메뉴 건너뛰기




Volumn 14, Issue 44, 2008, Pages 6786-6801

Dynamic localization of hepatocellular transporters in health and disease

Author keywords

Bile salts; cAMP; Cholestasis; Endocytosis; Hepatocellular transporters; Signaling pathways; Vesicular trafficking

Indexed keywords

4 PHENYLBUTYRIC ACID; ABC TRANSPORTER; ACTIN; ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ANTIBIOTIC AGENT; ANTIPORTER; AQUAPORIN; CARRIER PROTEIN; CHLORPROMAZINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLOSPORIN A; ESTRADIOL; LIPOPOLYSACCHARIDE; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; NONSTEROID ANTIINFLAMMATORY AGENT; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 2; ORGANIC ANION TRANSPORTER 3; ORGANIC ANION TRANSPORTER 4; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; SILIBININ; TAUROURSODEOXYCHOLIC ACID; TIOPRONIN; UNINDEXED DRUG; CHOLAGOGUE; XENOBIOTIC AGENT;

EID: 64049102360     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.14.6786     Document Type: Review
Times cited : (63)

References (135)
  • 1
    • 0033459277 scopus 로고    scopus 로고
    • The Role of the Sinusoidal Endothelium in Liver Function
    • Reichen J. The Role of the Sinusoidal Endothelium in Liver Function. News Physiol Sci 1999; 14: 117-121
    • (1999) News Physiol Sci , vol.14 , pp. 117-121
    • Reichen, J.1
  • 2
    • 0033470181 scopus 로고    scopus 로고
    • Bile Acids: The Good, the Bad, and the Ugly
    • Hofmann AF. Bile Acids: The Good, the Bad, and the Ugly. News Physiol Sci 1999; 14: 24-29
    • (1999) News Physiol Sci , vol.14 , pp. 24-29
    • Hofmann, A.F.1
  • 3
    • 0036256463 scopus 로고    scopus 로고
    • Mechanisms of hepatic transport of drugs: Implications for cholestatic drug reactions
    • DOI 10.1055/s-2002-30099
    • Bohan A, Boyer JL. Mechanisms of hepatic transport of drugs: implications for cholestatic drug reactions. Semin Liver Dis 2002; 22: 123-136 (Pubitemid 34496466)
    • (2002) Seminars in Liver Disease , vol.22 , Issue.2 , pp. 123-136
    • Bohan, A.1    Boyer, J.L.2
  • 5
    • 36849094413 scopus 로고    scopus 로고
    • Review article: The function and regulation of proteins involved in bile salt biosynthesis and transport
    • DOI 10.1111/j.1365-2036.2007.03522.x
    • Pellicoro A, Faber KN. Review article: The function and regulation of proteins involved in bile salt biosynthesis and transport. Aliment Pharmacol Ther 2007; 26 Suppl 2: 149-160 (Pubitemid 350233340)
    • (2007) Alimentary Pharmacology and Therapeutics , vol.26 , Issue.SUPPL. 2 , pp. 149-160
    • Pellicoro, A.1    Faber, K.N.2
  • 6
    • 25144450046 scopus 로고    scopus 로고
    • Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport
    • DOI 10.1007/s11095-005-6810-2
    • Ito K, Suzuki H, Horie T, Sugiyama Y. Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport. Pharm Res 2005; 22: 1559-1577 (Pubitemid 41355896)
    • (2005) Pharmaceutical Research , vol.22 , Issue.10 , pp. 1559-1577
    • Ito, K.1    Suzuki, H.2    Horie, T.3    Sugiyama, Y.4
  • 7
    • 34548103493 scopus 로고    scopus 로고
    • Role of OATP transporters in the disposition of drugs
    • DOI 10.2217/14622416.8.7.787
    • Niemi M. Role of OATP transporters in the disposition of drugs. Pharmacogenomics 2007; 8: 787-802 (Pubitemid 47288978)
    • (2007) Pharmacogenomics , vol.8 , Issue.7 , pp. 787-802
    • Niemi, M.1
  • 8
    • 0030753125 scopus 로고    scopus 로고
    • Molecular aspects of hepatobiliary transport
    • Müller M, Jansen PL. Molecular aspects of hepatobiliary transport. Am J Physiol 1997; 272: G1285-G1303
    • (1997) Am J Physiol , vol.272
    • Müller, M.1    Jansen, P.L.2
  • 9
    • 0037379362 scopus 로고    scopus 로고
    • Bile salt transporters: Molecular characterization, function, and regulation
    • Trauner M, Boyer JL. Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev 2003; 83: 633-671 (Pubitemid 36378680)
    • (2003) Physiological Reviews , vol.83 , Issue.2 , pp. 633-671
    • Trauner, M.1    Boyer, J.L.2
  • 10
    • 0034968246 scopus 로고    scopus 로고
    • Comparison of "type I" and "type II" organic cation transport by organic cation transporters and organic anion-transporting polypeptides
    • van Montfoort JE, Müller M, Groothuis GM, Meijer DK, Koepsell H, Meier PJ. Comparison of "type I" and "type II" organic cation transport by organic cation transporters and organic anion-transporting polypeptides. J Pharmacol Exp Ther 2001; 298: 110-115
    • (2001) J Pharmacol Exp Ther , vol.298 , pp. 110-115
    • Van Montfoort, J.E.1    Müller, M.2    Groothuis, G.M.3    Meijer, D.K.4    Koepsell, H.5    Meier, P.J.6
  • 11
    • 0025946645 scopus 로고
    • Cloning and characterization of a member of the rat multidrug resistance (mdr) gene family
    • Silverman JA, Raunio H, Gant TW, Thorgeirsson SS. Cloning and characterization of a member of the rat multidrug resistance (mdr) gene family. Gene 1991; 106: 229-236
    • (1991) Gene , vol.106 , pp. 229-236
    • Silverman, J.A.1    Raunio, H.2    Gant, T.W.3    Thorgeirsson, S.S.4
  • 12
    • 0030778079 scopus 로고    scopus 로고
    • Hepatic secretion of phospholipid vesicles in the mouse critically depends on mdr2 or MDR3 P-glycoprotein expression: Visualization by electron microscopy
    • Crawford AR, Smith AJ, Hatch VC, Oude Elferink RP, Borst P, Crawford JM. Hepatic secretion of phospholipid vesicles in the mouse critically depends on mdr2 or MDR3 P-glycoprotein expression. Visualization by electron microscopy. J Clin Invest 1997; 100: 2562-2567 (Pubitemid 27514896)
    • (1997) Journal of Clinical Investigation , vol.100 , Issue.10 , pp. 2562-2567
    • Crawford, A.R.1    Smith, A.J.2    Hatch, V.C.3    Oude Elferink, R.P.J.4    Borst, P.5    Crawford, J.M.6
  • 14
    • 0035831094 scopus 로고    scopus 로고
    • Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump
    • DOI 10.1016/S0005-2736(00)00355-2, PII S0005273600003552
    • Akita H, Suzuki H, Ito K, Kinoshita S, Sato N, Takikawa H, Sugiyama Y. Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump. Biochim Biophys Acta 2001; 1511: 7-16 (Pubitemid 32206667)
    • (2001) Biochimica et Biophysica Acta - Biomembranes , vol.1511 , Issue.1 , pp. 7-16
    • Akita, H.1    Suzuki, H.2    Ito, K.3    Kinoshita, S.4    Sato, N.5    Takikawa, H.6    Sugiyama, Y.7
  • 15
    • 0033104810 scopus 로고    scopus 로고
    • Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione
    • Paulusma CC, van Geer MA, Evers R, Heijn M, Ottenhoff R, Borst P, Oude Elferink RP. Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione. Biochem J 1999; 338 ( Pt 2): 393-401 (Pubitemid 129512263)
    • (1999) Biochemical Journal , vol.338 , Issue.1-2 , pp. 393-401
    • Paulusma, C.C.1    Van Geer, M.A.2    Evers, R.3    Heijn, M.4    Ottenhoff, R.5    Borst, P.6    Oude Elferink, R.P.J.7
  • 17
    • 0026497882 scopus 로고
    • Glutathione as a primary osmotic driving force in hepatic bile formation
    • Ballatori N, Truong AT. Glutathione as a primary osmotic driving force in hepatic bile formation. Am J Physiol 1992; 263: G617-G624
    • (1992) Am J Physiol , vol.263
    • Ballatori, N.1    Truong, A.T.2
  • 18
    • 33745698666 scopus 로고    scopus 로고
    • Cholangiocyte anion exchange and biliary bicarbonate excretion
    • Banales JM, Prieto J, Medina JF. Cholangiocyte anion exchange and biliary bicarbonate excretion. World J Gastroenterol 2006; 12: 3496-3511 (Pubitemid 43997027)
    • (2006) World Journal of Gastroenterology , vol.12 , Issue.22 , pp. 3496-3511
    • Banales, J.M.1    Prieto, J.2    Medina, J.F.3
  • 19
    • 0018003268 scopus 로고
    • Importance of bicarbonate in bile salt independent fraction of bile flow
    • Hardison WG, Wood CA. Importance of bicarbonate in bile salt independent fraction of bile flow. Am J Physiol 1978; 235: E158-E164
    • (1978) Am J Physiol , vol.235
    • Hardison, W.G.1    Wood, C.A.2
  • 20
    • 0034614467 scopus 로고    scopus 로고
    • Tissue-specific N-terminal isoforms from overlapping alternate promoters of the human AE2 anion exchanger gene
    • DOI 10.1006/bbrc.1999.1951
    • Medina JF, Lecanda J, Acín A, Ciesielczyk P, Prieto J. Tissue-specific N-terminal isoforms from overlapping alternate promoters of the human AE2 anion exchanger gene. Biochem Biophys Res Commun 2000; 267: 228-235 (Pubitemid 30072535)
    • (2000) Biochemical and Biophysical Research Communications , vol.267 , Issue.1 , pp. 228-235
    • Medina, J.F.1    Lecanda, J.2    Acin, A.3    Ciesielczyk, P.4    Prieto, J.5
  • 22
    • 0037151071 scopus 로고    scopus 로고
    • Expression and localization of aquaporin water channels in rat hepatocytes. Evidence for a role in canalicular bile secretion
    • DOI 10.1074/jbc.M202394200
    • Huebert RC, Splinter PL, Garcia F, Marinelli RA, LaRusso NF. Expression and localization of aquaporin water channels in rat hepatocytes. Evidence for a role in canalicular bile secretion. J Biol Chem 2002; 277: 22710-22717 (Pubitemid 34967250)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.25 , pp. 22710-22717
    • Huebert, R.C.1    Splinter, P.L.2    Garcia, F.3    Marinelli, R.A.4    Larusso, N.F.5
  • 23
    • 0035853805 scopus 로고    scopus 로고
    • The water channel aquaporin-8 is mainly intracellular in rat hepatocytes, and its plasma membrane insertion is stimulated by cyclic AMP
    • García F, Kierbel A, Larocca MC, Gradilone SA, Splinter P, LaRusso NF, Marinelli RA. The water channel aquaporin-8 is mainly intracellular in rat hepatocytes, and its plasma membrane insertion is stimulated by cyclic AMP. J Biol Chem 2001; 276: 12147-12152
    • (2001) J Biol Chem , vol.276 , pp. 12147-12152
    • García, F.1    Kierbel, A.2    Larocca, M.C.3    Gradilone, S.A.4    Splinter, P.5    LaRusso, N.F.6    Marinelli, R.A.7
  • 26
    • 0032995996 scopus 로고    scopus 로고
    • Short-term regulation of bile acid uptake by microfilament-dependent translocation of rat ntcp to the plasma membrane
    • DOI 10.1002/hep.510300136
    • Dranoff JA, McClure M, Burgstahler AD, Denson LA, Crawford AR, Crawford JM, Karpen SJ, Nathanson MH. Short-term regulation of bile acid uptake by microfilament-dependent translocation of rat ntcp to the plasma membrane. Hepatology 1999; 30: 223-229 (Pubitemid 29300590)
    • (1999) Hepatology , vol.30 , Issue.1 , pp. 223-229
    • Dranoff, J.A.1    McClure, M.2    Burgstahler, A.D.3    Denson, L.A.4    Crawford, A.R.5    Crawford, J.M.6    Karpen, S.J.7    Nathanson, M.H.8
  • 27
    • 0033369266 scopus 로고    scopus 로고
    • Role of the PI3K/PKB signaling pathway in cAMP-mediated translocation of rat liver Ntcp
    • Webster CR, Anwer MS. Role of the PI3K/PKB signaling pathway in cAMP-mediated translocation of rat liver Ntcp. Am J Physiol 1999; 277: G1165-G1172
    • (1999) Am J Physiol , vol.277
    • Webster, C.R.1    Anwer, M.S.2
  • 28
    • 33745757459 scopus 로고    scopus 로고
    • PKCzeta is required for microtubule-based motility of vesicles containing the ntcp transporter
    • Sarkar S, Bananis E, Nath S, Anwer MS, Wolkoff AW, Murray JW. PKCzeta is required for microtubule-based motility of vesicles containing the ntcp transporter. Traffic 2006; 7: 1078-1091
    • (2006) Traffic , vol.7 , pp. 1078-1091
    • Sarkar, S.1    Bananis, E.2    Nath, S.3    Anwer, M.S.4    Wolkoff, A.W.5    Murray, J.W.6
  • 30
    • 0027295492 scopus 로고
    • +/taurocholate cotransport by cyclic AMP
    • Grüne S, Engelking LR, Anwer MS. Role of intracellular calcium and protein kinases in the activation of hepatic Na+/taurocholate cotransport by cyclic AMP. J Biol Chem 1993; 268: 17734-17741 (Pubitemid 23260280)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.24 , pp. 17734-17741
    • Grune, S.1    Engelking, L.R.2    Anwer, M.S.3
  • 33
    • 0034703036 scopus 로고    scopus 로고
    • +/ taurocholate cotransport polypeptide is mediated via the phosphoinositide 3-kinase signaling pathway
    • DOI 10.1074/jbc.M002831200
    • Webster CR, Blanch CJ, Phillips J, Anwer MS. Cell swelling-induced translocation of rat liver Na(+)/ taurocholate cotransport polypeptide is mediated via the phosphoinositide 3-kinase signaling pathway. J Biol Chem 2000; 275: 29754-29760 (Pubitemid 32043858)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.38 , pp. 29754-29760
    • Webster, C.R.L.1    Blanch, C.J.2    Phillips, J.3    Anwer, M.S.4
  • 34
    • 2442681520 scopus 로고    scopus 로고
    • Cross-talk between protein kinases Czeta and B in cyclic AMP-mediated sodium taurocholate co-transporting polypeptide translocation in hepatocytes
    • DOI 10.1074/jbc.M309988200
    • McConkey M, Gillin H, Webster CR, Anwer MS. Crosstalk between protein kinases Czeta and B in cyclic AMP-mediated sodium taurocholate co-transporting polypeptide translocation in hepatocytes. J Biol Chem 2004; 279: 20882-20888 (Pubitemid 38656485)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.20 , pp. 20882-20888
    • McConkey, M.1    Gillin, H.2    Webster, C.R.L.3    Anwer, M.S.4
  • 35
    • 0027535742 scopus 로고
    • Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate
    • Nakanishi H, Brewer KA, Exton JH. Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 1993; 268: 13-16 (Pubitemid 23021278)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.1 , pp. 13-16
    • Nakanishi, H.1    Brewer, K.A.2    Exton, J.H.3
  • 37
    • 0037337159 scopus 로고    scopus 로고
    • Regulation of the ABC kinases by phosphorylation: Protein kinase C as a paradigm
    • DOI 10.1042/BJ20021626
    • Newton AC. Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm. Biochem J 2003; 370: 361-371 (Pubitemid 36315124)
    • (2003) Biochemical Journal , vol.370 , Issue.2 , pp. 361-371
    • Newton, A.C.1
  • 38
    • 42249111198 scopus 로고    scopus 로고
    • Protein kinase Cdelta mediates cyclic adenosine monophosphate-stimulated translocation of sodium taurocholate cotransporting polypeptide and multidrug resistant associated protein 2 in rat hepatocytes
    • DOI 10.1002/hep.22162
    • Schonhoff CM, Gillin H, Webster CR, Anwer MS. Protein kinase Cdelta mediates cyclic adenosine monophosphate stimulated translocation of sodium taurocholate cotransporting polypeptide and multidrug resistant associated protein 2 in rat hepatocytes. Hepatology 2008; 47: 1309-1316 (Pubitemid 351547917)
    • (2008) Hepatology , vol.47 , Issue.4 , pp. 1309-1316
    • Schonhoff, C.M.1    Gillin, H.2    Webster, C.R.L.3    Anwer, M.S.4
  • 40
    • 0032491597 scopus 로고    scopus 로고
    • +/taurocholate cotransport
    • DOI 10.1074/jbc.273.45.30039
    • Mukhopadhyay S, Webster CR, Anwer MS. Role of protein phosphatases in cyclic AMP-mediated stimulation of hepatic Na+/taurocholate cotransport. J Biol Chem 1998; 273: 30039-30045 (Pubitemid 28510023)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.45 , pp. 30039-30045
    • Mukhopadhyay, S.1    Webster, C.R.L.2    Anwer, M.S.3
  • 41
    • 0031738338 scopus 로고    scopus 로고
    • Sodium taurocholate cotransporting polypeptide is a serine, threonine phosphoprotein and is dephosphorylated by cyclic adenosine monophosphate
    • Mukhopadhyay S, Ananthanarayanan M, Stieger B, Meier PJ, Suchy FJ, Anwer MS. Sodium taurocholate cotransporting polypeptide is a serine, threonine phosphoprotein and is dephosphorylated by cyclic adenosine monophosphate. Hepatology 1998; 28: 1629-1636 (Pubitemid 28549134)
    • (1998) Hepatology , vol.28 , Issue.6 , pp. 1629-1636
    • Mukhopadhyay, S.1    Ananthanarayanan, M.2    Stieger, B.3    Meier, P.J.4    Suchy, F.J.5    Anwer, M.S.6
  • 42
    • 0035794226 scopus 로고    scopus 로고
    • +/bile acid cotransporter: Importance of the cytoplasmic tail to function and plasma membrane targeting
    • DOI 10.1074/jbc.M008797200
    • Sun AQ, Arrese MA, Zeng L, Swaby I, Zhou MM, Suchy FJ. The rat liver Na(+)/bile acid cotransporter. Importance of the cytoplasmic tail to function and plasma membrane targeting. J Biol Chem 2001; 276: 6825-6833 (Pubitemid 37373549)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.9 , pp. 6825-6833
    • Sun, A.-Q.1    Arrese, M.A.2    Zeng, L.3    Swaby, I.4    Zhou, M.-M.5    Suchy, F.J.6
  • 43
    • 0023928730 scopus 로고
    • Role of phosphoinositides in the regulation of liver function
    • Exton JH. Role of phosphoinositides in the regulation of liver function. Hepatology 1988; 8: 152-166
    • (1988) Hepatology , vol.8 , pp. 152-166
    • Exton, J.H.1
  • 44
    • 0024565413 scopus 로고
    • Evidence indicating that the glucagon-induced increase in cytoplasmic free Ca2+ concentration in hepatocytes is mediated by an increase in cyclic AMP concentration
    • Staddon JM, Hansford RG. Evidence indicating that the glucagon-induced increase in cytoplasmic free Ca2+ concentration in hepatocytes is mediated by an increase in cyclic AMP concentration. Eur J Biochem 1989; 179: 47-52
    • (1989) Eur J Biochem , vol.179 , pp. 47-52
    • Staddon, J.M.1    Hansford, R.G.2
  • 46
    • 39149089671 scopus 로고    scopus 로고
    • Membrane trafficking of the human organic anion-transporting polypeptide C (hOATPC)
    • Sun AQ, Ponamgi VM, Boyer JL, Suchy FJ. Membrane trafficking of the human organic anion-transporting polypeptide C (hOATPC). Pharm Res 2008; 25: 463-474
    • (2008) Pharm Res , vol.25 , pp. 463-474
    • Sun, A.Q.1    Ponamgi, V.M.2    Boyer, J.L.3    Suchy, F.J.4
  • 47
    • 0036196904 scopus 로고    scopus 로고
    • Trafficking of canalicular ABC transporters in hepatocytes
    • DOI 10.1146/annurev.physiol.64.081501.155793
    • Kipp H, Arias IM. Trafficking of canalicular ABC transporters in hepatocytes. Annu Rev Physiol 2002; 64: 595-608 (Pubitemid 34259242)
    • (2002) Annual Review of Physiology , vol.64 , pp. 595-608
    • Kipp, H.1    Arias, I.M.2
  • 48
    • 0035831541 scopus 로고    scopus 로고
    • Transporters on demand. Intrahepatic pools of canalicular ATP binding cassette transporters in rat liver
    • DOI 10.1074/jbc.M007794200
    • Kipp H, Pichetshote N, Arias IM. Transporters on demand: intrahepatic pools of canalicular ATP binding cassette transporters in rat liver. J Biol Chem 2001; 276: 7218-7224 (Pubitemid 37392025)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.10 , pp. 7218-7224
    • Kipp, H.1    Pichetshote, N.2    Arias, I.M.3
  • 49
    • 0034717284 scopus 로고    scopus 로고
    • Newly synthesized canalicular ABC transporters are directly targeted from the Golgi to the hepatocyte apical domain in rat liver
    • DOI 10.1074/jbc.M909875199
    • Kipp H, Arias IM. Newly synthesized canalicular ABC transporters are directly targeted from the Golgi to the hepatocyte apical domain in rat liver. J Biol Chem 2000; 275: 15917-15925 (Pubitemid 30366894)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.21 , pp. 15917-15925
    • Kipp, H.1    Arias, I.M.2
  • 50
    • 0033396432 scopus 로고    scopus 로고
    • Bile acid secretion and direct targeting of mdr1-green fluorescent protein from Golgi to the canalicular membrane in polarized WIF-B cells
    • Sai Y, Nies AT, Arias IM. Bile acid secretion and direct targeting of mdr1-green fluorescent protein from Golgi to the canalicular membrane in polarized WIF-B cells. J Cell Sci 1999; 112 ( Pt 24): 4535-4545 (Pubitemid 30034803)
    • (1999) Journal of Cell Science , vol.112 , Issue.24 , pp. 4535-4545
    • Sai, Y.1    Nies, A.T.2    Arias, I.M.3
  • 52
    • 0033543652 scopus 로고    scopus 로고
    • Canalicular export pumps traffic with polymeric immunoglobulin a receptor on the same microtubule-associated vesicle in rat liver
    • Soroka CJ, Pate MK, Boyer JL. Canalicular export pumps traffic with polymeric immunoglobulin A receptor on the same microtubule-associated vesicle in rat liver. J Biol Chem 1999; 274: 26416-26424 (Pubitemid 129520075)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.37 , pp. 26416-26424
    • Soroka, C.J.1    Pate, M.K.2    Boyer, J.L.3
  • 53
    • 3042720029 scopus 로고    scopus 로고
    • Intracellular trafficking of bile salt export pump (ABCB11) in polarized hepatic cells: Constitutive cycling between the canalicular membrane and rab11-positive endosomes
    • DOI 10.1091/mbc.E03-10-0737
    • Wakabayashi Y, Lippincott-Schwartz J, Arias IM. Intracellular trafficking of bile salt export pump (ABCB11) in polarized hepatic cells: constitutive cycling between the canalicular membrane and rab11-positive endosomes. Mol Biol Cell 2004; 15: 3485-3496 (Pubitemid 38850139)
    • (2004) Molecular Biology of the Cell , vol.15 , Issue.7 , pp. 3485-3496
    • Wakabayashi, Y.1    Lippincott-Schwartz, J.2    Arias, I.M.3
  • 54
    • 0031979439 scopus 로고    scopus 로고
    • Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets
    • Roelofsen H, Soroka CJ, Keppler D, Boyer JL. Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets. J Cell Sci 1998; 111 ( Pt 8): 1137-1145 (Pubitemid 28227113)
    • (1998) Journal of Cell Science , vol.111 , Issue.8 , pp. 1137-1145
    • Roelofsen, H.1    Soroka, C.J.2    Keppler, D.3    Boyer, J.L.4
  • 55
    • 0033652585 scopus 로고    scopus 로고
    • Control by signaling modulators of the sorting of canalicular transporters in rat hepatocyte couplets: Role of the cytoskeleton
    • Roma MG, Milkiewicz P, Elias E, Coleman R. Control by signaling modulators of the sorting of canalicular transporters in rat hepatocyte couplets: role of the cytoskeleton. Hepatology 2000; 32: 1342-1356
    • (2000) Hepatology , vol.32 , pp. 1342-1356
    • Roma, M.G.1    Milkiewicz, P.2    Elias, E.3    Coleman, R.4
  • 56
    • 0023266056 scopus 로고
    • Isolated rat hepatocyte couplets in short-term culture: Structural characteristics and plasma membrane reorganization
    • DOI 10.1002/hep.1840070203
    • Gautam A, Ng OC, Boyer JL. Isolated rat hepatocyte couplets in short-term culture: structural characteristics and plasma membrane reorganization. Hepatology 1987; 7: 216-223 (Pubitemid 17062708)
    • (1987) Hepatology , vol.7 , Issue.2 , pp. 216-223
    • Gautam, A.1    Oi-Cheng, N.2    Boyer, J.L.3
  • 57
    • 21244439989 scopus 로고    scopus 로고
    • Myosin II regulatory light chain is required for trafficking of bile salt export protein to the apical membrane in Madin-Darby canine kidney cells
    • DOI 10.1074/jbc.M502767200
    • Chan W, Calderon G, Swift AL, Moseley J, Li S, Hosoya H, Arias IM, Ortiz DF. Myosin II regulatory light chain is required for trafficking of bile salt export protein to the apical membrane in Madin-Darby canine kidney cells. J Biol Chem 2005; 280: 23741-23747 (Pubitemid 40884857)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.25 , pp. 23741-23747
    • Chan, W.1    Calderon, G.2    Swift, A.L.3    Moseley, J.4    Li, S.5    Hosoya, H.6    Arias, I.M.7    Ortiz, D.F.8
  • 59
    • 0028137803 scopus 로고
    • Regulation of activity and apical targeting of the Cl-/HCO3- exchanger in rat hepatocytes
    • Benedetti A, Strazzabosco M, Ng OC, Boyer JL. Regulation of activity and apical targeting of the Cl-/HCO3- exchanger in rat hepatocytes. Proc Natl Acad Sci USA 1994; 91: 792-796
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 792-796
    • Benedetti, A.1    Strazzabosco, M.2    Ng, O.C.3    Boyer, J.L.4
  • 60
    • 26544465226 scopus 로고    scopus 로고
    • The mechanisms whereby cAMP activates PI 3-kinase which regulates canalicular spgp
    • Abstract
    • Kagawa T, Misra S, Varticovski L, Arias IM. The mechanisms whereby cAMP activates PI 3-kinase which regulates canalicular spgp (Abstract). Hepatology 2000; 32: 306A
    • (2000) Hepatology , vol.32
    • Kagawa, T.1    Misra, S.2    Varticovski, L.3    Arias, I.M.4
  • 61
    • 0032500601 scopus 로고    scopus 로고
    • The role of phosphoinositide 3-kinase in taurocholate-induced trafficking of ATP-dependent canalicular transporters in rat liver
    • DOI 10.1074/jbc.273.41.26638
    • Misra S, Ujházy P, Gatmaitan Z, Varticovski L, Arias IM. The role of phosphoinositide 3-kinase in taurocholateinduced trafficking of ATP-dependent canalicular transporters in rat liver. J Biol Chem 1998; 273: 26638-26644 (Pubitemid 28471677)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.41 , pp. 26638-26644
    • Misra, S.1    Ujhazy, P.2    Gatmaitan, Z.3    Varticovski, L.4    Arias, I.M.5
  • 62
    • 0031459956 scopus 로고    scopus 로고
    • Activation of protein kinase C alpha and delta by bile acids: Correlation with bile acid structure and diacylglycerol formation
    • Rao YP, Stravitz RT, Vlahcevic ZR, Gurley EC, Sando JJ, Hylemon PB. Activation of protein kinase C alpha and delta by bile acids: correlation with bile acid structure and diacylglycerol formation. J Lipid Res 1997; 38: 2446-2454
    • (1997) J Lipid Res , vol.38 , pp. 2446-2454
    • Rao, Y.P.1    Stravitz, R.T.2    Vlahcevic, Z.R.3    Gurley, E.C.4    Sando, J.J.5    Hylemon, P.B.6
  • 63
    • 0034910937 scopus 로고    scopus 로고
    • MAPK activation and translocation of the bile salt export pump in rats
    • Kurz AK, Graf D, Schmitt M, Vom Dahl S, Häussinger D. Tauroursodesoxycholate-induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats. Gastroenterology 2001; 121: 407-419 (Pubitemid 32729388)
    • (2001) Gastroenterology , vol.121 , Issue.2 , pp. 407-419
    • Kurz, A.K.1    Graf, D.2    Schmitt, M.3    Vom Dahl, S.4    Haussinger, D.5
  • 64
    • 0030829597 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycholate in rat liver
    • DOI 10.1053/gast.1997.v113.pm9322526
    • Schliess F, Kurz AK, vom Dahl S, Häussinger D. Mitogen-activated protein kinases mediate the stimulation of bile acid secretion by tauroursodeoxycholate in rat liver. Gastroenterology 1997; 113: 1306-1314 (Pubitemid 27418985)
    • (1997) Gastroenterology , vol.113 , Issue.4 , pp. 1306-1314
    • Schliess, F.1    Kurz, A.K.2    Vom Dahl, S.3    Haussinger, D.4
  • 65
    • 0034663645 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase-dependent Ras activation by tauroursodesoxycholate in rat liver
    • DOI 10.1042/0264-6021:3500207
    • Kurz AK, Block C, Graf D, Dahl SV, Schliess F, Häussinger D. Phosphoinositide 3-kinase-dependent Ras activation by tauroursodesoxycholate in rat liver. Biochem J 2000; 350 Pt 1: 207-213 (Pubitemid 30681332)
    • (2000) Biochemical Journal , vol.350 , Issue.1 , pp. 207-213
    • Kurz, A.K.1    Block, C.2    Graf, D.3    Vom Dahl, S.4    Schliess, F.5    Haussinger, D.6
  • 66
    • 0842299393 scopus 로고    scopus 로고
    • Trafficking of the Bile Salt Export Pump from the Golgi to the Canalicular Membrane Is Regulated by the p38 MAP Kinase
    • DOI 10.1053/j.gastro.2003.11.003
    • Kubitz R, Sütfels G, Kühlkamp T, Kölling R, Häussinger D. Trafficking of the bile salt export pump from the Golgi to the canalicular membrane is regulated by the p38 MAP kinase. Gastroenterology 2004; 126: 541-553 (Pubitemid 38182311)
    • (2004) Gastroenterology , vol.126 , Issue.2 , pp. 541-553
    • Kubitz, R.1    Sutfels, G.2    Kuhlkamp, T.3    Kolling, R.4    Haussinger, D.5
  • 67
    • 0034192591 scopus 로고    scopus 로고
    • Hypoosmotic stress activates p38, ERK 1 and 2, and SAPK/JNK in rat hepatocytes
    • DOI 10.1006/jsre.2000.5866
    • Kim RD, Darling CE, Cerwenka H, Chari RS. Hypoosmotic stress activates p38, ERK 1 and 2, and SAPK/JNK in rat hepatocytes. J Surg Res 2000; 90: 58-66 (Pubitemid 30317178)
    • (2000) Journal of Surgical Research , vol.90 , Issue.1 , pp. 58-66
    • Kim, R.D.1    Darling, C.E.2    Cerwenka, H.3    Chari, R.S.4
  • 68
    • 0030031467 scopus 로고    scopus 로고
    • Regulation of taurocholate excretion by a hypo-osmolarity-activated signal transduction pathway in rat liver
    • DOI 10.1053/gast.1996.v110.pm8608896
    • Noé B, Schliess F, Wettstein M, Heinrich S, Häussinger D. Regulation of taurocholate excretion by a hypo-osmolarity-activated signal transduction pathway in rat liver. Gastroenterology 1996; 110: 858-865 (Pubitemid 26071853)
    • (1996) Gastroenterology , vol.110 , Issue.3 , pp. 858-865
    • Noe, B.1    Schliess, F.2    Wettstein, M.3    Heinrich, S.4    Haussinger, D.5
  • 70
    • 84989554808 scopus 로고
    • Immunohistochemical detection of chloride/bicarbonate anion exchangers in human liver
    • DOI 10.1016/0270-9139(94)90234-8
    • Martínez-Ansó E, Castillo JE, Díez J, Medina JF, Prieto J. Immunohistochemical detection of chloride/bicarbonate anion exchangers in human liver. Hepatology 1994; 19: 1400-1406 (Pubitemid 24166460)
    • (1994) Hepatology , vol.19 , Issue.6 , pp. 1400-1406
    • Martinez-Anso, E.1    Castillo, J.E.2    Diez, J.3    Medina, J.F.4    Prieto, J.5
  • 73
    • 37349096289 scopus 로고    scopus 로고
    • Aquaporins in the hepatobiliary tract. Which, where and what they do in health and disease
    • DOI 10.1111/j.1365-2362.2007.01897.x
    • Portincasa P, Palasciano G, Svelto M, Calamita G. Aquaporins in the hepatobiliary tract. Which, where and what they do in health and disease. Eur J Clin Invest 2008; 38: 1-10 (Pubitemid 350293857)
    • (2008) European Journal of Clinical Investigation , vol.38 , Issue.1 , pp. 1-10
    • Portincasa, P.1    Palasciano, G.2    Svelto, M.3    Calamita, G.4
  • 75
    • 14844313052 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase is involved in the glucagon-induced translocation of aquaporin-8 to hepatocyte plasma membrane
    • Gradilone SA, Carreras FI, Lehmann GL, Marinelli RA. Phosphoinositide 3-kinase is involved in the glucagon-induced translocation of aquaporin-8 to hepatocyte plasma membrane. Biol Cell 2005; 97: 831-836
    • (2005) Biol Cell , vol.97 , pp. 831-836
    • Gradilone, S.A.1    Carreras, F.I.2    Lehmann, G.L.3    Marinelli, R.A.4
  • 76
    • 24944534033 scopus 로고    scopus 로고
    • Expression and subcellular localization of aquaporin water channels in the polarized hepatocyte cell line, WIF-B
    • Gradilone SA, Tietz PS, Splinter PL, Marinelli RA, LaRusso NF. Expression and subcellular localization of aquaporin water channels in the polarized hepatocyte cell line, WIF-B. BMC Physiol 2005; 5: 13
    • (2005) BMC Physiol , vol.5 , pp. 13
    • Gradilone, S.A.1    Tietz, P.S.2    Splinter, P.L.3    Marinelli, R.A.4    LaRusso, N.F.5
  • 79
    • 0030457647 scopus 로고    scopus 로고
    • Disturbed structural interactions between microfilaments and tight junctions in rat hepatocytes during extrahepatic cholestasis induced by common bile duct ligation
    • DOI 10.1007/s004180050078
    • Song JY, Van Marle J, Van Noorden CJ, Frederiks WM. Disturbed structural interactions between microfilaments and tight junctions in rat hepatocytes during extrahepatic cholestasis induced by common bile duct ligation. Histochem Cell Biol 1996; 106: 573-580 (Pubitemid 26422762)
    • (1996) Histochemistry and Cell Biology , vol.106 , Issue.6 , pp. 573-580
    • Song, J.-Y.1    Van Marle, J.2    Van Noorden, C.J.F.3    Frederiks, W.M.4
  • 80
    • 42549096967 scopus 로고    scopus 로고
    • Hepatocellular transport in acquired cholestasis: New insights into functional, regulatory and therapeutic aspects
    • Lond
    • Roma MG, Crocenzi FA, Sánchez Pozzi EA. Hepatocellular transport in acquired cholestasis: new insights into functional, regulatory and therapeutic aspects. Clin Sci (Lond) 2008; 114: 567-588
    • (2008) Clin Sci , vol.114 , pp. 567-588
    • Roma, M.G.1    Crocenzi, F.A.2    Sánchez Pozzi, E.A.3
  • 81
    • 15444373825 scopus 로고    scopus 로고
    • Molecular regulation of hepatobiliary transport systems: Clinical implications for understanding and treating cholestasis
    • Trauner M, Wagner M, Fickert P, Zollner G. Molecular regulation of hepatobiliary transport systems: clinical implications for understanding and treating cholestasis. J Clin Gastroenterol 2005; 39: S111-S124 (Pubitemid 40397024)
    • (2005) Journal of Clinical Gastroenterology , vol.39 , Issue.4 SUPPL.
    • Trauner, M.1    Wagner, M.2    Fickert, P.3    Zollner, G.4
  • 83
    • 33644657346 scopus 로고    scopus 로고
    • Alteration of the expression of adenosine triphosphate-binding cassette transporters associated with bile acid and cholesterol transport in the rat liver and intestine during cholestasis
    • DOI 10.1111/j.1440-1746.2005.03950.x
    • Kamisako T, Ogawa H. Alteration of the expression of adenosine triphosphate-binding cassette transporters associated with bile acid and cholesterol transport in the rat liver and intestine during cholestasis. J Gastroenterol Hepatol 2005; 20: 1429-1434 (Pubitemid 43960843)
    • (2005) Journal of Gastroenterology and Hepatology , vol.20 , Issue.9 , pp. 1429-1434
    • Kamisako, T.1    Ogawa, H.2
  • 84
    • 0043170767 scopus 로고    scopus 로고
    • Unique reciprocal changes of hepatocellular membrane transporter expression and fluidity in rats with selective biliary obstruction
    • DOI 10.1016/S1386-6346(03)00084-6
    • Kanno K, Tazuma S, Niida S, Chayama K. Unique reciprocal changes of hepatocellular membrane transporter expression and fluidity in rats with selective biliary obstruction. Hepatol Res 2003; 26: 157-163 (Pubitemid 36927188)
    • (2003) Hepatology Research , vol.26 , Issue.2 , pp. 157-163
    • Kanno, K.1    Tazuma, S.2    Niida, S.3    Chayama, K.4
  • 85
    • 0033980287 scopus 로고    scopus 로고
    • Expression of the bile salt export pump is maintained after chronic cholestasis in the rat
    • Lee JM, Trauner M, Soroka CJ, Stieger B, Meier PJ, Boyer JL. Expression of the bile salt export pump is maintained after chronic cholestasis in the rat. Gastroenterology 2000; 118: 163-172 (Pubitemid 30020384)
    • (2000) Gastroenterology , vol.118 , Issue.1 , pp. 163-172
    • Lee, J.M.1    Trauner, M.2    Soroka, C.J.3    Stieger, B.4    Meier, P.J.5    Boyer, J.L.6
  • 86
    • 12344332518 scopus 로고    scopus 로고
    • Signaling modulation of bile salt-induced necrosis in isolated rat hepatocytes
    • DOI 10.1093/toxsci/kfi012
    • Borgognone M, Pérez LM, Basiglio CL, Ochoa JE, Roma MG. Signaling modulation of bile salt-induced necrosis in isolated rat hepatocytes. Toxicol Sci 2005; 83: 114-125 (Pubitemid 40123335)
    • (2005) Toxicological Sciences , vol.83 , Issue.1 , pp. 114-125
    • Borgognone, M.1    Perez, L.M.2    Basiglio, C.L.3    Ochoa, J.E.4    Roma, M.G.5
  • 87
    • 0027207769 scopus 로고
    • Evidence for involvement of oxygen free radicals in bile acid toxicity to isolated rat hepatocytes
    • DOI 10.1016/0270-9139(93)90164-I
    • Sokol RJ, Devereaux M, Khandwala R, O'Brien K. Evidence for involvement of oxygen free radicals in bile acid toxicity to isolated rat hepatocytes. Hepatology 1993; 17: 869-881 (Pubitemid 23150097)
    • (1993) Hepatology , vol.17 , Issue.5 , pp. 869-881
    • Sokol, R.J.1    Devereaux, M.2    Khandwala, R.3    O'Brien, K.4
  • 88
    • 0034769630 scopus 로고    scopus 로고
    • Free radical-triggered hepatic injury of experimental obstructive jaundice of rats involves overproduction of proinflammatory cytokines and enhanced activation of nuclear factor kappaB
    • Liu TZ, Lee KT, Chern CL, Cheng JT, Stern A, Tsai LY. Free radical-triggered hepatic injury of experimental obstructive jaundice of rats involves overproduction of proinflammatory cytokines and enhanced activation of nuclear factor kappaB. Ann Clin Lab Sci 2001; 31: 383-390 (Pubitemid 32988663)
    • (2001) Annals of Clinical and Laboratory Science , vol.31 , Issue.4 , pp. 383-390
    • Liu, T.-Z.1    Lee, K.-T.2    Chern, C.-L.3    Cheng, J.-T.4    Stern, A.5    Tsai, L.-Y.6
  • 89
    • 0036614376 scopus 로고    scopus 로고
    • Altered localization and activity of canalicular Mrp2 in estradiol-17beta-D-glucuronide-induced cholestasis
    • DOI 10.1053/jhep.2002.33327
    • Mottino AD, Cao J, Veggi LM, Crocenzi F, Roma MG, Vore M. Altered localization and activity of canalicular Mrp2 in estradiol-17beta-D-glucuronide- induced cholestasis. Hepatology 2002; 35: 1409-1419 (Pubitemid 34966895)
    • (2002) Hepatology , vol.35 , Issue.6 , pp. 1409-1419
    • Mottino, A.D.1    Cao, J.2    Veggi, L.M.3    Crocenzi, F.4    Roma, M.G.5    Vore, M.6
  • 91
    • 0035038177 scopus 로고    scopus 로고
    • Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver
    • Beuers U, Bilzer M, Chittattu A, Kullak-Ublick GA, Keppler D, Paumgartner G, Dombrowski F. Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver. Hepatology 2001; 33: 1206-1216
    • (2001) Hepatology , vol.33 , pp. 1206-1216
    • Beuers, U.1    Bilzer, M.2    Chittattu, A.3    Kullak-Ublick, G.A.4    Keppler, D.5    Paumgartner, G.6    Dombrowski, F.7
  • 93
    • 17144473982 scopus 로고    scopus 로고
    • Cyclosporin a induced internalization of the bile salt export pump in isolated rat hepatocyte couplets
    • DOI 10.1093/toxsci/71.2.276
    • Román ID, Fernández-Moreno MD, Fueyo JA, Roma MG, Coleman R. Cyclosporin A induced internalization of the bile salt export pump in isolated rat hepatocyte couplets. Toxicol Sci 2003; 71: 276-281 (Pubitemid 36285019)
    • (2003) Toxicological Sciences , vol.71 , Issue.2 , pp. 276-281
    • Roman, I.D.1    Fernandez-Moreno, M.D.2    Fueyo, J.A.3    Roma, M.G.4    Coleman, R.5
  • 96
    • 0024351792 scopus 로고
    • Oestradiol 17 beta-glucuronide increases tight-junctional permeability in rat liver
    • Kan KS, Monte MJ, Parslow RA, Coleman R. Oestradiol 17 beta-glucuronide increases tight-junctional permeability in rat liver. Biochem J 1989; 261: 297-300 (Pubitemid 19174795)
    • (1989) Biochemical Journal , vol.261 , Issue.1 , pp. 297-300
    • Kan, K.S.1    Monte, M.J.2    Parslow, R.A.3    Coleman, R.4
  • 97
    • 28844438345 scopus 로고    scopus 로고
    • Canalicular membrane localization of hepatocyte aquaporin-8 is preserved in estradiol-17beta-D-glucuronide-induced cholestasis [1]
    • DOI 10.1016/j.jhep.2005.08.021, PII S0168827805005660
    • Mottino AD, Carreras FI, Gradilone SA, Marinelli RA, Vore M. Canalicular membrane localization of hepatocyte aquaporin-8 is preserved in estradiol-17beta-D-glucuronide-induced cholestasis. J Hepatol 2006; 44: 232-233 (Pubitemid 41772538)
    • (2006) Journal of Hepatology , vol.44 , Issue.1 , pp. 232-233
    • Mottino, A.D.1    Carreras, F.I.2    Gradilone, S.A.3    Marinelli, R.A.4    Vore, M.5
  • 98
    • 0032902277 scopus 로고    scopus 로고
    • Early events in sepsis-associated cholestasis
    • Jansen PL, Müller M. Early events in sepsis-associated cholestasis. Gastroenterology 1999; 116: 486-488
    • (1999) Gastroenterology , vol.116 , pp. 486-488
    • Jansen, P.L.1    Müller, M.2
  • 99
    • 0030731742 scopus 로고    scopus 로고
    • Osmodependent dynamic localization of the multidrug resistance protein 2 in the rat hepatocyte canalicular membrane
    • Kubitz R, D'urso D, Keppler D, Häussinger D. Osmodependent dynamic localization of the multidrug resistance protein 2 in the rat hepatocyte canalicular membrane. Gastroenterology 1997; 113: 1438-1442
    • (1997) Gastroenterology , vol.113 , pp. 1438-1442
    • Kubitz, R.1    D'Urso, D.2    Keppler, D.3    Häussinger, D.4
  • 100
    • 0034657167 scopus 로고    scopus 로고
    • Electron-microscopic demonstration of multidrug resistance protein 2 (Mrp2) retrieval from the canalicular membrane in response to hyperosmolarity and lipopolysaccharide
    • DOI 10.1042/0264-6021:3480183
    • Dombrowski F, Kubitz R, Chittattu A, Wettstein M, Saha N, Häussinger D. Electron-microscopic demonstration of multidrug resistance protein 2 (Mrp2) retrieval from the canalicular membrane in response to hyperosmolarity and lipopolysaccharide. Biochem J 2000; 348 Pt 1: 183-188 (Pubitemid 30312147)
    • (2000) Biochemical Journal , vol.348 , Issue.1 , pp. 183-188
    • Dombrowski, F.1    Kubitz, R.2    Chittattu, A.3    Wettstein, M.4    Saha, N.5    Haussinger, D.6
  • 101
    • 0032944048 scopus 로고    scopus 로고
    • Regulation of the multidrug resistance protein 2 in the rat liver by lipopolysaccharide and dexamethasone
    • DOI 10.1016/S0016-5085(99)70138-1
    • Kubitz R, Wettstein M, Warskulat U, Häussinger D. Regulation of the multidrug resistance protein 2 in the rat liver by lipopolysaccharide and dexamethasone. Gastroenterology 1999; 116: 401-410 (Pubitemid 29055364)
    • (1999) Gastroenterology , vol.116 , Issue.2 , pp. 401-410
    • Kubitz, R.1    Wettstein, M.2    Warskulat, U.3    Haussinger, D.4
  • 102
    • 0035124048 scopus 로고    scopus 로고
    • Regulation of the dynamic localization of the rat Bsep gene-encoded bile salt export pump by anisoosmolarity
    • DOI 10.1053/jhep.2001.22648
    • Schmitt M, Kubitz R, Lizun S, Wettstein M, Häussinger D. Regulation of the dynamic localization of the rat Bsep gene-encoded bile salt export pump by anisoosmolarity. Hepatology 2001; 33: 509-518 (Pubitemid 32185211)
    • (2001) Hepatology , vol.33 , Issue.3 , pp. 509-518
    • Schmitt, M.1    Kubitz, R.2    Lizun, S.3    Wettstein, M.4    Haussinger, D.5
  • 103
    • 0036210277 scopus 로고    scopus 로고
    • Heat stress prevents impairment of bile acid transport in endotoxemic rats by a posttranscriptional mechanism
    • Bolder U, Schmidt A, Landmann L, Kidder V, Tange S, Jauch KW. Heat stress prevents impairment of bile acid transport in endotoxemic rats by a posttranscriptional mechanism. Gastroenterology 2002; 122: 963-973 (Pubitemid 34267280)
    • (2002) Gastroenterology , vol.122 , Issue.4 , pp. 963-973
    • Bolder, U.1    Schmidt, A.2    Landmann, L.3    Kidder, V.4    Tange, S.5    Jauch, K.6
  • 104
    • 33644839511 scopus 로고    scopus 로고
    • Heat stress enhances recovery of hepatocyte bile acid and organic anion transporters in endotoxemic rats by multiple mechanisms
    • DOI 10.1379/CSC-143R.1
    • Bolder U, Jeschke MG, Landmann L, Wolf F, de Sousa C, Schlitt HJ, Przkora R. Heat stress enhances recovery of hepatocyte bile acid and organic anion transporters in endotoxemic rats by multiple mechanisms. Cell Stress Chaperones 2006; 11: 89-100 (Pubitemid 43363829)
    • (2006) Cell Stress and Chaperones , vol.11 , Issue.1 , pp. 89-100
    • Bolder, U.1    Jeschke, M.G.2    Landmann, L.3    Wolf, F.4    De Sousa, C.5    Schlitt, H.-J.6    Przkora, R.7
  • 105
    • 0027234009 scopus 로고
    • Liver damage due to free radicals
    • Poli G. Liver damage due to free radicals. Br Med Bull 1993; 49: 604-620 (Pubitemid 23243833)
    • (1993) British Medical Bulletin , vol.49 , Issue.3 , pp. 604-620
    • Poli, G.1
  • 106
    • 41549129374 scopus 로고    scopus 로고
    • Oxidative stress: A radical way to stop making bile
    • Roma MG, Sanchez Pozzi EJ. Oxidative stress: a radical way to stop making bile. Ann Hepatol 2008; 7: 16-33
    • (2008) Ann Hepatol , vol.7 , pp. 16-33
    • Roma, M.G.1    Sanchez Pozzi, E.J.2
  • 107
    • 33645810797 scopus 로고    scopus 로고
    • Oxidative stress induces internalization of the bile salt export pump, Bsep, and bile salt secretory failure in isolated rat hepatocyte couplets: A role for protein kinase C and prevention by protein kinase A
    • Pérez LM, Milkiewicz P, Elias E, Coleman R, Sánchez Pozzi EJ, Roma MG. Oxidative stress induces internalization of the bile salt export pump, Bsep, and bile salt secretory failure in isolated rat hepatocyte couplets: a role for protein kinase C and prevention by protein kinase A. Toxicol Sci 2006; 91: 150-158
    • (2006) Toxicol Sci , vol.91 , pp. 150-158
    • Pérez, L.M.1    Milkiewicz, P.2    Elias, E.3    Coleman, R.4    Sánchez Pozzi, E.J.5    Roma, M.G.6
  • 108
    • 0033947842 scopus 로고    scopus 로고
    • Retrieval of the mrp2 gene encoded conjugate export pump from the canalicular membrane contributes to cholestasis induced by tert-Butyl hydroperoxide and chloro-dinitrobenzene
    • Schmitt M, Kubitz R, Wettstein M, vom Dahl S, Häussinger D. Retrieval of the mrp2 gene encoded conjugate export pump from the canalicular membrane contributes to cholestasis induced by tert-butyl hydroperoxide and chlorodinitrobenzene. Biol Chem 2000; 381: 487-495 (Pubitemid 30453827)
    • (2000) Biological Chemistry , vol.381 , Issue.5-6 , pp. 487-495
    • Schmitt, M.1    Kubitz, R.2    Wettstein, M.3    Vom Dahl, S.4    Haussinger, D.5
  • 109
    • 7444234246 scopus 로고    scopus 로고
    • Ethacrynic-acid-induced glutathione depletion and oxidative stress in normal and Mrp2-deficient rat liver
    • DOI 10.1016/j.freeradbiomed.2004.08.020, PII S0891584904006811
    • Ji B, Ito K, Sekine S, Tajima A, Horie T. Ethacrynic-acid-induced glutathione depletion and oxidative stress in normal and Mrp2-deficient rat liver. Free Radic Biol Med 2004; 37: 1718-1729 (Pubitemid 39441056)
    • (2004) Free Radical Biology and Medicine , vol.37 , Issue.11 , pp. 1718-1729
    • Ji, B.1    Ito, K.2    Sekine, S.3    Tajima, A.4    Horie, T.5
  • 110
    • 33745165982 scopus 로고    scopus 로고
    • Oxidative stress and Mrp2 internalization
    • Sekine S, Ito K, Horie T. Oxidative stress and Mrp2 internalization. Free Radic Biol Med 2006; 40: 2166-2174
    • (2006) Free Radic Biol Med , vol.40 , pp. 2166-2174
    • Sekine, S.1    Ito, K.2    Horie, T.3
  • 111
    • 41549142032 scopus 로고    scopus 로고
    • The mechanism of the increase of plasma bilirubin after hepatic ischemia-reperfusion in rats
    • Yu QY, Shu M, Dai JH, Ma JB, Yu Y, Liu DH. [The mechanism of the increase of plasma bilirubin after hepatic ischemia-reperfusion in rats] Zhonghua Ganzangbing Zazhi 2007; 15: 763-766
    • (2007) Zhonghua Ganzangbing Zazhi , vol.15 , pp. 763-766
    • Yu, Q.Y.1    Shu, M.2    Dai, J.H.3    Ma, J.B.4    Yu, Y.5    Liu, D.H.6
  • 114
    • 0242690430 scopus 로고    scopus 로고
    • Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis
    • DOI 10.1016/S0168-8278(03)00410-0
    • Kojima H, Nies AT, König J, Hagmann W, Spring H, Uemura M, Fukui H, Keppler D. Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis. J Hepatol 2003; 39: 693-702 (Pubitemid 37372176)
    • (2003) Journal of Hepatology , vol.39 , Issue.5 , pp. 693-702
    • Kojima, H.1    Nies, A.T.2    Konig, J.3    Hagmann, W.4    Spring, H.5    Uemura, M.6    Fukui, H.7    Keppler, D.8
  • 115
    • 34347349034 scopus 로고    scopus 로고
    • Clinical and pathological features of a prolonged type of acute intrahepatic cholestasis
    • DOI 10.1111/j.1872-034X.2007.00115.x
    • Watanabe N, Takashimizu S, Kojima S, Kagawa T, Nishizaki Y, Mine T, Matsuzaki S. Clinical and pathological features of a prolonged type of acute intrahepatic cholestasis. Hepatol Res 2007; 37: 598-607 (Pubitemid 47009245)
    • (2007) Hepatology Research , vol.37 , Issue.8 , pp. 598-607
    • Watanabe, N.1    Takashimizu, S.2    Kojima, S.3    Kagawa, T.4    Nishizaki, Y.5    Mine, T.6    Matsuzaki, S.7
  • 116
    • 0033019479 scopus 로고    scopus 로고
    • Changes in the localization of the rat canalicular conjugate export pump Mrp2 in phalloidin-induced cholestasis
    • Rost D, Kartenbeck J, Keppler D. Changes in the localization of the rat canalicular conjugate export pump Mrp2 in phalloidin-induced cholestasis. Hepatology 1999; 29: 814-821 (Pubitemid 29109596)
    • (1999) Hepatology , vol.29 , Issue.3 , pp. 814-821
    • Rost, D.1    Kartenbeck, J.2    Keppler, D.3
  • 117
    • 49749096373 scopus 로고    scopus 로고
    • Retrieval of the rat canalicular conjugate export pump Mrp2 is associated with a rearrangement of actin filaments and radixin in bile salt-induced cholestasis
    • Rost D, Kloeters-Plachky P, Stiehl A. Retrieval of the rat canalicular conjugate export pump Mrp2 is associated with a rearrangement of actin filaments and radixin in bile salt-induced cholestasis. Eur J Med Res 2008; 13: 314-318
    • (2008) Eur J Med Res , vol.13 , pp. 314-318
    • Rost, D.1    Kloeters-Plachky, P.2    Stiehl, A.3
  • 119
    • 33644839193 scopus 로고    scopus 로고
    • Regulation of drug transporters by PDZ adaptor proteins and nuclear receptors
    • DOI 10.1016/j.ejps.2005.11.006, PII S0928098705003362, Drug Transporters: Integration in Understanding ADME
    • Kato Y, Watanabe C, Tsuji A. Regulation of drug transporters by PDZ adaptor proteins and nuclear receptors. Eur J Pharm Sci 2006; 27: 487-500 (Pubitemid 43363340)
    • (2006) European Journal of Pharmaceutical Sciences , vol.27 , Issue.5 , pp. 487-500
    • Kato, Y.1    Watanabe, C.2    Tsuji, A.3
  • 120
    • 3543047295 scopus 로고    scopus 로고
    • Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells
    • DOI 10.1074/jbc.M404337200
    • Ortiz DF, Moseley J, Calderon G, Swift AL, Li S, Arias IM. Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells. J Biol Chem 2004; 279: 32761-33277 (Pubitemid 39014735)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.31 , pp. 32761-32770
    • Ortiz, D.F.1    Moseley, J.2    Calderon, G.3    Swift, A.L.4    Li, S.5    Arias, I.M.6
  • 123
    • 33748101755 scopus 로고    scopus 로고
    • Radixin Is Required to Maintain Apical Canalicular Membrane Structure and Function in Rat Hepatocytes
    • DOI 10.1053/j.gastro.2006.06.013, PII S0016508506012832
    • Wang W, Soroka CJ, Mennone A, Rahner C, Harry K, Pypaert M, Boyer JL. Radixin is required to maintain apical canalicular membrane structure and function in rat hepatocytes. Gastroenterology 2006; 131: 878-884 (Pubitemid 44307066)
    • (2006) Gastroenterology , vol.131 , Issue.3 , pp. 878-884
    • Wang, W.1    Soroka, C.J.2    Mennone, A.3    Rahner, C.4    Harry, K.5    Pypaert, M.6    Boyer, J.L.7
  • 124
    • 38049161371 scopus 로고    scopus 로고
    • The role of radixin in altered localization of canalicular conjugate export pump Mrp2 in cholestatic rat liver
    • Kojima H, Sakurai S, Yoshiji H, Uemura M, Yoshikawa M, Fukui H. The role of radixin in altered localization of canalicular conjugate export pump Mrp2 in cholestatic rat liver. Hepatol Res 2008; 38: 202-210
    • (2008) Hepatol Res , vol.38 , pp. 202-210
    • Kojima, H.1    Sakurai, S.2    Yoshiji, H.3    Uemura, M.4    Yoshikawa, M.5    Fukui, H.6
  • 125
    • 0027419589 scopus 로고
    • Cortactin, an 80/85-kilodalton pp60(src) substrate, is a filamentous actin-binding protein enriched in the cell cortex
    • Wu H, Parsons JT. Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-binding protein enriched in the cell cortex. J Cell Biol 1993; 120: 1417-1426 (Pubitemid 23081688)
    • (1993) Journal of Cell Biology , vol.120 , Issue.6 , pp. 1417-1426
    • Wu, H.1    Parsons, J.T.2
  • 127
    • 0034917954 scopus 로고    scopus 로고
    • Protein kinase C-dependent distribution of the multidrug resistance protein 2 from the canalicular to the basolateral membrane in human HepG2 cells
    • DOI 10.1053/jhep.2001.25959
    • Kubitz R, Huth C, Schmitt M, Horbach A, Kullak-Ublick G, Häussinger D. Protein kinase C-dependent distribution of the multidrug resistance protein 2 from the canalicular to the basolateral membrane in human HepG2 cells. Hepatology 2001; 34: 340-350 (Pubitemid 32702347)
    • (2001) Hepatology , vol.34 , Issue.2 , pp. 340-350
    • Kubitz, R.1    Huth, C.2    Schmitt, M.3    Horbach, A.4    Kullak-Ublick, G.5    Haussinger, D.6
  • 128
    • 58149393248 scopus 로고    scopus 로고
    • Ca(2+)-dependent protein kinase C isoforms are critical to estradiol 17beta-D-glucuronide-induced cholestasis in the rat
    • Crocenzi FA, Sánchez Pozzi EJ, Ruiz ML, Zucchetti AE, Roma MG, Mottino AD, Vore M. Ca(2+)-dependent protein kinase C isoforms are critical to estradiol 17beta-D-glucuronide-induced cholestasis in the rat. Hepatology 2008; 48: 1885-1895
    • (2008) Hepatology , vol.48 , pp. 1885-1895
    • Crocenzi, F.A.1    Sánchez Pozzi, E.J.2    Ruiz, M.L.3    Zucchetti, A.E.4    Roma, M.G.5    Mottino, A.D.6    Vore, M.7
  • 129
    • 0032985843 scopus 로고    scopus 로고
    • Modulation of protein kinase C by taurolithocholic acid in isolated rat hepatocytes
    • DOI 10.1002/hep.510290227
    • Beuers U, Probst I, Soroka C, Boyer JL, Kullak-Ublick GA, Paumgartner G. Modulation of protein kinase C by taurolithocholic acid in isolated rat hepatocytes. Hepatology 1999; 29: 477-482 (Pubitemid 29088452)
    • (1999) Hepatology , vol.29 , Issue.2 , pp. 477-482
    • Beuers, U.1    Probst, I.2    Soroka, C.3    Boyer, J.L.4    Kullak-Ublick, G.-A.5    Paumgartner, G.6
  • 130
    • 0038381474 scopus 로고    scopus 로고
    • Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets
    • DOI 10.1074/jbc.M209898200
    • Beuers U, Denk GU, Soroka CJ, Wimmer R, Rust C, Paumgartner G, Boyer JL. Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets. J Biol Chem 2003; 278: 17810-17818 (Pubitemid 36799385)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.20 , pp. 17810-17818
    • Beuers, U.1    Denk, G.U.2    Soroka, C.J.3    Wimmer, R.4    Rust, C.5    Paumgartner, G.6    Boyer, J.L.7
  • 131
    • 14844331730 scopus 로고    scopus 로고
    • Silibinin prevents cholestasis-associated retrieval of the bile salt export pump, Bsep, in isolated rat hepatocyte couplets: Possible involvement of cAMP
    • Crocenzi FA, Basiglio CL, Pérez LM, Portesio MS, Pozzi EJ, Roma MG. Silibinin prevents cholestasis-associated retrieval of the bile salt export pump, Bsep, in isolated rat hepatocyte couplets: possible involvement of cAMP. Biochem Pharmacol 2005; 69: 1113-1120
    • (2005) Biochem Pharmacol , vol.69 , pp. 1113-1120
    • Crocenzi, F.A.1    Basiglio, C.L.2    Pérez, L.M.3    Portesio, M.S.4    Pozzi, E.J.5    Roma, M.G.6
  • 132
    • 30944462200 scopus 로고    scopus 로고
    • Tauroursodeoxycholic acid inserts the bile salt export pump into canalicular membranes of cholestatic rat liver
    • DOI 10.1038/labinvest.3700371, PII 3700371
    • Dombrowski F, Stieger B, Beuers U. Tauroursodeoxycholic acid inserts the bile salt export pump into canalicular membranes of cholestatic rat liver. Lab Invest 2006; 86: 166-174 (Pubitemid 43117596)
    • (2006) Laboratory Investigation , vol.86 , Issue.2 , pp. 166-174
    • Dombrowski, F.1    Stieger, B.2    Beuers, U.3
  • 133
    • 52649131370 scopus 로고    scopus 로고
    • Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC alpha-/PKA-dependent mechanism in rat liver
    • Wimmer R, Hohenester S, Pusl T, Denk GU, Rust C, Beuers U. Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC alpha-/PKA-dependent mechanism in rat liver. Gut 2008; 57: 1448-1454
    • (2008) Gut , vol.57 , pp. 1448-1454
    • Wimmer, R.1    Hohenester, S.2    Pusl, T.3    Denk, G.U.4    Rust, C.5    Beuers, U.6
  • 134
    • 34250339695 scopus 로고    scopus 로고
    • 4-Phenylbutyrate enhances the cell surface expression and the transport capacity of wild-type and mutated bile salt export pumps
    • DOI 10.1002/hep.21630
    • Hayashi H, Sugiyama Y. 4-phenylbutyrate enhances the cell surface expression and the transport capacity of wild-type and mutated bile salt export pumps. Hepatology 2007; 45: 1506-1516 (Pubitemid 46918335)
    • (2007) Hepatology , vol.45 , Issue.6 , pp. 1506-1516
    • Hayashi, H.1    Sugiyama, Y.2
  • 135
    • 16244380478 scopus 로고    scopus 로고
    • Two common PFIC2 mutations are associated with the impaired membrane trafficking of BSEP/ABCB11
    • DOI 10.1002/hep.20627
    • Hayashi H, Takada T, Suzuki H, Akita H, Sugiyama Y. Two common PFIC2 mutations are associated with the impaired membrane trafficking of BSEP/ABCB11. Hepatology 2005; 41: 916-924 (Pubitemid 40462954)
    • (2005) Hepatology , vol.41 , Issue.4 , pp. 916-924
    • Hayashi, H.1    Takada, T.2    Suzuki, H.3    Akita, H.4    Sugiyama, Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.