메뉴 건너뛰기




Volumn 13, Issue 12, 2011, Pages 1907-1919

Phosphatidylinositol-3-kinase (PI3K) is activated by influenza virus vRNA via the pathogen pattern receptor Rig-I to promote efficient type I interferon production

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; INTERFERON; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN MAVS; RETINOIC ACID INDUCIBLE PROTEIN I; SMALL INTERFERING RNA; UBIQUITIN; UBIQUITIN TRIM25; UNCLASSIFIED DRUG; VIRUS RNA;

EID: 81355160349     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2011.01680.x     Document Type: Article
Times cited : (53)

References (45)
  • 2
    • 43449094679 scopus 로고    scopus 로고
    • Signal regulatory protein alpha negatively regulates both TLR3 and cytoplasmic pathways in type I interferon induction
    • Dong, L.W., Kong, X.N., Yan, H.X., Yu, L.X., Chen, L., Yang, W., etal. (2008) Signal regulatory protein alpha negatively regulates both TLR3 and cytoplasmic pathways in type I interferon induction. Mol Immunol 45: 3025-3035.
    • (2008) Mol Immunol , vol.45 , pp. 3025-3035
    • Dong, L.W.1    Kong, X.N.2    Yan, H.X.3    Yu, L.X.4    Chen, L.5    Yang, W.6
  • 3
    • 65549130101 scopus 로고    scopus 로고
    • A new player in a deadly game: influenza viruses and the PI3K/Akt signalling pathway
    • Ehrhardt, C., and Ludwig, S. (2009) A new player in a deadly game: influenza viruses and the PI3K/Akt signalling pathway. Cell Microbiol 11: 863-871.
    • (2009) Cell Microbiol , vol.11 , pp. 863-871
    • Ehrhardt, C.1    Ludwig, S.2
  • 4
    • 2942624370 scopus 로고    scopus 로고
    • Rac1 and PAK1 are upstream of IKK-epsilon and TBK-1 in the viral activation of interferon regulatory factor-3
    • Ehrhardt, C., Kardinal, C., Wurzer, W.J., Wolff, T., von Eichel-Streiber, C., Pleschka, S., etal. (2004) Rac1 and PAK1 are upstream of IKK-epsilon and TBK-1 in the viral activation of interferon regulatory factor-3. FEBS Lett 567: 230-238.
    • (2004) FEBS Lett , vol.567 , pp. 230-238
    • Ehrhardt, C.1    Kardinal, C.2    Wurzer, W.J.3    Wolff, T.4    von Eichel-Streiber, C.5    Pleschka, S.6
  • 5
    • 33745753573 scopus 로고    scopus 로고
    • Bivalent role of the phosphatidylinositol-3-kinase (PI3K) during influenza virus infection and host cell defence
    • Ehrhardt, C., Marjuki, H., Wolff, T., Nurnberg, B., Planz, O., Pleschka, S., and Ludwig, S. (2006) Bivalent role of the phosphatidylinositol-3-kinase (PI3K) during influenza virus infection and host cell defence. Cell Microbiol 8: 1336-1348.
    • (2006) Cell Microbiol , vol.8 , pp. 1336-1348
    • Ehrhardt, C.1    Marjuki, H.2    Wolff, T.3    Nurnberg, B.4    Planz, O.5    Pleschka, S.6    Ludwig, S.7
  • 6
    • 33947381763 scopus 로고    scopus 로고
    • Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses
    • Ehrhardt, C., Wolff, T., Pleschka, S., Planz, O., Beermann, W., Bode, J.G., etal. (2007a) Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses. J Virol 81: 3058-3067.
    • (2007) J Virol , vol.81 , pp. 3058-3067
    • Ehrhardt, C.1    Wolff, T.2    Pleschka, S.3    Planz, O.4    Beermann, W.5    Bode, J.G.6
  • 7
    • 35448948397 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase signaling by the nonstructural NS1 protein is not conserved among type A and B influenza viruses
    • Ehrhardt, C., Wolff, T., and Ludwig, S. (2007b) Activation of phosphatidylinositol 3-kinase signaling by the nonstructural NS1 protein is not conserved among type A and B influenza viruses. J Virol 81: 12097-12100.
    • (2007) J Virol , vol.81 , pp. 12097-12100
    • Ehrhardt, C.1    Wolff, T.2    Ludwig, S.3
  • 8
    • 78149333191 scopus 로고    scopus 로고
    • The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells
    • Eierhoff, T., Hrincius, E.R., Rescher, U., Ludwig, S., and Ehrhardt, C. (2010) The epidermal growth factor receptor (EGFR) promotes uptake of influenza A viruses (IAV) into host cells. PLoS Pathog 6: e1001099.
    • (2010) PLoS Pathog , vol.6
    • Eierhoff, T.1    Hrincius, E.R.2    Rescher, U.3    Ludwig, S.4    Ehrhardt, C.5
  • 10
    • 65549164536 scopus 로고    scopus 로고
    • Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I
    • Gack, M.U., Albrecht, R.A., Urano, T., Inn, K.S., Huang, I.C., Carnero, E., etal. (2009) Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I. Cell Host Microbe 5: 439-449.
    • (2009) Cell Host Microbe , vol.5 , pp. 439-449
    • Gack, M.U.1    Albrecht, R.A.2    Urano, T.3    Inn, K.S.4    Huang, I.C.5    Carnero, E.6
  • 11
    • 33749004778 scopus 로고    scopus 로고
    • Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling
    • Hale, B.G., Jackson, D., Chen, Y.H., Lamb, R.A., and Randall, R.E. (2006) Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling. Proc Natl Acad Sci USA 103: 14194-14199.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 14194-14199
    • Hale, B.G.1    Jackson, D.2    Chen, Y.H.3    Lamb, R.A.4    Randall, R.E.5
  • 13
    • 70649096928 scopus 로고    scopus 로고
    • Loss of function of the influenza A virus NS1 protein promotes apoptosis but this is not due to a failure to activate phosphatidylinositol 3-kinase (PI3K)
    • Jackson, D., Killip, M.J., Galloway, C.S., Russell, R.J., and Randall, R.E. (2010) Loss of function of the influenza A virus NS1 protein promotes apoptosis but this is not due to a failure to activate phosphatidylinositol 3-kinase (PI3K). Virology 396: 94-105.
    • (2010) Virology , vol.396 , pp. 94-105
    • Jackson, D.1    Killip, M.J.2    Galloway, C.S.3    Russell, R.J.4    Randall, R.E.5
  • 14
    • 0030585155 scopus 로고    scopus 로고
    • When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA
    • Jacobs, B.L., and Langland, J.O. (1996) When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA. Virology 219: 339-349.
    • (1996) Virology , vol.219 , pp. 339-349
    • Jacobs, B.L.1    Langland, J.O.2
  • 15
    • 0037154176 scopus 로고    scopus 로고
    • mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties
    • Kang, D.C., Gopalkrishnan, R.V., Wu, Q., Jankowsky, E., Pyle, A.M., and Fisher, P.B. (2002) mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties. Proc Natl Acad Sci USA 99: 637-642.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 637-642
    • Kang, D.C.1    Gopalkrishnan, R.V.2    Wu, Q.3    Jankowsky, E.4    Pyle, A.M.5    Fisher, P.B.6
  • 16
    • 33646342149 scopus 로고    scopus 로고
    • Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
    • Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., etal. (2006) Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441: 101-105.
    • (2006) Nature , vol.441 , pp. 101-105
    • Kato, H.1    Takeuchi, O.2    Sato, S.3    Yoneyama, M.4    Yamamoto, M.5    Matsui, K.6
  • 18
    • 51349087106 scopus 로고    scopus 로고
    • Innate immune response to viral infection
    • Koyama, S., Ishii, K.J., Coban, C., and Akira, S. (2008) Innate immune response to viral infection. Cytokine 43: 336-341.
    • (2008) Cytokine , vol.43 , pp. 336-341
    • Koyama, S.1    Ishii, K.J.2    Coban, C.3    Akira, S.4
  • 19
    • 40149111112 scopus 로고    scopus 로고
    • Avian influenza virus A/HK/483/97 (H5N1) NS1 protein induces apoptosis in human airway epithelial cells
    • Lam, W.Y., Tang, J.W., Yeung, A.C., Chiu, L.C., Sung, J.J., and Chan, P.K. (2008) Avian influenza virus A/HK/483/97 (H5N1) NS1 protein induces apoptosis in human airway epithelial cells. J Virol 82: 2741-2751.
    • (2008) J Virol , vol.82 , pp. 2741-2751
    • Lam, W.Y.1    Tang, J.W.2    Yeung, A.C.3    Chiu, L.C.4    Sung, J.J.5    Chan, P.K.6
  • 20
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak, K.J., and Schmittgen, T.D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 22
    • 0034066412 scopus 로고    scopus 로고
    • Viral double-stranded RNA, cytokines, and the flu
    • Majde, J.A. (2000) Viral double-stranded RNA, cytokines, and the flu. J Interferon Cytokine Res 20: 259-272.
    • (2000) J Interferon Cytokine Res , vol.20 , pp. 259-272
    • Majde, J.A.1
  • 23
    • 26444539685 scopus 로고    scopus 로고
    • Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner
    • Melchjorsen, J., Jensen, S.B., Malmgaard, L., Rasmussen, S.B., Weber, F., Bowie, A.G., etal. (2005) Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner. J Virol 79: 12944-12951.
    • (2005) J Virol , vol.79 , pp. 12944-12951
    • Melchjorsen, J.1    Jensen, S.B.2    Malmgaard, L.3    Rasmussen, S.B.4    Weber, F.5    Bowie, A.G.6
  • 24
    • 33846061693 scopus 로고    scopus 로고
    • Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus
    • Mibayashi, M., Martinez-Sobrido, L., Loo, Y.M., Cardenas, W.B., Gale, M., Jr, and Garcia-Sastre, A. (2007) Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus. J Virol 81: 514-524.
    • (2007) J Virol , vol.81 , pp. 514-524
    • Mibayashi, M.1    Martinez-Sobrido, L.2    Loo, Y.M.3    Cardenas, W.B.4    Gale Jr, M.5    Garcia-Sastre, A.6
  • 25
    • 0037057801 scopus 로고    scopus 로고
    • The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system
    • Neri, L.M., Borgatti, P., Capitani, S., and Martelli, A.M. (2002) The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system. Biochim Biophys Acta 1584: 73-80.
    • (2002) Biochim Biophys Acta , vol.1584 , pp. 73-80
    • Neri, L.M.1    Borgatti, P.2    Capitani, S.3    Martelli, A.M.4
  • 26
    • 33947171000 scopus 로고    scopus 로고
    • IFNbeta induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 protein
    • Opitz, B., Rejaibi, A., Dauber, B., Eckhard, J., Vinzing, M., Schmeck, B., etal. (2007) IFNbeta induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 protein. Cell Microbiol 9: 930-938.
    • (2007) Cell Microbiol , vol.9 , pp. 930-938
    • Opitz, B.1    Rejaibi, A.2    Dauber, B.3    Eckhard, J.4    Vinzing, M.5    Schmeck, B.6
  • 27
    • 77953627102 scopus 로고    scopus 로고
    • Human neuronal cells possess functional cytoplasmic and TLR-mediated innate immune pathways influenced by phosphatidylinositol-3 kinase signaling
    • Peltier, D.C., Simms, A., Farmer, J.R., and Miller, D.J. (2010) Human neuronal cells possess functional cytoplasmic and TLR-mediated innate immune pathways influenced by phosphatidylinositol-3 kinase signaling. J Immunol 184: 7010-7021.
    • (2010) J Immunol , vol.184 , pp. 7010-7021
    • Peltier, D.C.1    Simms, A.2    Farmer, J.R.3    Miller, D.J.4
  • 29
    • 7544225495 scopus 로고    scopus 로고
    • Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling
    • Sarkar, S.N., Peters, K.L., Elco, C.P., Sakamoto, S., Pal, S., and Sen, G.C. (2004) Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling. Nat Struct Mol Biol 11: 1060-1067.
    • (2004) Nat Struct Mol Biol , vol.11 , pp. 1060-1067
    • Sarkar, S.N.1    Peters, K.L.2    Elco, C.P.3    Sakamoto, S.4    Pal, S.5    Sen, G.C.6
  • 31
    • 0038363463 scopus 로고    scopus 로고
    • Triggering the interferon antiviral response through an IKK-related pathway
    • Sharma, S., tenOever, B.R., Grandvaux, N., Zhou, G.P., Lin, R., and Hiscott, J. (2003) Triggering the interferon antiviral response through an IKK-related pathway. Science 300: 1148-1151.
    • (2003) Science , vol.300 , pp. 1148-1151
    • Sharma, S.1    tenOever, B.R.2    Grandvaux, N.3    Zhou, G.P.4    Lin, R.5    Hiscott, J.6
  • 32
    • 33846160497 scopus 로고    scopus 로고
    • Influenza A virus NS1 protein activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway by direct interaction with the p85 subunit of PI3K
    • Shin, Y.K., Liu, Q., Tikoo, S.K., Babiuk, L.A., and Zhou, Y. (2007a) Influenza A virus NS1 protein activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway by direct interaction with the p85 subunit of PI3K. J Gen Virol 88: 13-18.
    • (2007) J Gen Virol , vol.88 , pp. 13-18
    • Shin, Y.K.1    Liu, Q.2    Tikoo, S.K.3    Babiuk, L.A.4    Zhou, Y.5
  • 33
    • 36349018937 scopus 로고    scopus 로고
    • SH3 binding motif 1 in influenza A virus NS1 protein is essential for PI3K/Akt signaling pathway activation
    • Shin, Y.K., Li, Y., Liu, Q., Anderson, D.H., Babiuk, L.A., and Zhou, Y. (2007b) SH3 binding motif 1 in influenza A virus NS1 protein is essential for PI3K/Akt signaling pathway activation. J Virol 81: 12730-12739.
    • (2007) J Virol , vol.81 , pp. 12730-12739
    • Shin, Y.K.1    Li, Y.2    Liu, Q.3    Anderson, D.H.4    Babiuk, L.A.5    Zhou, Y.6
  • 34
    • 0021876864 scopus 로고
    • Interferon-induced human protein with homology to protein Mx of influenza virus-resistant mice
    • Staeheli, P., and Haller, O. (1985) Interferon-induced human protein with homology to protein Mx of influenza virus-resistant mice. Mol Cell Biol 5: 2150-2153.
    • (1985) Mol Cell Biol , vol.5 , pp. 2150-2153
    • Staeheli, P.1    Haller, O.2
  • 35
    • 30444450839 scopus 로고    scopus 로고
    • Recognition of cytosolic DNA activates an IRF3-dependent innate immune response
    • Stetson, D.B., and Medzhitov, R. (2006) Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 24: 93-103.
    • (2006) Immunity , vol.24 , pp. 93-103
    • Stetson, D.B.1    Medzhitov, R.2
  • 36
    • 58049202272 scopus 로고    scopus 로고
    • Innate immunity to virus infection
    • Takeuchi, O., and Akira, S. (2009) Innate immunity to virus infection. Immunol Rev 227: 75-86.
    • (2009) Immunol Rev , vol.227 , pp. 75-86
    • Takeuchi, O.1    Akira, S.2
  • 37
    • 0029617947 scopus 로고
    • Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome
    • Thanos, D., and Maniatis, T. (1995) Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome. Cell 83: 1091-1100.
    • (1995) Cell , vol.83 , pp. 1091-1100
    • Thanos, D.1    Maniatis, T.2
  • 38
    • 0034653608 scopus 로고    scopus 로고
    • The PI3K-PDK1 connection: more than just a road to PKB
    • Vanhaesebroeck, B., and Alessi, D.R. (2000) The PI3K-PDK1 connection: more than just a road to PKB. Biochem J 346 (Part 3): 561-576.
    • (2000) Biochem J , vol.346 , Issue.3 PART , pp. 561-576
    • Vanhaesebroeck, B.1    Alessi, D.R.2
  • 39
    • 0033604577 scopus 로고    scopus 로고
    • Signaling by distinct classes of phosphoinositide 3-kinases
    • Vanhaesebroeck, B., and Waterfield, M.D. (1999) Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res 253: 239-254.
    • (1999) Exp Cell Res , vol.253 , pp. 239-254
    • Vanhaesebroeck, B.1    Waterfield, M.D.2
  • 41
    • 33646453915 scopus 로고    scopus 로고
    • Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses
    • Weber, F., Wagner, V., Rasmussen, S.B., Hartmann, R., and Paludan, S.R. (2006) Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses. J Virol 80: 5059-5064.
    • (2006) J Virol , vol.80 , pp. 5059-5064
    • Weber, F.1    Wagner, V.2    Rasmussen, S.B.3    Hartmann, R.4    Paludan, S.R.5
  • 42
    • 34447560071 scopus 로고    scopus 로고
    • Function of RIG-I-like receptors in antiviral innate immunity
    • Yoneyama, M., and Fujita, T. (2007) Function of RIG-I-like receptors in antiviral innate immunity. J Biol Chem 282: 15315-15318.
    • (2007) J Biol Chem , vol.282 , pp. 15315-15318
    • Yoneyama, M.1    Fujita, T.2
  • 43
    • 34250863768 scopus 로고    scopus 로고
    • Cytokine-independent upregulation of MDA5 in viral infection
    • Yount, J.S., Moran, T.M., and Lopez, C.B. (2007) Cytokine-independent upregulation of MDA5 in viral infection. J Virol 81: 7316-7319.
    • (2007) J Virol , vol.81 , pp. 7316-7319
    • Yount, J.S.1    Moran, T.M.2    Lopez, C.B.3
  • 44
    • 44449125726 scopus 로고    scopus 로고
    • MDA5 participates in the detection of paramyxovirus infection and is essential for the early activation of dendritic cells in response to Sendai Virus defective interfering particles
    • Yount, J.S., Gitlin, L., Moran, T.M., and Lopez, C.B. (2008) MDA5 participates in the detection of paramyxovirus infection and is essential for the early activation of dendritic cells in response to Sendai Virus defective interfering particles. J Immunol 180: 4910-4918.
    • (2008) J Immunol , vol.180 , pp. 4910-4918
    • Yount, J.S.1    Gitlin, L.2    Moran, T.M.3    Lopez, C.B.4
  • 45
    • 34250828457 scopus 로고    scopus 로고
    • Control of apoptosis in influenza virus-infected cells by up-regulation of Akt and p53 signaling
    • Zhirnov, O.P., and Klenk, H.D. (2007) Control of apoptosis in influenza virus-infected cells by up-regulation of Akt and p53 signaling. Apoptosis 12: 1419-1432.
    • (2007) Apoptosis , vol.12 , pp. 1419-1432
    • Zhirnov, O.P.1    Klenk, H.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.