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Volumn 27, Issue 1, 2007, Pages 31-43

Differential regulation of B-Raf isoforms by phosphorylation and autoinhibitory mechanisms

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; ISOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; NUCLEOTIDE;

EID: 33845731247     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.01265-06     Document Type: Article
Times cited : (32)

References (60)
  • 2
    • 0028809479 scopus 로고
    • The mouse B-raf gene encodes multiple protein isoforms with tissue-specific expression
    • Barnier, J. V., C. Papin, A. Eychene, O. Lecoq, and G. Calothy. 1995. The mouse B-raf gene encodes multiple protein isoforms with tissue-specific expression. J. Biol. Chem. 270:23381-23389.
    • (1995) J. Biol. Chem. , vol.270 , pp. 23381-23389
    • Barnier, J.V.1    Papin, C.2    Eychene, A.3    Lecoq, O.4    Calothy, G.5
  • 3
    • 0034659736 scopus 로고    scopus 로고
    • Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes
    • Busca, R., P. Abbe, F. Mantoux, E. Aberdam, C. Peyssonnaux, A. Eychene, J. P. Ortonne, and R. Ballotti. 2000. Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes. EMBO J. 19:2900-2910.
    • (2000) EMBO J. , vol.19 , pp. 2900-2910
    • Busca, R.1    Abbe, P.2    Mantoux, F.3    Aberdam, E.4    Peyssonnaux, C.5    Eychene, A.6    Ortonne, J.P.7    Ballotti, R.8
  • 4
    • 0142211228 scopus 로고    scopus 로고
    • Mutation of B-Raf in human choroidal melanoma cells mediates cell proliferation and transformation through the MEK/ERK pathway
    • Calipel, A., G. Lefevre, C. Pouponnot, F. Mouriaux, A. Eychene, and F. Mascarelli. 2003. Mutation of B-Raf in human choroidal melanoma cells mediates cell proliferation and transformation through the MEK/ERK pathway. J. Biol. Chem. 278:42409-42418.
    • (2003) J. Biol. Chem. , vol.278 , pp. 42409-42418
    • Calipel, A.1    Lefevre, G.2    Pouponnot, C.3    Mouriaux, F.4    Eychene, A.5    Mascarelli, F.6
  • 5
    • 0027213924 scopus 로고
    • Genomic organization and nucleotide sequence of the coding region of the chicken c-Rmil(B-raf-1) proto-oncogene
    • Calogeraki, I., J. V. Barnier, A. Eychène, M. P. Felder, G. Calothy, and M. Marx. 1993. Genomic organization and nucleotide sequence of the coding region of the chicken c-Rmil(B-raf-1) proto-oncogene. Biochem. Biophys. Res. Commun. 193:1324-1331.
    • (1993) Biochem. Biophys. Res. Commun. , vol.193 , pp. 1324-1331
    • Calogeraki, I.1    Barnier, J.V.2    Eychène, A.3    Felder, M.P.4    Calothy, G.5    Marx, M.6
  • 6
    • 0141815693 scopus 로고    scopus 로고
    • Regulation of Raf through phosphorylation and N terminus-C terminus interaction
    • Chong, H., and K. L. Guan. 2003. Regulation of Raf through phosphorylation and N terminus-C terminus interaction. J. Biol. Chem. 278:36269-36276.
    • (2003) J. Biol. Chem. , vol.278 , pp. 36269-36276
    • Chong, H.1    Guan, K.L.2
  • 7
    • 28044443680 scopus 로고    scopus 로고
    • Alterations of the BRAF gene in thyroid tumors
    • Ciampi, R., and Y. E. Nikiforov. 2005. Alterations of the BRAF gene in thyroid tumors. Endocr. Pathol. 16:163-172.
    • (2005) Endocr. Pathol. , vol.16 , pp. 163-172
    • Ciampi, R.1    Nikiforov, Y.E.2
  • 12
    • 0036236897 scopus 로고    scopus 로고
    • Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259
    • Dhillon, A. S., C. Pollock, H. Steen, P. E. Shaw, H. Mischak, and W. Kolch. 2002. Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259. Mol. Cell. Biol. 22:3237-3246.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 3237-3246
    • Dhillon, A.S.1    Pollock, C.2    Steen, H.3    Shaw, P.E.4    Mischak, H.5    Kolch, W.6
  • 13
    • 0037373062 scopus 로고    scopus 로고
    • A Raf-1 mutant that dissociates MEK/extracellular signal-regulated kinase activation from malignant transformation and differentiation but not proliferation
    • Dhillon, A. S., S. Meikle, C. Peyssonnaux, J. Grindlay, C. Kaiser, H. Steen, P. E. Shaw, H. Mischak, A. Eychène, and W. Kolch. 2003. A Raf-1 mutant that dissociates MEK/extracellular signal-regulated kinase activation from malignant transformation and differentiation but not proliferation. Mol. Cell. Biol. 23:1983-1993.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 1983-1993
    • Dhillon, A.S.1    Meikle, S.2    Peyssonnaux, C.3    Grindlay, J.4    Kaiser, C.5    Steen, H.6    Shaw, P.E.7    Mischak, H.8    Eychène, A.9    Kolch, W.10
  • 15
    • 0041529686 scopus 로고    scopus 로고
    • Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras
    • Dumaz, N., and R. Marais. 2003. Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras. J. Biol. Chem. 278:29819-29823.
    • (2003) J. Biol. Chem. , vol.278 , pp. 29819-29823
    • Dumaz, N.1    Marais, R.2
  • 16
    • 22544463087 scopus 로고    scopus 로고
    • Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways
    • Dumaz, N., and R. Marais. 2005. Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways. FEBS J. 272:3491-3504.
    • (2005) FEBS J. , vol.272 , pp. 3491-3504
    • Dumaz, N.1    Marais, R.2
  • 17
    • 0026653195 scopus 로고
    • Quail neuroretina c-Rmil(B-raf) proto-oncogene cDNAs encode two proteins of 93.5 and 95 kDa resulting from alternative splicing
    • Eychène, A., J. V. Barnier, P. Dezélée, M. Marx, D. Laugier, I. Calogeraki, and G. Calothy. 1992. Quail neuroretina c-Rmil(B-raf) proto-oncogene cDNAs encode two proteins of 93.5 and 95 kDa resulting from alternative splicing. Oncogene 7:1315-1323.
    • (1992) Oncogene , vol.7 , pp. 1315-1323
    • Eychène, A.1    Barnier, J.V.2    Dezélée, P.3    Marx, M.4    Laugier, D.5    Calogeraki, I.6    Calothy, G.7
  • 20
    • 29144462587 scopus 로고    scopus 로고
    • Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization
    • Garnett, M. J., S. Rana, H. Paterson, D. Barford, and R. Marais. 2005. Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization. Mol. Cell 20:963-969.
    • (2005) Mol. Cell , vol.20 , pp. 963-969
    • Garnett, M.J.1    Rana, S.2    Paterson, H.3    Barford, D.4    Marais, R.5
  • 23
    • 0023265819 scopus 로고
    • Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors
    • Hughes, S. H., J. J. Greenhouse, C. J. Petropoulos, and P. Sutrave. 1987. Adaptor plasmids simplify the insertion of foreign DNA into helper-independent retroviral vectors. J. Virol. 61:3004-3012.
    • (1987) J. Virol. , vol.61 , pp. 3004-3012
    • Hughes, S.H.1    Greenhouse, J.J.2    Petropoulos, C.J.3    Sutrave, P.4
  • 24
    • 0037013143 scopus 로고    scopus 로고
    • The conformational plasticity of protein kinases
    • Huse, M., and J. Kuriyan. 2002. The conformational plasticity of protein kinases. Cell 109:275-282.
    • (2002) Cell , vol.109 , pp. 275-282
    • Huse, M.1    Kuriyan, J.2
  • 27
    • 0035811597 scopus 로고    scopus 로고
    • Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions
    • Jaumot, M., and J. F. Hancock. 2001. Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions. Oncogene 20:3949-3958.
    • (2001) Oncogene , vol.20 , pp. 3949-3958
    • Jaumot, M.1    Hancock, J.F.2
  • 29
    • 0037379904 scopus 로고    scopus 로고
    • High prevalence of BRAF mutations in thyroid cancer: Genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma
    • Kimura, E. T., M. N. Nikiforova, Z. Zhu, J. A. Knauf, Y. E. Nikiforov, and J. A. Fagin. 2003. High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res. 63:1454-1457.
    • (2003) Cancer Res. , vol.63 , pp. 1454-1457
    • Kimura, E.T.1    Nikiforova, M.N.2    Zhu, Z.3    Knauf, J.A.4    Nikiforov, Y.E.5    Fagin, J.A.6
  • 30
    • 20144372793 scopus 로고    scopus 로고
    • Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation
    • Knauf, J. A., X. Ma, E. P. Smith, L. Zhang, N. Mitsutake, X. H. Liao, S. Refetoff, Y. E. Nikiforov, and J. A. Fagin. 2005. Targeted expression of BRAFV600E in thyroid cells of transgenic mice results in papillary thyroid cancers that undergo dedifferentiation. Cancer Res. 65:4238-4245.
    • (2005) Cancer Res. , vol.65 , pp. 4238-4245
    • Knauf, J.A.1    Ma, X.2    Smith, E.P.3    Zhang, L.4    Mitsutake, N.5    Liao, X.H.6    Refetoff, S.7    Nikiforov, Y.E.8    Fagin, J.A.9
  • 33
    • 0033531946 scopus 로고    scopus 로고
    • Nerve growth factor-stimulated B-Raf catalytic activity is refractory to inhibition by cAMP-dependent protein kinase
    • MacNicol, M. C., and A. M. MacNicol. 1999. Nerve growth factor-stimulated B-Raf catalytic activity is refractory to inhibition by cAMP-dependent protein kinase. J. Biol. Chem. 274:13193-13197.
    • (1999) J. Biol. Chem. , vol.274 , pp. 13193-13197
    • MacNicol, M.C.1    MacNicol, A.M.2
  • 34
    • 0031041171 scopus 로고    scopus 로고
    • Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases
    • Marais, R., Y. Light, H. F. Paterson, C. S. Mason, and C. J. Marshall. 1997. Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases. J. Biol. Chem. 272:4378-4383.
    • (1997) J. Biol. Chem. , vol.272 , pp. 4378-4383
    • Marais, R.1    Light, Y.2    Paterson, H.F.3    Mason, C.S.4    Marshall, C.J.5
  • 35
    • 0024119653 scopus 로고
    • A novel oncogene related to c-mil is transduced in chicken neuroretina cells induced to proliferate by infection with an avian lymphomatosis virus
    • Marx, M., A. Eychène, D. Laugier, C. Béchade, P. Crisanti, P. Dezélée, B. Pessac, and G. Calothy. 1988. A novel oncogene related to c-mil is transduced in chicken neuroretina cells induced to proliferate by infection with an avian lymphomatosis virus. EMBO J. 7:3369-3373.
    • (1988) EMBO J. , vol.7 , pp. 3369-3373
    • Marx, M.1    Eychène, A.2    Laugier, D.3    Béchade, C.4    Crisanti, P.5    Dezélée, P.6    Pessac, B.7    Calothy, G.8
  • 37
    • 29244487538 scopus 로고    scopus 로고
    • Expression of endogenous oncogenic V600EB-Raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts
    • Mercer, K., S. Giblett, S. Green, D. Lloyd, S. Darocha Dias, M. Plumb, R. Marais, and C. Pritchard. 2005. Expression of endogenous oncogenic V600EB-Raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts. Cancer Res. 65:11493-11500.
    • (2005) Cancer Res. , vol.65 , pp. 11493-11500
    • Mercer, K.1    Giblett, S.2    Green, S.3    Lloyd, D.4    Darocha Dias, S.5    Plumb, M.6    Marais, R.7    Pritchard, C.8
  • 38
    • 0035798067 scopus 로고    scopus 로고
    • Involvement of B-Raf in Ras-induced Raf-1 activation
    • Mizutani, S., K. Inouye, H. Koide, and Y. Kaziro. 2001. Involvement of B-Raf in Ras-induced Raf-1 activation. FEBS Lett. 507:295-298.
    • (2001) FEBS Lett. , vol.507 , pp. 295-298
    • Mizutani, S.1    Inouye, K.2    Koide, H.3    Kaziro, Y.4
  • 39
    • 0042178312 scopus 로고    scopus 로고
    • Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites
    • Ory, S., M. Zhou, T. P. Conrads, T. D. Veenstra, and D. K. Morrison. 2003. Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites. Curr. Biol. 13:1356-1364.
    • (2003) Curr. Biol. , vol.13 , pp. 1356-1364
    • Ory, S.1    Zhou, M.2    Conrads, T.P.3    Veenstra, T.D.4    Morrison, D.K.5
  • 40
    • 0029971008 scopus 로고    scopus 로고
    • Identification of signalling proteins interacting with B-Raf in the yeast two-hybrid system
    • Papin, C., A. Denouel, G. Calothy, and A. Eychène. 1996. Identification of signalling proteins interacting with B-Raf in the yeast two-hybrid system. Oncogene 12:2213-2221.
    • (1996) Oncogene , vol.12 , pp. 2213-2221
    • Papin, C.1    Denouel, A.2    Calothy, G.3    Eychène, A.4
  • 41
    • 0032544525 scopus 로고    scopus 로고
    • Modulation of kinase activity and oncogenic properties by alternative splicing reveals a novel regulatory mechanism for B-Raf
    • Papin, C., A. Denouel-Galy, D. Laugier, G. Calothy, and A. Eychène. 1998. Modulation of kinase activity and oncogenic properties by alternative splicing reveals a novel regulatory mechanism for B-Raf. J. Biol. Chem. 273:24939-24947.
    • (1998) J. Biol. Chem. , vol.273 , pp. 24939-24947
    • Papin, C.1    Denouel-Galy, A.2    Laugier, D.3    Calothy, G.4    Eychène, A.5
  • 43
    • 0033835922 scopus 로고    scopus 로고
    • Induction of postmitotic neuroretina cell proliferation by distinct Ras downstream signaling pathways
    • Peyssonnaux, C., S. Provot, M. P. Felder-Schmittbuhl, G. Calothy, and A. Eychène. 2000. Induction of postmitotic neuroretina cell proliferation by distinct Ras downstream signaling pathways. Mol. Cell. Biol. 20:7068-7079.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 7068-7079
    • Peyssonnaux, C.1    Provot, S.2    Felder-Schmittbuhl, M.P.3    Calothy, G.4    Eychène, A.5
  • 44
    • 0034762203 scopus 로고    scopus 로고
    • The Raf/MEK/ERK pathway: New concepts of activation
    • Peyssonnaux, C., and A. Eychène. 2001. The Raf/MEK/ERK pathway: new concepts of activation. Biol. Cell 93:53-62.
    • (2001) Biol. Cell , vol.93 , pp. 53-62
    • Peyssonnaux, C.1    Eychène, A.2
  • 45
    • 0028877441 scopus 로고
    • Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells
    • Pritchard, C. A., M. L. Samuels, E. Bosch, and M. McMahon. 1995. Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells. Mol. Cell. Biol. 15:6430-6442.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 6430-6442
    • Pritchard, C.A.1    Samuels, M.L.2    Bosch, E.3    McMahon, M.4
  • 46
    • 0034644733 scopus 로고    scopus 로고
    • Cell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteins
    • Qiu, W., S. Zhuang, F. C., von Lintig, G. R. Boss, and R. B. Pilz. 2000. Cell type-specific regulation of B-Raf kinase by cAMP and 14-3-3 proteins. J. Biol. Chem. 275:31921-31929.
    • (2000) J. Biol. Chem. , vol.275 , pp. 31921-31929
    • Qiu, W.1    Zhuang, S.2    Von Lintig, F.C.3    Boss, G.R.4    Pilz, R.B.5
  • 47
    • 0030853961 scopus 로고    scopus 로고
    • Negative regulation of Rat activity by binding of 14-3-3 to the amino terminus of Raf in vivo
    • Rommel, C., G. Radziwill, K. Moelling, and E. Hafen. 1997. Negative regulation of Rat activity by binding of 14-3-3 to the amino terminus of Raf in vivo. Mech. Dev. 64:95-104.
    • (1997) Mech. Dev. , vol.64 , pp. 95-104
    • Rommel, C.1    Radziwill, G.2    Moelling, K.3    Hafen, E.4
  • 49
    • 17344369139 scopus 로고    scopus 로고
    • Directing NGFs actions: It's a Rap
    • Stork, P. J. 2005. Directing NGFs actions: it's a Rap. Nat. Cell Biol. 7:338-339.
    • (2005) Nat. Cell Biol. , vol.7 , pp. 338-339
    • Stork, P.J.1
  • 50
    • 16844385887 scopus 로고    scopus 로고
    • Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase
    • Terai, K., and M. Matsuda. 2005. Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase. EMBO Rep. 6:251-255.
    • (2005) EMBO Rep. , vol.6 , pp. 251-255
    • Terai, K.1    Matsuda, M.2
  • 51
    • 18144373477 scopus 로고    scopus 로고
    • B-Raf and RaM are regulated by distinct autoregulatory mechanisms
    • Tran, N. H., X. Wu, and J. A. Frost. 2005. B-Raf and RaM are regulated by distinct autoregulatory mechanisms. J. Biol. Chem. 280:16244-16253.
    • (2005) J. Biol. Chem. , vol.280 , pp. 16244-16253
    • Tran, N.H.1    Wu, X.2    Frost, J.A.3
  • 52
    • 0026486878 scopus 로고
    • Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor
    • Traverse, S., N. Gomez, H. Paterson, C. Marshall, and P. Cohen. 1992. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor. Biochem. J. 288:351-355.
    • (1992) Biochem. J. , vol.288 , pp. 351-355
    • Traverse, S.1    Gomez, N.2    Paterson, H.3    Marshall, C.4    Cohen, P.5
  • 53
    • 0030963439 scopus 로고    scopus 로고
    • cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
    • Vossler, M. R., H. Yao, R. D. York, M. G. Pan, C. S. Rim, and P. J. Stork. 1997. cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway. Cell 89:73-82.
    • (1997) Cell , vol.89 , pp. 73-82
    • Vossler, M.R.1    Yao, H.2    York, R.D.3    Pan, M.G.4    Rim, C.S.5    Stork, P.J.6
  • 55
    • 0035328521 scopus 로고    scopus 로고
    • Active Ras induces heterodimerization of cRaf and BRaf
    • Weber, C. K., J. R. Slupsky, H. A. Kalmes, and U. R. Rapp. 2001. Active Ras induces heterodimerization of cRaf and BRaf. Cancer Res. 61:3595-3598.
    • (2001) Cancer Res. , vol.61 , pp. 3595-3598
    • Weber, C.K.1    Slupsky, J.R.2    Kalmes, H.A.3    Rapp, U.R.4
  • 58
    • 0034675919 scopus 로고    scopus 로고
    • Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601
    • Zhang, B. H., and K. L. Guan. 2000. Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601. EMBO J. 19:5429-5439.
    • (2000) EMBO J. , vol.19 , pp. 5429-5439
    • Zhang, B.H.1    Guan, K.L.2
  • 59
    • 0035943615 scopus 로고    scopus 로고
    • Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf
    • Zhang, B. H., E. D. Tang, T. Zhu, M. E. Greenberg, A. B. Vojtek, and K. L. Guan. 2001. Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf. J. Biol. Chem. 276:31620-31626.
    • (2001) J. Biol. Chem. , vol.276 , pp. 31620-31626
    • Zhang, B.H.1    Tang, E.D.2    Zhu, T.3    Greenberg, M.E.4    Vojtek, A.B.5    Guan, K.L.6
  • 60
    • 0033607633 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Raf by Akt (protein kinase B)
    • Zimmermann, S., and K. Moelling. 1999. Phosphorylation and regulation of Raf by Akt (protein kinase B). Science 286:1741-1744.
    • (1999) Science , vol.286 , pp. 1741-1744
    • Zimmermann, S.1    Moelling, K.2


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