An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice

Journal of Clinical Investigation

Volumn 121, Issue 4, 2011, Pages 1344-1348

  Gronych, Jan ^a   Korshunov, Andrey ^b   Bageritz, Josephine ^a   Milde, Till ^a,c   Jugold, Manfred ^a   Hambardzumyan, Dolores ^d   Remke, Marc ^a,c   Hartmann, Christian ^b   Witt, Hendrik ^a,c   Jones, David T W ^a   Witt, Olaf ^a,c   Heiland, Sabine ^c   Bendszus, Martin ^c   Holland, Eric C ^d   Pfister, Stefan ^a,c   Lichter, Peter ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; MITOGEN ACTIVATED PROTEIN KINASE; SORAFENIB;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL PROLIFERATION; GENE OVEREXPRESSION; GENE TRANSFER; MOUSE; NEURAL STEM CELL; NEWBORN; NONHUMAN; PILOCYTIC ASTROCYTOMA; PRIORITY JOURNAL;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTOMA; BASE SEQUENCE; BRAIN NEOPLASMS; DISEASE MODELS, ANIMAL; DNA PRIMERS; ENZYME ACTIVATION; GENE TRANSFER TECHNIQUES; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; MUTATION; ONCOGENES; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS B-RAF;

EID: 79953308458     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI44656     Document Type: Article

References (18)

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