732-7.
63. Nicholson KG, Colegate AE, Podda A, et al. Safety and antigenicity of non-adjuvanted and MF59-adjuvanted influenza A/Duck/ Singapore/97 (H5N3) vaccine: a randomised trial of two potential vaccines against H5N1 influenza. Lancet 2001;357:1937-43.
64. Stephenson I, Bugarini R, Nicholson KG, et al. Cross-reactivity to highly pathogenic avian influenza H5N1 viruses after vaccination with nonadjuvanted and MF59-adjuvanted influenza A/Duck/Singapore/97 (H5N3) vaccine: a potential priming strategy. J Infect Dis 2005;191:1210-5.
65. Webby RJ, Webster RG. Are we ready for pandemic influenza? Science 2003;302:1519-22.
66. Webby RJ, Perez DR, Coleman JS, et al. Responsiveness to a pandemic alert: use of reverse genetics for rapid development of influenza vaccines. Lancet 2004;363:1099-103.
67. Altman LC. Avian flu drug works in first tests. New York Times. August 7, 2005.
68. Belshe RB, Mendelman PM, Treanor J, et al. The efficacy of live attenuated, coldadapted, trivalent, intranasal influenzavirus vaccine in children. N Engl J Med 1998;338:1405-12.
69. Derrick JL, Gomersall CD. Protecting healthcare staff from severe acute respiratory syndrome: filtration capacity of multiple surgical masks. J Hosp Infect 2005;59:365-8.
70. Hayden FG, Belshe R, Villanueva C, et al. Management of influenza in households: a prospective, randomized comparison of oseltamivir treatment with or without post-exposure prophylaxis. J Infect Dis 2004;189:440-9.
71. Welliver R, Monto AS, Carewicz O, et al. Effectiveness of oseltamivir in preventing influenza in household contacts: a randomized controlled trial. JAMA 2001;285:748-54.