메뉴 건너뛰기




Volumn 314, Issue 3, 2005, Pages 1059-1067

Identification of the hepatic efflux transporters of organic anions using double-transfected Madin-Darby canine kidney II cells expressing human organic anion-transporting polypeptide 1B1 (OATP1B1)/multidrug resistance-associated protein 2, OATP1B1/multidrug resistance 1, and OATP1B1/breast cancer resistance protein

Author keywords

[No Author keywords available]

Indexed keywords

BREAST CANCER RESISTANCE PROTEIN; CERIVASTATIN; ESTRADIOL 17 GLUCURONIDE; ESTRONE SULFATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MULTIDRUG RESISTANCE PROTEIN 1; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTING POLYPEPTIDE 1B1; PLASMID VECTOR; PRAVASTATIN; UNCLASSIFIED DRUG;

EID: 22944446686     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.105.085589     Document Type: Article
Times cited : (181)

References (37)
  • 2
    • 0002186061 scopus 로고    scopus 로고
    • Rosuvastatin is a high affinity substrate of hepatic organic anion transporter OATP-C
    • Brown CDA, Windass A, Bleasby K, and Lauffart B (2001) Rosuvastatin is a high affinity substrate of hepatic organic anion transporter OATP-C. Atherosclerosis Suppl 2:90.
    • (2001) Atherosclerosis Suppl , vol.2 , pp. 90
    • Brown, C.D.A.1    Windass, A.2    Bleasby, K.3    Lauffart, B.4
  • 3
    • 0042354831 scopus 로고    scopus 로고
    • Transport of methotrexate, methotrexate polyglutamates and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: Effects of acquired mutations at R482 on methotrexate transport
    • Chen ZS, Robey RW, Belinsky MG, Shchaveleva I, Ren XQ, Sugimoto Y, Ross DD, Bates SE, and Kruh GD (2003) Transport of methotrexate, methotrexate polyglutamates and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport. Cancer Res 63:4048-4054.
    • (2003) Cancer Res , vol.63 , pp. 4048-4054
    • Chen, Z.S.1    Robey, R.W.2    Belinsky, M.G.3    Shchaveleva, I.4    Ren, X.Q.5    Sugimoto, Y.6    Ross, D.D.7    Bates, S.E.8    Kruh, G.D.9
  • 4
    • 0034753042 scopus 로고    scopus 로고
    • Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2
    • Cui Y, Konig J, and Keppler D (2001) Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2. Mol Pharmacol 60:934-943.
    • (2001) Mol Pharmacol , vol.60 , pp. 934-943
    • Cui, Y.1    Konig, J.2    Keppler, D.3
  • 5
    • 0032793959 scopus 로고    scopus 로고
    • OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine
    • Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, and Kim RB (1999) OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos 27:866-871.
    • (1999) Drug Metab Dispos , vol.27 , pp. 866-871
    • Cvetkovic, M.1    Leake, B.2    Fromm, M.F.3    Wilkinson, G.R.4    Kim, R.B.5
  • 7
    • 0026327875 scopus 로고
    • Regulation of 2-acetylaminofluorene-and 3-methylcholanthrene-mediated induction of multidrug resistance and cytochrome P450IA gene family expression in primary hepatocyte cultures and rat liver
    • Gant TW, Silverman JA, Bisgaard HC, Burt RK, Marino PA, and Thorgeirsson SS (1991) Regulation of 2-acetylaminofluorene-and 3-methylcholanthrene-mediated induction of multidrug resistance and cytochrome P450IA gene family expression in primary hepatocyte cultures and rat liver. Mol Carcinog 4:499-509.
    • (1991) Mol Carcinog , vol.4 , pp. 499-509
    • Gant, T.W.1    Silverman, J.A.2    Bisgaard, H.C.3    Burt, R.K.4    Marino, P.A.5    Thorgeirsson, S.S.6
  • 8
    • 0036889665 scopus 로고    scopus 로고
    • Endogenous drug transporters in in vitro and in vivo models for the prediction of drug disposition in man
    • Goh LB, Spears KJ, Yao D, Ayrton A, Morgan P, Roland Wolf C, and Friedberg T (2002) Endogenous drug transporters in in vitro and in vivo models for the prediction of drug disposition in man. Biochem Pharmacol 64:1569-1578.
    • (2002) Biochem Pharmacol , vol.64 , pp. 1569-1578
    • Goh, L.B.1    Spears, K.J.2    Yao, D.3    Ayrton, A.4    Morgan, P.5    Roland Wolf, C.6    Friedberg, T.7
  • 9
    • 0036206470 scopus 로고    scopus 로고
    • Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1) and canalicular multispecific organic anion transporter (cMOAT)
    • Guo A, Marinaro W, Hu P, and Sinko PJ (2002) Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1) and canalicular multispecific organic anion transporter (cMOAT). Drug Metab Dispos 30:457-463.
    • (2002) Drug Metab Dispos , vol.30 , pp. 457-463
    • Guo, A.1    Marinaro, W.2    Hu, P.3    Sinko, P.J.4
  • 10
    • 33645445093 scopus 로고    scopus 로고
    • Comparison of the P-glycoprotein-mediated transport of HMG-CoA reductase inhibitors across MDCK-MDR1 cell monolayers
    • online
    • Hirai S, Jacobson W, Djuvo S, Benet LZ, and Christians U (2001) Comparison of the P-glycoprotein-mediated transport of HMG-CoA reductase inhibitors across MDCK-MDR1 cell monolayers (Abstract). AAPS Pharm Sci 3:online.
    • (2001) AAPS Pharm Sci , vol.3
    • Hirai, S.1    Jacobson, W.2    Djuvo, S.3    Benet, L.Z.4    Christians, U.5
  • 11
    • 4644364576 scopus 로고    scopus 로고
    • Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans
    • Hirano M, Maeda K, Shitara Y, and Sugiyama Y (2004) Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. J Pharmacol Exp Ther 311:139-146.
    • (2004) J Pharmacol Exp Ther , vol.311 , pp. 139-146
    • Hirano, M.1    Maeda, K.2    Shitara, Y.3    Sugiyama, Y.4
  • 12
    • 0033601257 scopus 로고    scopus 로고
    • A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters
    • Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP, and Kirchgessner TG (1999) A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters. J Biol Chem 274:37161-37168.
    • (1999) J Biol Chem , vol.274 , pp. 37161-37168
    • Hsiang, B.1    Zhu, Y.2    Wang, Z.3    Wu, Y.4    Sasseville, V.5    Yang, W.P.6    Kirchgessner, T.G.7
  • 13
    • 0031726338 scopus 로고    scopus 로고
    • Adenosine triphosphate-dependent transport of estradiol-17beta(beta-D- glucuronide) in membrane vesicles by MDR1 expressed in insect cells
    • Huang L, Hoffman T, and Vore M (1998) Adenosine triphosphate-dependent transport of estradiol-17beta(beta-D-glucuronide) in membrane vesicles by MDR1 expressed in insect cells. Hepatology 28:1371-1377.
    • (1998) Hepatology , vol.28 , pp. 1371-1377
    • Huang, L.1    Hoffman, T.2    Vore, M.3
  • 14
    • 0035434397 scopus 로고    scopus 로고
    • Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A-reductase inhibitors (statins)
    • Igel M, Sudhop T, and von Bergmann K (2001) Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A-reductase inhibitors (statins). Eur J Clin Pharmacol 57:357-364.
    • (2001) Eur J Clin Pharmacol , vol.57 , pp. 357-364
    • Igel, M.1    Sudhop, T.2    Von Bergmann, K.3
  • 16
    • 9244254743 scopus 로고    scopus 로고
    • Functional analysis of single nucleotide polymorphisms of hepatic organic anion transporter OATP1B1 (OATP-C)
    • Iwai M, Suzuki H, Ieiri I, Otsubo K, and Sugiyama Y (2004) Functional analysis of single nucleotide polymorphisms of hepatic organic anion transporter OATP1B1 (OATP-C). Pharmacogenetics 14:749-757.
    • (2004) Pharmacogenetics , vol.14 , pp. 749-757
    • Iwai, M.1    Suzuki, H.2    Ieiri, I.3    Otsubo, K.4    Sugiyama, Y.5
  • 18
    • 0037733365 scopus 로고    scopus 로고
    • A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane
    • Konig J, Cui Y, Nies AT, and Keppler D (2000) A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am J Physiol Gastrointest Liver Physiol 278:G156-G164.
    • (2000) Am J Physiol Gastrointest Liver Physiol , vol.278
    • Konig, J.1    Cui, Y.2    Nies, A.T.3    Keppler, D.4
  • 19
    • 0344927562 scopus 로고    scopus 로고
    • Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity and MRP2-mediated drug resistance
    • Konig J, Nies AT, Cui Y, Leier I, and Keppler D (1999) Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity and MRP2-mediated drug resistance. Biochim Biophys Acta 1461:377-394.
    • (1999) Biochim Biophys Acta , vol.1461 , pp. 377-394
    • Konig, J.1    Nies, A.T.2    Cui, Y.3    Leier, I.4    Keppler, D.5
  • 22
    • 0033623722 scopus 로고    scopus 로고
    • Biliary excretion of 17beta-estradiol 17beta-D-glucuronide is predominantly mediated by cMOAT/MRP2
    • Morikawa A, Goto Y, Suzuki H, Hirohashi T, and Sugiyama Y (2000) Biliary excretion of 17beta-estradiol 17beta-D-glucuronide is predominantly mediated by cMOAT/MRP2. Pharm Res (NY) 17:546-552.
    • (2000) Pharm Res (NY) , vol.17 , pp. 546-552
    • Morikawa, A.1    Goto, Y.2    Suzuki, H.3    Hirohashi, T.4    Sugiyama, Y.5
  • 23
    • 0035012075 scopus 로고    scopus 로고
    • Human liver-specific organic anion transporter, LST-1, mediates uptake of pravastatin by human hepatocytes
    • Nakai D, Nakagomi R, Furuta Y, Tokui T, Abe T, Ikeda T, and Nishimura K (2001) Human liver-specific organic anion transporter, LST-1, mediates uptake of pravastatin by human hepatocytes. J Pharmacol Exp Ther 297:861-867.
    • (2001) J Pharmacol Exp Ther , vol.297 , pp. 861-867
    • Nakai, D.1    Nakagomi, R.2    Furuta, Y.3    Tokui, T.4    Abe, T.5    Ikeda, T.6    Nishimura, K.7
  • 26
    • 0037155204 scopus 로고    scopus 로고
    • Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and multidrug resistance-associated protein 2 (MRP2/ABCC2)
    • Sasaki M, Suzuki H, Ito K, Abe T, and Sugiyama Y (2002) Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and multidrug resistance-associated protein 2 (MRP2/ABCC2). J Biol Chem 277:6497-6503.
    • (2002) J Biol Chem , vol.277 , pp. 6497-6503
    • Sasaki, M.1    Suzuki, H.2    Ito, K.3    Abe, T.4    Sugiyama, Y.5
  • 27
    • 0028027840 scopus 로고
    • Multiple systems for the biliary excretion of organic anions in rats: Liquiritigenin conjugates as model compounds
    • Shimamura H, Suzuki H, Hanano M, Suzuki A, Tagaya O, Horie T, and Sugiyama Y (1994) Multiple systems for the biliary excretion of organic anions in rats: liquiritigenin conjugates as model compounds. J Pharmacol Exp Ther 271:370-378.
    • (1994) J Pharmacol Exp Ther , vol.271 , pp. 370-378
    • Shimamura, H.1    Suzuki, H.2    Hanano, M.3    Suzuki, A.4    Tagaya, O.5    Horie, T.6    Sugiyama, Y.7
  • 28
    • 0037310871 scopus 로고    scopus 로고
    • Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A
    • Shitara Y, Itoh T, Sato H, Li AP, and Sugiyama Y (2003) Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A. J Pharmacol Exp Ther 304:610-616.
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 610-616
    • Shitara, Y.1    Itoh, T.2    Sato, H.3    Li, A.P.4    Sugiyama, Y.5
  • 29
    • 0032434272 scopus 로고    scopus 로고
    • Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2
    • Suzuki H and Sugiyama Y (1998) Excretion of GSSG and glutathione conjugates mediated by MRP1 and cMOAT/MRP2. Semin Liver Dis 18:359-376.
    • (1998) Semin Liver Dis , vol.18 , pp. 359-376
    • Suzuki, H.1    Sugiyama, Y.2
  • 30
    • 0038265441 scopus 로고    scopus 로고
    • ABCG2 transports sulfated conjugates of steroids and xenobiotics
    • Suzuki M, Suzuki H, Sugimoto Y, and Sugiyama Y (2003) ABCG2 transports sulfated conjugates of steroids and xenobiotics. J Biol Chem 278:22644-22649.
    • (2003) J Biol Chem , vol.278 , pp. 22644-22649
    • Suzuki, M.1    Suzuki, H.2    Sugimoto, Y.3    Sugiyama, Y.4
  • 31
    • 0029026940 scopus 로고
    • Different biliary excretion systems for glucuronide and sulfate of a model compound; study using Eisai hyperbilirubinemic rats
    • Takenaka O, Horie T, Suzuki H, and Sugiyama Y (1995) Different biliary excretion systems for glucuronide and sulfate of a model compound; study using Eisai hyperbilirubinemic rats. J Pharmacol Exp Ther 274:1362-1369.
    • (1995) J Pharmacol Exp Ther , vol.274 , pp. 1362-1369
    • Takenaka, O.1    Horie, T.2    Suzuki, H.3    Sugiyama, Y.4
  • 32
    • 0033517778 scopus 로고    scopus 로고
    • Construction of Epstein-Barr virus-based expression vector containing mini-oriP
    • Tanaka J, Miwa Y, Miyoshi K, Ueno A, and Inoue H (1999) Construction of Epstein-Barr virus-based expression vector containing mini-oriP. Biochem Biophys Res Commun 264:938-943.
    • (1999) Biochem Biophys Res Commun , vol.264 , pp. 938-943
    • Tanaka, J.1    Miwa, Y.2    Miyoshi, K.3    Ueno, A.4    Inoue, H.5
  • 33
    • 0033975157 scopus 로고    scopus 로고
    • Role of P-glycoprotein in drug disposition
    • Tanigawara Y (2000) Role of P-glycoprotein in drug disposition. Ther Drug Monit 22:137-140.
    • (2000) Ther Drug Monit , vol.22 , pp. 137-140
    • Tanigawara, Y.1
  • 35
  • 36
    • 0034866642 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein
    • Wang E, Casciano CN, Clement RP, and Johnson WW (2001) HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein. Pharm Res (NY) 18:800-806.
    • (2001) Pharm Res (NY) , vol.18 , pp. 800-806
    • Wang, E.1    Casciano, C.N.2    Clement, R.P.3    Johnson, W.W.4
  • 37
    • 0030862073 scopus 로고    scopus 로고
    • Biliary excretion of pravastatin in rats: Contribution of the excretion pathway mediated by canalicular multispecific organic anion transporter
    • Yamazaki M, Akiyama S, Ni'inuma K, Nishigaki R, and Sugiyama Y (1997) Biliary excretion of pravastatin in rats: contribution of the excretion pathway mediated by canalicular multispecific organic anion transporter. Drug Metab Dispos 25:1123-1129.
    • (1997) Drug Metab Dispos , vol.25 , pp. 1123-1129
    • Yamazaki, M.1    Akiyama, S.2    Ni'inuma, K.3    Nishigaki, R.4    Sugiyama, Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.