Protracted haemangioblastic proliferation and differentiation in von Hippel-Lindau disease

Journal of Pathology

Volumn 216, Issue 4, 2008, Pages 514-520

  Shively, S B ^a,b   Beltaifa, S ^c   Gehrs, B ^c   Duong, H ^a   Smith, J ^a   Edwards, N A ^a   Lonser, R R ^a   Raffeld, M ^c   Vortmeyer, A O ^a,d  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b GEORGE WASHINGTON UNIVERSITY   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Development; Haemangioblastoma; HIF1 ; HIF2 ; Neoplasia; VEGF; VHL; Von Hippel Lindau

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; VON HIPPEL LINDAU PROTEIN;

ARTICLE; CARCINOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE COURSE; EMBRYO DEVELOPMENT; GENE SEQUENCE; GENE STRUCTURE; HEMANGIOBLASTOMA; HEMATOPOIESIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MESENCHYME; PRIORITY JOURNAL; VON HIPPEL LINDAU DISEASE;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELL PROLIFERATION; DISEASE PROGRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HEMANGIOBLASTOMA; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; NEOVASCULARIZATION, PHYSIOLOGIC; NERVOUS SYSTEM; VON HIPPEL-LINDAU DISEASE;

EID: 57149113915     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2435     Document Type: Article

References (27)

1. Latif F, Tory K, Gnarra J, Yao M, Duh FM, Orcutt ML, et al. Identification of the von Hippel-Lindau disease tumor suppressor gene. Science 1993;260:1317-1320.
2. Vortmeyer AO, Gnarra JR, Emmert-Buck MR, Katz D, Linehan WM, Oldfield EH, et al. von Hippel-Lindau gene deletion detected in the stromal cell component of a cerebellar hemangioblastoma associated with von Hippel-Lindau disease. Hum Pathol 1997;28:540-543.
3. Vortmeyer AO, Yuan Q, Lee YS, Zhuang Z, Oldfield EH. Developmental effects of von Hippel-Lindau gene deficiency. Ann Neurol 2004;55:721-728.
4. Vortmeyer AO, Tran M, Zeng W, Glasker S, Riley C, Tsokos M, et al. Evolution of VHL tumorigenesis in nerve root tissue. J Pathol 2006;210:374-382.
5. Lonser RR, Glenn GM, Walther M, Chew EY, Libutti SK, Linehan WM, et al. von Hippel-Lindau disease. Lancet 2003;361:2059-2067.
6. Stein AA, Schilp AO, Whitfield RD. The histogenesis of hemangioblastoma of the brain. J Neurosurg 1960;17:751-761.
7. Ho K. Ultrastructure of cerebellar capillary hemangioblastoma. I. Weibel-Palade bodies and stroma cell histogenesis. J Neuropathol Exp Neurol 1984;43:592-608.
8. Cushing H, Bailey P. Tumors Arising from the Blood-Vessels of the Brain. Angiomatous Malformations and Hemangioblastomas. Charles C Thomas: Springfield, 1928.
9. Omulecka A, Lach B, Alwasiak J, Gregor A. Immunohistochemical and ultrastructural studies of stromal cells in hemangioblastoma. Folia Neuropathol 1995;33:41-50.
10. Böhling T, Plate KH, Haltia MJ, Alitalo K, Neumann HPH. Von Hippel-Lindau disease and capillary haemangioblastoma. In Tumours of the Nervous System, Kleihues P, Cavenee WK (eds). International Agency for Research on Cancer Press: Lyon, 2000;223-226.
11. Ishizawa K, Komori T, Hirose T. Stromal cells in hemangioblastoma: neuroectodermal differentiation and morphological similarities to ependymoma. Pathol Int 2005;55:377-385.
12. Hasselblatt M, Jeibmann A, Gerss J, Behrens C, Rama B, Wassmann H, et al. Cellular and reticular variants of haemangioblastoma revisited: a clinicopathologic study of 88 cases. Neuropathol Appl Neurobiol 2005;31:618-622.
13. Rickert CH, Hasselblatt M, Jeibmann A, Paulus W. Cellular and reticular variants of hemangioblastoma differ in their cytogenetic profiles. Hum Pathol 2006;37:1452-1457.
14. Silver ML, Hennigar G. Cerebellar hemangioma (hemangioblastoma): a clinicopathological review of 40 cases. J Neurosurg 1952;9:484- 494.
15. Frank TS, Trojanowski JQ, Roberts SA, Brooks JJ. A detailed immunohistochemical analysis of cerebellar hemangioblastoma: an undifferentiated mesenchymal tumor. Mod Pathol 1989;2:638-651.
16. Burger PC, Scheithauer BW, Vogel FS. Surgical Pathology of the Nervous System and its Coverings (4th edn). Churchill Livingstone: Philadelphia, 2002.
17. Sabin FR. Preliminary note on the differentiation of angioblasts and the method by which they produce blood-vessels, blood-plasma and red blood-cells as seen in the living chick. Anat Rec 1917;13:199-204.
18. Choi K, Kennedy M, Kazarov ACPJ, Keller G. A common precursor for hematopoietic and endothelial cells. Development 1998;125:725-732.
19. Huber TL, Kouskoff V, Fehling HJ, Palis J, Keller G. Haemangioblast commitment is initiated in the primitive streak of the mouse embryo. Nature 2004;432:625-630.
20. Vortmeyer AO, Frank S, Jeong SY, Yuan K, Ikejiri B, Lee YS, et al. Developmental arrest of angioblastic lineage initiates tumorigenesis in von Hippel-Lindau disease. Cancer Res 2003;63:7051-7055.
21. Gläsker S, Li J, Xia JB, Okamoto H, Zeng W, Lonser RR, et al. Hemangioblastomas share protein expression with embryonal hemangioblast progenitor cell. Cancer Res 2006;66:4167-4172.
22. Park DM, Zhuang Z, Chen L, Szerlip N, Maric I, Li J, et al. von Hippel-Lindau disease-associated hemangioblastomas are derived from embryologic multipotent cells. PLoS Med 2007;4:333-341.
23. Sabin FR. Studies on the origin of the blood vessels and of red blood corpuscles as seen in the living blastoderm of chick during the second day of incubation. Carnegie Contrib Embryol 1920;9:215-262.
24. Ammerman JM, Lonser RR, Dambrosia J, Butman JA, Oldfield EH. Long-term natural history of hemangioblastomas in patients with von Hippel-Lindau disease: implications for treatment. J Neurosurg 2006;105:248-255.
25. Lonser RR, Vortmeyer AO, Butman JA, Gläsker S, Finn MA, Ammerman JM, et al. Edema is a precursor to central nervous system peritumoral cyst formation. Ann Neurol 2005;58:392-399.
26. Proescholdt MA, Heiss JD,Walbridge S, Muhlhauser J, Capogrossi MC, Oldfield EH, et al. Vascular endothelial growth factor (VEGF) modulates vascular permeability and inflammation in rat brain. J Neuropathol Exp Neurol 1999;58:613-627.
27. Maxwell PH. The HIF pathway in cancer. Semin Cell Dev Biol 2005;16:523-530.