Renal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cysts

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Schietke, Ruth E ^a   Hackenbeck, Thomas ^a   Tran, Maxine ^b   Günther, Regina ^a   Klanke, Bernd ^a   Warnecke, Christina L ^a   Knaup, Karl X ^a   Shukla, Deepa ^b   Rosenberger, Christian ^c   Koesters, Robert ^d   Bachmann, Sebastian ^c   Betz, Peter ^a   Schley, Gunnar ^a   Schödel, Johannes ^a   Willam, Carsten ^a   Winkler, Thomas ^a   Amann, Kerstin ^a   Eckardt, Kai Uwe ^a   Maxwell, Patrick ^b   Wiesener, Michael S ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d HÔPITAL TENON   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONATE DEHYDRATASE IX; COLLAGEN TYPE 1; ERYTHROPOIETIN; GLUCOSE TRANSPORTER 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; UVOMORULIN; VIMENTIN; VON HIPPEL LINDAU PROTEIN; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL PAS DOMAIN CONTAINING PROTEIN 1; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYO; FEMALE; HISTOLOGY; HORMONE SYNTHESIS; HUMAN; HUMAN TISSUE; HYPOXIA; KIDNEY CARCINOMA; KIDNEY CYST; KIDNEY FAILURE; KIDNEY FIBROSIS; KIDNEY MASS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; TISSUE REPAIR; TRANSCRIPTION INITIATION; ANIMAL; C57BL MOUSE; CELL STRAIN COS1; CELL STRAIN HEK293; CERCOPITHECUS; DRUG ANTAGONISM; FIBROSIS; GENE EXPRESSION; GENE SILENCING; GENETICS; HELA CELL; KIDNEY POLYCYSTIC DISEASE; KIDNEY TUBULE; METABOLISM; OPOSSUM; PATHOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

PYRONIA TITHONUS; RATTUS;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CERCOPITHECUS AETHIOPS; COS CELLS; FIBROSIS; GENE EXPRESSION; GENE SILENCING; HEK293 CELLS; HELA CELLS; HUMANS; KIDNEY DISEASES, CYSTIC; KIDNEY TUBULES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OPOSSUMS; RATS; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 84856486011     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031034     Document Type: Article

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