pH dependence of organic anion-transporting polypeptide 2B1 in Caco-2 cells: Potential role in antiretroviral drug oral bioavailability and drug-drug interactions

Journal of Pharmacology and Experimental Therapeutics

Volumn 334, Issue 3, 2010, Pages 1009-1022

  Kis, Olena ^a   Zastre, Jason A ^a,b   Ramaswamy, Manisha ^a   Bendayan, Reina ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIUM CHLORIDE; ANTIRETROVIRUS AGENT; ATAZANAVIR; ESTRONE SULFATE; NELFINAVIR; ORGANIC ANION TRANSPORTER 2; ORGANIC ANION TRANSPORTER 2B1; PROTEINASE INHIBITOR; RITONAVIR; TIPRANAVIR; UNCLASSIFIED DRUG; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ESTRONE; OLIGOPEPTIDE; ORGANIC ANION TRANSPORTER; PYRIDINE DERIVATIVE; SLCO2B1 PROTEIN, HUMAN;

ACIDIFICATION; ANIMAL CELL; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG BIOAVAILABILITY; DRUG TRANSPORT; DRUG UPTAKE; HUMAN; HUMAN CELL; IC 50; IMMUNOBLOTTING; INTESTINE EPITHELIUM; NONHUMAN; NUCLEOTIDE SEQUENCE; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOICHIOMETRY; ACTIVE TRANSPORT; ALGORITHM; ANALOGS AND DERIVATIVES; ANIMAL; BIOAVAILABILITY; CACO 2 CELL LINE; CELL LINE; CHEMISTRY; DOG; DRUG INTERACTION; METABOLISM; PH; WESTERN BLOTTING;

ALGORITHMS; ANIMALS; ANTI-HIV AGENTS; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT, ACTIVE; BLOTTING, WESTERN; CACO-2 CELLS; CELL LINE; DOGS; DRUG INTERACTIONS; ESTRONE; HUMANS; HYDROGEN-ION CONCENTRATION; OLIGOPEPTIDES; ORGANIC ANION TRANSPORTERS; PYRIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RITONAVIR;

EID: 77956247876     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.166314     Document Type: Article

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