Unique N-region determines low basal activity and limited inducibility of A-RAF kinase: The role of N-region in the evolutionary divergence of RAF kinase function in vertebrates

Journal of Biological Chemistry

Volumn 282, Issue 36, 2007, Pages 26575-26590

  Baljuls, Angela ^a   Mueller, Thomas ^a   Drexler, Hannes C A ^a   Hekman, Mirko ^a   Rapp, Ulf R ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC DOMAIN; SERINES; THREONINE;

AMINO ACIDS; ANIMALS; CATALYST ACTIVITY; ENZYME INHIBITION; MOLECULAR MODELING;

ENZYME ACTIVITY;

A RAF KINASE; B RAF KINASE; C RAF KINASE; GLYCINE; TYROSINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; GENETIC TRANSFECTION; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

AMINO ACID SUBSTITUTION; ANIMALS; CATALYTIC DOMAIN; CERCOPITHECUS AETHIOPS; COS CELLS; ENZYME ACTIVATION; ENZYME INDUCTION; EVOLUTION, MOLECULAR; HUMANS; ISOENZYMES; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS A-RAF; PROTO-ONCOGENE PROTEINS B-RAF; PROTO-ONCOGENE PROTEINS C-RAF; STRUCTURE-ACTIVITY RELATIONSHIP;

MAMMALIA; VERTEBRATA;

EID: 34548847447     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M702429200     Document Type: Article

References (47)

1. Kieber, J. J., Rothenberg, M., Roman, G., Feldmann, K. A., and Ecker, J. R. (1993) Cell 72, 427-441
2. Han, M., Golden, A., Han, Y., and Sternberg, P. W. (1993) Nature 363, 133-140
3. Mark, G. E., MacIntyre, R. J., Digan, M. E., Ambrosio, L., and Perrimon, N. (1987) Mol. Cell. Biol. 7, 2134-2140
4. Bonner, T. I., Kerby, S. B., Sutrave, P., Gunnell, M. A., Mark, G., and Rapp, U. R. (1985) Mol. Cell. Biol. 5, 1400-1407
5. Daum, G., Eisenmann-Tappe, I., Fries, H. W., Troppmair, J., and Rapp, U. R. (1994) Trends Biochem. Sci. 19, 474-480
6. Huleihel, M., Goldsborough, M., Cleveland, J., Gunnell, M., Bonner, T., and Rapp, U. R. (1986) Mol. Cell. Biol. 6, 2655-2662
7. Ikawa, S., Fukui, M., Ueyama, Y., Tamaoki, N., Yamamoto, T., and Toyoshima, K. (1988) Mol. Cell. Biol. 8, 2651-2654
8. Rapp, U. R., Gotz, R., and Albert, S. (2006) Cancer Cell 9, 9-12
9. Hagemann, C., and Rapp, U. R. (1999) Exp. Cell Res. 253, 34-46
10. Yuryev, A., and Wennogle, L. P. (1998) Cell Res. 8, 81-98
11. Rizzo, M. A., Kraft, C. A., Watkins, S. C., Levitan, E. S., and Romero, G. (2001) J. Biol. Chem. 276, 34928-34933
12. Hekman, M., Hamm, H., Villar, A. V., Bader, B., Kuhlmann, J., Nickel, J., and Rapp, U. R. (2002) J. Biol. Chem. 277, 24090-24102
13. Hekman, M., Wiese, S., Metz, R., Albert, S., Troppmair, J., Nickel, J., Sendtner, M., and Rapp, U. R. (2004) J. Biol. Chem. 279, 14074-14086
14. Weber, C. K., Slupsky, J. R., Kalmes, H. A., and Rapp, U. R. (2001) Cancer Res. 61, 3595-3598
15. Garnett, M. J., Rana, S., Paterson, H., Barford, D., and Marais, R. (2005) Mol. Cell 20, 963-969
16. Rushworth, L. K., Hindley, A. D., O'Neill, E., and Kolch, W. (2006) Mol. Cell. Biol. 26, 2262-2272
17. Morrison, D. K., Heidecker, G., Rapp, U. R., and Copeland, T. D. (1993) J. Biol. Chem. 268, 17309-17316
18. Guan, K. L., Figueroa, C., Brtva, T. R., Zhu, T., Taylor, J., Barber, T. D., and Vojtek, A. B. (2000) J. Biol. Chem. 275, 27354-27359
19. Zhang, B. H., and Guan, K. L. (2000) EMBO J. 19, 5429-5439
20. Chong, H., Lee, J., and Guan, K. L. (2001) EMBO J. 20, 3716-3727
21. Zhu, J., Balan, V., Bronisz, A., Balan, K., Sun, H., Leicht, D. T., Luo, Z., Qin, J., Avruch, J., and Tzivion, G. (2005) Mol. Biol. Cell 16, 4733-4744
22. Muslin, A. J., Tanner, J. W., Allen, P. M., and Shaw, A. S. (1996) Cell 84, 889-897
23. Yaffe, M. B., Rittinger, K., Volinia, S., Caron, P. R., Aitken, A., Leffers, H., Gamblin, S. J., Smerdon, S. J., and Cantley, L. C. (1997) Cell 91, 961-971
24. Fabian, J. R., Daar, I. O., and Morrison, D. K. (1993) Mol. Cell. Biol. 13, 7170-7179
25. Diaz, B., Barnard, D., Filson, A., MacDonald, S., King, A., and Marshall, M. (1997) Mol. Cell. Biol. 17, 4509-4516
26. Marais, R., Light, Y., Paterson, H. F., Mason, C. S., and Marshall, C. J. (1997) J. Biol. Chem. 272, 4378-4383
27. Mason, C. S., Springer, C. J., Cooper, R. G., Superti-Furga, G., Marshall, C. J., and Marais, R. (1999) EMBO J. 18, 2137-2148
28. Blom, N., Gammeltoft, S., and Brunak, S. (1999) J. Mol. Biol. 294, 1351-1362
29. Zang, M., Waelde, C. A., Xiang, X., Rana, A., Wen, R., and Luo, Z. (2001) J. Biol. Chem. 276, 25157-25165
30. Wixler, V., Smola, U., Schuler, M., and Rapp, U. (1996) FEBS Lett. 385, 131-137
31. Zhang, X. F., Settleman, J., Kyriakis, J. M., Takeuchi-Suzuki, E., Elledge, S. J., Marshall, M. S., Bruder, J. T., Rapp, U. R., and Avruch, J. (1993) Nature 364, 308-313
32. Stokoe, D., Macdonald, S. G., Cadwallader, K., Symons, M., and Hancock, J. F. (1994) Science 264, 1463-1467
33. Rizzo, M. A., Shome, K., Watkins, S. C., and Romero, G. (2000) J. Biol. Chem. 275, 23911-23918
34. Wan, P. T., Garnett, M. J., Roe, S. M., Lee, S., Niculescu-Duvaz, D., Good, V. M., Jones, C. M., Marshall, C. J., Springer, C. J., Barford, D., and Marais, R. (2004) Cell 116, 855-867
35. King, A. J., Sun, H., Diaz, B., Barnard, D., Miao, W., Bagrodia, S., and Marshall, M. S. (1998) Nature 396, 180-183
36. King, A. J., Wireman, R. S., Hamilton, M., and Marshall, M. S. (2001) FEBS Lett. 497, 6-14
37. Chiloeches, A., Mason, C. S., and Marais, R. (2001) Mol. Cell. Biol. 21, 2423-2434
38. Ritt, D. A., Zhou, M., Conrads, T. P., Veenstra, T. D., Copeland, T. D., and Morrison, D. K. (2007) Curr. Biol. 17, 179-184
39. Meggio, F., and Pinna, L. A. (2003) FASEB J. 17, 349-368
40. Blom, N., Sicheritz-Ponten, T., Gupta, R., Gammeltoft, S., and Brunak, S. (2004) Proteomics 4, 1633-1649
41. Ghosh, S., Strum, J. C., Sciorra, V. A., Daniel, L., and Bell, R. M. (1996) J. Biol. Chem. 271, 8472-8480
42. Emuss, V., Garnett, M., Mason, C., and Marais, R. (2005) Cancer Res. 65, 9719-9726
43. Pinna, L. A., and Ruzzene, M. (1996) Biochim. Biophys. Acta 1314, 191-225
44. Zhou, J., Shin, H. G., Yi, J., Shen, W., Williams, C. P., and Murray, K. T. (2002) Circ. Res. 91, 540-546
45. Alessi, D. R., Caudwell, F. B., Andjelkovic, M., Hemmings, B. A., and Cohen, P. (1996) FEBS Lett. 399, 333-338
46. Leighton, I. A., Dalby, K. N., Caudwell, F. B., Cohen, P. T., and Cohen, P. (1995) FEBS Lett. 375, 289-293
47. Fischer, A., Hekman, M., Kuhlmann, J., Rubio, I., Wiese, S., and Rapp, U. R. (2007) J. Biol. Chem. 282, in press