EPO's alter ego: Erythropoietin has multiple actions

Stem Cells

Volumn 20, Issue 6, 2002, Pages 485-492

  Lappin, Terence R ^a   Maxwell, A Peter ^a   Johnston, Patrick G ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Anemia; Drug target; Erythropoietin receptor; Pleiotropic effects; Quality of life; Recombinant human erythropoietin

Indexed keywords

CELL SURFACE RECEPTOR; ERYTHROPOIETIN RECEPTOR; HEMOGLOBIN; JANUS KINASE; RECOMBINANT ERYTHROPOIETIN; STAT5 PROTEIN;

ANEMIA; ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; AUTOCRINE EFFECT; BLOOD TRANSFUSION; BREAST TUMOR; CANCER THERAPY; CHRONIC DISEASE; COGNITION; DRUG TARGETING; ENDOCRINE FUNCTION; ERYTHROPOIESIS; FATIGUE; FEEDBACK SYSTEM; GONAD FUNCTION; HEMATOCRIT; MUSCLE TONE; NERVOUS TISSUE; PARACRINE SIGNALING; PLEIOTROPY; PROTEIN EXPRESSION; QUALITY OF LIFE; SHORT SURVEY; STOMACH MUCOSA; DRUG EFFECT; ENDOCRINE SYSTEM; HUMAN; NEOPLASM; PHYSIOLOGY; REVIEW;

JANUS;

ANEMIA; ENDOCRINE SYSTEM; ERYTHROPOIETIN, RECOMBINANT; HUMANS; NEOPLASMS;

EID: 0036455109     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.20-6-485     Document Type: Short Survey

References (61)

1. Groopman JE, Itri LM. Chemotherapy-induced anemia in adults: Incidence and treatment. J Natl Cancer Inst 1999;91:1616-1634.
2. Acs G, Acs P, Beckwith SM et al. Erythropoietin and erythropoietin receptor expression in human cancer. Cancer Res 2001;61:3561-3565.
3. Erslev AJ, Gabuzda TG. Pathophysiology of Blood, 3rd Ed. Philadelphia: WB Saunders, 1985:28-134.
4. Maxwell AP. Novel erythropoiesis stimulating protein in the management of the anemia of chronic renal failure. Kidney Int 2002;62:720-729.
5. Jacobs C, Hori WH, Macdougall IC et al. European best practice guidelines 9-13: Anaemia management. Nephrol Dial Transplant 2000;15(supp 4):33-42.
6. NKF-DOQI clinical practice guidelines for the treatment of anemia of chronic renal failure. Am J Kidney Dis 1997;30(suppl 3):S192-S240.
7. Jelkmann W. Proinflammatory cytokines lowering erythropoietin production. J Interferon Cytokine Res 1998;18:555-559.
8. Wood PA, Hrushesky WJ. Cisplatin-associated anemia: An erythropoietin deficiency syndrome. J Clin Invest 1995;95:1650-1659.
9. Bert P. La Pression Barometrique. Recherches de Physiologie Experimentale. Masson, Paris, 1878.
10. Erslev AJ. Blood and mountains. In: Wintrobe MM, ed. Blood, Pure and Eloquent. New York: McGraw Hill, 1980:257-280.
11. Viault F. Sur l'augmentation considerable du nombre des globules rouge dans le sang chez les habitants des hautes plateaux de l'Amerique du Sud. C R Acad Sci (Paris) 1890;111:917-918.
12. Carnot P, Deflandre C. Sur l'activite hemopoietique du serum au cours de la regeneration du sang. C R Acad Sci (Paris) 1906;143:384-386.
13. Bonsdorff E, Jalavisto E. A humoral mechanism in anoxic erythrocytosis. Acta Physiol Scand 1948;16:150-170.
14. Miyake T, Kung CK, Goldwasser E. Purification of human erythropoietin. J Biol Chem 1977;252:5558-5564.
15. Lin FK, Suggs S, Lin CH et al. Cloning and expression of the human erythropoietin gene. Proc Natl Acad Sci USA 1985;82:7580-7584.
16. Jacobs K, Shoemaker C, Rudersdorf R et al. Isolation and characterization of genomic and cDNA clones of human erythropoietin. Nature 1985;313:806-810.
17. Lai PH, Everett R, Wang FF et al. Structural characterization of human erythropoietin. J Biol Chem 1986;261:3116-3121.
18. Sasaki H, Bothner B, Dell A et al. Carbohydrate structure of erythropoietin expressed in Chinese hamster ovary cells by a human erythropoietin cDNA. J Biol Chem 1987;262:12059-12076.
19. Recny MA, Scoble HA, Kim Y. Structural characterization of natural human urinary and recombinant DNA-derived erythropoietin. Identification of des-arginine 166 erythropoietin. J Biol Chem 1987;262:17156-17163.
20. Tan CC, Eckardt KU, Ratcliffe PJ. Organ distribution of erythropoietin messenger RNA in normal and uremic rats. Kidney Int 1991;40:69-76.
21. Digicaylioglu M, Bichet S, Marti HH et al. Localization of specific erythropoietin binding sites in defined areas of the mouse brain. Proc Natl Acad Sci USA 1995;92:3717-3720.
22. Sakanaka M, Wen TC, Matsuda S et al. In vivo evidence that erythropoietin protects neurons from ischemic damage. Proc Natl Acad Sci USA 1998;95:4635-4640.
23. Sadamoto Y, Igase K, Sakanaka M et al. Erythropoietin prevents place navigation disability and cortical infarction in rats with permanent occlusion of the middle cerebral artery. Biochem Biophys Res Commun 1998;253:26-32.
24. Masuda S, Okano M, Yamagishi K et al. A novel site of erythropoietin production. Oxygen-dependent production in cultured rat astrocytes. J Biol Chem 1994;269:19488-19493.
25. Marti HH, Wenger RH, Rivas LA et al. Erythropoietin gene expression in human, monkey and murine brain. Eur J Neurosci 1996;8:666-676.
26. Marti HH, Gassmann M, Wenger RH et al. Detection of erythropoietin in human liquor: Intrinsic erythropoietin production in the brain. Kidney Int 1997;51:416-418.
27. Yasuda Y, Nagao M, Okano M et al. Localization of erythropoietin and erythropoietin receptor in postimplantation mouse embryos. Develop Growth Differ 1993;35:711-722.
28. Juul SE, Anderson DK, Li Y et al. Erythropoietin and erythropoietin receptor in the developing human central nervous system. Pediatr Res 1998;43:40-49.
29. Sasaki R, Masuda S, Nagao M. Erythropoietin: Multiple physiological functions and regulation of biosynthesis. [Review]. Biosci Biotechnol Biochem 2000;64:1775-1793.
30. Sasaki R, Masuda S, Nagao M. Pleiotropic functions and tissue-specific expression of erythropoietin [Review]. News Physiol Sci 2001;16:110-113.
31. Sawyer ST, Krantz SB, Sawada K. Receptors for erythropoietin in mouse and human erythroid cells and placenta. Blood 1989;74:103-109.
32. Anagnostou A, Lee ES, Kessimian N et al. Erythropoietin has a mitogenic and positive chemotactic effect on endothelial cells. Proc Natl Acad Sci USA 1990;87:5978-5982.
33. Carlini RG, Dusso AS, Obialo CI et al. Recombinant human erythropoietin (rHuEPO) increases endothelin-1 release by endothelial cells. Kidney Int 1993;43:1010-1014.
34. Nagai T, Akizawa T, Nakashima Y et al. Effects of rHuEpo on cellular proliferation and endothelin-1 production in cultured endothelial cells. Nephrol Dial Transplant 1995;10:1814-1819.
35. Carlini RG, Alonzo EJ, Dominguez J et al. Effect of recombinant human erythropoietin on endothelial cell apoptosis. Kidney Int 1999;55:546-553.
36. Alvarez Arroyo MV, Castilla MA, Gonzalez Pacheco FR et al. Role of vascular endothelial growth factor on erythropoietin-related endothelial cell proliferation. J Am Soc Nephrol 1998;9:1998-2004.
37. Vogel V, Kramer HJ, Backer A et al. Effects of erythropoietin on endothelin-1 synthesis and the cellular calcium messenger system in vascular endothelial cells. Am J Hypertens 1997;10:289-296.
38. 2+ mobilization and contraction in rat mesangial and aortic smooth muscle cultures. Exp Hematol 1996;24:392-397.
39. Liefelt L, Schmidt-Ott KM, Orzechowski HD et al. Transcriptional regulation of endothelin-1 by erythropoietin in endothelial cells. J Cardiovasc Pharmacol 1998;31(suppl 1):S464-S466.
40. Carlini RG, Reyes AA, Rothstein M, Recombinant human erythropoietin stimulates angiogenesis in vitro. Kidney Int 1995;47:740-745.
41. Ribatti D, Presta M, Vacca A et al. Human erythropoietin induces a pro-angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo. Blood 1999;93:2627-2636.
42. Masuda S, Nagao M, Takahata K et al. Functional erythropoietin receptor of the cells with neural characteristics. Comparison with receptor properties of erythroid cells, J Biol Chem 1993;268:11208-11216.
43. Yamaji R, Okada T, Moriya M et al. Brain capillary endothelial cells express two forms of erythropoietin receptor mRNA. Eur J Biochem 1996;239:494-500.
44. Morishita E, Masuda S, Nagao M et al. Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death. Neuroscience 1997;76:105-116.
45. Lewczuk P, Hasselblatt M, Kamrowski-Kruck H et al. Survival of hippocampal neurons in culture upon hypoxia: Effect of erythropoietin. Neuroreport 2000;11:3485-3488.
46. Nagai A, Nakagawa E, Choi HB et al. Erythropoietin and erythropoietin receptors in human CNS neurons, astrocytes, microglia, and oligodendrocytes grown in culture. J Neuropathol Exp Neurol 2001;60:386-392.
47. Koshimura K, Murakami Y, Sohmiya M et al. Effects of erythropoietin on neuronal activity. J Neurochem 1999;72:2565-2572.
48. Mioni R, Gottardello F, Bordon P et al. Evidence for specific binding and stimulatory effects of recombinant human erythropoietin on isolated adult rat Leydig cells. Acta Endocrinol (Copenh) 1992;127:459-465.
49. Foresta C, Mioni R, Bordon P et al. Erythropoietin and testicular steroidogenesis: The role of second messengers. Eur J Endocrinol 1995;132:103-108.
50. Foresta C, Mioni R, Bordon P et al. Erythropoietin stimulates testosterone production in man. J Clin Endocrinol Metab 1994;78:753-756.
51. Okada A, Kinoshita Y, Maekawa T et al. Erythropoietin stimulates proliferation of rat-cultured gastric mucosal cells, Digestion 1996;57:328-332.
52. Juul SE, Joyce AE, Zhao Y et al. Why is erythropoietin present in human milk? Studies of erythropoietin receptors on enterocytes of human and rat neonates. Pediatr Res 1999;46:263-268.
53. Wald MR, Borda ES, Sterin-Borda L. Mitogenic effect of erythropoietin on neonatal rat cardiomyocytes: Signal transduction pathways. J Cell Physiol 1996;167:461-468.
54. Kristal B, Shurtz-Swirkski R, Shasha SM et al. Interaction between erythropoietin and peripheral polymorphonuclear leukocytes in hemodialysis patients. Nephron 1999;81:406-413.
55. Sela S, Schurtz-Swirski R, Sharon R et al. The polymorphonuclear leukocyte - A new target for erythropoietin. Nephron 2001;88:205-210.
56. Ammarguellat F, Llovera M, Kelly PA et al. Low doses of EPO activate MAP kinases but not JAK2-STAT5 in rat vascular smooth muscle cells. Biochem Biophys Res Commun 2001;284:1031-1038.
57. Vogelzang NJ, Breitbart W, Cella D et al. Patient, caregiver, and oncologist perceptions of cancer-related fatigue: Results of a tripart assessment survey. The Fatigue Coalition. Semin Hematol 1997;34(suppl 2):4-12.
58. Breitbart W. Identifying patients at risk for, and treatment of major psychiatric complications of cancer, Support Care Cancer 1995;3:45-60.
59. Visser MR, Smets EM. Fatigue, depression and quality of life in cancer patients: How are they related? Support Care Cancer 1998;6:101-108.
60. Dimeo F, Stieglitz RD, Novelli-Fischer U et al. Correlation between physical performance and fatigue in cancer patients. Ann Oncol 1997;8:1251-1255.
61. Demetri GD, Kris M, Wade J et al. Quality-of-life benefit in chemotherapy patients treated with epoetin alfa is independent of disease response or tumor type: Results from a prospective community oncology study. J Clin Oncol 1998;16:3412-3425.