-
1
-
-
0028072991
-
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma
-
J.G. Herman, F. Latif, Y. Weng, M.I. Lerman, B. Zbar, S. Liu, D. Samid, D.S. Duan, J.R. Gnarra, and W.M. Linehan Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma Proc. Natl. Acad. Sci. U S A 91 1994 9700 9704
-
(1994)
Proc. Natl. Acad. Sci. U S A
, vol.91
, pp. 9700-9704
-
-
Herman, J.G.1
Latif, F.2
Weng, Y.3
Lerman, M.I.4
Zbar, B.5
Liu, S.6
Samid, D.7
Duan, D.S.8
Gnarra, J.R.9
Linehan, W.M.10
-
2
-
-
16644373473
-
Role of VHL gene mutation in human cancer
-
W.Y. Kim, and W.G. Kaelin Role of VHL gene mutation in human cancer J. Clin. Oncol. 22 2004 4991 5004
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 4991-5004
-
-
Kim, W.Y.1
Kaelin, W.G.2
-
3
-
-
33644510421
-
Genetic and epigenetic analysis of von Hippel-Lindau (VHL) gene alterations and relationship with clinical variables in sporadic renal cancer
-
R.E. Banks, P. Tirukonda, C. Taylor, N. Hornigold, D. Astuti, D. Cohen, E.R. Maher, A.J. Stanley, P. Harnden, A. Joyce, M. Knowles, and P.J. Selby Genetic and epigenetic analysis of von Hippel-Lindau (VHL) gene alterations and relationship with clinical variables in sporadic renal cancer Cancer Res. 66 2006 2000 2011
-
(2006)
Cancer Res.
, vol.66
, pp. 2000-2011
-
-
Banks, R.E.1
Tirukonda, P.2
Taylor, C.3
Hornigold, N.4
Astuti, D.5
Cohen, D.6
Maher, E.R.7
Stanley, A.J.8
Harnden, P.9
Joyce, A.10
Knowles, M.11
Selby, P.J.12
-
4
-
-
0030953635
-
The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins
-
A. Pause, S. Lee, R.A. Worrell, D.Y. Chen, W.H. Burgess, W.M. Linehan, and R.D. Klausner The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins Proc. Natl. Acad. Sci. U S A 94 1997 2156 2161
-
(1997)
Proc. Natl. Acad. Sci. U S A
, vol.94
, pp. 2156-2161
-
-
Pause, A.1
Lee, S.2
Worrell, R.A.3
Chen, D.Y.4
Burgess, W.H.5
Linehan, W.M.6
Klausner, R.D.7
-
5
-
-
0031907152
-
Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2
-
K.M. Lonergan, O. Iliopoulos, M. Ohh, T. Kamura, R.C. Conaway, J.W. Conaway, and W.G. Kaelin Jr. Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2 Mol. Cell Biol. 18 1998 732 741
-
(1998)
Mol. Cell Biol.
, vol.18
, pp. 732-741
-
-
Lonergan, K.M.1
Iliopoulos, O.2
Ohh, M.3
Kamura, T.4
Conaway, R.C.5
Conaway, J.W.6
Kaelin, Jr.W.G.7
-
6
-
-
0033597443
-
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase
-
T. Kamura, D.M. Koepp, M.N. Conrad, D. Skowyra, R.J. Moreland, O. Iliopoulos, W.S. Lane, W.G. Kaelin Jr., S.J. Elledge, R.C. Conaway, J.W. Harper, and J.W. Conaway Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase Science 284 1999 657 661
-
(1999)
Science
, vol.284
, pp. 657-661
-
-
Kamura, T.1
Koepp, D.M.2
Conrad, M.N.3
Skowyra, D.4
Moreland, R.J.5
Iliopoulos, O.6
Lane, W.S.7
Kaelin, Jr.W.G.8
Elledge, S.J.9
Conaway, R.C.10
Harper, J.W.11
Conaway, J.W.12
-
7
-
-
0033565672
-
The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity
-
J. Lisztwan, G. Imbert, C. Wirbelauer, M. Gstaiger, and W. Krek The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity Genes Dev. 13 1999 1822 1833
-
(1999)
Genes Dev.
, vol.13
, pp. 1822-1833
-
-
Lisztwan, J.1
Imbert, G.2
Wirbelauer, C.3
Gstaiger, M.4
Krek, W.5
-
8
-
-
0033574737
-
Structure of the VHL-ElonginC-ElonginB complex: Implications for VHL tumor suppressor function
-
C.E. Stebbins, W.G. Kaelin Jr., and N.P. Pavletich Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function Science 284 1999 455 461
-
(1999)
Science
, vol.284
, pp. 455-461
-
-
Stebbins, C.E.1
Kaelin, Jr.W.G.2
Pavletich, N.P.3
-
9
-
-
27544477748
-
The von Hippel-Lindau protein, HIF hydroxylation, and oxygen sensing
-
W.G. Kaelin Jr. The von Hippel-Lindau protein, HIF hydroxylation, and oxygen sensing Biochem. Biophys. Res. Commun. 338 2005 627 638
-
(2005)
Biochem. Biophys. Res. Commun.
, vol.338
, pp. 627-638
-
-
Kaelin, Jr.W.G.1
-
10
-
-
0041465022
-
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia
-
E. Berra, E. Benizri, A. Ginouves, V. Volmat, D. Roux, and J. Pouyssegur HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia EMBO J. 22 2003 4082 4090
-
(2003)
EMBO J.
, vol.22
, pp. 4082-4090
-
-
Berra, E.1
Benizri, E.2
Ginouves, A.3
Volmat, V.4
Roux, D.5
Pouyssegur, J.6
-
11
-
-
33947528891
-
Von Hippel-Lindau disease
-
W.G. Kaelin Von Hippel-Lindau disease Annu. Rev. Pathol. 2 2007 145 173
-
(2007)
Annu. Rev. Pathol.
, vol.2
, pp. 145-173
-
-
Kaelin, W.G.1
-
12
-
-
0141828145
-
Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
-
P. Staller, J. Sulitkova, J. Lisztwan, H. Moch, E.J. Oakeley, and W. Krek Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL Nature 425 2003 307 311
-
(2003)
Nature
, vol.425
, pp. 307-311
-
-
Staller, P.1
Sulitkova, J.2
Lisztwan, J.3
Moch, H.4
Oakeley, E.J.5
Krek, W.6
-
13
-
-
22244470409
-
Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: Von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor
-
D. Zagzag, B. Krishnamachary, H. Yee, H. Okuyama, L. Chiriboga, M.A. Ali, J. Melamed, and G.L. Semenza Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor Cancer Res. 65 2005 6178 6188
-
(2005)
Cancer Res.
, vol.65
, pp. 6178-6188
-
-
Zagzag, D.1
Krishnamachary, B.2
Yee, H.3
Okuyama, H.4
Chiriboga, L.5
Ali, M.A.6
Melamed, J.7
Semenza, G.L.8
-
14
-
-
84861356212
-
Complex cellular functions of the von Hippel-Lindau tumor suppressor gene: Insights from model organisms
-
in press
-
Hsu, T. (2012) Complex cellular functions of the von Hippel-Lindau tumor suppressor gene: insights from model organisms. Oncogene, in press.
-
(2012)
Oncogene
-
-
Hsu, T.1
-
15
-
-
36749102487
-
Multitasking by pVHL in tumour suppression
-
I.J. Frew, and W. Krek Multitasking by pVHL in tumour suppression Curr. Opin. Cell. Biol. 19 2007 685 690
-
(2007)
Curr. Opin. Cell. Biol.
, vol.19
, pp. 685-690
-
-
Frew, I.J.1
Krek, W.2
-
16
-
-
0036606006
-
VHL-mediated hypoxia regulation of cyclin D1 in renal carcinoma cells
-
R.S. Bindra, J.R. Vasselli, R. Stearman, W.M. Linehan, and R.D. Klausner VHL-mediated hypoxia regulation of cyclin D1 in renal carcinoma cells Cancer Res. 62 2002 3014 3019
-
(2002)
Cancer Res.
, vol.62
, pp. 3014-3019
-
-
Bindra, R.S.1
Vasselli, J.R.2
Stearman, R.3
Linehan, W.M.4
Klausner, R.D.5
-
17
-
-
70350064307
-
The role of VHL in clear-cell renal cell carcinoma and its relation to targeted therapy
-
P.E. Clark The role of VHL in clear-cell renal cell carcinoma and its relation to targeted therapy Kidney Int. 76 2009 939 945
-
(2009)
Kidney Int.
, vol.76
, pp. 939-945
-
-
Clark, P.E.1
-
18
-
-
33749238553
-
Discovery and development of sorafenib: A multikinase inhibitor for treating cancer
-
S. Wilhelm, C. Carter, M. Lynch, T. Lowinger, J. Dumas, R.A. Smith, B. Schwartz, R. Simantov, and S. Kelley Discovery and development of sorafenib: a multikinase inhibitor for treating cancer Nat. Rev. Drug Discovery 5 2006 835 844
-
(2006)
Nat. Rev. Drug Discovery
, vol.5
, pp. 835-844
-
-
Wilhelm, S.1
Carter, C.2
Lynch, M.3
Lowinger, T.4
Dumas, J.5
Smith, R.A.6
Schwartz, B.7
Simantov, R.8
Kelley, S.9
-
19
-
-
0344442763
-
Drosophila awd, the homolog of human nm23, regulates FGF receptor levels and functions synergistically with shi/dynamin during tracheal development
-
V. Dammai, B. Adryan, K.R. Lavenburg, and T. Hsu Drosophila awd, the homolog of human nm23, regulates FGF receptor levels and functions synergistically with shi/dynamin during tracheal development Genes Dev. 17 2003 2812 2824
-
(2003)
Genes Dev.
, vol.17
, pp. 2812-2824
-
-
Dammai, V.1
Adryan, B.2
Lavenburg, K.R.3
Hsu, T.4
-
20
-
-
49649105572
-
Endothelial function of von Hippel-Lindau tumor suppressor gene: Control of fibroblast growth factor receptor signaling
-
K.J. Champion, M. Guinea, V. Dammai, and T. Hsu Endothelial function of von Hippel-Lindau tumor suppressor gene: control of fibroblast growth factor receptor signaling Cancer Res. 68 2008 4649 4657
-
(2008)
Cancer Res.
, vol.68
, pp. 4649-4657
-
-
Champion, K.J.1
Guinea, M.2
Dammai, V.3
Hsu, T.4
-
21
-
-
33746886185
-
Primary cilium formation requires von hippel-lindau gene function in renal-derived cells
-
M.S. Lutz, and R.D. Burk Primary cilium formation requires von hippel-lindau gene function in renal-derived cells Cancer Res. 66 2006 6903 6907
-
(2006)
Cancer Res.
, vol.66
, pp. 6903-6907
-
-
Lutz, M.S.1
Burk, R.D.2
-
22
-
-
33751209189
-
The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth
-
B. Schermer, C. Ghenoiu, M. Bartram, R.U. Muller, F. Kotsis, M. Hohne, W. Kuhn, M. Rapka, R. Nitschke, H. Zentgraf, M. Fliegauf, H. Omran, G. Walz, and T. Benzing The von Hippel-Lindau tumor suppressor protein controls ciliogenesis by orienting microtubule growth J. Cell Biol. 175 2006 547 554
-
(2006)
J. Cell Biol.
, vol.175
, pp. 547-554
-
-
Schermer, B.1
Ghenoiu, C.2
Bartram, M.3
Muller, R.U.4
Kotsis, F.5
Hohne, M.6
Kuhn, W.7
Rapka, M.8
Nitschke, R.9
Zentgraf, H.10
Fliegauf, M.11
Omran, H.12
Walz, G.13
Benzing, T.14
-
23
-
-
33745819269
-
Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein
-
M.A. Esteban, S.K. Harten, M.G. Tran, and P.H. Maxwell Formation of primary cilia in the renal epithelium is regulated by the von Hippel-Lindau tumor suppressor protein J. Am. Soc. Nephrol. 17 2006 1801 1806
-
(2006)
J. Am. Soc. Nephrol.
, vol.17
, pp. 1801-1806
-
-
Esteban, M.A.1
Harten, S.K.2
Tran, M.G.3
Maxwell, P.H.4
-
24
-
-
33646140913
-
P53 stabilization and transactivation by a von Hippel-Lindau protein
-
J.S. Roe, H. Kim, S.M. Lee, S.T. Kim, E.J. Cho, and H.D. Youn P53 stabilization and transactivation by a von Hippel-Lindau protein Mol. Cell. 22 2006 395 405
-
(2006)
Mol. Cell.
, vol.22
, pp. 395-405
-
-
Roe, J.S.1
Kim, H.2
Lee, S.M.3
Kim, S.T.4
Cho, E.J.5
Youn, H.D.6
-
26
-
-
78149409458
-
Hypoxia-inducible factors as essential regulators of inflammation
-
H.Z. Imtiyaz, and M.C. Simon Hypoxia-inducible factors as essential regulators of inflammation Curr. Top. Microbiol. Immunol. 345 2010 105 120
-
(2010)
Curr. Top. Microbiol. Immunol.
, vol.345
, pp. 105-120
-
-
Imtiyaz, H.Z.1
Simon, M.C.2
-
27
-
-
70249099576
-
Interdependence of hypoxic and innate immune responses
-
V. Nizet, and R.S. Johnson Interdependence of hypoxic and innate immune responses Nat. Rev. Immunol. 9 2009 609 617
-
(2009)
Nat. Rev. Immunol.
, vol.9
, pp. 609-617
-
-
Nizet, V.1
Johnson, R.S.2
-
29
-
-
77956217067
-
Regulation of the HIF-1alpha level is essential for hematopoietic stem cells
-
K. Takubo, N. Goda, W. Yamada, H. Iriuchishima, E. Ikeda, Y. Kubota, H. Shima, R.S. Johnson, A. Hirao, M. Suematsu, and T. Suda Regulation of the HIF-1alpha level is essential for hematopoietic stem cells Cell Stem Cell 7 2010 391 402
-
(2010)
Cell Stem Cell
, vol.7
, pp. 391-402
-
-
Takubo, K.1
Goda, N.2
Yamada, W.3
Iriuchishima, H.4
Ikeda, E.5
Kubota, Y.6
Shima, H.7
Johnson, R.S.8
Hirao, A.9
Suematsu, M.10
Suda, T.11
-
30
-
-
33751168049
-
Neutrophils from patients with heterozygous germline mutations in the von Hippel Lindau protein (pVHL) display delayed apoptosis and enhanced bacterial phagocytosis
-
S.R. Walmsley, A.S. Cowburn, M.R. Clatworthy, N.W. Morrell, E.C. Roper, V. Singleton, P. Maxwell, M.K. Whyte, and E.R. Chilvers Neutrophils from patients with heterozygous germline mutations in the von Hippel Lindau protein (pVHL) display delayed apoptosis and enhanced bacterial phagocytosis Blood 108 2006 3176 3178
-
(2006)
Blood
, vol.108
, pp. 3176-3178
-
-
Walmsley, S.R.1
Cowburn, A.S.2
Clatworthy, M.R.3
Morrell, N.W.4
Roper, E.C.5
Singleton, V.6
Maxwell, P.7
Whyte, M.K.8
Chilvers, E.R.9
-
31
-
-
77955287615
-
Drosophila von Hippel-Lindau tumor suppressor gene function in epithelial tubule morphogenesis
-
A. Hsouna, G. Nallamothu, N. Kose, M. Guinea, V. Dammai, and T. Hsu Drosophila von Hippel-Lindau tumor suppressor gene function in epithelial tubule morphogenesis Mol. Cell Biol. 30 2010 3779 3794
-
(2010)
Mol. Cell Biol.
, vol.30
, pp. 3779-3794
-
-
Hsouna, A.1
Nallamothu, G.2
Kose, N.3
Guinea, M.4
Dammai, V.5
Hsu, T.6
-
32
-
-
0036111623
-
Endemic polycythemia in Russia: Mutation in the VHL gene
-
S.O. Ang, H. Chen, V.R. Gordeuk, A.I. Sergueeva, L.A. Polyakova, G.Y. Miasnikova, R. Kralovics, D.W. Stockton, and J.T. Prchal Endemic polycythemia in Russia: mutation in the VHL gene Blood Cells Mol. Dis. 28 2002 57 62
-
(2002)
Blood Cells Mol. Dis.
, vol.28
, pp. 57-62
-
-
Ang, S.O.1
Chen, H.2
Gordeuk, V.R.3
Sergueeva, A.I.4
Polyakova, L.A.5
Miasnikova, G.Y.6
Kralovics, R.7
Stockton, D.W.8
Prchal, J.T.9
-
33
-
-
36849013228
-
Von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2 alpha signaling and splenic erythropoiesis
-
M.M. Hickey, J.C. Lam, N.A. Bezman, W.K. Rathmell, and M.C. Simon Von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2 alpha signaling and splenic erythropoiesis J. Clin. Invest. 117 2007 3879 3889
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 3879-3889
-
-
Hickey, M.M.1
Lam, J.C.2
Bezman, N.A.3
Rathmell, W.K.4
Simon, M.C.5
-
34
-
-
67650634987
-
Zebrafish mutants in the von Hippel-Lindau tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia
-
E. van Rooijen, E.E. Voest, I. Logister, J. Korving, T. Schwerte, S. Schulte-Merker, R.H. Giles, and F.J. van Eeden Zebrafish mutants in the von Hippel-Lindau tumor suppressor display a hypoxic response and recapitulate key aspects of Chuvash polycythemia Blood 113 2009 6449 6460
-
(2009)
Blood
, vol.113
, pp. 6449-6460
-
-
Van Rooijen, E.1
Voest, E.E.2
Logister, I.3
Korving, J.4
Schwerte, T.5
Schulte-Merker, S.6
Giles, R.H.7
Van Eeden, F.J.8
-
35
-
-
79960146286
-
Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia
-
R.C. Russell, R.I. Sufan, B. Zhou, P. Heir, S. Bunda, S.S. Sybingco, S.N. Greer, O. Roche, S.A. Heathcote, V.W. Chow, L.M. Boba, T.D. Richmond, M.M. Hickey, D.L. Barber, D.A. Cheresh, M.C. Simon, M.S. Irwin, W.Y. Kim, and M. Ohh Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia Nat. Med. 17 2011 845 853
-
(2011)
Nat. Med.
, vol.17
, pp. 845-853
-
-
Russell, R.C.1
Sufan, R.I.2
Zhou, B.3
Heir, P.4
Bunda, S.5
Sybingco, S.S.6
Greer, S.N.7
Roche, O.8
Heathcote, S.A.9
Chow, V.W.10
Boba, L.M.11
Richmond, T.D.12
Hickey, M.M.13
Barber, D.L.14
Cheresh, D.A.15
Simon, M.C.16
Irwin, M.S.17
Kim, W.Y.18
Ohh, M.19
-
36
-
-
79952613173
-
Regulation of erythropoietin production
-
W. Jelkmann Regulation of erythropoietin production J. Physiol-London 589 2011 1251 1258
-
(2011)
J. Physiol-London
, vol.589
, pp. 1251-1258
-
-
Jelkmann, W.1
-
37
-
-
0027367661
-
Identification of the renal erythropoietin-producing cells using transgenic mice
-
P.H. Maxwell, M.K. Osmond, C.W. Pugh, A. Heryet, L.G. Nicholls, C.C. Tan, B.G. Doe, D.J. Ferguson, M.H. Johnson, and P.J. Ratcliffe Identification of the renal erythropoietin-producing cells using transgenic mice Kidney Int. 44 1993 1149 1162
-
(1993)
Kidney Int.
, vol.44
, pp. 1149-1162
-
-
Maxwell, P.H.1
Osmond, M.K.2
Pugh, C.W.3
Heryet, A.4
Nicholls, L.G.5
Tan, C.C.6
Doe, B.G.7
Ferguson, D.J.8
Johnson, M.H.9
Ratcliffe, P.J.10
-
38
-
-
0027410945
-
Co-localization of erythropoietin mRNA and ecto-5'-nucleotidase immunoreactivity in peritubular cells of rat renal cortex indicates that fibroblasts produce erythropoietin
-
S. Bachmann, M. Le Hir, and K.U. Eckardt Co-localization of erythropoietin mRNA and ecto-5'-nucleotidase immunoreactivity in peritubular cells of rat renal cortex indicates that fibroblasts produce erythropoietin J. Histochem. Cytochem. 41 1993 335 341
-
(1993)
J. Histochem. Cytochem.
, vol.41
, pp. 335-341
-
-
Bachmann, S.1
Le Hir, M.2
Eckardt, K.U.3
-
39
-
-
0028086474
-
Expression of a homologously recombined erythopoietin-SV40 T antigen fusion gene in mouse liver: Evidence for erythropoietin production by Ito cells
-
P.H. Maxwell, D.J. Ferguson, M.K. Osmond, C.W. Pugh, A. Heryet, B.G. Doe, M.H. Johnson, and P.J. Ratcliffe Expression of a homologously recombined erythopoietin-SV40 T antigen fusion gene in mouse liver: evidence for erythropoietin production by Ito cells Blood 84 1994 1823 1830
-
(1994)
Blood
, vol.84
, pp. 1823-1830
-
-
Maxwell, P.H.1
Ferguson, D.J.2
Osmond, M.K.3
Pugh, C.W.4
Heryet, A.5
Doe, B.G.6
Johnson, M.H.7
Ratcliffe, P.J.8
-
40
-
-
65449187188
-
Expression of erythropoietin and its receptor in human renal cell carcinoma
-
K. Papworth, A. Bergh, K. Grankvist, B. Ljungberg, and T. Rasmuson Expression of erythropoietin and its receptor in human renal cell carcinoma Tumour Biol. 30 2009 86 92
-
(2009)
Tumour Biol.
, vol.30
, pp. 86-92
-
-
Papworth, K.1
Bergh, A.2
Grankvist, K.3
Ljungberg, B.4
Rasmuson, T.5
-
41
-
-
0032211161
-
Coexpression of erythropoietin and vascular endothelial growth factor in nervous system tumors associated with von Hippel-Lindau tumor suppressor gene loss of function
-
M. Krieg, H.H. Marti, and K.H. Plate Coexpression of erythropoietin and vascular endothelial growth factor in nervous system tumors associated with von Hippel-Lindau tumor suppressor gene loss of function Blood 92 1998 3388 3393
-
(1998)
Blood
, vol.92
, pp. 3388-3393
-
-
Krieg, M.1
Marti, H.H.2
Plate, K.H.3
-
42
-
-
19944432163
-
Coexpression of erythropoietin and erythropoietin receptor in von Hippel-Lindau disease-associated renal cysts and renal cell carcinoma
-
Y.S. Lee, A.O. Vortmeyer, I.A. Lubensky, T.W. Vogel, B. Ikejiri, S. Ferlicot, G. Benoit, S. Giraud, E.H. Oldfield, W.M. Linehan, B.T. Teh, S. Richard, and Z. Zhuang Coexpression of erythropoietin and erythropoietin receptor in von Hippel-Lindau disease-associated renal cysts and renal cell carcinoma Clin. Cancer Res. 11 2005 1059 1064
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 1059-1064
-
-
Lee, Y.S.1
Vortmeyer, A.O.2
Lubensky, I.A.3
Vogel, T.W.4
Ikejiri, B.5
Ferlicot, S.6
Benoit, G.7
Giraud, S.8
Oldfield, E.H.9
Linehan, W.M.10
Teh, B.T.11
Richard, S.12
Zhuang, Z.13
-
43
-
-
33745802020
-
Coexpression of erythopoietin and erythopoietin receptor in sporadic clear cell renal cell carcinoma
-
K. Gong, N. Zhang, Z. Zhang, and Y.Q. Na Coexpression of erythopoietin and erythopoietin receptor in sporadic clear cell renal cell carcinoma Cancer Biol. Ther. 5 2006 582 585
-
(2006)
Cancer Biol. Ther.
, vol.5
, pp. 582-585
-
-
Gong, K.1
Zhang, N.2
Zhang, Z.3
Na, Y.Q.4
-
44
-
-
0242468041
-
Regulation of JAK-STAT signalling in the immune system
-
K. Shuai, and B. Liu Regulation of JAK-STAT signalling in the immune system Nat. Rev. Immunol. 3 2003 900 911
-
(2003)
Nat. Rev. Immunol.
, vol.3
, pp. 900-911
-
-
Shuai, K.1
Liu, B.2
-
45
-
-
2342631195
-
Congenital disorder of oxygen sensing: Association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors
-
V.R. Gordeuk, A.I. Sergueeva, G.Y. Miasnikova, D. Okhotin, Y. Voloshin, P.L. Choyke, J.A. Butman, K. Jedlickova, J.T. Prchal, and L.A. Polyakova Congenital disorder of oxygen sensing: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors Blood 103 2004 3924 3932
-
(2004)
Blood
, vol.103
, pp. 3924-3932
-
-
Gordeuk, V.R.1
Sergueeva, A.I.2
Miasnikova, G.Y.3
Okhotin, D.4
Voloshin, Y.5
Choyke, P.L.6
Butman, J.A.7
Jedlickova, K.8
Prchal, J.T.9
Polyakova, L.A.10
-
46
-
-
0036455109
-
EPO's alter ego: Erythropoietin has multiple actions
-
T.R. Lappin, A.P. Maxwell, and P.G. Johnston EPO's alter ego: erythropoietin has multiple actions Stem Cells 20 2002 485 492
-
(2002)
Stem Cells
, vol.20
, pp. 485-492
-
-
Lappin, T.R.1
Maxwell, A.P.2
Johnston, P.G.3
-
47
-
-
40449087690
-
The non-haematopoietic biological effects of erythropoietin
-
M.O. Arcasoy The non-haematopoietic biological effects of erythropoietin Br. J. Haematol. 141 2008 14 31
-
(2008)
Br. J. Haematol.
, vol.141
, pp. 14-31
-
-
Arcasoy, M.O.1
-
48
-
-
44349143198
-
Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth
-
S. Purhonen, J. Palm, D. Rossi, N. Kaskenpaa, I. Rajantie, S. Yla-Herttuala, K. Alitalo, I.L. Weissman, and P. Salven Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth Proc. Natl. Acad. Sci U S A 105 2008 6620 6625
-
(2008)
Proc. Natl. Acad. Sci U S A
, vol.105
, pp. 6620-6625
-
-
Purhonen, S.1
Palm, J.2
Rossi, D.3
Kaskenpaa, N.4
Rajantie, I.5
Yla-Herttuala, S.6
Alitalo, K.7
Weissman, I.L.8
Salven, P.9
-
49
-
-
80054993756
-
Promises and pitfalls in erythopoietin-mediated tissue protection: Are nonerythropoietic derivatives a way forward?
-
C.C. Hand, and M. Brines Promises and pitfalls in erythopoietin-mediated tissue protection: are nonerythropoietic derivatives a way forward? J. Investig. Med. 59 2011 1073 1082
-
(2011)
J. Investig. Med.
, vol.59
, pp. 1073-1082
-
-
Hand, C.C.1
Brines, M.2
-
50
-
-
0242721510
-
Erythropoietin as a critical component of breast cancer therapy: Survival, synergistic, and cognitive applications
-
B. Leyland-Jones, and J.A. O'Shaughnessy Erythropoietin as a critical component of breast cancer therapy: survival, synergistic, and cognitive applications Semin. Oncol. 30 2003 174 184
-
(2003)
Semin. Oncol.
, vol.30
, pp. 174-184
-
-
Leyland-Jones, B.1
O'Shaughnessy, J.A.2
-
51
-
-
0142186283
-
Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: Randomised, double-blind, placebo-controlled trial
-
M. Henke, R. Laszig, C. Rube, U. Schafer, K.D. Haase, B. Schilcher, S. Mose, K.T. Beer, U. Burger, C. Dougherty, and H. Frommhold Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial Lancet 362 2003 1255 1260
-
(2003)
Lancet
, vol.362
, pp. 1255-1260
-
-
Henke, M.1
Laszig, R.2
Rube, C.3
Schafer, U.4
Haase, K.D.5
Schilcher, B.6
Mose, S.7
Beer, K.T.8
Burger, U.9
Dougherty, C.10
Frommhold, H.11
-
52
-
-
0037767746
-
Expression of erythropoietin receptor splice variants in human cancer
-
M.O. Arcasoy, X. Jiang, and Z.A. Haroon Expression of erythropoietin receptor splice variants in human cancer Biochem. Biophys. Res. Commun. 307 2003 999 1007
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.307
, pp. 999-1007
-
-
Arcasoy, M.O.1
Jiang, X.2
Haroon, Z.A.3
-
53
-
-
0036850611
-
Erythropoietin is involved in growth and angiogenesis in malignant tumours of female reproductive organs
-
Y. Yasuda, Y. Fujita, S. Masuda, T. Musha, K. Ueda, H. Tanaka, H. Fujita, T. Matsuo, M. Nagao, R. Sasaki, and Y. Nakamura Erythropoietin is involved in growth and angiogenesis in malignant tumours of female reproductive organs Carcinogenesis 23 2002 1797 1805
-
(2002)
Carcinogenesis
, vol.23
, pp. 1797-1805
-
-
Yasuda, Y.1
Fujita, Y.2
Masuda, S.3
Musha, T.4
Ueda, K.5
Tanaka, H.6
Fujita, H.7
Matsuo, T.8
Nagao, M.9
Sasaki, R.10
Nakamura, Y.11
-
54
-
-
0038751965
-
Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its potential role in cervical carcinogenesis and tumor progression
-
G. Acs, P.J. Zhang, C.M. McGrath, P. Acs, J. McBroom, A. Mohyeldin, S. Liu, H. Lu, and A. Verma Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its potential role in cervical carcinogenesis and tumor progression Am. J. Pathol. 162 2003 1789 1806
-
(2003)
Am. J. Pathol.
, vol.162
, pp. 1789-1806
-
-
Acs, G.1
Zhang, P.J.2
McGrath, C.M.3
Acs, P.4
McBroom, J.5
Mohyeldin, A.6
Liu, S.7
Lu, H.8
Verma, A.9
-
55
-
-
0142043003
-
Pediatric tumor cells express erythropoietin and a functional erythropoietin receptor that promotes angiogenesis and tumor cell survival
-
S. Batra, N. Perelman, L.R. Luck, H. Shimada, and P. Malik Pediatric tumor cells express erythropoietin and a functional erythropoietin receptor that promotes angiogenesis and tumor cell survival Lab. Invest. 83 2003 1477 1487
-
(2003)
Lab. Invest.
, vol.83
, pp. 1477-1487
-
-
Batra, S.1
Perelman, N.2
Luck, L.R.3
Shimada, H.4
Malik, P.5
-
56
-
-
0037479926
-
Erythropoietin regulates tumour growth of human malignancies
-
Y. Yasuda, Y. Fujita, T. Matsuo, S. Koinuma, S. Hara, A. Tazaki, M. Onozaki, M. Hashimoto, T. Musha, K. Ogawa, H. Fujita, Y. Nakamura, H. Shiozaki, and H. Utsumi Erythropoietin regulates tumour growth of human malignancies Carcinogenesis 24 2003 1021 1029
-
(2003)
Carcinogenesis
, vol.24
, pp. 1021-1029
-
-
Yasuda, Y.1
Fujita, Y.2
Matsuo, T.3
Koinuma, S.4
Hara, S.5
Tazaki, A.6
Onozaki, M.7
Hashimoto, M.8
Musha, T.9
Ogawa, K.10
Fujita, H.11
Nakamura, Y.12
Shiozaki, H.13
Utsumi, H.14
-
57
-
-
34447120059
-
Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)
-
C. Peyssonnaux, A.S. Zinkernagel, R.A. Schuepbach, E. Rankin, S. Vaulont, V.H. Haase, V. Nizet, and R.S. Johnson Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs) J. Clin. Invest. 117 2007 1926 1932
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1926-1932
-
-
Peyssonnaux, C.1
Zinkernagel, A.S.2
Schuepbach, R.A.3
Rankin, E.4
Vaulont, S.5
Haase, V.H.6
Nizet, V.7
Johnson, R.S.8
-
58
-
-
78649921834
-
The relationship of erythropoietin overexpression with von Hippel-Lindau tumour suppressor gene mutations between hypoxia-inducible factor-1alpha and -2alpha in sporadic clear cell renal carcinoma
-
K. Gong, N. Zhang, K. Zhang, and Y. Na The relationship of erythropoietin overexpression with von Hippel-Lindau tumour suppressor gene mutations between hypoxia-inducible factor-1alpha and -2alpha in sporadic clear cell renal carcinoma Int. J. Mol. Med. 26 2010 907 912
-
(2010)
Int. J. Mol. Med.
, vol.26
, pp. 907-912
-
-
Gong, K.1
Zhang, N.2
Zhang, K.3
Na, Y.4
-
59
-
-
13244272302
-
Congenital polycythemia with homozygous and heterozygous mutations of von Hippel-Lindau gene: Five new Caucasian patients
-
M.C. Bento, K.T. Chang, Y. Guan, E. Liu, G. Caldas, R.A. Gatti, and J.T. Prchal Congenital polycythemia with homozygous and heterozygous mutations of von Hippel-Lindau gene: five new Caucasian patients Haematologica 90 2005 128 129
-
(2005)
Haematologica
, vol.90
, pp. 128-129
-
-
Bento, M.C.1
Chang, K.T.2
Guan, Y.3
Liu, E.4
Caldas, G.5
Gatti, R.A.6
Prchal, J.T.7
-
60
-
-
13244281831
-
Mutations in the von Hippel-Lindau (VHL) tumor suppressor gene and VHL-haplotype analysis in patients with presumable congenital erythrocytosis
-
H. Cario, K. Schwarz, N. Jorch, U. Kyank, P.E. Petrides, D.T. Schneider, R. Uhle, K.M. Debatin, and E. Kohne Mutations in the von Hippel-Lindau (VHL) tumor suppressor gene and VHL-haplotype analysis in patients with presumable congenital erythrocytosis Haematologica 90 2005 19 24
-
(2005)
Haematologica
, vol.90
, pp. 19-24
-
-
Cario, H.1
Schwarz, K.2
Jorch, N.3
Kyank, U.4
Petrides, P.E.5
Schneider, D.T.6
Uhle, R.7
Debatin, K.M.8
Kohne, E.9
-
61
-
-
0037441601
-
Mutations in the VHL gene in sporadic apparently congenital polycythemia
-
Y.D. Pastore, J. Jelinek, S. Ang, Y. Guan, E. Liu, K. Jedlickova, L. Krishnamurti, and J.T. Prchal Mutations in the VHL gene in sporadic apparently congenital polycythemia Blood 101 2003 1591 1595
-
(2003)
Blood
, vol.101
, pp. 1591-1595
-
-
Pastore, Y.D.1
Jelinek, J.2
Ang, S.3
Guan, Y.4
Liu, E.5
Jedlickova, K.6
Krishnamurti, L.7
Prchal, J.T.8
-
62
-
-
50549176891
-
The association of polycythemia with a cerebellar hemangioblastoma. The production of an erythropoiesis stimulating factor by the tumor
-
T.A. Waldmann, E.H. Levin, and M. Baldwin The association of polycythemia with a cerebellar hemangioblastoma. The production of an erythropoiesis stimulating factor by the tumor Am. J. Med. 31 1961 318 324
-
(1961)
Am. J. Med.
, vol.31
, pp. 318-324
-
-
Waldmann, T.A.1
Levin, E.H.2
Baldwin, M.3
-
63
-
-
78649829419
-
Human endothelial stem/progenitor cells, angiogenic factors and vascular repair
-
S.M. Watt, A. Athanassopoulos, A.L. Harris, and G. Tsaknakis Human endothelial stem/progenitor cells, angiogenic factors and vascular repair J R Soc. Interface 7 Suppl. 6 2010 S731 S751
-
(2010)
J R Soc. Interface
, vol.7
, Issue.SUPPL. 6
-
-
Watt, S.M.1
Athanassopoulos, A.2
Harris, A.L.3
Tsaknakis, G.4
-
65
-
-
77950950894
-
Macrophage diversity enhances tumor progression and metastasis
-
B.Z. Qian, and J.W. Pollard Macrophage diversity enhances tumor progression and metastasis Cell 141 2010 39 51
-
(2010)
Cell
, vol.141
, pp. 39-51
-
-
Qian, B.Z.1
Pollard, J.W.2
-
66
-
-
38149006909
-
Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis
-
D. Gao, D.J. Nolan, A.S. Mellick, K. Bambino, K. McDonnell, and V. Mittal Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis Science 319 2008 195 198
-
(2008)
Science
, vol.319
, pp. 195-198
-
-
Gao, D.1
Nolan, D.J.2
Mellick, A.S.3
Bambino, K.4
McDonnell, K.5
Mittal, V.6
-
67
-
-
79959737234
-
Increased mobilisation of circulating endothelial progenitors in von Hippel-Lindau disease and renal cell carcinoma
-
R.S. Bhatt, A.J. Zurita, A. O'Neill, A. Norden-Zfoni, L. Zhang, H.K. Wu, P.Y. Wen, D. George, V.P. Sukhatme, M.B. Atkins, and J.V. Heymach Increased mobilisation of circulating endothelial progenitors in von Hippel-Lindau disease and renal cell carcinoma Br. J. Cancer 105 2011 112 117
-
(2011)
Br. J. Cancer
, vol.105
, pp. 112-117
-
-
Bhatt, R.S.1
Zurita, A.J.2
O'Neill, A.3
Norden-Zfoni, A.4
Zhang, L.5
Wu, H.K.6
Wen, P.Y.7
George, D.8
Sukhatme, V.P.9
Atkins, M.B.10
Heymach, J.V.11
-
68
-
-
79953183344
-
Levels of circulating CD45(dim)CD34(+)VEGFR2(+) progenitor cells correlate with outcome in metastatic renal cell carcinoma patients treated with tyrosine kinase inhibitors
-
F. Farace, M. Gross-Goupil, E. Tournay, M. Taylor, N. Vimond, N. Jacques, F. Billiot, A. Mauguen, C. Hill, and B. Escudier Levels of circulating CD45(dim)CD34(+)VEGFR2(+) progenitor cells correlate with outcome in metastatic renal cell carcinoma patients treated with tyrosine kinase inhibitors Br. J. Cancer 104 2011 1144 1150
-
(2011)
Br. J. Cancer
, vol.104
, pp. 1144-1150
-
-
Farace, F.1
Gross-Goupil, M.2
Tournay, E.3
Taylor, M.4
Vimond, N.5
Jacques, N.6
Billiot, F.7
Mauguen, A.8
Hill, C.9
Escudier, B.10
-
69
-
-
38349141624
-
Novel somatic mutations of the VHL gene in an erythropoietin-producing renal carcinoma associated with secondary polycythemia and elevated circulating endothelial progenitor cells
-
F.H. Rad, A. Ulusakarya, S. Gad, M. Sibony, F. Juin, S. Richard, D. Machover, and G. Uzan Novel somatic mutations of the VHL gene in an erythropoietin-producing renal carcinoma associated with secondary polycythemia and elevated circulating endothelial progenitor cells Am. J. Hematol. 83 2008 155 158
-
(2008)
Am. J. Hematol.
, vol.83
, pp. 155-158
-
-
Rad, F.H.1
Ulusakarya, A.2
Gad, S.3
Sibony, M.4
Juin, F.5
Richard, S.6
MacHover, D.7
Uzan, G.8
-
70
-
-
0042738942
-
Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization
-
C. Heeschen, A. Aicher, R. Lehmann, S. Fichtlscherer, M. Vasa, C. Urbich, C. Mildner-Rihm, H. Martin, A.M. Zeiher, and S. Dimmeler Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization Blood 102 2003 1340 1346
-
(2003)
Blood
, vol.102
, pp. 1340-1346
-
-
Heeschen, C.1
Aicher, A.2
Lehmann, R.3
Fichtlscherer, S.4
Vasa, M.5
Urbich, C.6
Mildner-Rihm, C.7
Martin, H.8
Zeiher, A.M.9
Dimmeler, S.10
-
71
-
-
47949110692
-
Oxidative stress regulates expression of VEGFR1 in myeloid cells: Link to tumor-induced immune suppression in renal cell carcinoma
-
S. Kusmartsev, E. Eruslanov, H. Kubler, T. Tseng, Y. Sakai, Z. Su, S. Kaliberov, A. Heiser, C. Rosser, P. Dahm, D. Siemann, and J. Vieweg Oxidative stress regulates expression of VEGFR1 in myeloid cells: link to tumor-induced immune suppression in renal cell carcinoma J. Immunol. 181 2008 346 353
-
(2008)
J. Immunol.
, vol.181
, pp. 346-353
-
-
Kusmartsev, S.1
Eruslanov, E.2
Kubler, H.3
Tseng, T.4
Sakai, Y.5
Su, Z.6
Kaliberov, S.7
Heiser, A.8
Rosser, C.9
Dahm, P.10
Siemann, D.11
Vieweg, J.12
-
72
-
-
77955295091
-
Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation
-
H.Z. Imtiyaz, E.P. Williams, M.M. Hickey, S.A. Patel, A.C. Durham, L.J. Yuan, R. Hammond, P.A. Gimotty, B. Keith, and M.C. Simon Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation J. Clin. Invest. 120 2010 2699 2714
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 2699-2714
-
-
Imtiyaz, H.Z.1
Williams, E.P.2
Hickey, M.M.3
Patel, S.A.4
Durham, A.C.5
Yuan, L.J.6
Hammond, R.7
Gimotty, P.A.8
Keith, B.9
Simon, M.C.10
-
73
-
-
73949112134
-
Differentiation stage-specific requirement in hypoxia-inducible factor-1alpha-regulated glycolytic pathway during murine B cell development in bone marrow
-
H. Kojima, A. Kobayashi, D. Sakurai, Y. Kanno, H. Hase, R. Takahashi, Y. Totsuka, G.L. Semenza, M.V. Sitkovsky, and T. Kobata Differentiation stage-specific requirement in hypoxia-inducible factor-1alpha-regulated glycolytic pathway during murine B cell development in bone marrow J. Immunol. 184 2010 154 163
-
(2010)
J. Immunol.
, vol.184
, pp. 154-163
-
-
Kojima, H.1
Kobayashi, A.2
Sakurai, D.3
Kanno, Y.4
Hase, H.5
Takahashi, R.6
Totsuka, Y.7
Semenza, G.L.8
Sitkovsky, M.V.9
Kobata, T.10
-
74
-
-
0037423948
-
HIF-1alpha is essential for myeloid cell-mediated inflammation
-
T. Cramer, Y. Yamanishi, B.E. Clausen, I. Forster, R. Pawlinski, N. Mackman, V.H. Haase, R. Jaenisch, M. Corr, V. Nizet, G.S. Firestein, H.P. Gerber, N. Ferrara, and R.S. Johnson HIF-1alpha is essential for myeloid cell-mediated inflammation Cell 112 2003 645 657
-
(2003)
Cell
, vol.112
, pp. 645-657
-
-
Cramer, T.1
Yamanishi, Y.2
Clausen, B.E.3
Forster, I.4
Pawlinski, R.5
MacKman, N.6
Haase, V.H.7
Jaenisch, R.8
Corr, M.9
Nizet, V.10
Firestein, G.S.11
Gerber, H.P.12
Ferrara, N.13
Johnson, R.S.14
-
75
-
-
77956205122
-
The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche
-
T. Simsek, F. Kocabas, J. Zheng, R.J. Deberardinis, A.I. Mahmoud, E.N. Olson, J.W. Schneider, C.C. Zhang, and H.A. Sadek The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche Cell Stem Cell 7 2010 380 390
-
(2010)
Cell Stem Cell
, vol.7
, pp. 380-390
-
-
Simsek, T.1
Kocabas, F.2
Zheng, J.3
Deberardinis, R.J.4
Mahmoud, A.I.5
Olson, E.N.6
Schneider, J.W.7
Zhang, C.C.8
Sadek, H.A.9
-
76
-
-
0037133250
-
Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice
-
H. Kojima, H. Gu, S. Nomura, C.C. Caldwell, T. Kobata, P. Carmeliet, G.L. Semenza, and M.V. Sitkovsky Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice Proc. Natl. Acad. Sci. U S A 99 2002 2170 2174
-
(2002)
Proc. Natl. Acad. Sci. U S A
, vol.99
, pp. 2170-2174
-
-
Kojima, H.1
Gu, H.2
Nomura, S.3
Caldwell, C.C.4
Kobata, T.5
Carmeliet, P.6
Semenza, G.L.7
Sitkovsky, M.V.8
-
77
-
-
53049090443
-
Prognostic significance of aberrant promoter hypermethylation of CpG islands in patients with diffuse large B-cell lymphomas
-
K. Amara, M. Trimeche, S. Ziadi, A. Laatiri, M. Hachana, and S. Korbi Prognostic significance of aberrant promoter hypermethylation of CpG islands in patients with diffuse large B-cell lymphomas Ann. Oncol. 19 2008 1774 1786
-
(2008)
Ann. Oncol.
, vol.19
, pp. 1774-1786
-
-
Amara, K.1
Trimeche, M.2
Ziadi, S.3
Laatiri, A.4
Hachana, M.5
Korbi, S.6
-
78
-
-
75649133610
-
Differential genome-wide array-based methylation profiles in prognostic subsets of chronic lymphocytic leukemia
-
M. Kanduri, N. Cahill, H. Goransson, C. Enstrom, F. Ryan, A. Isaksson, and R. Rosenquist Differential genome-wide array-based methylation profiles in prognostic subsets of chronic lymphocytic leukemia Blood 115 2010 296 305
-
(2010)
Blood
, vol.115
, pp. 296-305
-
-
Kanduri, M.1
Cahill, N.2
Goransson, H.3
Enstrom, C.4
Ryan, F.5
Isaksson, A.6
Rosenquist, R.7
-
79
-
-
67049096242
-
Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells
-
A.K. Ghosh, T.D. Shanafelt, A. Cimmino, C. Taccioli, S. Volinia, C.G. Liu, G.A. Calin, C.M. Croce, D.A. Chan, A.J. Giaccia, C. Secreto, L.E. Wellik, Y.K. Lee, D. Mukhopadhyay, and N.E. Kay Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells Blood 113 2009 5568 5574
-
(2009)
Blood
, vol.113
, pp. 5568-5574
-
-
Ghosh, A.K.1
Shanafelt, T.D.2
Cimmino, A.3
Taccioli, C.4
Volinia, S.5
Liu, C.G.6
Calin, G.A.7
Croce, C.M.8
Chan, D.A.9
Giaccia, A.J.10
Secreto, C.11
Wellik, L.E.12
Lee, Y.K.13
Mukhopadhyay, D.14
Kay, N.E.15
-
80
-
-
81555196342
-
HDAC inhibitors and decitabine are highly synergistic and associated with unique gene-expression and epigenetic profiles in models of DLBCL
-
M. Kalac, L. Scotto, E. Marchi, J. Amengual, V.E. Seshan, G. Bhagat, N. Ulahannan, V.V. Leshchenko, A.M. Temkin, S. Parekh, B. Tycko, and O.A. O'Connor HDAC inhibitors and decitabine are highly synergistic and associated with unique gene-expression and epigenetic profiles in models of DLBCL Blood 118 2011 5506 5516
-
(2011)
Blood
, vol.118
, pp. 5506-5516
-
-
Kalac, M.1
Scotto, L.2
Marchi, E.3
Amengual, J.4
Seshan, V.E.5
Bhagat, G.6
Ulahannan, N.7
Leshchenko, V.V.8
Temkin, A.M.9
Parekh, S.10
Tycko, B.11
O'Connor, O.A.12
-
81
-
-
28044440647
-
Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction
-
A.K. Neumann, J. Yang, M.P. Biju, S.K. Joseph, R.S. Johnson, V.H. Haase, B.D. Freedman, and L.A. Turka Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction Proc. Natl. Acad. Sci. U S A 102 2005 17071 17076
-
(2005)
Proc. Natl. Acad. Sci. U S A
, vol.102
, pp. 17071-17076
-
-
Neumann, A.K.1
Yang, J.2
Biju, M.P.3
Joseph, S.K.4
Johnson, R.S.5
Haase, V.H.6
Freedman, B.D.7
Turka, L.A.8
-
82
-
-
4744343476
-
Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes
-
M.P. Biju, A.K. Neumann, S.J. Bensinger, R.S. Johnson, L.A. Turka, and V.H. Haase Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes Mol. Cell. Biol. 24 2004 9038 9047
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 9038-9047
-
-
Biju, M.P.1
Neumann, A.K.2
Bensinger, S.J.3
Johnson, R.S.4
Turka, L.A.5
Haase, V.H.6
-
83
-
-
33749512970
-
Cutting edge: Hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes
-
D. Lukashev, B. Klebanov, H. Kojima, A. Grinberg, A. Ohta, L. Berenfeld, R.H. Wenger, and M. Sitkovsky Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes J. Immunol. 177 2006 4962 4965
-
(2006)
J. Immunol.
, vol.177
, pp. 4962-4965
-
-
Lukashev, D.1
Klebanov, B.2
Kojima, H.3
Grinberg, A.4
Ohta, A.5
Berenfeld, L.6
Wenger, R.H.7
Sitkovsky, M.8
-
84
-
-
36849008476
-
Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival
-
M. Thiel, C.C. Caldwell, S. Kreth, S. Kuboki, P. Chen, P. Smith, A. Ohta, A.B. Lentsch, D. Lukashev, and M.V. Sitkovsky Targeted deletion of HIF-1alpha gene in T cells prevents their inhibition in hypoxic inflamed tissues and improves septic mice survival PLoS One 2 2007 e853
-
(2007)
PLoS One
, vol.2
, pp. 853
-
-
Thiel, M.1
Caldwell, C.C.2
Kreth, S.3
Kuboki, S.4
Chen, P.5
Smith, P.6
Ohta, A.7
Lentsch, A.B.8
Lukashev, D.9
Sitkovsky, M.V.10
-
85
-
-
10744233368
-
Hypoxia-inducible factor regulates survival of antigen receptor-driven T cells
-
Y. Makino, H. Nakamura, E. Ikeda, K. Ohnuma, K. Yamauchi, Y. Yabe, L. Poellinger, Y. Okada, C. Morimoto, and H. Tanaka Hypoxia-inducible factor regulates survival of antigen receptor-driven T cells J. Immunol. 171 2003 6534 6540
-
(2003)
J. Immunol.
, vol.171
, pp. 6534-6540
-
-
Makino, Y.1
Nakamura, H.2
Ikeda, E.3
Ohnuma, K.4
Yamauchi, K.5
Yabe, Y.6
Poellinger, L.7
Okada, Y.8
Morimoto, C.9
Tanaka, H.10
-
86
-
-
80052277906
-
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1
-
E.V. Dang, J. Barbi, H.Y. Yang, D. Jinasena, H. Yu, Y. Zheng, Z. Bordman, J. Fu, Y. Kim, H.R. Yen, W. Luo, K. Zeller, L. Shimoda, S.L. Topalian, G.L. Semenza, C.V. Dang, D.M. Pardoll, and F. Pan Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1 Cell 146 2011 772 784
-
(2011)
Cell
, vol.146
, pp. 772-784
-
-
Dang, E.V.1
Barbi, J.2
Yang, H.Y.3
Jinasena, D.4
Yu, H.5
Zheng, Y.6
Bordman, Z.7
Fu, J.8
Kim, Y.9
Yen, H.R.10
Luo, W.11
Zeller, K.12
Shimoda, L.13
Topalian, S.L.14
Semenza, G.L.15
Dang, C.V.16
Pardoll, D.M.17
Pan, F.18
-
87
-
-
67349114782
-
FOXP3 and the regulation of Treg/Th17 differentiation
-
S.F. Ziegler, and J.H. Buckner FOXP3 and the regulation of Treg/Th17 differentiation Microbes Infect. 11 2009 594 598
-
(2009)
Microbes Infect.
, vol.11
, pp. 594-598
-
-
Ziegler, S.F.1
Buckner, J.H.2
-
88
-
-
22144492953
-
HIF-1alpha expression regulates the bactericidal capacity of phagocytes
-
C. Peyssonnaux, V. Datta, T. Cramer, A. Doedens, E.A. Theodorakis, R.L. Gallo, N. Hurtado-Ziola, V. Nizet, and R.S. Johnson HIF-1alpha expression regulates the bactericidal capacity of phagocytes J. Clin. Invest. 115 2005 1806 1815
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 1806-1815
-
-
Peyssonnaux, C.1
Datta, V.2
Cramer, T.3
Doedens, A.4
Theodorakis, E.A.5
Gallo, R.L.6
Hurtado-Ziola, N.7
Nizet, V.8
Johnson, R.S.9
-
89
-
-
80051549232
-
Interactions between nitric oxide and hypoxia-inducible factor signaling pathways in inflammatory disease
-
N. Olson, and A. van der Vliet Interactions between nitric oxide and hypoxia-inducible factor signaling pathways in inflammatory disease Nitric Oxide 25 2011 125 137
-
(2011)
Nitric Oxide
, vol.25
, pp. 125-137
-
-
Olson, N.1
Van Der Vliet, A.2
-
90
-
-
77949725833
-
The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice
-
M.M. Hickey, T. Richardson, T. Wang, M. Mosqueira, E. Arguiri, H. Yu, Q.C. Yu, C.C. Solomides, E.E. Morrisey, T.S. Khurana, M. Christofidou-Solomidou, and M.C. Simon The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice J. Clin. Invest. 120 2010 827 839
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 827-839
-
-
Hickey, M.M.1
Richardson, T.2
Wang, T.3
Mosqueira, M.4
Arguiri, E.5
Yu, H.6
Yu, Q.C.7
Solomides, C.C.8
Morrisey, E.E.9
Khurana, T.S.10
Christofidou-Solomidou, M.11
Simon, M.C.12
-
91
-
-
0033870281
-
The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages
-
K.L. Talks, H. Turley, K.C. Gatter, P.H. Maxwell, C.W. Pugh, P.J. Ratcliffe, and A.L. Harris The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages Am. J. Pathol. 157 2000 411 421
-
(2000)
Am. J. Pathol.
, vol.157
, pp. 411-421
-
-
Talks, K.L.1
Turley, H.2
Gatter, K.C.3
Maxwell, P.H.4
Pugh, C.W.5
Ratcliffe, P.J.6
Harris, A.L.7
-
93
-
-
57049135813
-
Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis
-
K. Kimura, M. Iwano, D.F. Higgins, Y. Yamaguchi, K. Nakatani, K. Harada, A. Kubo, Y. Akai, E.B. Rankin, E.G. Neilson, V.H. Haase, and Y. Saito Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis Am. J. Physiol. Renal Physiol. 295 2008 F1023 F1029
-
(2008)
Am. J. Physiol. Renal Physiol.
, vol.295
-
-
Kimura, K.1
Iwano, M.2
Higgins, D.F.3
Yamaguchi, Y.4
Nakatani, K.5
Harada, K.6
Kubo, A.7
Akai, Y.8
Rankin, E.B.9
Neilson, E.G.10
Haase, V.H.11
Saito, Y.12
-
94
-
-
36849021771
-
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
-
D.F. Higgins, K. Kimura, W.M. Bernhardt, N. Shrimanker, Y. Akai, B. Hohenstein, Y. Saito, R.S. Johnson, M. Kretzler, C.D. Cohen, K.U. Eckardt, M. Iwano, and V.H. Haase Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition J. Clin. Invest. 117 2007 3810 3820
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 3810-3820
-
-
Higgins, D.F.1
Kimura, K.2
Bernhardt, W.M.3
Shrimanker, N.4
Akai, Y.5
Hohenstein, B.6
Saito, Y.7
Johnson, R.S.8
Kretzler, M.9
Cohen, C.D.10
Eckardt, K.U.11
Iwano, M.12
Haase, V.H.13
-
95
-
-
84856486011
-
Renal tubular HIF-2alpha expression requires VHL inactivation and causes fibrosis and cysts
-
R.E. Schietke, T. Hackenbeck, M. Tran, R. Gunther, B. Klanke, C.L. Warnecke, K.X. Knaup, D. Shukla, C. Rosenberger, R. Koesters, S. Bachmann, P. Betz, G. Schley, J. Schodel, C. Willam, T. Winkler, K. Amann, K.U. Eckardt, P. Maxwell, and M.S. Wiesener Renal tubular HIF-2alpha expression requires VHL inactivation and causes fibrosis and cysts PLoS One 7 2012 e31034
-
(2012)
PLoS One
, vol.7
, pp. 31034
-
-
Schietke, R.E.1
Hackenbeck, T.2
Tran, M.3
Gunther, R.4
Klanke, B.5
Warnecke, C.L.6
Knaup, K.X.7
Shukla, D.8
Rosenberger, C.9
Koesters, R.10
Bachmann, S.11
Betz, P.12
Schley, G.13
Schodel, J.14
Willam, C.15
Winkler, T.16
Amann, K.17
Eckardt, K.U.18
Maxwell, P.19
Wiesener, M.S.20
more..
-
96
-
-
0037377756
-
Von Hippel-Lindau protein-mediated repression of tumor necrosis factor alpha translation revealed through use of cDNA arrays
-
S. Galban, J. Fan, J.L. Martindale, C. Cheadle, B. Hoffman, M.P. Woods, G. Temeles, J. Brieger, J. Decker, and M. Gorospe Von Hippel-Lindau protein-mediated repression of tumor necrosis factor alpha translation revealed through use of cDNA arrays Mol. Cell. Biol. 23 2003 2316 2328
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 2316-2328
-
-
Galban, S.1
Fan, J.2
Martindale, J.L.3
Cheadle, C.4
Hoffman, B.5
Woods, M.P.6
Temeles, G.7
Brieger, J.8
Decker, J.9
Gorospe, M.10
-
97
-
-
0033135109
-
Transforming growth factor beta1 is a target for the von Hippel-Lindau tumor suppressor and a critical growth factor for clear cell renal carcinoma
-
S. Ananth, B. Knebelmann, W. Gruning, M. Dhanabal, G. Walz, I.E. Stillman, and V.P. Sukhatme Transforming growth factor beta1 is a target for the von Hippel-Lindau tumor suppressor and a critical growth factor for clear cell renal carcinoma Cancer Res. 59 1999 2210 2216
-
(1999)
Cancer Res.
, vol.59
, pp. 2210-2216
-
-
Ananth, S.1
Knebelmann, B.2
Gruning, W.3
Dhanabal, M.4
Walz, G.5
Stillman, I.E.6
Sukhatme, V.P.7
-
98
-
-
34948883495
-
PVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2
-
H. Yang, Y.A. Minamishima, Q. Yan, S. Schlisio, B.L. Ebert, X. Zhang, L. Zhang, W.Y. Kim, A.F. Olumi, and W.G. Kaelin Jr. PVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2 Mol. Cell. 28 2007 15 27
-
(2007)
Mol. Cell.
, vol.28
, pp. 15-27
-
-
Yang, H.1
Minamishima, Y.A.2
Yan, Q.3
Schlisio, S.4
Ebert, B.L.5
Zhang, X.6
Zhang, L.7
Kim, W.Y.8
Olumi, A.F.9
Kaelin, Jr.W.G.10
-
99
-
-
23844527189
-
Mechanism of von Hippel-Lindau protein-mediated suppression of nuclear factor kappa B activity
-
J. An, and M.B. Rettig Mechanism of von Hippel-Lindau protein-mediated suppression of nuclear factor kappa B activity Mol. Cell. Biol. 25 2005 7546 7556
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 7546-7556
-
-
An, J.1
Rettig, M.B.2
-
100
-
-
67650151005
-
Cancer-related inflammation, the seventh hallmark of cancer: Links to genetic instability
-
F. Colotta, P. Allavena, A. Sica, C. Garlanda, and A. Mantovani Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability Carcinogenesis 30 2009 1073 1081
-
(2009)
Carcinogenesis
, vol.30
, pp. 1073-1081
-
-
Colotta, F.1
Allavena, P.2
Sica, A.3
Garlanda, C.4
Mantovani, A.5
-
101
-
-
77950346282
-
Immunity, inflammation, and cancer
-
S.I. Grivennikov, F.R. Greten, and M. Karin Immunity, inflammation, and cancer Cell 140 2010 883 899
-
(2010)
Cell
, vol.140
, pp. 883-899
-
-
Grivennikov, S.I.1
Greten, F.R.2
Karin, M.3
-
102
-
-
68849127181
-
Inflammation and colorectal cancer
-
S. Kraus, and N. Arber Inflammation and colorectal cancer Curr. Opin. Pharmacol. 9 2009 405 410
-
(2009)
Curr. Opin. Pharmacol.
, vol.9
, pp. 405-410
-
-
Kraus, S.1
Arber, N.2
-
104
-
-
33644688772
-
Diabetes and insulin secretion: The ATP-sensitive K+ channel (K ATP) connection
-
J.C. Koster, M.A. Permutt, and C.G. Nichols Diabetes and insulin secretion: the ATP-sensitive K+ channel (K ATP) connection Diabetes 54 2005 3065 3072
-
(2005)
Diabetes
, vol.54
, pp. 3065-3072
-
-
Koster, J.C.1
Permutt, M.A.2
Nichols, C.G.3
-
105
-
-
61749090485
-
Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice
-
J. Cantley, C. Selman, D. Shukla, A.Y. Abramov, F. Forstreuter, M.A. Esteban, M. Claret, S.J. Lingard, M. Clements, S.K. Harten, H. Asare-Anane, R.L. Batterham, P.L. Herrera, S.J. Persaud, M.R. Duchen, P.H. Maxwell, and D.J. Withers Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice J. Clin. Invest. 119 2009 125 135
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 125-135
-
-
Cantley, J.1
Selman, C.2
Shukla, D.3
Abramov, A.Y.4
Forstreuter, F.5
Esteban, M.A.6
Claret, M.7
Lingard, S.J.8
Clements, M.9
Harten, S.K.10
Asare-Anane, H.11
Batterham, R.L.12
Herrera, P.L.13
Persaud, S.J.14
Duchen, M.R.15
Maxwell, P.H.16
Withers, D.J.17
-
106
-
-
56549094039
-
PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells
-
J. Zehetner, C. Danzer, S. Collins, K. Eckhardt, P.A. Gerber, P. Ballschmieter, J. Galvanovskis, K. Shimomura, F.M. Ashcroft, B. Thorens, P. Rorsman, and W. Krek PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells Genes Dev. 22 2008 3135 3146
-
(2008)
Genes Dev.
, vol.22
, pp. 3135-3146
-
-
Zehetner, J.1
Danzer, C.2
Collins, S.3
Eckhardt, K.4
Gerber, P.A.5
Ballschmieter, P.6
Galvanovskis, J.7
Shimomura, K.8
Ashcroft, F.M.9
Thorens, B.10
Rorsman, P.11
Krek, W.12
-
107
-
-
79953167224
-
Vhl is required for normal pancreatic beta cell function and the maintenance of beta cell mass with age in mice
-
D. Choi, E.P. Cai, S.A. Schroer, L. Wang, and M. Woo Vhl is required for normal pancreatic beta cell function and the maintenance of beta cell mass with age in mice Lab. Invest. 91 2011 527 538
-
(2011)
Lab. Invest.
, vol.91
, pp. 527-538
-
-
Choi, D.1
Cai, E.P.2
Schroer, S.A.3
Wang, L.4
Woo, M.5
-
108
-
-
61949412026
-
A role for von Hippel-Lindau protein in pancreatic beta-cell function
-
S. Puri, D.A. Cano, and M. Hebrok A role for von Hippel-Lindau protein in pancreatic beta-cell function Diabetes 58 2009 433 441
-
(2009)
Diabetes
, vol.58
, pp. 433-441
-
-
Puri, S.1
Cano, D.A.2
Hebrok, M.3
-
109
-
-
64549146243
-
Deciphering von Hippel-Lindau (VHL/Vhl)-associated pancreatic manifestations by inactivating Vhl in specific pancreatic cell populations
-
H.C. Shen, A. Adem, K. Ylaya, A. Wilson, M. He, D. Lorang, S.M. Hewitt, K. Pechhold, D.M. Harlan, I.A. Lubensky, L.S. Schmidt, W.M. Linehan, and S.K. Libutti Deciphering von Hippel-Lindau (VHL/Vhl)-associated pancreatic manifestations by inactivating Vhl in specific pancreatic cell populations PLoS One 4 2009 e4897
-
(2009)
PLoS One
, vol.4
, pp. 4897
-
-
Shen, H.C.1
Adem, A.2
Ylaya, K.3
Wilson, A.4
He, M.5
Lorang, D.6
Hewitt, S.M.7
Pechhold, K.8
Harlan, D.M.9
Lubensky, I.A.10
Schmidt, L.S.11
Linehan, W.M.12
Libutti, S.K.13
-
110
-
-
77957311262
-
The hypoxia response pathway and beta-cell function
-
J. Cantley, S.T. Grey, P.H. Maxwell, and D.J. Withers The hypoxia response pathway and beta-cell function Diabetes Obes. Metab. 12 Suppl 2 2010 159 167
-
(2010)
Diabetes Obes. Metab.
, vol.12
, Issue.SUPPL. 2
, pp. 159-167
-
-
Cantley, J.1
Grey, S.T.2
Maxwell, P.H.3
Withers, D.J.4
-
111
-
-
33845729488
-
Molecular pathology and CXCR4 expression in surgically excised retinal hemangioblastomas associated with von Hippel-Lindau disease
-
X. Liang, D. Shen, Y. Huang, C. Yin, C.M. Bojanowski, Z. Zhuang, and C.C. Chan Molecular pathology and CXCR4 expression in surgically excised retinal hemangioblastomas associated with von Hippel-Lindau disease Ophthalmology 114 2007 147 156
-
(2007)
Ophthalmology
, vol.114
, pp. 147-156
-
-
Liang, X.1
Shen, D.2
Huang, Y.3
Yin, C.4
Bojanowski, C.M.5
Zhuang, Z.6
Chan, C.C.7
-
112
-
-
51949103244
-
Neurologic manifestations of von Hippel-Lindau disease
-
J.A. Butman, W.M. Linehan, and R.R. Lonser Neurologic manifestations of von Hippel-Lindau disease JAMA 300 2008 1334 1342
-
(2008)
JAMA
, vol.300
, pp. 1334-1342
-
-
Butman, J.A.1
Linehan, W.M.2
Lonser, R.R.3
-
113
-
-
24644458578
-
Edema is a precursor to central nervous system peritumoral cyst formation
-
R.R. Lonser, A.O. Vortmeyer, J.A. Butman, S. Glasker, M.A. Finn, J.M. Ammerman, M.J. Merrill, N.A. Edwards, Z. Zhuang, and E.H. Oldfield Edema is a precursor to central nervous system peritumoral cyst formation Ann. Neurol. 58 2005 392 399
-
(2005)
Ann. Neurol.
, vol.58
, pp. 392-399
-
-
Lonser, R.R.1
Vortmeyer, A.O.2
Butman, J.A.3
Glasker, S.4
Finn, M.A.5
Ammerman, J.M.6
Merrill, M.J.7
Edwards, N.A.8
Zhuang, Z.9
Oldfield, E.H.10
-
114
-
-
33646784025
-
Proteomic analysis of hemangioblastoma cyst fluid
-
S. Glasker, A.O. Vortmeyer, R.R. Lonser, I.A. Lubensky, H. Okamoto, J.B. Xia, J. Li, E. Milne, J.A. Kowalak, E.H. Oldfield, and Z. Zhuang Proteomic analysis of hemangioblastoma cyst fluid Cancer Biol. Ther. 5 2006 549 553
-
(2006)
Cancer Biol. Ther.
, vol.5
, pp. 549-553
-
-
Glasker, S.1
Vortmeyer, A.O.2
Lonser, R.R.3
Lubensky, I.A.4
Okamoto, H.5
Xia, J.B.6
Li, J.7
Milne, E.8
Kowalak, J.A.9
Oldfield, E.H.10
Zhuang, Z.11
-
115
-
-
18844474899
-
Loss of heterozygosity and somatic mutations of the VHL tumor suppressor gene in sporadic cerebellar hemangioblastomas
-
J.Y. Lee, S.M. Dong, W.S. Park, N.J. Yoo, C.S. Kim, J.J. Jang, J.G. Chi, B. Zbar, I.A. Lubensky, W.M. Linehan, A.O. Vortmeyer, and Z. Zhuang Loss of heterozygosity and somatic mutations of the VHL tumor suppressor gene in sporadic cerebellar hemangioblastomas Cancer Res. 58 1998 504 508
-
(1998)
Cancer Res.
, vol.58
, pp. 504-508
-
-
Lee, J.Y.1
Dong, S.M.2
Park, W.S.3
Yoo, N.J.4
Kim, C.S.5
Jang, J.J.6
Chi, J.G.7
Zbar, B.8
Lubensky, I.A.9
Linehan, W.M.10
Vortmeyer, A.O.11
Zhuang, Z.12
-
116
-
-
0030958304
-
Von Hippel-Lindau gene deletion detected in the stromal cell component of a cerebellar hemangioblastoma associated with von Hippel-Lindau disease
-
A.O. Vortmeyer, J.R. Gnarra, M.R. Emmert-Buck, D. Katz, W.M. Linehan, E.H. Oldfield, and Z. Zhuang Von Hippel-Lindau gene deletion detected in the stromal cell component of a cerebellar hemangioblastoma associated with von Hippel-Lindau disease Hum. Pathol. 28 1997 540 543
-
(1997)
Hum. Pathol.
, vol.28
, pp. 540-543
-
-
Vortmeyer, A.O.1
Gnarra, J.R.2
Emmert-Buck, M.R.3
Katz, D.4
Linehan, W.M.5
Oldfield, E.H.6
Zhuang, Z.7
-
117
-
-
85047696006
-
Somatic point mutation of the wild-type allele detected in tumors of patients with VHL germline deletion
-
A.O. Vortmeyer, S.C. Huang, S.D. Pack, C.A. Koch, I.A. Lubensky, E.H. Oldfield, and Z. Zhuang Somatic point mutation of the wild-type allele detected in tumors of patients with VHL germline deletion Oncogene 21 2002 1167 1170
-
(2002)
Oncogene
, vol.21
, pp. 1167-1170
-
-
Vortmeyer, A.O.1
Huang, S.C.2
Pack, S.D.3
Koch, C.A.4
Lubensky, I.A.5
Oldfield, E.H.6
Zhuang, Z.7
-
118
-
-
0028929991
-
Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas
-
S. Wizigmann-Voos, G. Breier, W. Risau, and K.H. Plate Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas Cancer Res. 55 1995 1358 1364
-
(1995)
Cancer Res.
, vol.55
, pp. 1358-1364
-
-
Wizigmann-Voos, S.1
Breier, G.2
Risau, W.3
Plate, K.H.4
-
119
-
-
33646256563
-
Hemangioblastomas share protein expression with embryonal hemangioblast progenitor cell
-
S. Glasker, J. Li, J.B. Xia, H. Okamoto, W. Zeng, R.R. Lonser, Z. Zhuang, E.H. Oldfield, and A.O. Vortmeyer Hemangioblastomas share protein expression with embryonal hemangioblast progenitor cell Cancer Res. 66 2006 4167 4172
-
(2006)
Cancer Res.
, vol.66
, pp. 4167-4172
-
-
Glasker, S.1
Li, J.2
Xia, J.B.3
Okamoto, H.4
Zeng, W.5
Lonser, R.R.6
Zhuang, Z.7
Oldfield, E.H.8
Vortmeyer, A.O.9
-
120
-
-
10744226679
-
Developmental arrest of angioblastic lineage initiates tumorigenesis in von Hippel-Lindau disease
-
A.O. Vortmeyer, S. Frank, S.Y. Jeong, K. Yuan, B. Ikejiri, Y.S. Lee, D. Bhowmick, R.R. Lonser, R. Smith, G. Rodgers, E.H. Oldfield, and Z. Zhuang Developmental arrest of angioblastic lineage initiates tumorigenesis in von Hippel-Lindau disease Cancer Res. 63 2003 7051 7055
-
(2003)
Cancer Res.
, vol.63
, pp. 7051-7055
-
-
Vortmeyer, A.O.1
Frank, S.2
Jeong, S.Y.3
Yuan, K.4
Ikejiri, B.5
Lee, Y.S.6
Bhowmick, D.7
Lonser, R.R.8
Smith, R.9
Rodgers, G.10
Oldfield, E.H.11
Zhuang, Z.12
-
121
-
-
33847631722
-
Von Hippel-Lindau disease-associated hemangioblastomas are derived from embryologic multipotent cells
-
D.M. Park, Z. Zhuang, L. Chen, N. Szerlip, I. Maric, J. Li, T. Sohn, S.H. Kim, I.A. Lubensky, A.O. Vortmeyer, G.P. Rodgers, E.H. Oldfield, and R.R. Lonser Von Hippel-Lindau disease-associated hemangioblastomas are derived from embryologic multipotent cells PLoS Med. 4 2007 e60
-
(2007)
PLoS Med.
, vol.4
, pp. 60
-
-
Park, D.M.1
Zhuang, Z.2
Chen, L.3
Szerlip, N.4
Maric, I.5
Li, J.6
Sohn, T.7
Kim, S.H.8
Lubensky, I.A.9
Vortmeyer, A.O.10
Rodgers, G.P.11
Oldfield, E.H.12
Lonser, R.R.13
-
122
-
-
57149113915
-
Protracted haemangioblastic proliferation and differentiation in von Hippel-Lindau disease
-
S.B. Shively, S. Beltaifa, B. Gehrs, H. Duong, J. Smith, N.A. Edwards, R. Lonser, M. Raffeld, and A.O. Vortmeyer Protracted haemangioblastic proliferation and differentiation in von Hippel-Lindau disease J. Pathol. 216 2008 514 520
-
(2008)
J. Pathol.
, vol.216
, pp. 514-520
-
-
Shively, S.B.1
Beltaifa, S.2
Gehrs, B.3
Duong, H.4
Smith, J.5
Edwards, N.A.6
Lonser, R.7
Raffeld, M.8
Vortmeyer, A.O.9
-
124
-
-
60149110371
-
The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage
-
C. Lancrin, P. Sroczynska, C. Stephenson, T. Allen, V. Kouskoff, and G. Lacaud The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage Nature 457 2009 892 895
-
(2009)
Nature
, vol.457
, pp. 892-895
-
-
Lancrin, C.1
Sroczynska, P.2
Stephenson, C.3
Allen, T.4
Kouskoff, V.5
Lacaud, G.6
-
125
-
-
60149102751
-
Continuous single-cell imaging of blood generation from haemogenic endothelium
-
H.M. Eilken, S. Nishikawa, and T. Schroeder Continuous single-cell imaging of blood generation from haemogenic endothelium Nature 457 2009 896 900
-
(2009)
Nature
, vol.457
, pp. 896-900
-
-
Eilken, H.M.1
Nishikawa, S.2
Schroeder, T.3
-
126
-
-
0023117304
-
Selective localization of gamma-enolase in stromal cells of cerebellar hemangioblastomas
-
J.A. Feldenzer, and P.E. McKeever Selective localization of gamma-enolase in stromal cells of cerebellar hemangioblastomas Acta Neuropathol. 72 1987 281 285
-
(1987)
Acta Neuropathol.
, vol.72
, pp. 281-285
-
-
Feldenzer, J.A.1
McKeever, P.E.2
-
127
-
-
0023901266
-
Haemangioblastoma. An immunohistochemical study of ten cases
-
J.W. Grant, P.J. Gallagher, and C. Hedinger Haemangioblastoma. An immunohistochemical study of ten cases Acta Neuropathol. 76 1988 82 86
-
(1988)
Acta Neuropathol.
, vol.76
, pp. 82-86
-
-
Grant, J.W.1
Gallagher, P.J.2
Hedinger, C.3
-
128
-
-
0029451586
-
Immunohistochemical and ultrastructural studies of stromal cells in hemangioblastoma
-
A. Omulecka, B. Lach, J. Alwasiak, and A. Gregor Immunohistochemical and ultrastructural studies of stromal cells in hemangioblastoma Folia Neuropathol. 33 1995 41 50
-
(1995)
Folia Neuropathol.
, vol.33
, pp. 41-50
-
-
Omulecka, A.1
Lach, B.2
Alwasiak, J.3
Gregor, A.4
-
129
-
-
23244438102
-
Stromal cells in hemangioblastoma: Neuroectodermal differentiation and morphological similarities to ependymoma
-
K. Ishizawa, T. Komori, and T. Hirose Stromal cells in hemangioblastoma: neuroectodermal differentiation and morphological similarities to ependymoma Pathol. Int. 55 2005 377 385
-
(2005)
Pathol. Int.
, vol.55
, pp. 377-385
-
-
Ishizawa, K.1
Komori, T.2
Hirose, T.3
-
130
-
-
34147125874
-
Metastatic renal cell carcinoma to hemangioblastoma in von Hippel-Lindau disease
-
A.D. Polydorides, M.K. Rosenblum, and M.A. Edgar Metastatic renal cell carcinoma to hemangioblastoma in von Hippel-Lindau disease Arch. Pathol. Lab. Med. 131 2007 641 645
-
(2007)
Arch. Pathol. Lab. Med.
, vol.131
, pp. 641-645
-
-
Polydorides, A.D.1
Rosenblum, M.K.2
Edgar, M.A.3
-
131
-
-
0029974011
-
Different expression of adhesion molecules on stromal cells and endothelial cells of capillary hemangioblastoma
-
T. Bohling, A. Maenpaa, T. Timonen, L. Vantunen, A. Paetau, and M. Haltia Different expression of adhesion molecules on stromal cells and endothelial cells of capillary hemangioblastoma Acta Neuropathol. 92 1996 461 466
-
(1996)
Acta Neuropathol.
, vol.92
, pp. 461-466
-
-
Bohling, T.1
Maenpaa, A.2
Timonen, T.3
Vantunen, L.4
Paetau, A.5
Haltia, M.6
-
132
-
-
0018616985
-
Astrocytes in hemangioblastomas of the central nervous system and their relationship to stromal cells
-
J.J. Kepes, S.S. Rengachary, and S.H. Lee Astrocytes in hemangioblastomas of the central nervous system and their relationship to stromal cells Acta Neuropathol. 47 1979 99 104
-
(1979)
Acta Neuropathol.
, vol.47
, pp. 99-104
-
-
Kepes, J.J.1
Rengachary, S.S.2
Lee, S.H.3
-
133
-
-
27944507362
-
Cellular and reticular variants of haemangioblastoma revisited: A clinicopathologic study of 88 cases
-
M. Hasselblatt, A. Jeibmann, J. Gerss, C. Behrens, B. Rama, H. Wassmann, and W. Paulus Cellular and reticular variants of haemangioblastoma revisited: a clinicopathologic study of 88 cases Neuropathol. Appl. Neurobiol. 31 2005 618 622
-
(2005)
Neuropathol. Appl. Neurobiol.
, vol.31
, pp. 618-622
-
-
Hasselblatt, M.1
Jeibmann, A.2
Gerss, J.3
Behrens, C.4
Rama, B.5
Wassmann, H.6
Paulus, W.7
-
134
-
-
79961027723
-
Developmentally arrested structures preceding cerebellar tumors in von Hippel-Lindau disease
-
S.B. Shively, E.A. Falke, J. Li, M.G. Tran, E.R. Thompson, P.H. Maxwell, E. Roessler, E.H. Oldfield, R.R. Lonser, and A.O. Vortmeyer Developmentally arrested structures preceding cerebellar tumors in von Hippel-Lindau disease Mod. Pathol. 24 2011 1023 1030
-
(2011)
Mod. Pathol.
, vol.24
, pp. 1023-1030
-
-
Shively, S.B.1
Falke, E.A.2
Li, J.3
Tran, M.G.4
Thompson, E.R.5
Maxwell, P.H.6
Roessler, E.7
Oldfield, E.H.8
Lonser, R.R.9
Vortmeyer, A.O.10
-
135
-
-
2142811530
-
Developmental effects of von Hippel-Lindau gene deficiency
-
A.O. Vortmeyer, Q. Yuan, Y.S. Lee, Z. Zhuang, and E.H. Oldfield Developmental effects of von Hippel-Lindau gene deficiency Ann. Neurol. 55 2004 721 728
-
(2004)
Ann. Neurol.
, vol.55
, pp. 721-728
-
-
Vortmeyer, A.O.1
Yuan, Q.2
Lee, Y.S.3
Zhuang, Z.4
Oldfield, E.H.5
-
136
-
-
33750509188
-
Evolution of VHL tumourigenesis in nerve root tissue
-
A.O. Vortmeyer, M.G. Tran, W. Zeng, S. Glasker, C. Riley, M. Tsokos, B. Ikejiri, M.J. Merrill, M. Raffeld, Z. Zhuang, R.R. Lonser, P.H. Maxwell, and E.H. Oldfield Evolution of VHL tumourigenesis in nerve root tissue J. Pathol. 210 2006 374 382
-
(2006)
J. Pathol.
, vol.210
, pp. 374-382
-
-
Vortmeyer, A.O.1
Tran, M.G.2
Zeng, W.3
Glasker, S.4
Riley, C.5
Tsokos, M.6
Ikejiri, B.7
Merrill, M.J.8
Raffeld, M.9
Zhuang, Z.10
Lonser, R.R.11
Maxwell, P.H.12
Oldfield, E.H.13
-
137
-
-
84858225214
-
Identification of hepatic niche harboring human acute lymphoblastic leukemic cells via the SDF-1/CXCR4 axis
-
I. Kato, A. Niwa, T. Heike, H. Fujino, M.K. Saito, K. Umeda, H. Hiramatsu, M. Ito, M. Morita, Y. Nishinaka, S. Adachi, F. Ishikawa, and T. Nakahata Identification of hepatic niche harboring human acute lymphoblastic leukemic cells via the SDF-1/CXCR4 axis PLoS One 6 2011 e27042
-
(2011)
PLoS One
, vol.6
, pp. 27042
-
-
Kato, I.1
Niwa, A.2
Heike, T.3
Fujino, H.4
Saito, M.K.5
Umeda, K.6
Hiramatsu, H.7
Ito, M.8
Morita, M.9
Nishinaka, Y.10
Adachi, S.11
Ishikawa, F.12
Nakahata, T.13
-
138
-
-
53949096541
-
CXCL12/CXCR4 signalling in neuronal cell migration
-
M.C. Tiveron, and H. Cremer CXCL12/CXCR4 signalling in neuronal cell migration Curr. Opin. Neurobiol. 18 2008 237 244
-
(2008)
Curr. Opin. Neurobiol.
, vol.18
, pp. 237-244
-
-
Tiveron, M.C.1
Cremer, H.2
|