Aberrant B-Raf signaling in human cancer - 10 years from bench to bedside

Critical Reviews in Oncogenesis

Volumn 17, Issue 1, 2012, Pages 97-121

  Röring, Michael ^a   Brummer, Tilman ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

A raf; BRAF; CRAF; Dabrafenib; ERK; Kinase inhibitor; MEK; Raf 1; Sorafenib; Vemurafenib

Indexed keywords

2 [4 (2 DIMETHYLAMINOETHOXY)PHENYL] 4 (1 HYDROXYIMINO 5 INDANYL) 5 (4 PYRIDINYL) 1H IMIDAZOLE; ADENOSINE TRIPHOSPHATE; ARGININE; B RAF KINASE; B RAF KINASE INHIBITOR; DABRAFENIB; N [3 (5 CHLORO 1H PYRROLO[2,3 B]PYRIDINE 3 CARBONYL) 2,4 DIFLUOROPHENYL]PROPANESULFONAMIDE; RAF PROTEIN; VEMURAFENIB; ANTINEOPLASTIC AGENT; BRAF PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR;

AMINO TERMINAL SEQUENCE; ARTICLE; CARCINOGENESIS; CELL AGING; COLORECTAL CARCINOMA; DIMERIZATION; DRUG APPROVAL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME STRUCTURE; EPITHELIAL MESENCHYMAL TRANSITION; GLIA; HEMATOLOGIC MALIGNANCY; HUMAN; MELANOMA; METHYLATION; MUTATION; NONHUMAN; OLIGODENDROGLIA; ONCOGENE INDUCED SENESCENCE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; THYROID CARCINOMA; THYROID PAPILLARY CARCINOMA; ANIMAL; BIOLOGICAL MODEL; DRUG ANTAGONISM; DRUG EFFECT; DRUG RESISTANCE; GENETICS; HOSPITAL INFORMATION SYSTEM; METABOLISM; METHODOLOGY; MOLECULARLY TARGETED THERAPY; NEOPLASM; PHYSIOLOGY; REVIEW; TIME; TRANSLATIONAL RESEARCH; VALIDATION STUDY;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; DRUG RESISTANCE, NEOPLASM; HUMANS; MODELS, BIOLOGICAL; MOLECULAR TARGETED THERAPY; MUTATION; NEOPLASMS; POINT-OF-CARE SYSTEMS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS B-RAF; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSLATIONAL MEDICAL RESEARCH; VALIDATION STUDIES AS TOPIC;

EID: 84861490287     PISSN: 08939675     EISSN: 21626448     Source Type: Journal    
DOI: 10.1615/CritRevOncog.v17.i1.70     Document Type: Article

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