Predominant contribution of organic anion transporting polypeptide OATP-B (OATP2B1) to apical uptake of estrone-3-sulfate by human intestinal Caco-2 cells

Drug Metabolism and Disposition

Volumn 34, Issue 8, 2006, Pages 1423-1431

  Sai, Yoshimichi ^a   Kaneko, Yosuke ^a   Ito, Satsuki ^a   Mitsuoka, Keisuke ^a   Kato, Yukio ^a   Tamai, Ikumi ^b   Artursson, Per ^c   Tsuji, Akira ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BROMSULFOPHTHALEIN; ESTRONE SULFATE; ORGANIC ANION TRANSPORTER 2; ORGANIC ANION TRANSPORTING POLYPEPTIDE B; ORGANIC ANION TRANSPORTING POLYPEPTIDE D; ORGANIC ANION TRANSPORTING POLYPEPTIDE E; PENICILLIN G; PRASTERONE SULFATE; PRAVASTATIN; UNCLASSIFIED DRUG;

APICAL MEMBRANE; ARTICLE; BINDING AFFINITY; CELL STRAIN CACO 2; CELL STRAIN HEK293; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG INHIBITION; DRUG TRANSPORT; DRUG UPTAKE; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; JEJUNUM; JEJUNUM BIOPSY; KIDNEY; KINETICS; MALE; MEMBRANE VESICLE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMALL INTESTINE;

ADULT; CACO-2 CELLS; CELL MEMBRANE; ESTRONE; FEMALE; HUMANS; JEJUNUM; MALE; MIDDLE AGED; ORGANIC ANION TRANSPORTERS; RNA, MESSENGER;

EID: 33746048844     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.106.009530     Document Type: Article

References (40)

1. Abe T, Kakyo M, Tokui T, Nakagomi R, Nishio T, Nakai D, Nomura H, Unno M, Suzuki M, Naitoh T, Matsuno S, and Yawo H (1999) Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J Biol Chem 274:17159-17163.
2. Abe T, Unno M, Onogawa T, Tokui T, Kondo TN, Nakagomi R, Adachi H, Fujiwara K, Okabe M, Suzuki T, et al. (2001) LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology 120:1689-1699.
3. Adachi H, Suzuki T, Abe M, Asano N, Mizutamari H, Tanemoto M, Nishio T, Onogawa T, Toyohara T, Kasai S, et al. (2003) Molecular characterization of human and rat organic anion transporter OATP-D. Am J Physiol 285:F1188-F1197.
4. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
5. Cui Y, Konig J, Leier I, Buchholz U, and Keppler D (2001) Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J Biol Chem 276:9626-9630.
6. Hagenbuch B and Meier PJ (2003) The superfamily of organic anion transporting polypeptides. Biochim Biophys Acta 1609:1-18.
7. Honjo H (1979) Estrogen metabolism and enterohepatic circulation. Nippon Rinsho 37:46-52.
8. Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, and Kirchgessner TG (1999) A novel human hepatic organic anion transporting polypeptide (OATP-2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem 274:37161-37168.
9. Ishikawa T, Tsuji A, Inui K, Sai Y, Anzai N, Wada M, Endou H, and Sumino Y (2004) The genetic polymorphism of drug transporters: functional analysis approaches. Pharmacogenomics 5:67-99.
10. + exchanger isoform 3 in human colon adenocarcinoma cell line Caco-2. Protein kinase C-mediated inhibition of the exchanger. J Biol Chem 273:8790-8798.
11. Kobayashi D, Nozawa T, Imai K, Nezu J, Tsuji A, and Tamai I (2003) Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane. J Pharmacol Exp Ther 306:703-708.
12. Konig J, Cui Y, Nies AT, and Keppler D (2000) Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. J Biol Chem 275:23161-23168.
13. Kullak-Ublick GA, Hagenbuch B, Stieger B, Schteingart CD, Hofmann AF, Wolkoff AW, and Meier PJ (1995) Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology 109:1274-1282.
14. Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, and Meier PJ (2001) Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology 120:525-533.
15. Lu R, Kanai N, Bao Y, and Schuster VL (1996) Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT). J Clin Investig 98:1142-1149.
16. Mikkaichi T, Suzuki T, Onogawa T, Tanemoto M, Mizutamari H, Okada M, Chaki T, Masuda S, Tokui T, Eto N, et al. (2004) Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney. Proc Natl Acad Sci USA 101:3569-3574.
17. Naruhashi K, Sai Y, Tamai I, Suzuki N, and Tsuji A (2002) PepT1 mRNA expression is induced by starvation and its level correlates with absorptive transport of cefadroxil longitudinally in the rat intestine. Pharm Res (NY) 19:1417-1423.
18. Nozawa T, Imai K, Nezu J, Tsuji A, and Tamai I (2004) Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human. J Pharmacol Exp Ther 308:438-445.
19. Nozawa T, Nakajima M, Tamai I, Noda K, Nezu J, Sai Y, Tsuji A, and Yokoi T (2002) Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis. J Pharmacol Exp Ther 302:804-813.
20. Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, and Meier PJ (2002) Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol 16:2283-2296.
21. Pizzagalli F, Varga Z, Huber RD, Folkers G, Meier PJ, and St-Pierre MV (2003) Identification of steroid sulfate transport processes in the human mammary gland. J Clin Endocrinol Metab 88:3902-3912.
22. Saeki T, Matoba K, Furukawa H, Kirifuji K, Kanamoto R, and Iwami K (1999) Characterization, cDNA cloning, and functional expression of mouse ileal sodium-dependent bile acid transporter. J Biochem (Tokyo) 125:846-851.
23. Shiau YF, Fernandez P, Jackson MJ, and McMonagle S (1985) Mechanisms maintaining a low-pH microclimate in the intestine. Am J Physiol 248:G608-G617.
24. Stelzner M, Hoagland V, and Somasundaram S (2000) Distribution of bile acid absorption and bile acid transporter gene message in the hamster ileum. Pflueg Arch Eur J Physiol 440:157-162.
25. St-Pierre MV, Hagenbuch B, Ugele B, Meier PJ, and Stallmach T (2002) Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta. J Clin Endocrinol Metab 87:1856-1863.
26. Sun D, Lennernas H, Welage LS, Barnett JL, Landowski CP, Foster D, Fleisher D, Lee KD, and Amidon GL (2002) Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugs. Pharm Res (NY) 19:1400-1416.
27. Taipalensuu J, Tornblom H, Lindberg G, Einarsson C, Sjoqvist F, Melhus H, Garberg P, Sjostrom B, Lundgren B, and Artursson P (2001) Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers. J Pharmacol Exp Ther 299:164-170.
28. +-coupled transport of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney. Biochim Biophys Acta 1512:273-284.
29. Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, and Tsuji A (2000a) Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun 273:251-260.
30. Tamai I, Nozawa T, Koshida M, Nezu J, Sai Y, and Tsuji A (2001b) Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C. Pharm Res (NY) 18:1262-1269.
31. Tamai I, Ogihara T, Takanaga H, Maeda H, and Tsuji A (2000b) Anion antiport mechanism is involved in transport of lactic acid across intestinal epithelial brush-border membrane. Biochem Biophys Acta 1468:285-292.
32. Tamai I, Sai Y, Ono A, Kido Y, Yabuuchi H, Takanaga H, Satoh E, Ogihara T, Amano O, Iseki S, et al. (1999) Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1. J Pharm Pharmacol 51:1113-1121.
33. Tamai I, Takanaga H, Maeda H, Ogihara T, Yoneda M, and Tsuji A (1995) Proton-cotransport of pravastatin across intestinal brush-border membrane. Pharm Res (NY) 12:1727-1732.
34. Tamai I, Takanaga H, Maeda H, Yabuuchi H, Sai Y, Suzuki Y, and Tsuji A (1996) Intestinal brush-border membrane transport of monocarboxylic acids mediated by proton-coupled transport and anion antiport mechanism. J Pharm Pharmacol 49:108-112.
35. Tavelin S, Grasjo J, Taipalensuu J, Ocklind G, and Artursson P (2002) Applications of epithelial cell culture in studies of drug transport. Methods Mol Biol 188:233-272.
36. + exchanger. Gastroenterology 122:1322-1333.
37. Ugele B, St-Pierre MV, Pihusch M, Bahn A, and Hantschmann P (2003) Characterization and identification of steroid sulfate transporters of human placenta. Am J Physiol 284:E390-E398.
38. Walker D, Thwaites DT, Simmons NL, Gilbert HJ, and Hirst BH (1998) Substrate upregulation of the human small intestinal peptide transporter, hPepT1. J Physiol 507:697-706.
39. +/oligopeptide transporter 1. Drug Metab Pharmacokinet 20:443-451.
40. Yamaoka K, Tanigawara Y, Nakagawa T, and Uno T (1981) A pharmacokinetic analysis program (MULTI) for microcomputer. J Pharmacobiodyn 4:879-885.