Biochemical and molecular characterization of the novel BRAF V599Ins mutation detected in a classic papillary thyroid carcinoma

Oncogene

Volumn 25, Issue 30, 2006, Pages 4235-4240

  Moretti, S ^a   Macchiarulo, A ^a   De Falco, V ^b   Avenia, N ^a   Barbi, F ^a   Carta, C ^c   Cavaliere, A ^a   Melillo, R M ^b   Passeri, L ^a   Santeusanio, F ^a   Tartaglia, M ^c   Santoro, M ^b   Puxeddu, E ^a,d  

^a UNIVERSITY OF PERUGIA   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^d Dipartimento di Medicina Interna   (Italy)

Author keywords

BRAF mutation; Kinase assay; Molecular dynamic simulation; Papillary thyroid carcinoma

Indexed keywords

B RAF KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PHOSPHOTRANSFERASE; S6 KINASE;

ARTICLE; CATALYSIS; CELL STRAIN 3T3; CELL TRANSFORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ELECTRICITY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME CONFORMATION; ENZYME DEGRADATION; ENZYME INACTIVATION; EVALUATION; GENE FUNCTION; GENE IDENTIFICATION; GENE INSERTION SEQUENCE; GENE MUTATION; GENETIC ANALYSIS; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MUTATIONAL ANALYSIS; PAPILLARY CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIMULATION; THYROID CARCINOMA;

AGED; ANIMALS; CARCINOMA, PAPILLARY; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; FEMALE; HUMANS; MICE; MUTAGENESIS, INSERTIONAL; NIH 3T3 CELLS; PROTO-ONCOGENE PROTEINS B-RAF; THERMODYNAMICS; THYROID NEOPLASMS; TRANSFECTION;

EID: 33746076323     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1209448     Document Type: Article

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